Lack of mast cell reactivity during leukemic infiltration of the rat mesentery under syngeneic and allogeneic conditions
Tóm tắt
The ultrastructural morphology of mast cells localized in rat mesenteries was studied after intraperitoneal implantation of L 5222 rat leukemia cells in syngeneic and allogenic hosts. It became evident that the mast cells in the syngeneic (BDIX rat) as well as the allogeneic system (BN rat) showed nor morphological alterations. Degranulation was never observed. This is in contrast to the behavior of macrophages which displayed a strong phagocytotic activity in allogeneic hosts. Thus, it seems that mast cells, under the present experimental conditions, remained inactive during a phase of intense tumor rejection.
Tài liệu tham khảo
Bartholeyns J, Bouclier M (1984) Involvement of histamine in growth of mouse and rat tumors: Antitumoral properties of monofluoromethyhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Cancer Res 44: 639–645
Bienenstock J, Befus AD, Denburg J, Goodacre R, Pearce F, Shanahan F (1983) Mast cell heterogeneity. In: Monogr allergy 18. Karger, Basel, pp 124–128
Farram E, Nelson DS (1980) Mouse mast cells as anti-tumor effector cells. Cell Immunol 55: 294–301
Fawcett D (1955) An experimental study of mast cell degranulation and regeneration. Anat Rec 121: 29–51
Haemmerli G, Felix H (1977) Motility and cytoplasmic filamentous structures of L5222 and BNML leukemia cells. Leukemia Res 1: 209–218
Haemmerli G, Sträuli P (1978) Motility of L5222 leukemia cells within the mesentery. Virchows Arch [Cell Pathol] 29: 167–177
Hartveit F (1981) Mast cells and metachromasia in human breast cancer: Their occurrence, significance and consequence: A preliminary report. J Pathol 134: 7–11
Henderson WR, Chi EY, Jong EC, Klebanoff SJ (1981) Mast cell-mediated tumor-cell cytotoxicity. Role of the peroxidase system. J Exp Med 153: 520–533
Holgate ST (1983) Mast cells and their mediators. In: Holborow EJ, Reeves WG (eds) Immunology in medicine, second edition. Grune and Stratton, London New York, pp 79–94
Hoelzer D, Harris EB (1973) The failure of normal haemopoiesis in rats during the development of acute leukemia. Acta Hematol 49: 36–47
Hoelzer D, Calvo W, Meyer-Hamme K-D, Harris EB (1973) Cell distribution and proliferation pattern of a transferable acute leukemia in rats. JNCI 50: 1545–1553
Ivankovic S, Zeller WJ (1974) Leukämie L5222 des Rattenstammes BDIX. Eine durch Äthylnitrosoharnstoff induzierte monozytär-myeloische, transplantierbare Form für zytochemische und chemotherapeutische Studien. Blut XXVIII: 288–292
Nielson EH, Clausen J (1982) Short communication: Electron microscopic study of the regeneration in vivo of rat peritoneal mast cells after histamine secretion. Cell Tissue Res 224: 465–468
Piepkorn MW, Daynes RA (1983) Heparin effect on DNA synthesis in a murine fibrosarcoma cell line: Influence of anionic density. JNCI 71: 615–618
Pourreau-Schneider N, Felix H, Haemmerli G, Sträuli P (1977) The role of cellular locomotion in leukemic infiltration. An organ culture study on penetration of L 5222 in rat leukemia cells into the chick embryo mesonephros. Virchows Arch [Cell Pathol] 23: 257–264
Scott KG, Scheline RR, Stone RS (1958) Mast cells and sarcoma growth in the rat. Cancer Res 18: 927–931
Stäuli P, Haemmerli G, Tschenett C, Krstic RV (1981) Different modes of mesenteric infiltration displayed by two rat leukemias. A study by scanning and transmission electron microscopy and by microcinematography. Virchows Arch [Cell Pathol] 35: 93–108
Wilhelms OH (1980) Selective antigen-stimulated release of proteolytic activity from rat mast cells. Agents Actions 10: 498–502
Woolley DE (1984) Collagenolytic mechanisms in tumor cell invasion. Cancer Metast Rev 3: 361–372