Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province

Lawrence JS, Heberden Oration (1970) 1969: rheumatoid arthritis: nature or nurture? Ann Rheum Dis 29:357–379

Orozco G, Rueda B, Martin J (2006) Genetic basis of rheumatoid arthritis. Biomed Pharmacother 60:656–662

Wordsworth BP, Lanchbury JS, Sakkas LI, Welsh KI, Panayi GS, Bell JI (1989) HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA classII region. Proc Natl Acad Sci 86:10049–10053

Deighton CM, Walker DJ, Griffiths ID, Roberts DF (1989) The contribution of HLA to rheumatoid arthritis. Clin Genet 36:178–182

Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P, Barrera P et al (2004) The toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum 50:999–1001

Kilding R, Akil M, Till S, Amos R, Winfield J, Iles MM et al (2003) A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis. Clin Exp Rheumatol 21:340–342

Sanchez E, Orozco G, Lopez-Nevot MA, Jimenez-Alonso J, Martin J (2004) Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 63:54–57

Sheedy FJ, Marinou I, O’Neill LAJ, Wilson AG (2008) The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to or severity of rheumatoid arthritis. Ann Rheum Dis 67:1328–1331

Medzhitov R, Preston-Hurlburt P Jr, Janeway CA (1997) A human homologous of the drosophila toll protein signals activation of adaptive immunity. Nature 388:394–397

Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675–680

Poltorak A, He X, Smirnova I et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085–2088

Hoshino K, Takeuchi O, Kawai T et al (1999) Toll-like receptor 4 (TLR4)–deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749–3752

Ohashi K, Burkart V, Flohe S, Kolb H (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164:558–561

Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T et al (2002) Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor4. J Exp Med 195:99–111

Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J et al (2001) The extra domain A of fibronectin activates toll-like receptor 4. J Biol Chem 276:10229–10233

Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M et al (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187–191

Erridge C, Stewart J, Poxton IR (2003) Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 197:1787–1791

Hang JQ, Zhou W, Zhang HX et al (2004) TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population. J Endotoxin Res 10:238–240

Duan ZX, Zhu PF, Dong H et al (2007) Functional significance of the TLR4/11367 polymorphism identified in Chinese Han population. Shock 28:160–164

Guo QS, Xia B, Jiang Y et al (2005) Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients. Postgrad Med J 81:526–529

Cheng PL, Eng HL, Chou MH, You HL, Lin TM (2007) Genetic polymorphisms of viral infection associated Toll-like receptors in Chinese population. Transl Res 150:311–318

Lin YC, Chang YM, Yu JM, Yen JH, Chang JG, Hu CJ (2005) Toll-like receptor 4 gene C119A but no Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis 180:305–309

Okayama N, Fujimura K, Suehiro Y et al (2002) Simple genotype analysis of the Asp299Gly polymorphism of the toll like receptor 4 gene that is associated with lipopolysaccharide hyporesponsiveness. J Clin Lab Anal 16:56–58

Nakada TA, Hirasawa H, Oda S et al (2005) Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients. J Surg Res 129:322–328

Kim YS, Hwang YJ, Kim SY, Yang SM, Lee KY, Park IB (2008) Rarity of TLR4 Asp299Gly and Thr399Ile polymorphisms in the Korean population. Yonsei Med J 49:58–62

Mockenhaupt FP, Cramer JP, Hamann L et al (2006) Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci 103:177–182

Arbour NC, Lorenz E, Schutte BC et al (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187–191

Adam R, Sturrock RD, Gracie JA (2006) TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis. Ann Rheum Dis 65:1099–1101

Agnese DM, Calvano JE, Hahm SJ et al (2002) Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gramnegative infections. J Infect Dis 186:1522–1525

Carvalhoa A, Marquesb A, Maciela P, Rodrigues F (2007) Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel method applied to the analysis of the Portuguese population. Mol Cell Probes 21:316–320

Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, Aderem A (2005) Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires’ disease. Proc Natl Acad Sci 102:487–2489

Paulus SC, Hirschfeld AF, Victor RE, Brunstein J, Thomas E, Turvey SE (2007) Common human toll-like receptor 4 polymorphisms—role in susceptibility to respiratory syncytial virus infection and functional immunological relevance. Clin Immunol 123:252–257

Rezazadeh M, Hajilooi M, Rafiei A et al (2006) TLR4 polymorphism in Iranian patients with brucellosis. J Infect 53:206–210