La microbiota intestinal en el paciente crítico

de Nadal, 2011, Controlling gene expression in response to stress, Nat Rev Genet., 12, 833, 10.1038/nrg3055 Rao, 2008, Adrenergic polymorphism and the human stress response, Ann N Y Acad Sci., 1148, 282, 10.1196/annals.1410.085 Rautanen, 2015, Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study, The Lancet Respiratory medicine., 3, 53, 10.1016/S2213-2600(14)70290-5 Christie, 2012, Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma, PloS one., 7, e28268, 10.1371/journal.pone.0028268 Kertai, 2015, Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery, Am Heart J., 170, 10.1016/j.ahj.2015.06.009 Kertai, 2015, Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery, BMJ Open., 5, e006920, 10.1136/bmjopen-2014-006920 Stafford-Smith, 2015, Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci, Kidney Int., 88, 823, 10.1038/ki.2015.161 Lankelma, 2017, Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study, Intensive Care Med., 43, 59, 10.1007/s00134-016-4613-z Ojima M, Motooka D, Shimizu K, Gotoh K, Shintani A, Yoshiya K, et al. Metagenomic Analysis Reveals Dynamic Changes of Whole Gut Microbiota in the Acute Phase of Intensive Care Unit Patients. Dig Dis Sci. 61:1628-34. Buffie, 2013, Microbiota-mediated colonization resistance against intestinal pathogens, Nat Rev Immunol., 13, 790, 10.1038/nri3535 Schuijt, 2016, The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia, Gut., 65, 575, 10.1136/gutjnl-2015-309728 Robinson, 2014, Viruses and the Microbiota, Annu Rev Virol., 1, 55, 10.1146/annurev-virology-031413-085550 Pfeiffer, 2011, The intestinal microbiota and viral susceptibility, Front Microbiol., 2, 92, 10.3389/fmicb.2011.00092 Villarino, 2016, Composition of the gut microbiota modulates the severity of malaria, Proc Natl Acad Sci U S A., 113, 2235, 10.1073/pnas.1504887113 Zaborin, 2014, Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness, MBio., 5, e01361, 10.1128/mBio.01361-14 Mason, 2012, Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy, Infection and immunity, 80, 3371, 10.1128/IAI.00449-12 Hu, 2013, Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota, Nature communications., 4, 2151, 10.1038/ncomms3151 Pamer, 2016, Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens, Science., 352, 535, 10.1126/science.aad9382 van Vught, 2016, Incidence Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis, JAMA., 315, 1469, 10.1001/jama.2016.2691 Willing, 2011, Shifting the balance: antibiotic effects on host-microbiota mutualism, Nature reviews Microbiology., 9, 233, 10.1038/nrmicro2536 Alsan, 2015, Out-of-pocket health expenditures and antimicrobial resistance in low-income and middle-income countries: an economic analysis, The Lancet Infectious diseases., 15, 1203, 10.1016/S1473-3099(15)00149-8 Prestinaci, 2015, Antimicrobial resistance: a global multifaceted phenomenon, Pathog Glob Health., 109, 309, 10.1179/2047773215Y.0000000030 Agarwal, 2012, Intensive care unit experience of haemopoietic stem cell transplant patients, Intern Med J., 42, 748, 10.1111/j.1445-5994.2011.02533.x Kellum, 2013, Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1), Crit Care., 17, 204, 10.1186/cc11454 Russell PS, Mittal A, Brown L, McArthur C, Phillips AJ, Petrov M, et al. Admission, management and outcomes of acute pancreatitis in intensive care. ANZ J Surg. 2016. Mittal, 2016, Autoimmune Encephalitis in the ICU: Analysis of Phenotypes, Serologic Findings, and Outcomes. Neurocrit Care., 24, 240, 10.1007/s12028-015-0196-8 Kirkman, 2014, The intensive care management of acute ischemic stroke: an overview, Intensive Care Med., 40, 640, 10.1007/s00134-014-3266-z Trompette, 2014, Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis, Nature medicine., 20, 159, 10.1038/nm.3444 Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 500:232-6. Narushima, 2014, Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia, Gut microbes., 5, 333, 10.4161/gmic.28572 Mathewson, 2016, Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease, Nat Immunol., 17, 505, 10.1038/ni.3400 Reddy, 2004, Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect, Proc Natl Acad Sci U S A., 101, 3921, 10.1073/pnas.0400380101 Reddy, 2008, Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice, J Clin Invest., 118, 2562 Sun, 2009, Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3, J Immunol., 182, 5899, 10.4049/jimmunol.0804388 Taur, 2014, The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation, Blood., 124, 1174, 10.1182/blood-2014-02-554725 Jang, 2009, Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury, Am J Physiol Renal Physiol., 297, F1457, 10.1152/ajprenal.90769.2008 Andrade-Oliveira, 2015, Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion, J Am Soc Nephrol., 26, 1877, 10.1681/ASN.2014030288 Ochoa-Reparaz, 2010, Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression, J Immunol., 185, 4101, 10.4049/jimmunol.1001443 Ochoa-Reparaz, 2010, A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease, Mucosal Immunol., 3, 487, 10.1038/mi.2010.29 Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature., 472, 57, 10.1038/nature09922 Lam, 2012, Intestinal microbiota determine severity of myocardial infarction in rats, FASEB J., 26, 1727, 10.1096/fj.11-197921 Benakis, 2016, Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells, Nature medicine., 10.1038/nm.4068 Winek, 2016, Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke, Stroke., 47, 1354, 10.1161/STROKEAHA.115.011800 Yeh A, Rogers MB, Firek B, Neal MD, Zuckerbraun BS, Morowitz MJ. Dysbiosis Across Multiple Body Sites in Critically Ill Adult Surgical Patients. Shock. 46:649-54. Denny, 2016, Local and Long-Distance Calling: Conversations between the Gut Microbiota and Intra- and Extra-Gastrointestinal Tract Infections, Front Cell Infect Microbiol., 6, 41, 10.3389/fcimb.2016.00041 Lagunes, 2016, Invasive candidiasis: from mycobiome to infection, therapy, and prevention, European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology., 35, 1221, 10.1007/s10096-016-2658-0 Yooseph, 2015, Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection, BMC Genomics., 16, 631, 10.1186/s12864-015-1819-3 Ichinohe, 2011, Microbiota regulates immune defense against respiratory tract influenza A virus infection, Proc Natl Acad Sci U S A., 108, 5354, 10.1073/pnas.1019378108 Fagundes, 2012, Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice, J Immunol., 188, 1411, 10.4049/jimmunol.1101682 Antonopoulos, 2009, Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation, Infection and immunity., 77, 2367, 10.1128/IAI.01520-08 Kennedy, 1985, Effect of various antibiotics on gastrointestinal colonization and dissemination by Candida albicans, Sabouraudia., 23, 265, 10.1080/00362178585380391 Ostrosky-Zeichner, 2007, Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting, European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology., 26, 271, 10.1007/s10096-007-0270-z Cohen, 2010, Early prediction of Candida glabrata fungemia in nonneutropenic critically ill patients, Crit Care Med., 38, 826, 10.1097/CCM.0b013e3181cc4734 Savage, 1969, Microbial interference between indigenous yeast and lactobacilli in the rodent stomach, J Bacteriol., 98, 1278, 10.1128/JB.98.3.1278-1283.1969 Wagner, 2000, Probiotic effects of feeding heat-killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-colonized immunodeficient mice, J Food Prot., 63, 638, 10.4315/0362-028X-63.5.638 van der Waaij, 1974, Determination of the colonization resistance of the digestive tract of individual mice, J Hyg (Lond)., 72, 379, 10.1017/S0022172400023615 Van der Waaij, 1990, The colonization resistance of the digestive tract in different animal species and in man; a comparative study, Epidemiol Infect., 105, 237, 10.1017/S0950268800047841 Riddle, 2009, Clostridium difficile infection in the intensive care unit, Infect Dis Clin North Am., 23, 727, 10.1016/j.idc.2009.04.011 Seekatz, 2014, Clostridium difficile and the microbiota, J Clin Invest., 124, 4182, 10.1172/JCI72336 Yu, 2015, Identification of toxemia in patients with Clostridium difficile infection, PloS one., 10, e0124235, 10.1371/journal.pone.0124235 Milani, 2016, Gut microbiota composition and Clostridium difficile infection in hospitalized elderly individuals: a metagenomic study, Sci Rep., 6, 25945, 10.1038/srep25945 Rea, 2012, Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota, J Clin Microbiol., 50, 867, 10.1128/JCM.05176-11 Zhang, 2015, Insight into alteration of gut microbiota in Clostridium difficile infection and asymptomatic C. difficile colonization, Anaerobe., 34, 1, 10.1016/j.anaerobe.2015.03.008 Hirsch, 2015, Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection, BMC Infect Dis., 15, 191, 10.1186/s12879-015-0930-z Gough, 2011, Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection, Clin Infect Dis., 53, 994, 10.1093/cid/cir632 Donaldson, 2016, Gut biogeography of the bacterial microbiota, Nature reviews Microbiology., 14, 20, 10.1038/nrmicro3552 Baumler, 2016, Interactions between the microbiota and pathogenic bacteria in the gut, Nature., 535, 85, 10.1038/nature18849 Zipperer, 2016, Human commensals producing a novel antibiotic impair pathogen colonization, Nature., 535, 511, 10.1038/nature18634 Gutierrez, 2013, beta-Lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity, Nature communications., 4, 1610, 10.1038/ncomms2607 Prudhomme, 2006, Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae, Science., 313, 89, 10.1126/science.1127912 Claverys, 2006, Induction of competence regulons as a general response to stress in gram-positive bacteria, Annu Rev Microbiol., 60, 451, 10.1146/annurev.micro.60.080805.142139 Slager, 2014, Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin, Cell., 157, 395, 10.1016/j.cell.2014.01.068 Jee, 2016, Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing, Nature., 534, 693, 10.1038/nature18313 van Schaik, 2015, The human gut resistome, Philos Trans R Soc Lond B Biol Sci., 370, 20140087, 10.1098/rstb.2014.0087 Luyt CE, Brechot N, Trouillet JL, Chastre J. Antibiotic stewardship in the intensive care unit. Crit Care. 18:480. Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 13:1057-98. Salyers, 2004, Human intestinal bacteria as reservoirs for antibiotic resistance genes, Trends Microbiol., 12, 412, 10.1016/j.tim.2004.07.004 Shoemaker, 2001, Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon, Appl Environ Microbiol., 67, 561, 10.1128/AEM.67.2.561-568.2001 Iredell, 2016, Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications, BMJ., 352, h6420, 10.1136/bmj.h6420 Modi, 2014, Antibiotics and the gut microbiota, J Clin Invest., 124, 4212, 10.1172/JCI72333 Doucet-Populaire, 1991, Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice, Antimicrob Agents Chemother., 35, 185, 10.1128/AAC.35.1.185 Stecher, 2012, Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae, Proc Natl Acad Sci U S A., 109, 1269, 10.1073/pnas.1113246109 Modi, 2013, Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome, Nature., 499, 219, 10.1038/nature12212 Brandl, 2008, Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits, Nature., 455, 804, 10.1038/nature07250