LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings

Springer Science and Business Media LLC
Kefaya El-Sayed1, Amany R. Youssef1, Nicola Hay, A. Osman2
1Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
2Cardiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Tóm tắt

Abstract Background Coronary artery disease (CAD) is the main cause of death in Egypt. Many LDL-R gene locus single nucleotide polymorphisms (SNP) are found to be associated with the risk of CAD. This research aimed to assess the allelic and genotypic frequencies of rs1122608 SNP and their association with the extent of vessel affection and lipid profile in a population of Egyptians.100 CAD patients and 100 healthy controls of Egyptians were included. PCR–RFLP was used to genotype rs1122608 SNPs. Results Significantly higher proportion of ‘T’ allele among patient (risk allele). This association is of low strength (ϕ lies between 0.1 and 0.3). A participant with ‘T’ allele has 1.95 times higher odds to exhibit CAD versus a participant with ‘G’ allele. Significantly higher proportion of ‘T/T’ genotype among cases versus control (risk genotype). This association is of low strength (Cramer’s V lies between 0.1 and 0.3). A participant with ‘T/T’ genotype has 4.5 times higher odds to exhibit CAD versus a participant with ‘G/G’. Gensini score showed no significant association with rs1122608 genotypes (p = 0.863). Conclusions The mutant GT and TT genotypes and minor T allele of rs1122608 were positively correlated with CAD and considered as independent risk factors for CAD.

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