Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver

Journal of Hepatology - Tập 32 - Trang 900-910 - 2000
Harri A Järveläinen1, Che Fang2, Magnus Ingelman-Sundberg2, Tuomo A Lukkari1, Helmuth Sippel3, Kai O Lindros
1Alcohol Research Center, National Public Health Institute, Finland
2Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
3Department of Forensic Medicine, University of Helsinki, Finland

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Simpson, 1997, Cytokines and the liver, J Hepatol, 27, 1120, 10.1016/S0168-8278(97)80160-2 Bode, 1987, Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess, J Hepatol, 4, 8, 10.1016/S0168-8278(87)80003-X Nanji, 1994, Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease, Proc Soc Exp Biol Med, 205, 243, 10.3181/00379727-205-43703 Järveläinen, 1999, Effect of chronic co-administration of endotoxin and ethanol on rat liver pathology and pro- and anti-inflammatory cytokines, Hepatology, 29, 1503, 10.1002/hep.510290508 Adachi, 1995, Antibiotics prevent liver injury in rats following long-term exposure to ethanol, Gastroenterology, 108, 218, 10.1016/0016-5085(95)90027-6 Hansen, 1994, The role of tumor necrosis factor-α in acute endotoxin-induced hepatotoxicity in ethanol-fed rats, Hepatology, 20, 461, 10.1002/hep.1840200228 Järveläinen, 1997, Alcohol-induced expression of the CD14 endotoxin receptor protein in rat Kupffer cells, Alcohol Clin Exp Res, 21, 1547, 10.1111/j.1530-0277.1997.tb04488.x Morimoto, 1993, Role of cytochrome P4502E1 in alcohol liver disease pathogenesis, Alcohol, 10, 459, 10.1016/0741-8329(93)90065-V Lindros, 1995, Alcoholic liver disease: pathobiological aspects, J Hepatol, 7, 10.1016/S0168-8278(21)80001-X Morimoto, 1995, Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors, Hepatology, 21, 1610 Ekstöm, 1989, Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-450 IIE1), Biochem Pharmacol, 38, 1313, 10.1016/0006-2952(89)90338-9 Ingelman-Sundberg, 1993, Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease, Alcohol, 10, 447, 10.1016/0741-8329(93)90063-T Koop, 1992, Oxidative and reductive metabolism by cytochrome P-450 2E1, FASEB J, 6, 724, 10.1096/fasebj.6.2.1537462 Fang, 1998, Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole, Hepatology, 27, 1304, 10.1002/hep.510270516 Koop, 1997, Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1, Mol Pharmacol, 51, 944, 10.1124/mol.51.6.944 Tsukamoto, 1985, Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet, Hepatology, 5, 224, 10.1002/hep.1840050212 Abril, 1997, Binge-type alcohol intake recruits immune cells into rat liver and stimulates Kupffer cell release of cytokines and superoxide prior to any evidence of overt liver injury, 303 Enomoto, 1998, Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin, Gastroenterology, 115, 443, 10.1016/S0016-5085(98)70211-2 Abril, 1995, Enhanced Kupffer cell function characterizes the recovery period following binge type alcohol intake in rats, 75 Zhong, 1999, Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers, J Pharmacol Exp Ther, 290, 611 Lindros, 1998, A new oral low-carbohydrate alcohol liquid diet producing liver lesions: a preliminary account, Alcohol Alcohol, 33, 347, 10.1093/oxfordjournals.alcalc.a008403 Laskin, 1997, Role of hepatic macrophages in inflammation and tissue injury, 161 Saarinen, 1993, A rapid method to study heterogenous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates, Hepatology, 17, 466, 10.1002/hep.1840170317 Quistorff, 1987, Dual-digitonin perfusion. Concurrent sampling of periportal and perivenous cytosols of rat liver for determination of metabolites and enzyme activities, Biochem J, 243, 87, 10.1042/bj2430087 Lindros, 1985, Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes, Biochem J, 228, 757, 10.1042/bj2280757 Hu, 1995, Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation, Biochem Pharmacol, 50, 155, 10.1016/0006-2952(95)00128-M Johansson, 1988, Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies, Biochemistry, 27, 1925, 10.1021/bi00406a019 Koop, 1986, The hydroxylation of p-nitrophenol by rabbit ethanol-inducible P450 isoenzyme 3a, Mol Pharmacol, 29, 399 Habig, 1974, Glutathione S-transferase. The first enzymatic step in mercapturic acid formation, J Biol Chem, 249, 7130, 10.1016/S0021-9258(19)42083-8 Carmagnol, 1983, Selenium-dependent and non-selenium-dependent glutathione peroxidases in human tissue extracts, Biochim Biophys Acta, 759, 49, 10.1016/0304-4165(83)90188-5 Oinonen, 1995, Hormonal regulation of the zonated expression of cytochrome P450 3A in rat liver, Biochem J, 309, 55, 10.1042/bj3090055 Katz, 1990, Rapid analysis and purification of polymerase chain reaction products by high-performance liquid chromatography, Biotechniques, 8, 546 Lindros, 1997, Selective centrilobular expression of the aryl hydrocarbon receptor in rat liver, J Pharmacol Exp Ther, 280, 506 Dijkstra, 1985, The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3, Immunology, 54, 589 Hardonk, 1992, Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopoulation, J Leukoc Biol, 52, 296, 10.1002/jlb.52.3.296 Kilty, 1998, Glutathione S-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays, Chem Biol Interact, 24, 123, 10.1016/S0009-2797(97)00156-7 Day, 1998, Hepatic steatosis: innocent bystander or guilty party?, Hepatology, 27, 1463, 10.1002/hep.510270601 Bhagwandeen, 1987, Endotoxin induced hepatic necrosis in rats on an alcohol diet, J Pathol, 152, 47, 10.1002/path.1711520107 Caraceni, 1997, Rat hepatocytes isolated from alcohol-induced fatty liver have an increased sensitivity to anoxic injury, Hepatology, 25, 943, 10.1002/hep.510250426 Rai, 1996, Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines, Shock, 6, 243, 10.1097/00024382-199610000-00003 Roland, 1999, Gadolinium blocks rat kupffer cell calcium channels: relevance to calcium-dependent prostaglandin E2 synthesis and septic mortality, Hepatology, 29, 756, 10.1002/hep.510290345 Wright, 1990, Mathison JC: CD14, a receptor of lipopolysaccharide-binding protein, Science, 249, 1429, 10.1126/science.1698311 Tomita, 1994, Immunohistochemical phenotyping of liver macrophages in normal and diseased human liver, Hepatology, 20, 317, 10.1002/hep.1840200208 Matsuura, 1994, Upregulation of mouse CD14 expression in Kupffer cells by lipopolysaccharide, J Exp Med, 179, 1671, 10.1084/jem.179.5.1671 Su, 1998, CD14 and lipopolysaccharide binding protein expression in a rat model of alcoholic liver disease, Am J Pathol, 152, 841 Liu, 1998, Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia, Infect Immun, 66, 5089, 10.1128/IAI.66.11.5089-5098.1998 Ahmad, 1999, Inhibition of macrophages with gadolinium chloride alters intercellular adhesion molecule-1 expression in the liver during acute endotoxemia in rats, Hepatology, 29, 728, 10.1002/hep.510290324 Rüttinger, 1996, In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade, J Hepatol, 25, 960, 10.1016/S0168-8278(96)80302-3 Armbrust, 1996, Functional characterization of two different Kupffer cell populations of normal rat liver, J Hepatol, 25, 518, 10.1016/S0168-8278(96)80212-1 Qu, 1998, Stimulation of oxygen uptake by prostaglandin E2 is oxygen dependent in perfused rat liver, Am J Physiol, 275, G542 Su, 1995, Lipopolysaccharide binding protein participation in cellular activation by LPS, Crit Rev Immunol, 15, 201, 10.1615/CritRevImmunol.v15.i3-4.10 Wan, 1995, Role of lipopolysaccharide (LPS), interleukin-1, interleukin-6, tumor necrosis factor, and dexamethasone in regulation of LPS-binding protein expression in normal hepatocytes and hepatocytes from LPS-treated rats, Infect Immun, 63, 2435, 10.1128/IAI.63.7.2435-2442.1995 Schumann, 1996, The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins, Mol Cell Biol, 16, 3490, 10.1128/MCB.16.7.3490 Albano, 1996, Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol, Hepatology, 23, 155, 10.1002/hep.510230121 Ingelman-Sundberg, 1988, Lipid peroxidation dependent on ethanol-inducible cytochrome P-450 from rat liver, Adv Biosci, 71, 43 Morimoto, 1995, Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors, Hepatology, 21, 1610 Koop, 1991, Identification and induction of cytochrome P450 2E1 in rat Kupffer cells, J Pharmacol Exp Ther, 258, 1072 Morgan, 1997, Regulation of cytochromes P450 during inflammation and infection, Drug Metab Rev, 29, 1129, 10.3109/03602539709002246 Badger, 1997, Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity, Toxicology, 121, 143, 10.1016/S0300-483X(97)00065-6 Ingelman-Sundberg, 1988, Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver, Biochem Biophys Res Commun, 157, 55, 10.1016/S0006-291X(88)80010-X Kera, 1987, Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes, Biochem Pharmacol, 36, 2003, 10.1016/0006-2952(87)90500-4 Ishii, 1997, Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress, J Gastroenterol Hepatol, 12, S272, 10.1111/j.1440-1746.1997.tb00510.x Blum, 1995, Inactivation of glutathione peroxidase by superoxide radical, Arch Biochem Biophys, 240, 500, 10.1016/0003-9861(85)90056-6 Rouach, 1997, Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology, Hepatology, 25, 351, 10.1002/hep.510250216 Enomoto, 1999, Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells, Hepatology, 29, 1680, 10.1002/hep.510290633