Kognition und Epilepsien

Der Nervenarzt - Tập 79 - Trang 77-92 - 2008
H. Stefan1, E. Pauli1
1Epilepsiezentrum – Neurologische Klinik, Universitätsklinikum Erlangen, Erlangen, Deutschland

Tóm tắt

Die vorliegenden Befunde sprechen insgesamt dafür, dass kognitive Defizite in unterschiedlichem Ausmaß bei chronischen, auch nicht symptomatischen Epilepsien initial vorhanden und als Symptome im Rahmen der den Anfällen zugrunde liegenden oder deren Entwicklung begleitenden hirnphysiologischen Veränderungen aufzufassen sind. Der mutmaßlich additive Effekt der Anfälle ist noch eine nicht abschließend beantwortete Frage. Sekundär kann das Ausmaß der kognitiven Beeinträchtigung über einen 3 Jahrzehnte langen, ungünstigen Verlauf mit häufigen sekundär generalisierten Anfällen hinweg zunehmen. Hier ist die Untersuchung von Langzeitverläufen der kognitiven Leistungen bei den verschiedenen Epilepsiesyndromen wichtig, um deren Rolle bei der kognitiven Entwicklung zu erforschen. Aber auch die erfolgreiche Behandlung birgt Risiken. So stehen bei der operativen Behandlung linksseitiger Temporallappenepilepsie Gedächtnisdefizite im Vordergrund. Die kognitiven Nebenwirkungen der medikamentösen Behandlung können für den Patienten erheblich benachteiligende Wirkungen haben. Die Notwendigkeit ihrer individuellen Erfassung rückt heute zunehmend in den Blickpunkt der Aufmerksamkeit. Sie liefert die Voraussetzung für eine individuell optimierte medikamentöse und epilepsiechirurgische Therapie.

Tài liệu tham khảo

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