Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice

Renzi, 2013, Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats, Hepatology, 57, 1130, 10.1002/hep.26105 Glaser, 2014, Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice, Gastroenterology, 146, 1795, 10.1053/j.gastro.2014.02.030 Desmet, 1995, Histopathology of cholestasis, Verh Dtsch Ges Pathol, 79, 233 Li, 2004, The pathology of cholestasis, Semin Liv Dis, 24, 21, 10.1055/s-2004-823099 Alpini, 1988, Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules, J Clin Invest, 81, 569, 10.1172/JCI113355 Glaser, 2009, Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium, Lab Invest, 89, 456, 10.1038/labinvest.2009.6 Han, 2014, Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis, Am J Physiol Gastrointest Liver Physiol, 307, G894, 10.1152/ajpgi.00288.2014 Alpini, 1998, Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation, Am J Physiol Gastrointest Liver Physiol, 274, G767, 10.1152/ajpgi.1998.274.4.G767 Alvaro, 2007, Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver, Gastroenterology, 132, 415, 10.1053/j.gastro.2006.07.023 Maroni, 2015, Functional and structural features of cholangiocytes in health and disease, Cell Mol Gastroenterol Hepatol, 1, 368, 10.1016/j.jcmgh.2015.05.005 Hall C, Sato K, Wu N et al, Regulators of cholangiocyte proliferation. Gene Expr 2016, (E-pub ahead of print). Wells, 2008, Cellular sources of extracellular matrix in hepatic fibrosis, Clin Liver Dis, 12, 759, 10.1016/j.cld.2008.07.008 Friedman, 2000, Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury, J Biol Chem, 275, 2247, 10.1074/jbc.275.4.2247 Wallace, 2008, Liver fibrosis, Biochem J, 411, 1, 10.1042/BJ20071570 Friedman, 2008, Hepatic fibrosis – overview, Toxicology, 254, 120, 10.1016/j.tox.2008.06.013 Wu, 2016, The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF-beta1 biliary secretion, Hepatology, 64, 865, 10.1002/hep.28622 Kerr, 2011, MicroRNAs and liver disease, Trans Res, 157, 241, 10.1016/j.trsl.2011.01.008 Fabian, 2010, Regulation of mRNA translation and stability by microRNAs, Annu Rev Biochem, 79, 351, 10.1146/annurev-biochem-060308-103103 Djuranovic, 2012, miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay, Science, 336, 237, 10.1126/science.1215691 Alisi, 2011, Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease, Lab Invest, 91, 283, 10.1038/labinvest.2010.166 Pogribny, 2010, Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice, Lab Invest, 90, 1437, 10.1038/labinvest.2010.113 Murakami, 2011, The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families, PLoS One, 6, e16081, 10.1371/journal.pone.0016081 Meng, 2007, MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer, Gastroenterology, 133, 647, 10.1053/j.gastro.2007.05.022 Chusorn, 2013, Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis, Tumour Biol, 34, 1579, 10.1007/s13277-013-0688-0 Dattaroy, 2015, Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis, Am J Physiol Gastrointest Liver Physiol, 308, G298, 10.1152/ajpgi.00346.2014 Francis, 2014, Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury, J Biol Chem, 289, 27526, 10.1074/jbc.M114.602383 Venter, 2015, Development and functional characterization of extrahepatic cholangiocyte lines from normal rats, Dig Liver Dis, 47, 964, 10.1016/j.dld.2015.07.012 de Vree, 1998, Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis, Proc Natl Acad Sci USA, 95, 282, 10.1073/pnas.95.1.282 Graf, 2014, Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling, Am J Physiol Gastrointest Liver Physiol, 307, G813, 10.1152/ajpgi.00188.2014 Friedman, 2008, Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol Rev, 88, 125, 10.1152/physrev.00013.2007 Kennedy, 2014, Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents, Lab Invest, 94, 1406, 10.1038/labinvest.2014.129 LeSage, 1996, Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion, Gastroenterology, 111, 1633, 10.1016/S0016-5085(96)70027-6 DeMorrow, 2013, Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms, Am J Physiol Gastrointest Liver Physiol, 305, G250, 10.1152/ajpgi.00140.2013 Baghdasaryan, 2010, Curcumin improves sclerosing cholangitis in Mdr2−/− mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation, Gut, 59, 521, 10.1136/gut.2009.186528 Glaser, 2007, Knockout of alpha-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice, Lab Invest, 87, 914, 10.1038/labinvest.3700602 Khanizadeh, 2015, Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells, Gastroenterol Hepatol Bed Bench, 8, 262 Wei, 2013, MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling, Biomed Pharmacother, 67, 387, 10.1016/j.biopha.2013.03.014 Zhang, 2013, 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression, Br J Pharmacol, 170, 649, 10.1111/bph.12323 Sayed, 2008, MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths, Mol Biol Cell, 19, 3272, 10.1091/mbc.e08-02-0159 Lu, 2014, miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth, Mol Cancer Res, 12, 890, 10.1158/1541-7786.MCR-13-0419 Wang, 2015, MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitroin vivo by targeting PTPN14 and PTEN, Oncotarget, 6, 5932, 10.18632/oncotarget.3465 Krichevsky, 2009, miR-21: a small multi-faceted RNA, J Cell Mol Med, 13, 39, 10.1111/j.1582-4934.2008.00556.x Chang, 2010, Hepatic stellate cell-specific gene silencing induced by an artificial microRNA for antifibrosis in vitro, Dig Dis Sci, 55, 642, 10.1007/s10620-009-1021-z Maubach, 2011, miRNA studies in in vitroin vivo activated hepatic stellate cells, World J Gastroenterol, 17, 2748, 10.3748/wjg.v17.i22.2748 Marquez, 2010, Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans, Lab Invest, 90, 1727, 10.1038/labinvest.2010.126 Kinnman, 2003, The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis, Lab Invest, 83, 163, 10.1097/01.LAB.0000054178.01162.E4 Kinnman, 2001, Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury, Lab Invest, 81, 1709, 10.1038/labinvest.3780384 Masyuk, 2010, Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia, Am J Physiol Gastrointest Liver Physiol, 299, G990, 10.1152/ajpgi.00093.2010 Castoldi, 2016, Isolation and characterization of vesicular and non-vesicular microRNAs circulating in sera of partially hepatectomized rats, Sci Rep, 6, 31869, 10.1038/srep31869