Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

Neuron - Tập 16 Số 3 - Trang 675-686 - 1996
Jeffrey D. Rothstein1, Margaret Dykes‐Hoberg1, Carlos A. Pardo2, Lynn A. Bristol1, Jin Li1, Ralph W. Kuncl1, Yoshikatsu Kanai3, Matthias A. Hediger4, Yanfeng Wang5, Jerry P Schielke6, Devin Welty5
1Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
2Department of Neuropathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
3Department of Pharmacology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo, 181, Japan
4Department of Medicine, Renal Division, Brigham and Woman's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
5Department of Pharmacokinetics and Drug, Metabolism, USA
6Department of Neuroscience Pharmacology, Parke–Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA

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Tài liệu tham khảo

Arriza, 1994, Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex, J. Neurosci, 14, 5559, 10.1523/JNEUROSCI.14-09-05559.1994

Attwell, 1993, Nonvesicular release of neurotransmitter, Neuron, 11, 401, 10.1016/0896-6273(93)90145-H

Barks, 1994, The glutamate uptake inhibitor L-trans-2,4-pyrrolidine dicarboxylate is neurotoxic in neonatal rat brain, Mol. Chem. Neuropath, 23, 201, 10.1007/BF02815412

Fairman, 1995, An excitatory amino-acid transporter with properties of a ligand-gated chloride channel, Nature, 375, 599, 10.1038/375599a0

Hajos, 1986, Reversible and irreversible neuronal damage caused by excitatory amino acid analogues in rat cerebellar slices, J. Neurosci, 18, 417, 10.1016/0306-4522(86)90163-6

Hertz, 1979, Functional interactions between neurons and astrocytes. I. Turnover and metabolism of putative amino acid transmitters, Prog. Neurobiol, 13, 277, 10.1016/0301-0082(79)90018-2

Isaacson, 1993, The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus, J. Neurophysiol, 70, 2187, 10.1152/jn.1993.70.5.2187

Kanai, 1992, Primary structure and functional characterization of a high affinity glutamate transporter, Nature, 360, 467, 10.1038/360467a0

Kanai, Y., and Hediger, M.A. (1995). High affinity glutamate transporters: physiological and pathophysiological relevance in the central nervous system. In Excitatory Amino Acids, D.W. Brann and V.B. Mahesh, eds. (Boca Ratan, FL: CRC Press), in press.

Kanai, 1995, Neuronal high affinity glutamate transport in the rat central nervous system, Neuroreport, 6, 2357, 10.1097/00001756-199511270-00020

Kanai, 1995, Electrogenic properties of the epithelial and neuronal high affinity glutamate transporter, (, 1995). J. Biol. Chem., 16561

Lehre, 1995, Differential expression of two glutamate transporters in rat brain, J. Neurosci, 15, 1835, 10.1523/JNEUROSCI.15-03-01835.1995

Maki, 1994, The glutamate uptake inhibitor L-trans- pyrrolidine-2,4-dicarboxylate depresses excitatory synaptic transmission via a presynaptic mechanism in cultured hippocampal neurons, J. Neurosci, 14, 6754, 10.1523/JNEUROSCI.14-11-06754.1994

Mennerick, 1994, Glial contributions to excitatory neurotransmission in cultured hippocampal cells, Nature, 368, 59, 10.1038/368059a0

Merlis, 1940, Artificial cerebrospinal fluid, Amer. J. Physiol, 131, 67, 10.1152/ajplegacy.1940.131.1.67

Nicholls, 1990, The release and uptake of excitatory amino acids, Trends Pharmacol. Sci, 11, 462, 10.1016/0165-6147(90)90129-V

Norenberg, 1979, Fine structural localization of glutamine synthetase in astrocytes in brain, Brain Res, 161, 303, 10.1016/0006-8993(79)90071-4

Olney, 1969, Glutamate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion, J. Neuropath. Exp. Neurol, 28, 455, 10.1097/00005072-196907000-00007

Olney, 1983, “Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology, Brain Res. Bull, 10, 699, 10.1016/0361-9230(83)90038-2

Pines, 1992, Cloning and expression of a rat brain L-glutamate transporter, Nature, 360, 464, 10.1038/360464a0

Pow, 1994, Glutamate in some retinal neurons is derived soley from glia, Neuroscience, 60, 355, 10.1016/0306-4522(94)90249-6

Riepe, 1977, Müeller cell localisation of glutamine synthetase in rat retina, Nature, 268, 654, 10.1038/268654a0

Robinson, 1993, Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures, J. Neurochem, 61, 2099, 10.1111/j.1471-4159.1993.tb07447.x

Rothstein, 1995, Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity, J. Neurochem, 65, 643, 10.1046/j.1471-4159.1995.65020643.x

Rothstein, 1992, Decreased brain and spinal cord glutamate transport in amyotrophic lateral sclerosis, New Engl. J. Med, 326, 1464, 10.1056/NEJM199205283262204

Rothstein, 1993, Chronic glutamate uptake inhibition produces a model of slow neurotoxicity, Proc. Natl. Acad. Sci. USA, 90, 6591, 10.1073/pnas.90.14.6591

Rothstein, 1994, Localization of neuronal and glial glutamate transporters, Neuron, 13, 713, 10.1016/0896-6273(94)90038-8

Rothstein, 1995, Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis, Ann. Neurol, 38, 73, 10.1002/ana.410380114

Sarantis, 1993, Glutamate uptake from the synaptic cleft does not shape the decay of non-NMDA component of the synaptic current, Neuron, 11, 541, 10.1016/0896-6273(93)90158-N

Shaw, 1994, [3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease, Brain Res, 655, 195, 10.1016/0006-8993(94)91614-4

Shimada, 1993, Ischemia-induced accumulation of extracellular amino acids in cerebral cortex, white matter, and cerebrospinal fluid, J. Neurochem, 60, 66, 10.1111/j.1471-4159.1993.tb05823.x

Storck, 1992, Structure, expression, and functional analysis of a Na+-dependent glutamate/aspartate transporter from rat brain, Proc. Natl. Acad. Sci. USA, 89, 10955, 10.1073/pnas.89.22.10955

Tong, 1994, Block of glutamate transporters potentiates postsynaptic excitation, Neuron, 13, 1195, 10.1016/0896-6273(94)90057-4

Wagner, 1994, Gene inhibition using antisense oligodeoxynucleotides, Nature, 372, 333, 10.1038/372333a0

Whitesell, 1993, Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides, Proc. Natl. Acad. Sci. USA, 90, 4665, 10.1073/pnas.90.10.4665