Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance

2014, WHO

2016, The continuing plague of extended-spectrum β-lactamase-producing Enterobacteriaceae infections, Infect Dis Clin N Am, 30, 347, 10.1016/j.idc.2016.02.003

2012, A swordless knight: epidemiology and molecular characteristics of the blaKPC-negative sequence type 258 Klebsiella pneumoniae clone, J Clin Microbiol, 50, 3180, 10.1128/JCM.00987-12

2011, Introduction of OXA-48-producing Enterobacteriaceae to Israeli hospitals by medical tourism, J Antimicrob Chemoth, 66, 2763, 10.1093/jac/dkr382

2016, The resistance mechanism and clonal distribution of tigecycline-nonsusceptible Klebsiella pneumoniae isolates in Korea, Yonsei Med J, 57, 641, 10.3349/ymj.2016.57.3.641

2009, Emergence of KPC-producing Pseudomonas aeruginosa in Trinidad and Tobago, J Clin Microbiol, 47, 2670, 10.1128/JCM.00362-09

2007, Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster, J Antimicrob Chemoth, 59, 786, 10.1093/jac/dkl562

2016, CTX-M-15 in combination with aac(6’)-Ib-cr is the most prevalent mechanism of resistance both in Escherichia coli and Klebsiella pneumoniae, including K. pneumoniae ST258, in an ICU in Uruguay, J Glob Antimicrob Resist, 6, 5, 10.1016/j.jgar.2016.02.001

1983, Comparative study of imipenem in severe infections, J Antimicrob Chemoth, 12, 141, 10.1093/jac/12.suppl_D.141

2013, Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?, Clin Microbiol Rev, 26, 185, 10.1128/CMR.00059-12

2012, Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic, J Antimicrob Chemoth, 67, 1651, 10.1093/jac/dks115

2009, KPC-2-producing Enterobacter cloacae and Pseudomonas putida coinfection in a liver transplant recipient, Antimicrob Agents Ch, 53, 292, 10.1128/AAC.00931-08

1973, Mechanisms of antibiotic resistance in bacteria, Annu Rev Biochem, 42, 471, 10.1146/annurev.bi.42.070173.002351

1994, Replication control of plasmid R1: disruption of an inhibitory RNA structure that sequesters the repA ribosome-binding site permits tap-independent RepA synthesis, Mol Microbiol, 12, 49, 10.1111/j.1365-2958.1994.tb00994.x

2011, Detection of a VIM-27-producing Klebsiella pneumoniae isolate in a patient following surgical tourism in Greece, Antimicrob Agents Ch, 55, 4488, 10.1128/AAC.00688-11

2009, Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America, Clin Infect Dis, 48, 1, 10.1086/595011

2015, Genomic analysis of the emergence and rapid global dissemination of the clonal group 258 Klebsiella pneumoniae pandemic, PLoS One, 10, e0133727, 10.1371/journal.pone.0133727

2015, Epidemiology and management of emerging drug-resistant Gram-negative bacteria: extended-spectrum β-lactamases and beyond, Urol Clin North Am, 42, 493, 10.1016/j.ucl.2015.05.005

2001, Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat, Clin Microbiol Rev, 14, 933, 10.1128/CMR.14.4.933-951.2001

2016, Correlation of β-lactamase production and colistin resistance among Enterobacteriaceae isolates from a Global Surveillance Program, Antimicrob Agents Ch, 60, 1385, 10.1128/AAC.01870-15

1997, Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the loss of an outer membrane protein, Antimicrob Agents Ch, 41, 563, 10.1128/AAC.41.3.563

2007, Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York, Clin Infect Dis, 44, 972, 10.1086/512370

2015, Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation, Environ Microbiol, 17, 4690, 10.1111/1462-2920.13016

2010, Bench-to-bedside review: the role of β-lactamases in antibiotic-resistant Gram-negative infections, Crit Care, 14, 224, 10.1186/cc8892

2010, Updated functional classification of beta-lactamases, Antimicrob Agents Ch, 54, 969, 10.1128/AAC.01009-09

2008, Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital, Antimicrob Agents Ch, 52, 2014, 10.1128/AAC.01539-07

2015, The changing epidemiology of hospital outbreaks due to ESBL-producing Klebsiella pneumoniae: the CTX-M-15 type consolidation, Future Microbiol, 10, 1063, 10.2217/fmb.15.22

2016, Outbreak of Klebsiella pneumoniae carbapenemase-producing K pneumoniae: a systematic review, Am J Infect Control

2014, MgrB inactivation is a common mechanism of colistin resistance in KPC-producing Klebsiella pneumoniae of clinical origin, Antimicrob Agents Ch, 58, 5696, 10.1128/AAC.03110-14

2012, Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe, Clin Microbiol Infect, 18, 413, 10.1111/j.1469-0691.2012.03821.x

2008, Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe, Clin Microbiol Infect, 14, 144

2013, High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality, Clin Microbiol Infect, 19, E23, 10.1111/1469-0691.12070

2005, Identification of plasmids by PCR-based replicon typing, J Microbiol Methods, 63, 219, 10.1016/j.mimet.2005.03.018

2012, Evolution of IncA/C blaCMY-2-carrying plasmids by acquisition of the blaNDM-1 carbapenemase gene, Antimicrob Agents Ch, 56, 783, 10.1128/AAC.05116-11

2014, In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing, Antimicrob Agents Ch, 58, 3895, 10.1128/AAC.02412-14

2001, SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae, Antimicrob Agents Ch, 45, 2856, 10.1128/AAC.45.10.2856-2861.2001

2013, Complete nucleotide sequence of a blaKPC-harboring IncI2 plasmid and its dissemination in New Jersey and New York hospitals, Antimicrob Agents Ch, 57, 5019, 10.1128/AAC.01397-13

2013, Complete sequence of a bla(KPC-2)-harboring IncFII(K1) plasmid from a Klebsiella pneumoniae sequence type 258 strain, Antimicrob Agents Ch, 57, 1542, 10.1128/AAC.02332-12

2014, Comparative genomic analysis of KPC-encoding pKpQIL-like plasmids and their distribution in New Jersey and New York Hospitals, Antimicrob Agents Ch, 58, 2871, 10.1128/AAC.00120-14

2014, Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding, Trends Microbiol, 22, 686, 10.1016/j.tim.2014.09.003

2014, Epidemic Klebsiella pneumoniae ST258 is a hybrid strain, mBio, 5, e01355

2013, Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258, J Antimicrob Chemoth, 68, 74, 10.1093/jac/dks370

2014, Mix and match of KPC-2 encoding plasmids in Enterobacteriaceae-comparative genomics, Diagn Micr Infec Dis, 79, 255, 10.1016/j.diagmicrobio.2014.03.008

2011, Genetic evolution and clinical impact in extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae, Infect Genet Evol, 11, 1499, 10.1016/j.meegid.2011.06.001

2007, Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides, J Biol Chem, 282, 15569, 10.1074/jbc.M701454200

2016, Plasmid dynamics in KPC-positive Klebsiella pneumoniae during long-term patient colonization, mBio, 7

2013, CTX-M-type β-lactamases: a successful story of antibiotic resistance, Int J Med Microbiol, 303, 305, 10.1016/j.ijmm.2013.02.008

2010, Origins and evolution of antibiotic resistance, Microbiol Mol Biol R, 74, 417, 10.1128/MMBR.00016-10

1969, Gram-negative bacilli in burns, J Clin Pathol, 22, 634, 10.1136/jcp.22.6.634

2015, Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation, PLoS Pathog, 11, e1004627, 10.1371/journal.ppat.1004627

2013, Elucidating the Regulon of Multidrug Resistance Regulator RarA in Klebsiella pneumoniae, Antimicrob Agents Ch, 57, 1603, 10.1128/AAC.01998-12

1997, Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae, Antimicrob Agents Ch, 41, 699, 10.1128/AAC.41.3.699

2014, Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae, P Natl Acad Sci USA, 111, 4988, 10.1073/pnas.1321364111

2005, Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates, J Clin Microbiol, 43, 4178, 10.1128/JCM.43.8.4178-4182.2005

2014, Co-production of NDM-1 and OXA-232 by Klebsiella pneumoniae, Emerg Infect Dis, 20, 163, 10.3201/eid2001.130904

2015, Carbapenemase-producing Enterobacteriaceae, Semin Resp Crit Care, 36, 74, 10.1055/s-0035-1544208

2016, Aminoglycoside resistance: the emergence of acquired 16S ribosomal RNA methyltransferases, Infect Dis Clin N Am, 30, 523, 10.1016/j.idc.2016.02.011

2013, Plasmid content of a clinically relevant Klebsiella pneumoniae clone from the Czech Republic producing CTX-M-15 and QnrB1, Antimicrob Agents Ch, 57, 1073, 10.1128/AAC.01886-12

2014, Extended-spectrum-beta-lactamases, AmpC beta-lactamases and plasmid mediated quinolone resistance in Klebsiella spp. from companion animals in Italy, PLoS One, 9, e90564, 10.1371/journal.pone.0090564

2009, Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system, J Antimicrob Chemoth, 1102

2014, OXA β-lactamases, Clin Microbiol Rev, 27, 241, 10.1128/CMR.00117-13

2014, Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses, J Antimicrob Chemoth, 69, 2676, 10.1093/jac/dku217

2009, Mechanism of action of and resistance to quinolones, Microb Biotechnol, 2, 40, 10.1111/j.1751-7915.2008.00063.x

2005, Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections, Clin Infect Dis, 40, 1333, 10.1086/429323

2016, Control of infectious mortality due to carbapenemase-producing Klebsiella pneumoniae in hematopoietic stem cell transplantation, Bone Marrow Transpl

2016, Double copies of bla(KPC-3)::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy, Antimicrob Agents Ch, 60, 646, 10.1128/AAC.01886-15

2012, Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid, J Clin Microbiol, 50, 3768, 10.1128/JCM.01892-12

2003, Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation, Antimicrob Agents Ch, 47, 2565, 10.1128/AAC.47.8.2565-2571.2003

2012, Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants, Antimicrob Agents Ch, 56, 2143, 10.1128/AAC.05308-11

2008, Clinical and economic impact of common multidrug-resistant gram-negative bacilli, Antimicrob Agents Ch, 52, 813, 10.1128/AAC.01169-07

2013, Successful control of an outbreak of colonization by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae sequence type 258 in a neonatal intensive care unit, Italy, J Hosp Infect, 85, 233, 10.1016/j.jhin.2013.08.004

2015, Empiric therapy for hospital-acquired, Gram-negative complicated intra-abdominal infection and complicated urinary tract infections: a systematic literature review of current and emerging treatment options, BMC Infect Dis, 15, 313, 10.1186/s12879-015-1054-1

2007, Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTX-M-3, Antimicrob Agents Ch, 51, 3789, 10.1128/AAC.00457-07

2010, Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient, Emerg Infect Dis, 16, 1014, 10.3201/eid1606.091671

2010, Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008, Antimicrob Agents Ch, 54, 2687, 10.1128/AAC.01359-09

2008, Household transmission of carbapenemase-producing Klebsiella pneumoniae, Emerg Infect Dis, 14, 859, 10.3201/eid1405.071340

1983, Clinical evaluation of norfloxacin versus cotrimoxazole in urinary tract infections, Eur J Clin Microbiol, 2, 260, 10.1007/BF02029529

2015, Characterization of quinolone resistance mechanisms in Enterobacteriaceae recovered from diseased companion animals in Europe, Vet Microbiol

2016, Phenotypic and molecular characterization of antimicrobial resistance in Klebsiella spp. isolates from companion animals in Japan: clonal dissemination of multidrug-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae, Front Microbiol, 7, 1021

2000, Functional analysis of the active site of a metallo-beta-lactamase proliferating in Japan, Antimicrob Agents Ch, 44, 2304, 10.1128/AAC.44.9.2304-2309.2000

2012, Unmet medical need in infectious diseases, Clin Infect Dis, 54, 1677, 10.1093/cid/cis275

2004, Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp, Antimicrob Agents Ch, 48, 4438, 10.1128/AAC.48.11.4438-4440.2004

2016, Outbreak by ventilator-associated ST11 K. pneumoniae with co-production of CTX-M-24 and KPC-2 in a SICU of a tertiary teaching hospital in Central China, Front Microbiol, 7, 1190

2013, Copy number change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate, PLoS One, 8, e62774, 10.1371/journal.pone.0062774

2009, AmpC beta-lactamases, Clin Microbiol Rev, 22, 161, 10.1128/CMR.00036-08

2014, Plasmid-mediated quinolone resistance, Microbiol Spectr, 2

2014, Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin, Antimicrob Agents Ch, 58, 4762, 10.1128/AAC.00084-14

2016, Acquisition of broad-spectrum cephalosporin resistance leading to colistin resistance in Klebsiella pneumoniae, Antimicrob Agents Ch, 60, 3199, 10.1128/AAC.00237-16

2008, Cefuroxime non-susceptibility in multidrug-resistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels, J Antimicrob Chemoth, 62, 986, 10.1093/jac/dkn296

2015, Genomic and functional characterization of qnr-encoding plasmids from municipal wastewater biosolid Klebsiella pneumoniae isolates, Front Microbiol, 6, 1354

2017, Colistin: still a lifesaver for the 21st century?, Expert Opin Drug Met, 13, 59, 10.1080/17425255.2017.1230200

2015, Community-acquired pyelonephritis in pregnancy caused by KPC-producing Klebsiella pneumoniae, Antimicrob Agents Ch, 59, 4375, 10.1128/AAC.00553-15

2009, Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258, Antimicrob Agents Ch, 53, 3365, 10.1128/AAC.00126-09

1985, Evolution of plasmid-coded resistance to broad-spectrum cephalosporins, Antimicrob Agents Ch, 28, 302, 10.1128/AAC.28.2.302

1987, Imipenem and ceftazidime resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae, J Antimicrob Chemoth, 19, 136, 10.1093/jac/19.1.136

1980, Site-specific deletion at the replication origin of the antibiotic resistance factor R1, Mol Gen Genet, 177, 413, 10.1007/BF00271479

2016, Aminoglycosides: an overview, Cold Spring Harb Perspect Med, 6

2009, Ertapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates, J Clin Microbiol, 47, 969, 10.1128/JCM.00651-08

2010, Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain, J Antimicrob Chemoth, 65, 243, 10.1093/jac/dkp417

2016, Global dissemination of carbapenemase-producing Klebsiella pneumoniae: epidemiology, genetic context, treatment options, and detection methods, Front Microbiol, 7, 895

2015, Spread of KPC-producing carbapenem-resistant Enterobacteriaceae: the importance of super-spreaders and rectal KPC concentration, Clin Microbiol Infect, 21, 470.e1, 10.1016/j.cmi.2014.12.015

2016, Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study, Lancet Infect Dis, 16, 161, 10.1016/S1473-3099(15)00424-7

2005, Tigecycline: what is it, and where should it be used?, J Antimicrob Chemoth, 56, 611, 10.1093/jac/dki291

2012, Current epidemiology and growing resistance of gram-negative pathogens, Korean J Intern Med, 27, 128, 10.3904/kjim.2012.27.2.128

2006, The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter, Trends Microbiol, 14, 413, 10.1016/j.tim.2006.07.008

2011, Analysis of the networks controlling the antimicrobial-peptide-dependent induction of Klebsiella pneumoniae virulence factors, Infect Immun, 79, 3718, 10.1128/IAI.05226-11

2013, Complete sequence of an IncN plasmid, pIMP-HZ1, carrying blaIMP-4 in a Klebsiella pneumoniae strain associated with medical travel to China, Antimicrob Agents Ch, 57, 1561, 10.1128/AAC.02298-12

2016, Characterization of ESBL- and AmpC-producing and fluoroquinolone-resistant Enterobacteriaceae isolated from mouflons (Ovis orientalis musimon) in Austria and Germany, PLoS One, 11, e0155786, 10.1371/journal.pone.0155786

2016, Molecular evolution of a Klebsiella pneumoniae ST278 isolate harboring blaNDM-7 and involved in nosocomial transmission, J Infect Dis, 214, 798, 10.1093/infdis/jiw240

2009, High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6’)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals, Antimicrob Agents Chemother, 53, 519, 10.1128/AAC.00886-08

2012, Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance, Clin Microbiol Infect, 18, 268, 10.1111/j.1469-0691.2011.03570.x

2011, Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan, Antimicrob Agents Chemother, 55, 593, 10.1128/AAC.01020-10

2008, Extended-spectrum beta-lactamases and the permeability barrier, Clin Microbiol Infect, 14, 82

1996, In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins, Antimicrob Agents Chemother, 40, 342, 10.1128/AAC.40.2.342

1998, Quinolone resistance from a transferable plasmid, The Lancet, 351, 797, 10.1016/S0140-6736(97)07322-4

2015, The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae, Clin Microbiol Rev, 28, 565, 10.1128/CMR.00116-14

2002, AcrAB efflux system: expression and contribution to fluoroquinolone resistance in Klebsiella spp, Antimicrob Agents Ch, 46, 3984, 10.1128/AAC.46.12.3984-3986.2002

2016, Reducing the impact of carbapenem-resistant Enterobacteriaceae on vulnerable patient groups: what can be done?, Curr Opin Infect Dis

2010, Sequence of pNL194, a 79.3-kilobase IncN plasmid carrying the blaVIM-1 metallo-beta-lactamase gene in Klebsiella pneumoniae, Antimicrob Agents Ch, 54, 4497, 10.1128/AAC.00665-10

2003, Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2, Antimicrob Agents Ch, 47, 1297, 10.1128/AAC.47.4.1297-1300.2003

2008, Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria, PLoS Genet, 4, e1000233, 10.1371/journal.pgen.1000233

2007, Klebsiella pneumoniae isolate producing at least eight different beta-lactamases, including AmpC and KPC beta-lactamases, Antimicrob Agents Ch, 51, 800, 10.1128/AAC.01143-06

2013, The global spread of healthcare-associated multidrug-resistant bacteria: a perspective from Asia, Clin Infect Dis, 56, 1310, 10.1093/cid/cit020

2013, Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases, Lancet Infect Dis, 13, 785, 10.1016/S1473-3099(13)70190-7

2012, Role of ISKpn7 and deletions in blaKPC gene expression, Antimicrob Agents Ch, 56, 4753, 10.1128/AAC.00334-12

2016, The current case of quinolones: synthetic approaches and antibacterial activity, Mol Basel, 21, 268

2013, Investigation of mutation distribution in DNA gyrase and topoisomerase IV genes in ciprofloxacin-non-susceptible Enterobacteriaceae isolated from blood cultures in a tertiary care university hospital in South Korea, 2005-2010, Int J Antimicrob Ag, 41, 126, 10.1016/j.ijantimicag.2012.10.004

2012, Reduced susceptibility to chlorhexidine among extremely-drug-resistant strains of Klebsiella pneumoniae, J Hosp Infect, 81, 15, 10.1016/j.jhin.2012.02.007

2014, Biofilm formation and susceptibility to gentamicin and colistin of extremely drug-resistant KPC-producing Klebsiella pneumoniae, J Antimicrob Ch, 69, 1027, 10.1093/jac/dkt487

2006, Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel, Antimicrob Agents Ch, 50, 3098, 10.1128/AAC.00438-06

2003, Occurrence and phenotypic characteristics of extended-spectrum beta-lactamases among members of the family Enterobacteriaceae at the Tel-Aviv Medical Center (Israel) and evaluation of diagnostic tests, J Clin Microbiol, 41, 155, 10.1128/JCM.41.1.155-158.2003

2009, First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States, Antimicrob Agents Ch, 53, 818, 10.1128/AAC.00987-08

2008, Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15, J Antimicrob Ch, 61, 273

2014, IS5 element integration, a novel mechanism for rapid in vivo emergence of tigecycline nonsusceptibility in Klebsiella pneumoniae, Antimicrob Agents Ch, 58, 6151, 10.1128/AAC.03053-14

2005, Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae, J Antimicrob Chemoth, 56, 463, 10.1093/jac/dki245

2012, Emergence of an autochthonous and community-acquired NDM-1-producing Klebsiella pneumoniae in Europe, Clin Infect Dis, 54, 150, 10.1093/cid/cir720

2014, The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide, Clin Microbiol Infect, 20, 821, 10.1111/1469-0691.12719

2006, Plasmid R1–replication and its control, Plasmid, 55, 1, 10.1016/j.plasmid.2005.07.002

2014, Molecular epidemiology of KPC-producing Escherichia coli: occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid, Antimicrob Agents Ch, 58, 4234, 10.1128/AAC.02182-13

2009, Conjugative plasmid transfer and adhesion dynamics in an Escherichia coli biofilm, Appl Environ Microb, 75, 6783, 10.1128/AEM.00974-09

2000, Mosaic plasmids and mosaic replicons: evolutionary lessons from the analysis of genetic diversity in IncFII-related replicons, Microbiology, 146, 2267

2016, Colistin and tigecycline resistance in carbapenemase-producing Gram-negative bacteria: emerging resistance mechanisms and detection methods, J Appl Microbiol, 121, 601, 10.1111/jam.13169

2016, The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3, J Antimicrob Chemoth

2010, Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence, Antimicrob Agents Ch, 54, 177, 10.1128/AAC.00715-09

2015, Characterization of pKP-M1144, a novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate, Antimicrob Agents Ch, 59, 5065, 10.1128/AAC.00937-15

2010, Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase, Antimicrob Agents Ch, 54, 890, 10.1128/AAC.00693-09

2014, Travel-related carbapenemase-producing Gram-negative bacteria in Alberta, Canada: the first 3 years, J Clin Microbiol, 52, 1575, 10.1128/JCM.00162-14

2008, Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France, Antimicrob Agents Ch, 52, 3725, 10.1128/AAC.00163-08

2016, A structure-based classification of class A β-lactamases, a broadly diverse family of enzymes, Clin Microbiol Rev, 29, 29, 10.1128/CMR.00019-15

2015, First report of a multidrug-resistant Klebsiella pneumoniae of sequence type 11 causing sepsis in a free-ranging beaver (Castor fiber), Environ Microbiol Rep, 7, 351, 10.1111/1758-2229.12257

2007, Gene cloning and characterization of KdeA, a multidrug efflux pump from Klebsiella pneumoniae, Biol Pharm Bull, 30, 1962, 10.1248/bpb.30.1962

2015, Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance, Antimicrob Agents Ch, 59, 5873, 10.1128/AAC.01019-15

1998, Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors, Clin Microbiol Rev, 11, 589, 10.1128/CMR.11.4.589

2012, Genetic features of the widespread plasmid coding for the carbapenemase OXA-48, Antimicrob Agents Ch, 56, 559, 10.1128/AAC.05289-11

2004, Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae, Antimicrob Agents Ch, 48, 15, 10.1128/AAC.48.1.15-22.2004

2013, Extended-spectrum β-lactamase CTX-M-15-producing Klebsiella pneumoniae of sequence type ST274 in companion animals, Antimicrob Agents Ch, 57, 2372, 10.1128/AAC.02622-12

2010, Emergence of KPC-producing Pseudomonas aeruginosa in the United States, Antimicrob Agents Ch, 54, 3072, 10.1128/AAC.00513-10

2015, The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae, J Antimicrob Chemother, 70, 75, 10.1093/jac/dku323

2013, Aminoglycoside therapy in infectious diseases, Expert Opin Pharmaco, 14, 1585, 10.1517/14656566.2013.806486

2007, Carbapenemases: the versatile beta-lactamases, Clin Microbiol Rev, 20, 440, 10.1128/CMR.00001-07

2014, Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success, Trends Microbiol, 22, 438, 10.1016/j.tim.2014.04.007

2010, Detection of KPC in Acinetobacter spp. in Puerto Rico, Antimicrob Agents Ch, 54, 1354, 10.1128/AAC.00899-09

2011, Country-to-country transfer of patients and the risk of multi-resistant bacterial infection, Clin Infect Dis, 53, 49, 10.1093/cid/cir273

2012, qnr, aac(6’)-Ib-cr and qepA genes in Escherichia coli and Klebsiella spp.: genetic environments and plasmid and chromosomal location, J Antimicrob Chemoth, 67, 886, 10.1093/jac/dkr548

2005, Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae, Antimicrob Agents Ch, 49, 1017, 10.1128/AAC.49.3.1017-1022.2005

1994, Resistance to fluoroquinolones in Pseudomonas aeruginosa and Klebsiella pneumoniae, Scand J Infect Dis, 26, 317, 10.3109/00365549409011801

2015, Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome, Antimicrob Agents Ch, 59, 2849, 10.1128/AAC.04895-14

2012, Plasmid-mediated resistance in Enterobacteriaceae: changing landscape and implications for therapy, Drugs, 72, 1, 10.2165/11597960-000000000-00000

2014, An ongoing national intervention to contain the spread of carbapenem-resistant enterobacteriaceae, Clin Infect Dis, 58, 697, 10.1093/cid/cit795

2016, Transferable resistance to colistin: a new but old threat, J Antimicrob Chemoth, 71, 2066, 10.1093/jac/dkw274

2014, Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland, Int J Antimicrob Ag, 44, 260, 10.1016/j.ijantimicag.2014.05.008

2015, A plasmid bearing the bla(CTX-M-15) gene and phage P1-like sequences from a sequence type 11 Klebsiella pneumoniae isolate, Antimicrob Agents Chemoth, 59, 6608, 10.1128/AAC.00265-15

2009, Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient, Clin Infect Dis, 49, 1736, 10.1086/648077

2013, Characterization of plasmid-mediated quinolone resistance (PMQR) genes in extended-spectrum beta-lactamase-producing Enterobacteriaceae pediatric clinical isolates in Mexico, PLoS One, 8, e77968, 10.1371/journal.pone.0077968

1987, Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase, J Antimicrob Chemoth, 20, 323, 10.1093/jac/20.3.323

2003, Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates, J Antimicrob Chemoth, 51, 711, 10.1093/jac/dkg124

2013, KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance, Antimicrob Agents Ch, 57, 4449, 10.1128/AAC.02284-12

2012, Functional characterization of a novel outer membrane porin KpnO, regulated by PhoBR two-component system in Klebsiella pneumoniae NTUH-K2044, PLoS One, 7, e41505, 10.1371/journal.pone.0041505

2013, Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs, J Antimicrob Chemoth, 68, 2802, 10.1093/jac/dkt259

The Review on Antimicrobial Resistance, Final report

2008, Detection of KPC-2 in a clinical isolate of Proteus mirabilis and first reported description of carbapenemase resistance caused by a KPC beta-lactamase in P. mirabilis, J Clin Microbiol, 46, 3080, 10.1128/JCM.00979-08

2014, Fitness cost associated with resistance to fluoroquinolones is diverse across clones of Klebsiella pneumoniae and may select for CTX-M-15 type extended-spectrum β-lactamase, Eur J Clin Microbiol Infect Diseases, 33, 837, 10.1007/s10096-013-2022-6

2014, A suitable streptomycin-resistant mutant for constructing unmarked in-frame gene deletions using rpsL as a counter-selection marker, PLoS One, 9, e109258, 10.1371/journal.pone.0109258

2013, KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen, Antimicrob Agents Chemother, 57, 5144, 10.1128/AAC.01052-13

1988, Emergence of bacterial resistance to cefamandole in vivo due to outer membrane protein deficiency, Eur J Clin Microbiol, 7, 776, 10.1007/BF01975046

2012, The role of international travel in the worldwide spread of multiresistant Enterobacteriaceae, J Antimicrob Chemoth, 67, 2090, 10.1093/jac/dks214

2012, Complete sequencing of an IncH plasmid carrying the blaNDM-1, blaCTX-M-15 and qnrB1 genes, J Antimicrob Chemother, 67, 1645, 10.1093/jac/dks114

2014, Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance, Antimicrob Agents Ch, 58, 1707, 10.1128/AAC.01803-13

2010, Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants, J Antimicrob Chemoth, 65, 2518, 10.1093/jac/dkq347

2007, First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase, Antimicrob Agents Ch, 51, 1553, 10.1128/AAC.01405-06

2004, Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop, Antimicrob Agents Ch, 48, 2905, 10.1128/AAC.48.8.2905-2910.2004

1963, Nalidixic acid in urinary infections, Br Med J, 2, 1311, 10.1136/bmj.2.5368.1311

2016, Overview: global and local impact of antibiotic resistance, Infect Dis Clin N Am, 30, 313, 10.1016/j.idc.2016.02.001

2015, Evolution and dissemination of OqxAB-like efflux pumps, an emerging quinolone resistance determinant among members of Enterobacteriaceae, Antimicrob Agents Ch, 59, 3290, 10.1128/AAC.00310-15

2011, Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance, FEMS Microbiol Rev, 35, 736, 10.1111/j.1574-6976.2011.00268.x

2007, The antibiotic resistome: the nexus of chemical and genetic diversity, Nat Rev Microbiol, 5, 175, 10.1038/nrmicro1614

2015, Genomic and Transcriptomic Analyses of Colistin-Resistant Clinical Isolates of Klebsiella pneumoniae Reveal Multiple Pathways of Resistance, Antimicrob Agents Ch, 59, 536, 10.1128/AAC.04037-14

2015, Extensive capsule locus variation and large-scale genomic recombination within the Klebsiella pneumoniae clonal group 258, Genome Biol Evol, 7, 1267, 10.1093/gbe/evv062

2015, Associations of the major international high-risk resistant clones and virulent clones with specific ompK36 allele groups in Klebsiella pneumoniae in Taiwan, New Microbes New Infect, 5, 1, 10.1016/j.nmni.2015.01.002

2010, Sequence analysis of pKF3-70 in Klebsiella pneumoniae: probable origin from R100-like plasmid of Escherichia coli, PLoS One, 5, e8601, 10.1371/journal.pone.0008601

2001, Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae, Antimicrob Agents Chemother, 45, 1151, 10.1128/AAC.45.4.1151-1161.2001

2009, Characterization of a new metallo-beta-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India, Antimicrob Agents Ch, 53, 5046, 10.1128/AAC.00774-09

2009, Prevalence of 16S rRNA methylase genes in Klebsiella pneumoniae isolates from a Chinese teaching hospital: coexistence of rmtB and armA genes in the same isolate, Diagn Micr Infec Dis, 64, 57, 10.1016/j.diagmicrobio.2009.01.020

2015, Mobile genetic elements related to the diffusion of plasmid-mediated AmpC β-lactamases or carbapenemases from Enterobacteriaceae: findings from a multicenter study in Spain, Antimicrob Agents Ch, 59, 5260, 10.1128/AAC.00562-15

2008, High-level carbapenem resistance in a Citrobacter freundii clinical isolate is due to a combination of KPC-2 production and decreased porin expression, J Med Microbiol, 57, 332, 10.1099/jmm.0.47576-0

2007, Plasmid-mediated carbapenem-hydrolysing beta-lactamase KPC-2 in carbapenem-resistant Serratia marcescens isolates from Hangzhou, China, J Antimicrob Chemoth, 59, 574, 10.1093/jac/dkl541

2016, Dissemination of the mcr-1 colistin resistance gene, Lancet Infect Dis, 16, 292, 10.1016/S1473-3099(16)00063-3

2009, Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug-resistant Klebsiella pneumoniae strain isolated in China, Antimicrob Agents Ch, 53, 5291, 10.1128/AAC.00032-09

2015, Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae, Sci Rep, 5, 15082, 10.1038/srep15082

2015, Extended-spectrum-β-lactamase-producing Enterobacteriaceae isolated from vegetables imported from the Dominican Republic, India, Thailand, and Vietnam, Appl Environ Microb, 81, 3115, 10.1128/AEM.00258-15