Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway

Neifert, 2020 Toth, 2018, Intracranial aneurysms: review of current science and management, Vasc. Med., 23, 276, 10.1177/1358863X18754693 Fujii, 2013, Early brain injury, an evolving frontier in subarachnoid hemorrhage research, Transl Stroke Res, 4, 432, 10.1007/s12975-013-0257-2 Kamp, 2020, Experimental aneurysmal subarachnoid hemorrhage: tiding over, Transl Stroke Res, 11, 1, 10.1007/s12975-019-00726-7 Fumoto, 2019, The role of oxidative stress in microvascular disturbances after experimental subarachnoid hemorrhage, Transl Stroke Res, 10, 684, 10.1007/s12975-018-0685-0 Mead, 2007, Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system, Br. J. Pharmacol., 151, 1143, 10.1038/sj.bjp.0707295 Pasquier, 2014, Molecular evolution of GPCRs: kisspeptin/kisspeptin receptors, J. Mol. Endocrinol., 52, T101, 10.1530/JME-13-0224 Kotani, 2001, The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54, J. Biol. Chem., 276, 34631, 10.1074/jbc.M104847200 Navarro, 2020, Metabolic regulation of kisspeptin - the link between energy balance and reproduction, Nat. Rev. Endocrinol., 16, 407, 10.1038/s41574-020-0363-7 Murphy, 2005, Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis, J. Neuroendocrinol., 17, 519, 10.1111/j.1365-2826.2005.01328.x Abreu, 2016, Pubertal development and regulation, Lancet Diabet. Endocrinol, 4, 254, 10.1016/S2213-8587(15)00418-0 Dhillo, 2005, Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males, J. Clin. Endocrinol. Metab., 90, 6609, 10.1210/jc.2005-1468 Aydin, 2010, Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats, Cell Biochem. Funct., 28, 293, 10.1002/cbf.1656 Akkaya, 2014, Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats, J. Biochem. Mol. Toxicol., 28, 373, 10.1002/jbt.21573 Castano, 2009, Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?, Peptides, 30, 10, 10.1016/j.peptides.2008.07.025 Fu, 2020, Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3beta pathway in rats, J. Orthop. Surg. Res., 15, 275, 10.1186/s13018-020-01790-8 Arslan, 2013, Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury, Stem Cell Res., 10, 301, 10.1016/j.scr.2013.01.002 Chen, 2013, Hydroxysafflor yellow A protects against cerebral ischemia-reperfusion injury by anti-apoptotic effect through PI3K/Akt/GSK3beta pathway in rat, Neurochem. Res., 38, 2268, 10.1007/s11064-013-1135-8 Pampillo, 2009, Regulation of GPR54 signaling by GRK2 and {beta}-arrestin, Mol. Endocrinol., 23, 2060, 10.1210/me.2009-0013 Sun, 1800, Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3ss pathways, Biochim. Biophys. Acta, 912 Ma, 2016, Pramipexole-induced hypothermia reduces early brain injury via PI3K/AKT/GSK3beta pathway in subarachnoid hemorrhage rats, Sci. Rep., 6 Duan, 2019, Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3beta/Nrf2 signaling, J. Neuroinflammation, 16, 24, 10.1186/s12974-019-1406-7 d'Anglemont de Tassigny, 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, PloS One, 12, 10.1371/journal.pone.0176821 Milton, 2012, Kisspeptin prevention of amyloid-beta peptide neurotoxicity in vitro, ACS Chem. Neurosci., 3, 706, 10.1021/cn300045d Duris, 2011, Sampling of CSF via the cisterna magna and blood collection via the heart affects brain water content in a rat SAH model, Transl Stroke Res., 2, 232, 10.1007/s12975-010-0063-z Sugawara, 2008, A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model, J. Neurosci. Methods, 167, 327, 10.1016/j.jneumeth.2007.08.004 Zhan, 2012, Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats, Crit. Care Med., 40, 1291, 10.1097/CCM.0b013e31823da96d Fang, 2020, Pituitary adenylate cyclase-activating polypeptide attenuates brain edema by protecting blood-brain barrier and glymphatic system After subarachnoid hemorrhage in rats, Neurotherapeutics., 17, 1954, 10.1007/s13311-020-00925-3 Okada, 2019, FGF-2 attenuates neuronal apoptosis via FGFR3/PI3k/akt signaling pathway after subarachnoid hemorrhage, Mol. Neurobiol., 56, 8203, 10.1007/s12035-019-01668-9 Wolfe, 2018, The emerging role(s) for kisspeptin in metabolism in mammals, Front. Endocrinol., 9, 184, 10.3389/fendo.2018.00184 Kirby, 2010, International union of basic and clinical pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function, Pharmacol. Rev., 62, 565, 10.1124/pr.110.002774 Chen, 2019, beta-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury, J. Cell Mol. Med., 23, 3325, 10.1111/jcmm.14223 Ayer, 2008, Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm, Acta Neurochir. Suppl., 104, 33, 10.1007/978-3-211-75718-5_7 Gaetani, 1998, Oxidative stress in the human brain after subarachnoid hemorrhage, J. Neurosurg., 89, 748, 10.3171/jns.1998.89.5.0748 Yang, 2017, The updated role of oxidative stress in subarachnoid hemorrhage, Curr. Drug Deliv., 14, 832, 10.2174/1567201813666161025115531 Aslan, 2017, The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats, Taiwan. J. Obstet. Gynecol., 56, 456, 10.1016/j.tjog.2016.12.018 Liu, 2016, Kisspeptin regulation of neuronal activity throughout the central nervous system, Endocrinol Metab (Seoul), 31, 193, 10.3803/EnM.2016.31.2.193 Yang, 2020, Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men, JCI Insight, 5, 10.1172/jci.insight.133633 Jiang, 2015, Kisspeptin-13 enhances memory and mitigates memory impairment induced by Abeta1-42 in mice novel object and object location recognition tasks, Neurobiol. Learn. Mem., 123, 187, 10.1016/j.nlm.2015.05.010 Ebrahimi Khonacha, 2019, Kisspeptin-13 improves spatial memory consolidation and retrieval against amyloid-beta pathology, Iran. J. Pharm. Res. (IJPR), 18, 169 Golzar, 2015, The effects of kisspeptin-10 on migration and proliferation of endothelial cell, Adv. Biomed. Res., 4, 41, 10.4103/2277-9175.151250 Olbrich, 2010, Kisspeptin-10 inhibits bone-directed migration of GPR54-positive breast cancer cells: evidence for a dose-window effect, Gynecol. Oncol., 119, 571, 10.1016/j.ygyno.2010.08.018 Thompson, 2009, Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms, Br. J. Pharmacol., 156, 609, 10.1111/j.1476-5381.2008.00061.x Sato, 2017, Potent vasoconstrictor kisspeptin-10 induces atherosclerotic plaque progression and instability: reversal by its receptor GPR54 antagonist, J Am Heart Assoc, 6, 10.1161/JAHA.117.005790 Szereszewski, 2010, GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Galpha(q/11) and beta-arrestin-dependent manner, PloS One, 5, 10.1371/journal.pone.0012964 Wang, 2018, beta-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke, J. Neuroinflammation, 15, 102, 10.1186/s12974-018-1142-4 Zhang, 2009, beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis, Cell. Signal., 21, 1195, 10.1016/j.cellsig.2009.03.010 Jacobs, 2012, GSK-3beta: a bifunctional role in cell death pathways, Int J Cell Biol, 10.1155/2012/930710 Ali, 2018, Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer's disease, Mol. Neurobiol., 55, 6076, 10.1007/s12035-017-0798-6 Tomita, 2008, Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase, J. Med. Chem., 51, 7645, 10.1021/jm800930w Mi, 2009, The distribution of kisspeptin and its receptor GPR54 in rat dorsal root ganglion and up-regulation of its expression after CFA injection, Brain Res. Bull., 78, 254, 10.1016/j.brainresbull.2008.12.003 Tabuchi, 2015, Relationship between postmenopausal estrogen deficiency and aneurysmal subarachnoid hemorrhage, Behav. Neurol., 2015, 720141, 10.1155/2015/720141