Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes

Translational Research - Tập 166 - Trang 474-484.e4 - 2015
Irene Zubiri1, Maria Posada-Ayala1, Alberto Benito-Martin2, Aroa S. Maroto1, Marta Martin-Lorenzo1, Pablo Cannata-Ortiz3, Fernando de la Cuesta4, Laura Gonzalez-Calero1, Maria G. Barderas4, Beatriz Fernandez-Fernandez2, Alberto Ortiz2, Fernando Vivanco1,5, Gloria Alvarez-Llamas1
1Department of Immunology, IIS-Fundación Jiménez Díaz, UAM, REDINREN, Madrid, Spain
2Department of Nephrology/UAM/IRSIN, IIS-Fundación Jiménez Díaz, REDINREN, Madrid, Spain
3Department of Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain
4Department of Vascular Physiopathology, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain
5Department of Biochemistry and Molecular Biology I, Universidad Complutense, Madrid, Spain

Tài liệu tham khảo

Chiarelli, 2003, Kidney involvement and disease in patients with diabetes, Panminerva Med, 45, 23 Vallon, 2012, Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney, Annu Rev Physiol, 74, 351, 10.1146/annurev-physiol-020911-153333 Tang, 2011, Diabetic tubulopathy: an emerging entity, Contrib Nephrol, 170, 124, 10.1159/000325647 Sanchez-Nino, 2010, BASP1 promotes apoptosis in diabetic nephropathy, J Am Soc Nephrol, 21, 610, 10.1681/ASN.2009020227 Ucero, 2013, A polymeric nanomedicine diminishes inflammatory events in renal tubular cells, PLoS One, 8, e51992, 10.1371/journal.pone.0051992 Sanchez-Nino, 2015, Albumin-induced apoptosis of tubular cells is modulated by BASP1, Cell Death Dis, 6, e1644, 10.1038/cddis.2015.1 Caramori, 2000, The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient?, Diabetes, 49, 1399, 10.2337/diabetes.49.9.1399 Fioretto, 1994, Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria, Diabetes, 43, 1358, 10.2337/diab.43.11.1358 Bangstad, 1993, Early glomerulopathy is present in young, type 1 (insulin-dependent) diabetic patients with microalbuminuria, Diabetologia, 36, 523, 10.1007/BF02743268 Gross, 2005, Diabetic nephropathy: diagnosis, prevention, and treatment, Diabetes Care, 28, 164, 10.2337/diacare.28.1.164 de la Cuesta, 2011, A proteomic focus on the alterations occurring at the human atherosclerotic coronary intima, Mol Cell Proteomics, 10, M110, 10.1074/mcp.M110.003517 de la Cuesta, 2012, Secretome analysis of atherosclerotic and non-atherosclerotic arteries reveals dynamic extracellular remodeling during pathogenesis, J Proteomics, 75, 2960, 10.1016/j.jprot.2011.12.005 Simpson, 2009, Exosomes: proteomic insights and diagnostic potential, Expert Rev Proteomics, 6, 267, 10.1586/epr.09.17 Mathivanan, 2010, Exosomes: extracellular organelles important in intercellular communication, J Proteomics, 73, 1907, 10.1016/j.jprot.2010.06.006 Sanchez-Nino, 2009, The MIF receptor CD74 in diabetic podocyte injury, J Am Soc Nephrol, 20, 353, 10.1681/ASN.2008020194 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 Darde, 2010, Analysis of the plasma proteome associated with acute coronary syndrome: does a permanent protein signature exist in the plasma of ACS patients?, J Proteome Res, 9, 4420, 10.1021/pr1002017 Shevchenko, 1996, Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels, Anal Chem, 68, 850, 10.1021/ac950914h Perkins, 1999, Probability-based protein identification by searching sequence databases using mass spectrometry data, Electrophoresis, 20, 3551, 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 Zubiri, 2014, Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis, J Proteomics, 96, 92, 10.1016/j.jprot.2013.10.037 Zubiri, 2013, Proteomic analysis of urinary exosomes in cardiovascular and associated kidney diseases by two-dimensional electrophoresis and LC-MS/MS, Methods Mol Biol, 1000, 209, 10.1007/978-1-62703-405-0_16 Gonzales, 2010, Isolation and purification of exosomes in urine, Methods Mol Biol, 641, 89, 10.1007/978-1-60761-711-2_6 2013, KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease, Kidney Int Suppl, 3, 1 MacLean, 2010, Skyline: an open source document editor for creating and analyzing targeted proteomics experiments, Bioinformatics, 26, 966, 10.1093/bioinformatics/btq054 Tervaert, 2010, Pathologic classification of diabetic nephropathy, J Am Soc Nephrol, 21, 556, 10.1681/ASN.2010010010 Gonzalez-Calero, 2014, Exosomes: a potential key target in cardio-renal syndrome, Front Immunol, 5, 465, 10.3389/fimmu.2014.00465 Lange, 2008, Selected reaction monitoring for quantitative proteomics: a tutorial, Mol Syst Biol, 4, 222, 10.1038/msb.2008.61 Merchant, 2010, Proteomic discovery of diabetic nephropathy biomarkers, Adv Chronic Kidney Dis, 17, 480, 10.1053/j.ackd.2010.09.001 Thongboonkerd, 2011, Study of diabetic nephropathy in the proteomic era, Contrib Nephrol, 170, 172, 10.1159/000325657 Scott, 2011, Senescence marker protein 30: functional and structural insights to its unknown physiological function, Biomol Concepts, 2, 469, 10.1515/BMC.2011.041 Yamaguchi, 2011, The transcriptional regulation of regucalcin gene expression, Mol Cell Biochem, 346, 147, 10.1007/s11010-010-0601-8 Senmaru, 2012, Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice, J Clin Biochem Nutr, 50, 114, 10.3164/jcbn.11-52 Hasegawa, 2010, Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion, Endocrinology, 151, 529, 10.1210/en.2009-1163 Matsui-Hirai, 2011, Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide, J Pharmacol Exp Ther, 337, 591, 10.1124/jpet.110.177584 Fujita, 1996, Gene regulation of senescence marker protein-30 (SMP30): coordinated up-regulation with tissue maturation and gradual down-regulation with aging, Mech Ageing Dev, 87, 219, 10.1016/0047-6374(96)01711-3 Nakagawa, 2008, Nuclear localization of regucalcin is enhanced in culture with protein kinase C activation in cloned normal rat kidney proximal tubular epithelial NRK52E cells, Int J Mol Med, 21, 605 Yumura, 2006, Accelerated tubular cell senescence in SMP30 knockout mice, Histol Histopathol, 21, 1151 Kurota, 1995, Suppressed expression of calcium-binding protein regucalcin mRNA in the renal cortex of rats with chemically induced kidney damage, Mol Cell Biochem, 151, 55, 10.1007/BF01076896 Yamaguchi, 2012, Regucalcin, cell signalling-related protein: its multifunctional role in kidney cell regulation, OA Biotechnology, 1, 2, 10.13172/2052-0069-1-1-269 Wu, 2011, Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues, Anal Bioanal Chem, 399, 3431, 10.1007/s00216-010-4463-4 Klawitter, 2010, Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study, J Proteome Res, 9, 865, 10.1021/pr900761m Chiusolo, 2008, Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants, Toxicol Lett, 182, 84, 10.1016/j.toxlet.2008.08.014 Arbillaga, 2008, Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration, Toxicol Appl Pharmacol, 230, 197, 10.1016/j.taap.2008.02.018 Misawa, 2001, Involvement of nuclear factor-1 (NF1) binding motif in the regucalcin gene expression of rat kidney cortex: the expression is suppressed by cisplatin administration, Mol Cell Biochem, 219, 29, 10.1023/A:1011040805597 Moon, 2011, Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy, Proteomics, 11, 2459, 10.1002/pmic.201000443 Zhou, 2006, Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury, Kidney Int, 70, 1847, 10.1038/sj.ki.5001874 Miranda, 2010, Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease, Kidney Int, 78, 191, 10.1038/ki.2010.106 Schanstra, 2015, Diagnosis and prediction of CKD progression by assessment of urinary peptides, J Am Soc Nephrol, 10.1681/ASN.2014050423