Key nutrients and growth factors for the neonatal gastrointestinal tract

Clinics in Perinatology - Tập 29 Số 1 - Trang 65-96 - 2002
Douglas G. Burrin1, Barbara J. Stoll
1USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. [email protected]

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Akisu, 1998, Effect of dietary N-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice: N-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine, Biol Neonate, 74, 31, 10.1159/000014008

Alexander, 1999, Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestine, Am J Physiol, 277, G619

Ball, 1999, Adequate oral threonine is critical for mucin production and mucosal growth by the neonatal piglet gut, 31

Baracos, 2000, Anabolic and catabolic media//tors of intestinal protein turnover: A new experimental approach, Curr Opin Clin Nutr Metab Care, 3, 183, 10.1097/00075197-200005000-00004

Barlow, 1974, An experimental study of acute neonatal entercolitis: The importance of breast milk, J Pediatr Surg, 9, 595, 10.1016/0022-3468(74)90093-1

Barnard, 1995, Epidermal growth factor-related peptides and their relevance to gastointesinal pathophysiology, Gastroenterology, 108, 564, 10.1016/0016-5085(95)90087-X

Battezzati, 1995, Oxidation of glutamic acid by the splanchnic bed in humans, Am J Physiol, 269, E269

Benhamou, 1997, Human recombinant growth hormone increases small bowel lengthening after massive small bowel resection in piglets, J Pediatr Surg, 32, 1332, 10.1016/S0022-3468(97)90315-8

Bernt, 1999, Human milk as a carrier of biochemical messages, Acta Paediatr Suppl, 430, 27, 10.1111/j.1651-2227.1999.tb01298.x

Berseth, 1987, Breast-milk-enhanced intestinal and somatic growth in neonatal rats, Biol Neonate, 51, 53, 10.1159/000242631

Berseth, 1987, Enhancement of intestinal growth in neonatal rats by epidermal growth factor in milk, Am J Physiol, 253, G662

Berseth, 1995, Minimal enteral feedings, Clin Perinatol, 22, 195, 10.1016/S0095-5108(18)30308-7

Berseth, 1983, Comparison of the gastrointestinal growth-promoting effects of rat colostrums and mature milk in newborn rats in vivo, Am J Clin Nutr, 37, 52, 10.1093/ajcn/37.1.52

Bertolo, 1998, Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically, J Nutr, 128, 1752, 10.1093/jn/128.10.1752

Bertolo, 1999, A comparison of parenteral and enteral feeding in neonatal piglets, including an assessment of the utilization of a glutamine-rich, pediatric elemental diet, J Parenter Enteral Nutr, 23, 47, 10.1177/014860719902300247

Binder, 1989, Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon, Gastroenterology, 96, 989, 10.1016/0016-5085(89)91614-4

Blachier, 1995, Metabolism of L-arginine through polyamine and nitric oxide synthase pathways in proliferative or differentiated human colon carcinoma cells, Biochem Biophys Acta, 1268, 255, 10.1016/0167-4889(95)00083-5

Boza, 1996, Ribonucleic acid nucleotides in maternal and fetal tissues derive almost exclusively from synthesis de novo in pregnant mice, J Nutr, 126, 1749

Bragg, 1991, Influence of nutrient delivery on gut structure and function, Nutrition, 7, 237

Brand-Miller, 1998, Digestion of human milk oligosaccharides by healthy infants evaluated by the lactulose hydrogen breath test, J Pediatr, 133, 95, 10.1016/S0022-3476(98)70185-4

Brunton, 1999, Proline ameliorates arginine deficiency during enteral but not parenteral feeding in neonatal piglets, Am J Physiol, 277, E223

Buchman, 1995, Parenteral nutrition is associated with intestinal morphologic and functional changes in humans, J Parenter Enteral Nutr, 19, 453, 10.1177/0148607195019006453

Bugaut, 1993, Biological effects of short-chain fatty acids in nonruminant mammals, Ann Rev Nutr, 13, 217, 10.1146/annurev.nu.13.070193.001245

Burrin, 1995, Nutrient-independent and nutrient-dependent factors stimulate protein synthesis in colostrum-fed newborn pigs, Pediatr Res, 37, 593, 10.1203/00006450-199505000-00006

Burrin, 1991, Stage of development and fasting affect protein synthetic activity in the gastrointestinal tissues of suckling pigs, J Nutr, 121, 1099, 10.1093/jn/121.7.1099

Burrin, 1999, Transgenic hypersecretion of des(1–3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups, J Nutr, 129, 51, 10.1093/jn/129.1.51

Burrin, 2001, Glucagon-like peptide 2: A nutrient-responsive gut growth factor, J Nutr, 131, 709, 10.1093/jn/131.3.709

Burrin, 1994, Supplemental alanylglutamine, organ growth and nitrogen metabolism in neonatal pigs fed by total parenteral nutrition, J Parenter Enteral Nutr, 18, 313, 10.1177/0148607194018004313

Burrin, 2001, Oral IGF-I alters the posttranslational processing, but not the activity of lactase-phlorizin hydrolase in formula-fed neonatal pigs, J Nutr, 131, 2235, 10.1093/jn/131.9.2235

Burrin, 2000, GLP-2 stimulates intestinal growth by suppressing proteolysis and apoptosis in parenterally fed premature piglets, Am J Physiol, 279, G1249

Burrin, 2000, Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: How much is enough?, Am J Clin Nutr, 71, 1603, 10.1093/ajcn/71.6.1603

Burrin, 1999, Dexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs, Am J Physiol, 276, E269

Burrin, 1996, Orally administered IGF-I increases intestinal mucosal growth in formula-fed neonatal pigs, Am J Physiol, 270, R1085

Buts, 1998, Bioactive factors in milk, Arch Pediatr, 5, 298, 10.1016/S0929-693X(97)89374-8

Buts, 1997, Expression of insulin receptors and of 60-kDa receptor substrate in rat mature and immature enterocytes, Am J Physiol, 273, G217

Buts, 1985, Role of dietary protein adaptation at weaning in the development of the rat gastrointestinal tract, Pediatr Res, 19, 857, 10.1203/00006450-198508000-00017

Buts, 1990, Refeeding after starvation in the rat: Comparative effects of lipids, proteins and carbohydrates on jejunal and ileal mucosal adapta tion, Eur J Clin Invest, 20, 441, 10.1111/j.1365-2362.1990.tb01882.x

Byrne, 1995, Growth hormone, glutamine, and modified diet enhance nutrient absorption in patients with severe short bowel syn drome, J Parenter Enteral Nutr, 19, 296, 10.1177/0148607195019004296

Calder, 2001, Omega-3 polyunsaturated fatty acids, inflammation and immunity, 109

Caplan, 2001, Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model, Pediatr Res, 49, 647, 10.1203/00006450-200105000-00007

Carlson, 1998, Lower incidence of necrotizing enterocolitis in infants fed a preterm formula with egg phospholipids, Pediatr Res, 44, 491, 10.1203/00006450-199810000-00005

Carver, 1999, Dietary nucleotides: Effects on the immune and gastrointestinal systems, Acta Paediatr Suppl, 88, 83, 10.1111/j.1651-2227.1999.tb01306.x

Castillo, 1991, Pituitary regulation of postnatal small intestinal ontogeny in the rat: Differential regulation of digestive hydrolase maturation by thyroxine and growth hormone, Endocrinology, 129, 1417, 10.1210/endo-129-3-1417

Catassi, 1995, Intestinal permeability changes during the first month: Effect of natural versus artificial feeding, J Pediat Gastroenterol, 21, 383, 10.1097/00005176-199511000-00003

Cheeseman, 1997, Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo, Am J Physiol, 273, R1965

Cherbut, 1997, Effects of short-chain fatty acids on gastrointestinal motility, Scand J Gastroenterol, 222, 58, 10.1080/00365521.1997.11720720

Chu, 1995, Role of bombesin on gut mucosal growth, Ann Surg, 222, 94, 10.1097/00000658-199507000-00015

Chu, 1995, Bombesin stimulates mucosal growth in jejunal and ileal Thiry-Vella fistulas, Ann Surg, 221, 602, 10.1097/00000658-199505000-00018

Chung, 1992, Effect of neurostensin on gut mucosal growth in rats with jejunal and ileal Thiry-Vella fistulas, Gastroentrology, 103, 1254, 10.1016/0016-5085(92)91512-3

Clausen, 1995, Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis, Gut, 37, 684, 10.1136/gut.37.5.684

Collins, 1999, Probiotics, prebiotics, and synbiotics: Approaches for modulating the microbial ecology of the gut, Am J Clin Nutr, 1052S, 10.1093/ajcn/69.5.1052s

Cosgrove, 1998, Perinatal and infant nutrition, Nucleotides Nutrition, 14, 748

Cummings, 1997, Role of intestinal bacteria in nutrient metabolism, J Parenter Enteral Nutr, 21, 357, 10.1177/0148607197021006357

Cynober, 1994, Can arginine and ornithine support gut functions?, Gut, 35, S42, 10.1136/gut.35.1_Suppl.S42

Cynober, 1999, The use of alpha-keoglutarate salts in clinical nutrition and metabolic care, Curr Opin Clin Nutr Metab Care, 2, 33, 10.1097/00075197-199901000-00007

Darmaun, 1997, Glutamine metabolism in very low birth weight infants, Pediatr Res, 41, 391, 10.1203/00006450-199703000-00015

Deitch, 1994, Bacterial translocation: The influence of dietary variables, Gut, 25, S23, 10.1136/gut.35.1_Suppl.S23

DeMarco, 1999, Inhibition of glutamine synthetase decreases proliferation of cultured rat intestinal epithelial cells, J Nutr, 129, 57, 10.1093/jn/129.1.57

Dockray, 1994, Physiology of enteric neuropeptides, 169

Donovan, 1997, Orally administered iodinated recombinant human insulin-like growth factor-I is poorly absorbed by the newborn piglet, J Pediatr Gastroenterol Nutr, 24, 174, 10.1097/00005176-199702000-00011

Donovan, 1994, Growth factors in milk as mediators of infant development, Ann Rev Nutr, 14, 147, 10.1146/annurev.nu.14.070194.001051

Drucker, 1998, Glucagon-like peptides, Diabetes, 47, 159, 10.2337/diabetes.47.2.159

Drucker, 1999, Glucagon-like peptide 2, Trends Endocrinol Metabol, 10, 153, 10.1016/S1043-2760(98)00136-2

Engfer, 2000, Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract, Am J Clin Nutr, 71, 1589, 10.1093/ajcn/71.6.1589

Evers, 1999, Expression of the neurotensin/neuromedin N gene in the gut, 425

Evers, 1990, Differential effects of gut hormones on pancreatic and intestinal growth during administration of an elemental diet, Ann Surg, 21, 630

Fan, 1999, Immunohistochemical localization of vascular endothelial growth factor in the globule leukocyte/mucosal mast cell of the rat respiratory and digestive tracts, Histochem Cell Biol, 111, 13, 10.1007/s004180050328

Fiocchi, 1998, Inflammatory bowel disease: Etiology and pathogenesis, Gastroenterology, 115, 182, 10.1016/S0016-5085(98)70381-6

Firmansyah, 1989, Biochemical and morphological changes in the digestive tract of rats after prenatal and postnatal malnutrition, Am J Clin Nutr, 50, 261, 10.1093/ajcn/50.2.261

Frankel, 1993, Glutamine enhancement of structure and function in transplanted small intestine in the rat, J Parenter Enteral Nutr, 17, 47, 10.1177/014860719301700147

Ganessunker, 1999, Total parenteral nutrition alters molecular and cellular indices of intestinal inflammation in neonatal piglets, J Parenter Enteral Nutr, 23, 337, 10.1177/0148607199023006337

Gardiner, 1995, Novel substrates to maintain gut integrity, Nutr Res Rev, 8, 43, 10.1079/NRR19950006

Glasscock, 1990, Pituitary control of growth in the neonatal rat: Effects of neonatal hypophysectomy on somatic and organ growth, serum insulin-like growth factors (IGF)-I and-II levels, and expression of IGF binding proteins, Endocrinology, 127, 1792, 10.1210/endo-127-4-1792

Go, 1994, Breast milk protects the neonate from bacterial translocation, J Pediatr Surg, 29, 1059, 10.1016/0022-3468(94)90279-8

Göke, 1998, Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor, Am J Physiol, 274, G809

Goldstein, 1985, The effects of total parenteral nutrition on gastrointestinal growth and development, J Pediatr Surg, 20, 785, 10.1016/S0022-3468(85)80044-0

Gomez, 1999, Peptide YY, 551

Gomez, 1995, Intestinal peptide YY: Ontogeny of gene expression in rat bowel and trophic actions on rat and mouse bowel, Am J Physiol, 268, G71

Goodlad, 1990, Is peptide YY trophic to the intestinal epithelium of parenterally fed rats?, Digestion, 46, 177, 10.1159/000200383

Goodlad, 1992, Cell proliferation in the small intestine and colon of intravenously fed rats: Effects of urogastrone-epidermal growth factor, Cell Prolif, 25, 393, 10.1111/j.1365-2184.1992.tb01449.x

Grant, 1988, Use of L-glutamine in total parenteral nutrition, J Surg Res, 44, 506, 10.1016/0022-4804(88)90155-2

Groos, 1996, Parenteral versus enteral nutrition: Morphological changes in human adult intestinal mucosa, J Submicrosc Cytol Pathol, 28, 61

Grosvenor, 1993, Hormones and growth factors in milk, Endocr Rev, 14, 710, 10.1210/edrv-14-6-710

Guedon, 1986, Decreased brush border hydrolase activities without gross morphologic changes in human intestinal mucosa after prolonged total parenteral nutrition of adults, Gastroenterology, 90, 373, 10.1016/0016-5085(86)90935-2

Gulluoglu, 1999, Bombesin ameliorates colonic damage in experimental colitis, Dig Dis Sci, 44, 1531, 10.1023/A:1026646523284

Hague, 1997, Butyrate acts as a survival factor for colonic epithelial cells: Further fuel for the in vivo versus in vitro debate, Gastroenterology, 112, 1036, 10.1053/gast.1997.v112.agast971036

Haisch, 2000, Oxidation of glutamine by the splanchinic bed in humans, Am J Physiol, 278, E593

Hamosh, 2001, Bioactive factors in human milk, Pediatr Clin North Am, 69, 10.1016/S0031-3955(05)70286-8

Heird, 2001, The role of polyunsaturated fatty acids in term and preterm infants and breastfeeding mothers, Pediatr Clin North Am, 48, 173, 10.1016/S0031-3955(05)70292-3

Henning, 1994, Ontogeny of the intestinal mucosa, 571

Higashiguchi, 1993, Effect of glutamine on protein synthesis in isolated intestinal epithelial cells, J Parenter Enteral Nutr, 17, 307, 10.1177/0148607193017004307

Holst, 1997, Enteroglucagon, Ann Rev Physiol, 59, 257, 10.1146/annurev.physiol.59.1.257

Horvath, 1996, Isocaloric glutamine-free diet and the morphology and function of rat small intestine, J Parenter Enteral Nutr, 20, 128, 10.1177/0148607196020002128

Houle, 2000, Investigation of three doses of oral insulin-like growth factor-I on jejunal lactase phlorizin hydrolase activity and gene expression and enterocyte proliferation and migration in piglets, Pediatr Res, 48, 497, 10.1203/00006450-200010000-00013

Hylander, 1998, Human milk feedings and infection among very low birth weight infants, Pediatrics, 102, E38, 10.1542/peds.102.3.e38

Iiboshi, 1994, Total parenteral nutrition decreases luminal mucous gel and increases permeability of small intestine, J Parenter Enteral Nutr, 18, 346, 10.1177/0148607194018004346

Inoue, 1993, Effect of glutamine-supplemented total parenteral nutrition on recovery of the small intestine after starvation atrophy, J Parenter Enteral Nutr, 17, 165, 10.1177/0148607193017002165

Izukura, 1992, Neurotensin augments intestinal regeneration after small bowel resection in rats, Ann Surg, 215, 520, 10.1097/00000658-199205000-00015

Jaeger, 1990, Effect of orally administered epidermal growth factor on the jejunal mucosa of weaned pigs, Am J Vet Res, 51, 471, 10.2460/ajvr.1990.51.03.471

Jass, 1985, Diet, butyric acid and differentiation of gastrointestinal tract tumors, Med Hypotheses, 18, 113, 10.1016/0306-9877(85)90043-X

Jeejeebhoy, 2001, Total parenteral nutrition: Potion or poison?, Am J Clin Nutr, 74, 160, 10.1093/ajcn/74.2.160

Jenkins, 1994, Mechanisms of small intestinal adaptation, Dig Dis, 12, 15, 10.1159/000171433

Jeppessen, 1999, Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure, Gut, 45, 559, 10.1136/gut.45.4.559

Johnson, 1994, Regulation of gastrointestinal mucosal growth, 611

Jones, 1999, Gastrointestinal mucosal regeneration: Role of growth factors, Front Biosci, 4, d303, 10.2741/A428

Kagnoff, 1997, Epithelial cells as sensors for microbial infection, J Clin Invest, 100, 6, 10.1172/JCI119522

Kandil, 1995, L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line, Am J Physiol, 269, G591

Karkashan, 1992, Effect of bombesin on the development of the neonatal rabbit gastrointestinal tract, Biol Neonate, 61, 92, 10.1159/000243536

Kato, 1998, Enhancement of intestinal adaptation by hepatocyte growth factor, J Pediatr Surg, 33, 235, 10.1016/S0022-3468(98)90438-9

Kelly, 1992, Characterization and autoradiographic localization of the epidermal growth factor receptor in the jejunum of neonatal and weaned pigs, Reprod Fertil Dev, 4, 183, 10.1071/RD9920183

Kien, 1996, Digestion, absorption, and fermentation of carbohydrates in the newborn, Clin Perinatol, 23, 211, 10.1016/S0095-5108(18)30239-2

Kim, 1998, Apoptosis of human intestinal epithelial cells after bacterial invasion, J Clin Invest, 102, 1815, 10.1172/JCI2466

Klagsbrun, 1978, Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts, 75, 5057

Koh, 1997, Gastrin deficiency results in altered gastric differentiation, Gastroenterology, 113, 1015, 10.1016/S0016-5085(97)70199-9

Koldovsky, 1994, Hormonally active peptides in human milk, Acta Paediatr, 402, 89, 10.1111/j.1651-2227.1994.tb13368.x

Koldovsky, 1996, The potential physiological significance of milk-borne hormonally active substances for the neonate, J Mammary Gland Biol Neoplasia, 1, 317, 10.1007/BF02018084

Kollman, 1999, Dietary lipids influence intestinal adaptation after massive bowel resection, J Parenter Enteral Nutr, 28, 41

Koruda, 1990, Parenteral nutrition supplemented with short-chain fatty acids: Effect on the small-bowel mucosa in normal rats, Am J Clin Nutr, 51, 685, 10.1093/ajcn/51.4.685

Kunz, 2000, Oligosaccharides in human milk: Structural, functional, and metabolic aspects, Annu Rev Nutr, 20, 699, 10.1146/annurev.nutr.20.1.699

Lacourse, 1999, Pancreatic function in CCK-deficient mice: Adaptation to dietary protein does not require CCK, Am J Physiol, 276, G1302

Lopez-Navarro, 1996, Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine in rats, Gastroenterology, 110, 1760, 10.1053/gast.1996.v110.pm8964401

Lucas, 1986, Gut hormones and minimal enteral feeding, Acta Paediatr Scand, 75, 719, 10.1111/j.1651-2227.1986.tb10280.x

Lund, 1998, Molecular basis of intestinal adaptation: The role of the insulin-like growth factor system, Ann N Y Acad Sci, 859, 18, 10.1111/j.1749-6632.1998.tb11108.x

MacDonald, 1999, The role of insulin-like growth factors in small intestinal cell growth and development, Horm Metab Res, 31, 103, 10.1055/s-2007-978706

Mackie, 1999, Developmental microbial ecology of the neonatal gastrointestinal tract, Am J Clin Nutr, 69, 1035S, 10.1093/ajcn/69.5.1035s

Malo, 1982, Influence of epidermal growth factor on the development of suckling mouse intestinal mucosa, Gastroenterology, 83, 28, 10.1016/S0016-5085(82)80280-1

Marchbank, 1995, Luminal epidermal growth factor is trophic to the small intestine of parenterally fed rats, Clin Sci, 89, 117, 10.1042/cs0890117

Matthews, 1993, Splanchnic bed utilization of glutamine and glutamic acid in humans, Am J Physiol, 264, E848

Michail, 1995, Effect of glutamine-supplemented elemental diet on mucosal adaptation following bowel resection in rats, J Pediatr Gastroenterol Nutr, 21, 394, 10.1097/00005176-199511000-00005

Miyasaka, 1999, Disruption of cholecystokinin (CCK)-B receptor gene did not modify bile or pancreatic secretion or pancreatic growth: A study in CCK-B receptor gene knockout mice, Pancreas, 19, 114, 10.1097/00006676-199908000-00002

Mordrelle, 2000, EAAT1 is involved in transport of L-glutamate during differentiation of the Caco-2 cell line, Am J Physiol, 279, G366

Morgan, 1996, Characterization of IGF-I receptors in the porcine small intestine during postnatal development, J Nutr Biochem, 7, 339, 10.1016/0955-2863(96)00054-X

Morgan, 1987, Total parenteral nutrition and intestinal development: A neonatal model, J Pediatr Surg, 22, 541, 10.1016/S0022-3468(87)80217-8

Morin, 1980, Small intestinal and colonic changes induced by a chemically defined diet, Dig Dis Sci, 25, 123, 10.1007/BF01308310

Mortensen, 1991, Microcirculatory and trophic effects of short chain fatty acids in the human rectum after Hartmann's procedure, Br J Surg, 78, 1208, 10.1002/bjs.1800781019

Neu, 1999, Glutamine supplementation in low-birth-weight infants: Mechanisms of action, J Parenter Enteral Nutr, 23, S49, 10.1177/014860719902300513

Ney, 1999, Effects of insulin-like growth factor-I and growth hormone in models of parenteral nutrition, J Parenter Enteral Nutr, 23, S184, 10.1177/014860719902300603

Ney, 1999, Investigation of insulin-like growth factor (IGF)-I and insulin receptor binding and expression in jejunum of parenterally fed rats treated with IGF-I or growth hormone, Endocrinology, 140, 4850, 10.1210/en.140.10.4850

Nusrat, 1994, Hepatocyte growth factor/scatter factor effects on epeithelia, J Clin Invest, 93, 2056, 10.1172/JCI117200

Okunieff, 1998, In vivo radioprotective effects of angiogenic growth factors on the small bowel of C3H mice, Radiat Res, 150, 204, 10.2307/3579856

O'Loughlin, 1985, Effect of epidermal growth factor on ontogeny of the gastrointestinal tract, Am J Physiol, 249, G674

Panigrahi, 1997, Role of glutamine in bacterial transcytosis and epithelial cell injury, J Parenter Enteral Nutr, 21, 75, 10.1177/014860719702100275

Papaconstantinou, 1998, Glutamine deprivation induces apoptosis in intestinal epithelial cells, Surgery, 124, 152, 10.1016/S0039-6060(98)70115-1

Park, 1994, Dexamethasone inhibits mucosal adaptation after small bowel resection, Am J Physiol, 266, G497

Park, 1999, Enteral insulin-like growth factor-I augments intestinal disaccharidase activity in piglets receiving total parenteral nutrition, J Parenter Enteral Nutr, 29, 198

Penttila, 1998, Transforming growth factor-beta levels in maternal milk and expression in postnatal rat duodenum and ileum, Pediatr Res, 44, 524, 10.1203/00006450-199810000-00010

Peterson, 1997, GH elevates serum IGF-I levels but does not alter mucosal atrophy in parenterally fed rats, Am J Physiol, 272, G1100

Petersen, 2001, Glucagon-like peptide 2 has differential effects on small intestine growth and function in fetal and neonatal pigs, Am J Physiol, 281, R1986

Piguet, 1999, TNF-induced enterocyte apoptosis and detachment in mice: Induction of caspases and prevention by a caspase inhibitor ZVAD-fmk, Lab Invest, 79, 495

Pironi, 1994, Morphologic and cytoproliferative patterns of duodenal mucosa in two patients after long-term total parenteral nutrition: Changes with oral refeeding and relation to intestinal resection, J Parenter Enteral Nutr, 18, 351, 10.1177/0148607194018004351

Plaisancie, 1996, Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon, J Endocrinol, 151, 421, 10.1677/joe.0.1510421

Platell, 1993, The influence of parenteral glutamine and branched-chain amino acids on total parenteral nutrition-induced atrophy of the gut, J Parenter Enteral Nutr, 17, 348, 10.1177/0148607193017004348

Playford, 1998, Effects of keratinocyte growth factor (KGF) on gut growth and repair, J Pathol, 184, 316, 10.1002/(SICI)1096-9896(199803)184:3<316::AID-PATH3>3.0.CO;2-#

Poldovsky, 1999, Mucosal immunity and inflammation V. Innate mechanisms of mucosal defense and repair: The best offense is a good defense, Am J Physiol, 277, G495

Poldovsky, 1994, Peptide growth factors in the gastrointestinal tract, 129

Poldovsky, 1993, Regulation of intestinal epithelial proliferation: a few answers, many questions, Am J Physiol, 264, G179

Puccio, 1989, Bombesin ingestion stimulates epithelial digestive cell proliferation in suckling rats, Am J Physiol, 256, G328

Quaroni, 1999, Glucocorticoids have pleiotropic effects on small intestinal crypt cells, Am J Physiol, 277, G1027

Rafferty, 1994, Sepsis in rats stimulates cellular proliferation in the mucosa of the small intestine, Gastroenterology, 107, 121, 10.1016/0016-5085(94)90069-8

Rasmussen, 1988, Faecal concentrations and production rates of short chain fatty acids in normal neonates, Acta Paediatr Scand, 77, 365, 10.1111/j.1651-2227.1988.tb10661.x

Raul, 1996, Intestinal adaptation to nutritional stress, 55, 279

Read, 1992, Insulin-like growth factor-I and its N-terminal modified analogues induce marked gut growth in dexamethasone-treated rats, J Endocrinol, 133, 421, 10.1677/joe.0.1330421

Reeds, 1996, Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs, Am J Physiol, 270, E413

Reimer, 1996, Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats, Endocrinology, 137, 3948, 10.1210/en.137.9.3948

Rhoads, 1999, Glutamine signaling in intestinal cells, J Parenter Enteral Nutr, 23, S38, 10.1177/014860719902300510

Roediger, 1982, Utilization of nutrients by isolated epithelial cells of the rat colon, Gastroenterology, 83, 424, 10.1016/S0016-5085(82)80339-9

Rossi, 1993, Small intestinal mucosa changes, including epithelial cell proliferative activity, of children receiving total parenteral nutrition (TPN), Dig Dis Sci, 38, 1608, 10.1007/BF01303167

Sagor, 1985, Influence of somatostatin and bombesin on plasma enteroglucagon and cell proliferation after intestinal resection in the rat, Gut, 26, 89, 10.1136/gut.26.1.89

Sakata, 1987, Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: A possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors, Br J Nutr, 58, 95, 10.1079/BJN19870073

Sangild, 2000, How does the foetal gastrointestinal tract develop in preparation for enteral nutrition after birth?, Livestock Production Science, 66, 141, 10.1016/S0301-6226(00)00221-9

Scheppach, 1995, Role of short-chain fatty acids in the prevention of colorectal cancer, Eur J Cancer, 31A, 1077, 10.1016/0959-8049(95)00165-F

Schober, 1990, Perinatal expression of type I IGF receptors in porcine small intestine, Endocrinology, 126, 1125, 10.1210/endo-126-2-1125

Schroder, 1999, Mediation of differentiating effects of butyrate on the intestinal cell line Caco-2 by transforming growth factor-beta 1, Eur J Nutr, 38, 45, 10.1007/s003940050045

Schwarz, 1994, Effects of feeding on the small intestinal mucosa of beagle pups during the first 5 d of life, Am J Clin Nutr, 60, 879, 10.1093/ajcn/60.6.879

Scolapio, 1997, Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: A randomized, controlled study, Gastroenterology, 113, 1074, 10.1053/gast.1997.v113.pm9322500

Scott, 1981, Differential effect of glucocorticoids on structure and function of adult rat jejunum, Am J Physiol, 241, G306

Searle, 1998, Growth factors and gut function, 57, 403

Shulman, 1988, Effect of different total parenteral nutrition fuel mixes on small intestinal growth and differentiation in the infant miniature pig, Gastroenterology, 95, 85, 10.1016/0016-5085(88)90294-6

Shulman, 1990, Oral insulin increases small intestinal mass and disaccharidase activity in the newborn miniature pig, Pediatr Res, 28, 171, 10.1203/00006450-199008000-00018

Shulman, 1994, Bolus versus continuous feedings stimulate small-intestinal growth and development in the newborn pig, J Pediatr Gastroenterol Nutr, 18, 350, 10.1097/00005176-199404000-00017

Shulman, 1998, Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants, Pediatr Res, 44, 519, 10.1203/00006450-199810000-00009

Shulman, 1998, Early feeding, feeding tolerance, and lactase activity in preterm infants, J Pediatr, 133, 645, 10.1016/S0022-3476(98)70105-2

Siafakas, 1999, Vascular endothelial growth factor (VEGF) is present in human breast milk and its receptor is present on intestinal epithelial cells, Pediatr Res, 45, 652, 10.1203/00006450-199905010-00007

Smith, 1990, Glutamine metabolism and its physiologic importance, J Parenter Enteral Nutr, 14, 1S, 10.1177/014860719001400402

Souba, 1991, Glutamine: A key substrate for the splanchnic bed, Annu Rev Nutr, 11, 285, 10.1146/annurev.nu.11.070191.001441

Staley, 1998, Rat milk dietary long arginine insulin-like growth factor I promote intestinal growth if newborn rat pups, Pediatr Res, 44, 512, 10.1203/00006450-199810000-00008

Steeb, 1998, Systemically but not orogastrically delivered insulin-like growth factor (IGF)-I and long [Arg3]IGF-I stimulates intestinal disaccharidase activity in two age groups of suckling rats, Pediatr Res, 44, 663, 10.1203/00006450-199811000-00008

Steeb, 1997, Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats, Am J Physiol, 272, G522

Stein, 1994, Comparison of intravenous nutrients on gut mucosal protein synthesis, J Parenter Enteral Nutr, 18, 447, 10.1177/0148607194018005447

Steinwender, 1996, Effect of early nutritional deprivation and diet on translocation of bacteria from the gastrointestinal tract in the newborn rat, Pediatr Res, 39, 415, 10.1203/00006450-199603000-00007

Stoll, 1999, Substrate oxidation by the portal drained viscera of fed piglets, Am J Physiol, 277, E168

Stoll, 2000, Enteral carbohydrate and lipid inhibit small intestinal proteolysis in neonatal pigs, FASEB J, 14, A558

Stoll, 2000, Enteral nutrient intake determines the rate of intestinal protein synthesis and accretion in neonatal pigs, Am J Physiol, 279, G288

Stoll, 1998, Catabolism dominates the first-pass intestinal metabolism of dietaryessential amino acids in milk protein-fed piglets, J Nutr, 128, 614, 10.1093/jn/128.3.606

Stoll, 2000, Feeding an elemental diet versus a milk-based formula does not decrease intestinal mucosal growth in infant pigs, J Pediatr Gastroenterol Nutr, 31, S169

Su, 1997, Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: Cell type specificity and effects of extracellular matrix, J Cell Biol, 139, 1533, 10.1083/jcb.139.6.1533

Tamada, 1992, The dipeptide alanyl-glutamine prevents intestinal mucosal atrophy in parenterally fed rats, Parenter Enteral Nutr, 16, 110, 10.1177/0148607192016002110

Tappenden, 1998, Systemic short-chain fatty acids rapidly alter gastrointestinal structure, function, and expression of early response genes, Dig Dis Sci, 43, 1526, 10.1023/A:1018819032620

Tappenden, 1996, Short-chain fatty acids increase proglucagon and ornithine decarboxylase messenger RNAs after intestinal resection in rats, J Parenter Enteral Nutr, 20, 357, 10.1177/0148607196020005357

Thompson, 1986, Developmental differences in the effect of natural feeding on early enteric mucosal growth of guinea pigs, J Pediatr Gastroentrol Nutr, 5, 643, 10.1097/00005176-198607000-00023

Thompson, 1999, Epidermal growth factor inhibits somatostatin-induced apoptosis, J Surg Res, 81, 95, 10.1006/jsre.1998.5468

Thompson, 1999, Epidermal growth factor and the short bowel syndrome, J Parenter Enteral Nutr, 23, S113, 10.1177/014860719902300528

Trahair, 1997, Systemic and luminal influences on the perinatal development of the gut, Equine Vet J, 24, 40, 10.1111/j.2042-3306.1997.tb05077.x

Troyer, 2001, Growth retardation, duodenal lesions, and aberrantileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha, Gastroenterology, 121, 68, 10.1053/gast.2001.25478

Tsujinaka, 1997, Role of supplementation of a nucleic acid solution on the intestinal mucosa under total parenteral nutrition, Nutrition, 13, 369, 10.1016/S0899-9007(96)00375-9

Uauy, 1994, Role of nucleotides in intestinal development and repair: Implications for infant nutrition, J Nutr, 124, 1436S, 10.1093/jn/124.suppl_8.1436S

Ulshen, 1993, Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone, Gastroenterology, 104, 973, 10.1016/0016-5085(93)90263-C

Ulshen, 1991, Effects of nursing on growth and development of small bowel mucosa in newborn piglets, Pediatr Res, 30, 337, 10.1203/00006450-199110000-00009

Uribe, 1997, Nonmitogenic actions of growth factors: An integrated view of their role in intestinal physiology and pathophysiology, Gastroenterology, 112, 255

Vanderhoof, 1984, Effect of high percentage medium-chain triglyceride diet on mucosal adaptation following massive bowel resection in rats, J Parenter Enteral Nutr, 8, 685, 10.1177/0148607184008006685

Vanderhoof, 1997, Growth hormone and glutamine do not stimulate intestinal adaptation following massive small bowel resection in the rat, J Pediatr Gastroenterol Nutr, 25, 327, 10.1097/00005176-199709000-00016

Vanderhoof, 1994, Effects of dietary menhaden oil on mucosal adaptation after small bowel resection in rats, Gastroenterology, 106, 94, 10.1016/S0016-5085(94)94589-6

van der Hulst, 1993, Glutamine and the preservation of gut integrity, Lancet, 341, 1363, 10.1016/0140-6736(93)90939-E

Van Goudoever, 2001, Secretion of trophic gut peptides is not different in bolus- and continuously fed piglets, J Nutr, 131, 729, 10.1093/jn/131.3.729

Varga, 1998, Different actions of CCK on pancreatic and gastric growth in the rat: Effect of CCK(A) receptor blockade, Br J Pharmacol, 124, 435, 10.1038/sj.bjp.0701811

Velasco, 1999, Intestinal lengthening and growth hormone in extreme short bowel syndrome: A case report, J Pediatr Surg, 34, 1423, 10.1016/S0022-3468(99)90027-1

Velazquez, 1997, Butyrate and the colonocyte: Production, absorption, metabolism, and therapeutic implications, Adv Exp Med Biol, 427, 123, 10.1007/978-1-4615-5967-2_14

Velasquez, 1994, Developing intestine is injured during absorption of oleic acid but not its ethyl ester, J Clin Invest, 93, 479, 10.1172/JCI116996

Velazquez, 1996, The scientific rationale and clinical application of short-chain fatty acids and medium-chain triacylglycerols, 55, 49

Wallace, 2000, Nitric oxide in mucosal defense: A little goes a long way, Gastroenterology, 119, 512, 10.1053/gast.2000.9304

Walsh, 1994, Gastrointestinal hormones, 1

Wang, 1997, Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice, J Clin Invest, 100, 1425, 10.1172/JCI119663

Wang, 1997, Local hormone networks and intestinal T cell homeostasis, Science, 275, 1937, 10.1126/science.275.5308.1937

Wang, 1996, Expression of the ornithine decarboxylase gene in response to asparagine in intestinal epithelial cells, Am J Physiol, 271, G164

Weiss, 1999, Glutamine synthetase: A key enzyme for intestinal epithelial differentiation?, J Parenter Enteral Nutr, 23, 140, 10.1177/0148607199023003140

Windmueller, 1980, Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats: Quantitative importance of glutamine, glutamate, and aspartate, J Biol Chem, 255, 107, 10.1016/S0021-9258(19)86270-1

Wøjdemann, 1998, Glucagon-like peptide-2 inhibits centrally induced antral motility in pigs, Scand J Gastroenterol, 33, 828, 10.1080/00365529850171486

Wøjdemann, 1999, Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2, J Clin Endocrinol Metab, 84, 2513, 10.1210/jc.84.7.2513

Wong, 1999, Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation, J Parenter Enteral Nutr, 23, S83, 10.1177/014860719902300521

Wright, 1978, The effect of single and of multiple doses of prednisolone tertiary butyl acetate on cell population kinetics in the small bowel mucosa of the rat, Virchows Arch B Cell Pathol, 28, 339, 10.1007/BF02889082

Wu, 2000, A cortisol surge mediates the enhanced polyamine synthesis in procine enterocytes during weaning, Am J Physiol, 279, R554

Wu, 2000, Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets, Am J Physiol, 279, E395

Wu, 1998, Arginine metabolism: Nitric oxide and beyond, Biochem J, 336, 1, 10.1042/bj3360001

Wykes, 1996, Chronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition, J Nutr, 126, 1481, 10.1093/jn/126.5.1481

Xiao, 1999, Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans, Gastroenterology, 117, 99, 10.1016/S0016-5085(99)70555-X

Xu, 1994, Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets, Biol Neonate, 66, 280, 10.1159/000244118

Xu, 2000, Postnatal adaptation of the gastrointestinal tract in neonatal pigs: A possible role of milk-borne growth factors, Livestock Production Science, 66, 95, 10.1016/S0301-6226(00)00217-7

Yamada, 1998, Hepatocyte growth factor in human breast milk, Am J Reprod Immunol, 40, 112, 10.1111/j.1600-0897.1998.tb00399.x

Yeh, 1978, Hormonal influences on the growth and enzymic differentiation of the small intestine of the hypophysectomized rat, Growth, 42, 495

Young, 1982, Gastrointestinal response to oral versus gastric feeding of defined formula diets, Am J Clin Nutr, 35, 715, 10.1093/ajcn/35.4.715

Young, 1990, Insulin-like growth factors and the developing and mature rat small intestine: Receptors and biological actions, Digestion, 2, 240, 10.1159/000200392

Ziegler, 1992, Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition and bone marrow transplantation, 116, 821

Ziegler, 1999, Interactions between nutrients and peptide growth factors in intestinal growth, repair, and function, JPEN J Parenter Enteral Nutr, 23, S174, 10.1177/014860719902300602

Zijlstra, 1994, Effect of orally administrered epidermal growth factor on intestinal recovery of neonatal pigs infected with rotavirus, J Pediatr Gas troenterol Nutr, 19, 382, 10.1097/00005176-199411000-00003