Ketone bodies as signaling metabolites
Tài liệu tham khảo
Fontana, 2006, Excessive adiposity, calorie restriction, and aging, JAMA, 295, 1577, 10.1001/jama.295.13.1577
Kenyon, 2010, The genetics of ageing, Nature, 464, 504, 10.1038/nature08980
Bjedov, 2011, A longer and healthier life with TOR down-regulation: genetics and drugs, Biochem. Soc. Trans., 39, 460, 10.1042/BST0390460
Someya, 2010, Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction, Cell, 143, 802, 10.1016/j.cell.2010.10.002
Shimazu, 2013, Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor, Science, 339, 211, 10.1126/science.1227166
Katada, 2012, Connecting threads: epigenetics and metabolism, Cell, 148, 24, 10.1016/j.cell.2012.01.001
Stein, 2012, The dynamic regulation of NAD metabolism in mitochondria, Trends Endocrinol. Metab., 23, 420, 10.1016/j.tem.2012.06.005
Shyh-Chang, 2013, Influence of threonine metabolism on S-adenosylmethionine and histone methylation, Science, 339, 222, 10.1126/science.1226603
Berg, 2012
Cahill, 1966, Hormone–fuel interrelationships during fasting, J. Clin. Invest., 45, 1751, 10.1172/JCI105481
Robinson, 1980, Physiological roles of ketone bodies as substrates and signals in mammalian tissues, Physiol. Rev., 60, 143, 10.1152/physrev.1980.60.1.143
Cahill, 2006, Fuel metabolism in starvation, Annu. Rev. Nutr., 26, 1, 10.1146/annurev.nutr.26.061505.111258
Koeslag, 1980, Post-exercise ketosis, J. Physiol., 301, 79, 10.1113/jphysiol.1980.sp013190
Kim do, 2008, The ketogenic diet and epilepsy, Curr. Opin. Clin. Nutr. Metab. Care, 11, 113, 10.1097/MCO.0b013e3282f44c06
London, 1986, Effects of fasting on ketone body concentrations in healthy men of different ages, J. Gerontol., 41, 599, 10.1093/geronj/41.5.599
Freemantle, 2009, Metabolic response to a ketogenic breakfast in the healthy elderly, J. Nutr. Health Aging, 13, 293, 10.1007/s12603-009-0026-9
Thumelin, 1993, Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney, Biochem. J., 292, 493, 10.1042/bj2920493
Zhang, 2011, Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes, Am. J. Physiol. Endocrinol. Metab., 300, E287, 10.1152/ajpendo.00308.2010
Fink, 1988, Pseudoketogenesis in the perfused rat heart, J. Biol. Chem., 263, 18036, 10.1016/S0021-9258(19)81320-0
Weidemann, 1969, The fuel of respiration of rat kidney cortex, Biochem. J., 112, 149, 10.1042/bj1120149
Fukao, 1997, Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases, Pediatr. Res., 42, 498, 10.1203/00006450-199710000-00013
Fukao, 2004, Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry, Prostaglandins Leukot. Essent. Fatty Acids, 70, 243, 10.1016/j.plefa.2003.11.001
Hegardt, 1999, Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis, Biochem. J., 338, 569, 10.1042/0264-6021:3380569
Wolfrum, 2004, Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes, Nature, 432, 1027, 10.1038/nature03047
Wolfrum, 2003, Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization, Proc. Natl. Acad. Sci. U.S.A., 100, 11624, 10.1073/pnas.1931483100
von Meyenn, 2013, Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism, Cell Metab., 17, 436, 10.1016/j.cmet.2013.01.014
Badman, 2007, Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states, Cell Metab., 5, 426, 10.1016/j.cmet.2007.05.002
Badman, 2009, Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis, Endocrinology, 150, 4931, 10.1210/en.2009-0532
Sengupta, 2010, mTORC1 controls fasting-induced ketogenesis and its modulation by ageing, Nature, 468, 1100, 10.1038/nature09584
Shimazu, 2010, SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production, Cell Metab., 12, 654, 10.1016/j.cmet.2010.11.003
Hebert, 2013, Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome, Mol. Cell, 49, 186, 10.1016/j.molcel.2012.10.024
Rardin, 2013, Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways, Proc. Natl. Acad. Sci. U.S.A., 110, 6601, 10.1073/pnas.1302961110
Quant, 1990, Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme, Eur. J. Biochem., 187, 169, 10.1111/j.1432-1033.1990.tb15291.x
Quant, 1989, Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity and decreases succinyl-CoA content in liver, Biochem. J., 262, 159, 10.1042/bj2620159
He, 2012, Mitochondrial sirtuins: regulators of protein acylation and metabolism, Trends Endocrinol. Metab., 23, 467, 10.1016/j.tem.2012.07.004
Turko, 2001, Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase, Am. J. Physiol. Heart Circ. Physiol., 281, H2289, 10.1152/ajpheart.2001.281.6.H2289
Pellerin, 2005, Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain, J. Neurosci. Res., 79, 55, 10.1002/jnr.20307
Balietti, 2010, Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain, Ageing Res. Rev., 9, 273, 10.1016/j.arr.2010.02.003
Hugo, 2012, A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting, Genes Dev., 26, 282, 10.1101/gad.180968.111
Hankermeyer, 1999, Polyhydroxybutyrate: plastic made and degraded by microorganisms, Rev. Environ. Contam. Toxicol., 159, 1
NCBI Resource Coordinators, 2013, Database resources of the National Center for Biotechnology Information, Nucleic Acids Res., 41, D8, 10.1093/nar/gks1189
Tunaru, 2003, PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect, Nat. Med., 9, 352, 10.1038/nm824
Taggart, 2005, (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G, J. Biol. Chem., 280, 26649, 10.1074/jbc.C500213200
Offermanns, 2011, International Union of Basic and Clinical Pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B), Pharmacol. Rev., 63, 269, 10.1124/pr.110.003301
Kimura, 2011, Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41), Proc. Natl. Acad. Sci. U.S.A., 108, 8030, 10.1073/pnas.1016088108
Blad, 2012, G protein-coupled receptors for energy metabolites as new therapeutic targets, Nat. Rev. Drug Discov., 11, 603, 10.1038/nrd3777
Layden, 2013, Short chain fatty acids and their receptors: new metabolic targets, Transl. Res., 161, 131, 10.1016/j.trsl.2012.10.007
Gregoretti, 2004, Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis, J. Mol. Biol., 338, 17, 10.1016/j.jmb.2004.02.006
Yang, 2008, The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men, Nat. Rev. Mol. Cell Biol., 9, 206, 10.1038/nrm2346
Mihaylova, 2013, Metabolic reprogramming by class I and II histone deacetylases, Trends Endocrinol. Metab., 24, 48, 10.1016/j.tem.2012.09.003
New, 2012, HDAC inhibitor-based therapies: can we interpret the code?, Mol. Oncol., 6, 637, 10.1016/j.molonc.2012.09.003
Glozak, 2005, Acetylation and deacetylation of non-histone proteins, Gene, 363, 15, 10.1016/j.gene.2005.09.010
Cousens, 1979, Different accessibilities in chromatin to histone acetylase, J. Biol. Chem., 254, 1716, 10.1016/S0021-9258(17)37831-6
Bolden, 2006, Anticancer activities of histone deacetylase inhibitors, Nat. Rev. Drug Discov., 5, 769, 10.1038/nrd2133
Vannini, 2004, Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor, Proc. Natl. Acad. Sci. U.S.A., 101, 15064, 10.1073/pnas.0404603101
Somoza, 2004, Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases, Structure, 12, 1325, 10.1016/j.str.2004.04.012
Wang, 2005, Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases, J. Med. Chem., 48, 6936, 10.1021/jm0505011
Sekhavat, 2007, Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate, Biochem. Cell Biol., 85, 751, 10.1139/O07-145
Madiraju, 2009, Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation, Epigenetics, 4, 399, 10.4161/epi.4.6.9767
Wellen, 2009, ATP-citrate lyase links cellular metabolism to histone acetylation, Science, 324, 1076, 10.1126/science.1164097
Muoio, 2012, Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility, Cell Metab., 15, 764, 10.1016/j.cmet.2012.04.005
Anson, 2005, The diet restriction paradigm: a brief review of the effects of every-other-day feeding, Age, 27, 17, 10.1007/s11357-005-3286-2
Hatori, 2012, Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet, Cell Metab., 15, 848, 10.1016/j.cmet.2012.04.019
Bainbridge, 1925, The reduced sensitivity to insulin of rats and mice fed on a carbohydrate-free, excess-fat diet, J. Physiol., 60, 293, 10.1113/jphysiol.1925.sp002248
Burcelin, 2002, Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet, Am. J. Physiol. Endocrinol. Metab., 282, E834, 10.1152/ajpendo.00332.2001
Kinzig, 2010, Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet, Endocrinology, 151, 3105, 10.1210/en.2010-0175
Borghjid, 2012, Response of C57Bl/6 mice to a carbohydrate-free diet, Nutr. Metab. (Lond.), 9, 69, 10.1186/1743-7075-9-69
Garbow, 2011, Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet, Am. J. Physiol. Gastrointest. Liver Physiol., 300, G956, 10.1152/ajpgi.00539.2010
Freedland, 2008, Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis, Prostate, 68, 11, 10.1002/pros.20683
Mavropoulos, 2009, The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model, Cancer Prev. Res. (Phila.), 2, 557, 10.1158/1940-6207.CAPR-08-0188
McDaniel, 2011, The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway, Epilepsia, 52, e7, 10.1111/j.1528-1167.2011.02981.x
Kennedy, 2007, A high-fat, ketogenic diet induces a unique metabolic state in mice, Am. J. Physiol. Endocrinol. Metab., 292, E1724, 10.1152/ajpendo.00717.2006
Badman, 2009, A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss, Am. J. Physiol. Endocrinol. Metab., 297, E1197, 10.1152/ajpendo.00357.2009
Jornayvaz, 2010, A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain, Am. J. Physiol. Endocrinol. Metab., 299, E808, 10.1152/ajpendo.00361.2010
Srivastava, 2013, A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice, IUBMB Life, 65, 58, 10.1002/iub.1102
Laeger, 2010, Role of beta-hydroxybutyric acid in the central regulation of energy balance, Appetite, 54, 450, 10.1016/j.appet.2010.04.005
Schugar, 2012, Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease, Curr. Opin. Clin. Nutr. Metab. Care, 15, 374, 10.1097/MCO.0b013e3283547157
Orentreich, 1993, Low methionine ingestion by rats extends life span, J. Nutr., 123, 269
Pamplona, 2006, Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection, Biochim. Biophys. Acta, 1757, 496, 10.1016/j.bbabio.2006.01.009
Ables, 2012, Methionine-restricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density, PLoS ONE, 7, e51357, 10.1371/journal.pone.0051357
Hirschey, 2011, SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome, Mol. Cell, 44, 177, 10.1016/j.molcel.2011.07.019
Ahola-Erkkila, 2010, Ketogenic diet slows down mitochondrial myopathy progression in mice, Hum. Mol. Genet., 19, 1974, 10.1093/hmg/ddq076
Houtkooper, 2012, Sirtuins as regulators of metabolism and healthspan, Nat. Rev. Mol. Cell Biol., 13, 225, 10.1038/nrm3293
Poplawski, 2011, Reversal of diabetic nephropathy by a ketogenic diet, PLoS ONE, 6, e18604, 10.1371/journal.pone.0018604
Harvie, 2013, The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women, Br. J. Nutr., 1
Westman, 2008, The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus, Nutr. Metab. (Lond.), 5, 36, 10.1186/1743-7075-5-36
Nordmann, 2006, Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials, Arch. Intern. Med., 166, 285, 10.1001/archinte.166.3.285
Hartman, 2007, Clinical aspects of the ketogenic diet, Epilepsia, 48, 31, 10.1111/j.1528-1167.2007.00914.x
Kashiwaya, 2013, A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease, Neurobiol. Aging, 34, 1530, 10.1016/j.neurobiolaging.2012.11.023
Henderson, 2009, Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial, Nutr. Metab. (Lond.), 6, 31, 10.1186/1743-7075-6-31
Reger, 2004, Effects of beta-hydroxybutyrate on cognition in memory-impaired adults, Neurobiol. Aging, 25, 311, 10.1016/S0197-4580(03)00087-3
Tieu, 2003, D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease, J. Clin. Invest., 112, 892, 10.1172/JCI200318797
Vanitallie, 2005, Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study, Neurology, 64, 728, 10.1212/01.WNL.0000152046.11390.45
Zhao, 2006, A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis, BMC Neurosci., 7, 29, 10.1186/1471-2202-7-29
Noh, 2008, Neuroprotective effects of the ketogenic diet, Epilepsia, 49, 120, 10.1111/j.1528-1167.2008.01855.x
Lim, 2011, D-beta-hydroxybutyrate is protective in mouse models of Huntington's disease, PLoS ONE, 6, e24620, 10.1371/journal.pone.0024620
Sadri-Vakili, 2006, Mechanisms of disease: histone modifications in Huntington's disease, Nat. Clin. Pract. Neurol., 2, 330, 10.1038/ncpneuro0199
Kashiwaya, 2000, D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease, Proc. Natl. Acad. Sci. U.S.A., 97, 5440, 10.1073/pnas.97.10.5440
Hu, 2009, Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats, Ann. Clin. Lab. Sci., 39, 76
Appelberg, 2009, The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat, J. Neurotrauma, 26, 497, 10.1089/neu.2008.0664
Puchowicz, 2008, Neuroprotection in diet-induced ketotic rat brain after focal ischemia, J. Cereb. Blood Flow Metab., 28, 1907, 10.1038/jcbfm.2008.79
Tai, 2008, Ketogenic diet prevents cardiac arrest-induced cerebral ischemic neurodegeneration, J. Neural Transm., 115, 1011, 10.1007/s00702-008-0050-7
Masuda, 2005, D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures, J. Neurosci. Res., 80, 501, 10.1002/jnr.20464
Samoilova, 2010, Chronic in vitro ketosis is neuroprotective but not anti-convulsant, J. Neurochem., 113, 826, 10.1111/j.1471-4159.2010.06645.x
Juge, 2010, Metabolic control of vesicular glutamate transport and release, Neuron, 68, 99, 10.1016/j.neuron.2010.09.002
Miller, 2009, Cell stress and new emphasis on multiplex resistance mechanisms, J. Gerontol. Ser. A: Biol. Sci. Med. Sci., 64, 179, 10.1093/gerona/gln072
Shore, 2012, Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways, PLoS Genet., 8, e1002792, 10.1371/journal.pgen.1002792
Alam, 2001, Resuscitation-induced pulmonary apoptosis and intracellular adhesion molecule-1 expression in rats are attenuated by the use of Ketone Ringer's solution, J. Am. Coll. Surg., 193, 255, 10.1016/S1072-7515(01)01004-3
Koustova, 2003, Ketone and pyruvate Ringer's solutions decrease pulmonary apoptosis in a rat model of severe hemorrhagic shock and resuscitation, Surgery, 134, 267, 10.1067/msy.2003.245
Ayuste, 2006, Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications of conventional Ringer's solution, J. Trauma, 60, 52, 10.1097/01.ta.0000200156.05397.0b
Jaskille, 2006, Hepatic apoptosis after hemorrhagic shock in rats can be reduced through modifications of conventional Ringer's solution, J. Am. Coll. Surg., 202, 25, 10.1016/j.jamcollsurg.2005.08.027
Klein, 2010, Small-volume D-beta-hydroxybutyrate solution infusion increases survivability of lethal hemorrhagic shock in rats, Shock, 34, 565, 10.1097/SHK.0b013e3181e15063
Mulier, 2012, Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock, Resuscitation, 83, 253, 10.1016/j.resuscitation.2011.08.003
Zou, 2002, DL-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts, Am. J. Physiol. Heart Circ. Physiol., 283, H1968, 10.1152/ajpheart.00250.2002
Mihaylova, 2011, Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis, Cell, 145, 607, 10.1016/j.cell.2011.03.043
Knutson, 2008, Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks, EMBO J., 27, 1017, 10.1038/emboj.2008.51
Fajas, 2002, The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation, Dev Cell, 3, 903, 10.1016/S1534-5807(02)00360-X
Bhaskara, 2010, Hdac3 is essential for the maintenance of chromatin structure and genome stability, Cancer Cell, 18, 436, 10.1016/j.ccr.2010.10.022
Gao, 2009, Butyrate improves insulin sensitivity and increases energy expenditure in mice, Diabetes, 58, 1509, 10.2337/db08-1637
Zhang, 2007, Sodium butyrate prevents lethality of severe sepsis in rats, Shock, 27, 672, 10.1097/SHK.0b013e31802e3f4c
Ni, 2010, Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice, Respir. Res., 11, 33, 10.1186/1465-9921-11-33
Fischer, 2007, Recovery of learning and memory is associated with chromatin remodelling, Nature, 447, 178, 10.1038/nature05772
Peleg, 2010, Altered histone acetylation is associated with age-dependent memory impairment in mice, Science, 328, 753, 10.1126/science.1186088
Guan, 2009, HDAC2 negatively regulates memory formation and synaptic plasticity, Nature, 459, 55, 10.1038/nature07925
Graff, 2012, An epigenetic blockade of cognitive functions in the neurodegenerating brain, Nature, 483, 222, 10.1038/nature10849
Kim, 2008, Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity, Neuron, 60, 803, 10.1016/j.neuron.2008.10.015
Dobbin, 2013, SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons, Nat. Neurosci., 16, 1008, 10.1038/nn.3460
Kim, 1999, Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae, Mol. Biol. Cell, 10, 3125, 10.1091/mbc.10.10.3125
Kaeberlein, 2010, Lessons on longevity from budding yeast, Nature, 464, 513, 10.1038/nature08981
Yi, 2012, Function and molecular mechanism of acetylation in autophagy regulation, Science, 336, 474, 10.1126/science.1216990
Rogina, 2002, Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction, Science, 298, 1745, 10.1126/science.1078986
Rogina, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proc. Natl. Acad. Sci. U.S.A., 101, 15998, 10.1073/pnas.0404184101
Mannervik, 1999, The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo, Proc. Natl. Acad. Sci. U.S.A., 96, 6797, 10.1073/pnas.96.12.6797
Zhao, 2005, Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors, J. Exp. Biol., 208, 697, 10.1242/jeb.01439
Kang, 2002, Life extension in Drosophila by feeding a drug, Proc. Natl. Acad. Sci. U.S.A., 99, 838, 10.1073/pnas.022631999
Evason, 2008, Valproic acid extends Caenorhabditis elegans lifespan, Aging Cell, 7, 305, 10.1111/j.1474-9726.2008.00375.x
Lagger, 2002, Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression, EMBO J., 21, 2672, 10.1093/emboj/21.11.2672
Zimmermann, 2007, Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice, Cancer Res., 67, 9047, 10.1158/0008-5472.CAN-07-0312
Wilting, 2010, Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis, EMBO J., 29, 2586, 10.1038/emboj.2010.136
Dovey, 2010, Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation, Proc. Natl. Acad. Sci. U.S.A., 107, 8242, 10.1073/pnas.1000478107
Kossoff, 2012, Ketogenic diets: new advances for metabolism-based therapies, Curr. Opin. Neurol., 25, 173, 10.1097/WCO.0b013e3283515e4a
Schwer, 2009, Calorie restriction alters mitochondrial protein acetylation, Aging Cell, 8, 604, 10.1111/j.1474-9726.2009.00503.x