Kaposi's sarcoma herpesvirus-induced endothelial cell reprogramming supports viral persistence and contributes to Kaposi's sarcoma tumorigenesis

Current Opinion in Virology - Tập 26 - Trang 156-162 - 2017
Silvia Gramolelli1, Päivi M Ojala1,2,3
1Research Programs Unit, Translational Cancer Biology, University of Helsinki, Biomedicum Helsinki, P.O. Box 63 (Haartmaninkatu 8), University of Helsinki FIN-00014, Finland
2Foundation for the Finnish Cancer Institute, Helsinki, Finland
3Section of Virology, Division of Infectious Diseases, Department of Medicine, Imperial College London, London, UK

Tài liệu tham khảo

Chang, 1994, Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science, 266, 1865, 10.1126/science.7997879 Russo, 1996, Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8), Proc Natl Acad Sci U S A, 93, 14862, 10.1073/pnas.93.25.14862 Cesarman, 1995, Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas, N Engl J Med, 332, 1186, 10.1056/NEJM199505043321802 Soulier, 1995, Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease, Blood, 86, 1276, 10.1182/blood.V86.4.1276.bloodjournal8641276 Wong, 2017, Modulation of oncogenic signaling networks by Kaposi's sarcoma-associated herpesvirus, Biol Chem Dittmer, 2016, Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy, J Clin Invest, 126, 3165, 10.1172/JCI84418 Abere, 2016, KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma, Curr Opin Virol, 20, 11, 10.1016/j.coviro.2016.07.008 Gramolelli, 2015, The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma, J Pathol, 235, 368, 10.1002/path.4441 Schulz, 2015, Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis, Curr Opin Virol, 14, 116, 10.1016/j.coviro.2015.08.016 Mendez, 2000, Kaposi's sarcoma and transplantation, Herpes, 7, 18 Wood, 2008, The malignant potential of HIV-associated Kaposi sarcoma, Cancer Cell Int, 8, 14, 10.1186/1475-2867-8-14 Gessain, 2005, Spindle cells and their role in Kaposi's sarcoma, Int J Biochem Cell Biol, 37, 2457, 10.1016/j.biocel.2005.01.018 Wang, 2004, Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma, Nat Genet, 36, 687, 10.1038/ng1384 Cheng, 2011, KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition, Cell Host Microbe, 10, 577, 10.1016/j.chom.2011.10.011 Weich, 1991, AIDS-associated Kaposi's sarcoma-derived cells in long-term culture express and synthesize smooth muscle alpha-actin, Am J Pathol, 139, 1251 Pyakurel, 2006, Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development, Int J Cancer, 119, 1262, 10.1002/ijc.21969 Simonart, 2002, Expression of the fibroblast/macrophage marker 1B10 by spindle cells in Kaposi's sarcoma lesions and by Kaposi's sarcoma-derived tumor cells, J Cutan Pathol, 29, 72, 10.1034/j.1600-0560.2002.290202.x Sturzl, 1995, Identification of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma: a combined in vitro and in vivo analysis, Oncogene, 10, 2007 Cancian, 2013, Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogramming, Trends Cell Biol, 23, 421, 10.1016/j.tcb.2013.04.001 Ojala, 2014, Manipulation of endothelial cells by KSHV: implications for angiogenesis and aberrant vascular differentiation, Semin Cancer Biol, 26, 69, 10.1016/j.semcancer.2014.01.008 Wang, 2008, Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells, Cancer Res, 68, 4640, 10.1158/0008-5472.CAN-07-5988 Gasperini, 2012, Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling, Cancer Res, 72, 1157, 10.1158/0008-5472.CAN-11-3067 Cheng, 2012, Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses, Future Microbiol, 7, 1191, 10.2217/fmb.12.95 Radu, 2013, Kaposi sarcoma, Arch Pathol Lab Med, 137, 289, 10.5858/arpa.2012-0101-RS Pantanowitz, 2008, Kaposi sarcoma in unusual locations, BMC Cancer, 8, 190, 10.1186/1471-2407-8-190 Dorfman, 1988, Kaposi's sarcoma: evidence supporting its origin from the lymphatic system, Lymphology, 21, 45 Dupin, 1999, Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma, Proc Natl Acad Sci U S A, 96, 4546, 10.1073/pnas.96.8.4546 Benevenuto de Andrade, 2014, Expression of PROX-1 in oral Kaposi's sarcoma spindle cells, J Oral Pathol Med, 43, 132, 10.1111/jop.12097 Della Bella, 2008, Peripheral blood endothelial progenitors as potential reservoirs of Kaposi's sarcoma-associated herpesvirus, PLoS ONE, 3, e1520, 10.1371/journal.pone.0001520 Calcaterra, 2017, Increased frequency and vasculogenic potential of endothelial colony-forming cells in patients with Kaposi's sarcoma, J Invest Dermatol, 10.1016/j.jid.2017.02.979 Browning, 1994, Identification and culture of Kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controls, Blood, 84, 2711, 10.1182/blood.V84.8.2711.2711 Douglas, 2007, Kaposi's sarcoma: a model of both malignancy and chronic inflammation, Panminerva Med, 49, 119 Hong, 2002, Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate, Dev Dyn, 225, 351, 10.1002/dvdy.10163 Wigle, 2002, An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype, EMBO J, 21, 1505, 10.1093/emboj/21.7.1505 Wigle, 1999, Prox1 function is required for the development of the murine lymphatic system, Cell, 98, 769, 10.1016/S0092-8674(00)81511-1 Bixel, 2008, Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells, Genes Dev, 22, 3232, 10.1101/gad.1751908 Johnson, 2008, Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity, Genes Dev, 22, 3282, 10.1101/gad.1727208 Petrova, 2002, Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor, EMBO J, 21, 4593, 10.1093/emboj/cdf470 Hong, 2004, Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus, Nat Genet, 36, 683, 10.1038/ng1383 Carroll, 2004, Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation, Virology, 328, 7, 10.1016/j.virol.2004.07.008 Emuss, 2009, KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia, PLoS Pathog, 5, e1000616, 10.1371/journal.ppat.1000616 Hansen, 2010, KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming, Genes Dev, 24, 195, 10.1101/gad.553410 Mocroft, 1996, Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group, AIDS, 10, 1101 Spano, 2000, Factors predictive of disease progression and death in AIDS-related Kaposi's sarcoma, HIV Med, 1, 232, 10.1046/j.1468-1293.2000.00034.x Glesby, 1996, Use of antiherpes drugs and the risk of Kaposi's sarcoma: data from the Multicenter AIDS Cohort Study, J Infect Dis, 173, 1477, 10.1093/infdis/173.6.1477 Staskus, 1997, Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells, J Virol, 71, 715, 10.1128/JVI.71.1.715-719.1997 Cavallin, 2014, Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi's sarcoma associated with HIV/AIDS, PLoS Pathog, 10, e1004154, 10.1371/journal.ppat.1004154 Mesri, 2013, Molecular studies and therapeutic targeting of Kaposi's sarcoma herpesvirus (KSHV/HHV-8) oncogenesis, Immunol Res, 57, 159, 10.1007/s12026-013-8458-z Glaunsinger, 2004, Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover, Mol Cell, 13, 713, 10.1016/S1097-2765(04)00091-7 Glaunsinger, 2004, Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis, J Exp Med, 200, 391, 10.1084/jem.20031881 Chandriani, 2007, Host transcript accumulation during lytic KSHV infection reveals several classes of host responses, PLoS ONE, 2, e811, 10.1371/journal.pone.0000811 Grundhoff, 2004, Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis, J Clin Invest, 113, 124, 10.1172/JCI200417803 Lagunoff, 2002, De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells, J Virol, 76, 2440, 10.1128/jvi.76.5.2440-2448.2002 McAllister, 2007, Endothelial cell- and lymphocyte-based in vitro systems for understanding KSHV biology, Curr Top Microbiol Immunol, 312, 211 Sturzl, 2013, Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line, Int J Cancer, 132, 1954, 10.1002/ijc.27849 Renne, 1998, Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells, J Virol, 72, 5182, 10.1128/JVI.72.6.5182-5188.1998 Drexler, 1998, Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas), Leukemia, 12, 1507, 10.1038/sj.leu.2401160 Mutlu, 2007, In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma, Cancer Cell, 11, 245, 10.1016/j.ccr.2007.01.015 Austgen, 2012, Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells, J Virol, 86, 1877, 10.1128/JVI.06600-11 Chang, 2013, A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity, Cell Host Microbe, 13, 429, 10.1016/j.chom.2013.03.009 Yogev, 2013, Redefining KSHV latency, Cell Host Microbe, 13, 373, 10.1016/j.chom.2013.04.003 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 Weitzman, 2004, Interactions of viruses with the cellular DNA repair machinery, DNA Repair (Amst), 3, 1165, 10.1016/j.dnarep.2004.03.018 Hollingworth, 2015, Modulation of DNA damage and repair pathways by human tumour viruses, Viruses, 7, 2542, 10.3390/v7052542 Koopal, 2007, Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis, PLoS Pathog, 3, 1348, 10.1371/journal.ppat.0030140 Singh, 2014, Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment, J Virol, 88, 2821, 10.1128/JVI.03126-13 Jackson, 2014, A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells, PLoS Pathog, 10, e1004098, 10.1371/journal.ppat.1004098 Hollingworth, 2015, Activation of DNA damage response pathways during lytic replication of KSHV, Viruses, 7, 2908, 10.3390/v7062752 Balistreri, 2016, Oncogenic herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication, PLoS Pathog, 12, e1005424, 10.1371/journal.ppat.1005424 Hosseinipour, 2014, Viral profiling identifies multiple subtypes of Kaposi's sarcoma, MBio, 5, 10.1128/mBio.01633-14