KRAS mutations are associated with inferior clinical outcome in patients with metastatic colorectal cancer, but are not predictive for benefit with cediranib

European Journal of Cancer - Tập 49 - Trang 2424-2432 - 2013
John C. Smith1, Laura Brooks2, Paulo M. Hoff3,4, Gael McWalter5, Simon Dearden5, Shethah R. Morgan2, David Wilson2, Jane D. Robertson2, Juliane M. Jürgensmeier6
1Former AstraZeneca (RDG), Macclesfield, UK
2Clinical Oncology, AstraZeneca, Macclesfield, UK
3Instituto do Cancer do Estado de São Paulo, Universidade de São Paulo, São Paulo, Brazil
4Centro de Oncologia, Hospital Sírio Libanês, São Paulo, Brazil
5Personalised Healthcare and Biomarkers, AstraZeneca, Macclesfield, UK
6Translational Sciences, Oncology, AstraZeneca, Macclesfield, UK

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