Judah Folkman, một người tiên phong trong nghiên cứu về sự hình thành mạch máu

Domenico Ribatti1
1Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

Tóm tắt

Hơn 30 năm trước, Judah Folkman đã tìm ra một cách tư duy cách mạng về ung thư. Ông đã giả thuyết rằng để tồn tại và phát triển, các khối u cần có mạch máu, và bằng cách cắt đứt nguồn cung cấp máu, một khối u ung thư có thể bị đói và giảm thiểu khối u. Những gì ban đầu được xem là một phương pháp cách mạng để điều trị ung thư đã phát triển thành một trong những lĩnh vực nghiên cứu khoa học thú vị nhất hiện nay. Qua nhiều năm, Folkman và một đội ngũ ngày càng mở rộng của các nhà nghiên cứu đã phân lập các protein và khám phá các quá trình điều hòa sự hình thành mạch máu. Trong khi đó, một thế hệ nghiên cứu về sự hình thành mạch máu mới đã xuất hiện, mở rộng lĩnh vực nghiên cứu vào những lĩnh vực mới của bệnh lý con người và đào sâu vào việc xem xét các quy trình sinh học cơ bản chịu trách nhiệm cho những căn bệnh đó.

Từ khóa

#ung thư #hình thành mạch máu #Judah Folkman #nghiên cứu khoa học

Tài liệu tham khảo

Ide AG, Baker NH, Warren SL (1939) Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. AJR 32:891–899 Algire GH, Chalkley HW (1945) Vascular reactions of normal and malignant tissue in vivo. J Natl Cancer Inst 6:73–85 Melwin RM, Algire GH (1956) The role of graft and host vessels in vascularization of grafts of normal and neoplastic tissues. J Natl Cancer Inst 17:23–33 Greenblatt M, Shubik P (1968) Tumor angiogenesis: transfilter diffusion studied in the hamster by the transparent chamber technique. J Natl Cancer Inst 41:1111–1124 Ehrman RL, Knoth M (1968) Choriocarcinoma: transfilter stimulation of vasoproliferation in the hamster cheek pouch studied by light and electron microscopy. J Natl Cancer Inst 41:1329–1341 Folkman MJ, Long DM, Becker FF (1963) Growth and metastasis of tumor in organ culture. Cancer 16:453–467 Gimbrone MA Jr, Aster RH, Cotran RS, Corkery J, Jandl JH, Folkman J (1969) Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature 222:33–36 Green HSN (1941) Heterologous transplantation of mammalian tumors: I. The transfer of rabbit tumors to alien species. J Exp Med 73:461–474 Folkman J (1971) Tumor angiogenesis. Therapeutic implications. N Engl J Med 285:1182–1186 Gimbrone MA Jr, Cotran RS, Folkman J (1974) Tumor growth and neovascularization: an experimental model using rabbit cornea. J Natl Cancer Inst 52:413–427 Gimbrone MA, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136:261–276 Gimbrone MA, Leapman S, Cotran RS, Folkman J (1973) Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst 50:219–228 Folkman J, Hochberg M (1983) Self-regulation of growth in three dimensions. J Exp Med 138:745–753 Knighton D, Ausprunk D, Tapper D, Folkman J (1977) Avascular and vascular phases of tumour growth in the chick embryo. Br J Cancer 35:347–356 Brem S, Brem H, Folkman J, Finkelstein D, Patz G (1976) Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Res 36:2807–2812 Ausprunk DH, Knighton DR, Folkman J (1974) Differentiation of vascular endothelium in the chick chorioallantois: a structural and autoradiographic study. Dev Biol 38:237–248 Ausprunk DH, Knighton DR, Folkman J (1975) Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. Am J Pathol 79:597–618 Folkman J, Watson K, Ingber D, Hanahan D (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339:58–61 Folkman J, Merler E, Abernathy C, Williams G (1971) Isolation of a tumor fraction responsible for angiogenesis. J Exp Med 133:275–288 Tuan D, Smith S, Folkman J, Merler E (1973) Isolation of the nonhistone proteins of rat Walker 256 carcinoma. Their association with tumor angiogenesis. Biochemistry 12:3159–3165 Mc Auslan BR, Hoffman H (1979) Endothelium stimulating factor from Walker carcinoma cells. Relation to tumor angiogenic factor. Exp Cell Res 119:181–190 Weiss JB, Brown RA, Kumar S, Phillips P (1979) An angiogenic factor isolated from tumours: a potent low-molecular weight compound. Br J Cancer 40:493–496 Fenselau A, Kaiser D, Wallis K (1981) Nucleoside requirements for the in vivo growth of bovine aortic endothelial cells. J Cell Physiol 108:375–384 Cavallo T, Sade R, Folkman J, Cotran RS (1972) Tumor angiogenesis: rapid induction of endothelial mitosis demonstrated by autoradiography. J Cell Biol 54:408–420 Cavallo T, Sade R, Folkman J, Cotran RS (1973) Ultrastructural autoradiographic studies of the early vasoproliferative response in tumor angiogenesis. Am J Pathol 70:345–362 Holmgren L, O’Reilly MS, Folkman J (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1:149–153 Brem S, Cotran R, Folkman J (1972) Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst 48:347–356 Weidner N, Semple JP, Welch WR, Folkman J (1971) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324:1–8 Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G (1992) Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast cancer. J Natl Cancer Inst 84:1875–1887 Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J (1993) Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 143:401–409 Eisenstein R, Sorgente N, Soble L, Miller A, Kuettner KE (1973) The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme. Am J Pathol 73:765–774 Brem H, Folkman J (1975) Inhibition of tumor angiogenesis mediated by cartilage. J Exp Med 141:427–439 Langer R, Conn H, Vacanti J, Haudenschild C, Folkman J (1980) Control of tumor growth in animals by infusion of an angiogenesis inhibitor. Proc Natl Acad Sci USA 77:4331–4335 Fotsis T, Zhang Y, Pepper MS, Adlercreutz H, Montesano R, Nawroth PP, Schweigerer L (1994) The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumor growth. Nature 368:237–239 D’Amato RJ, Lin CM, Flynn E, Folkman J, Hamel E (1994) 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc Natl Acad Sci USA 91:3964–3968 Brouty-Boye D, Zetter BR (1980) Inhibition of cell motility by interferon. Science 208:516–518 Ezekowitz RA, Mulliken JB, Folkman J (1972) Interferon alfa-2a therapy for lifethreatening hemangiomas of infancy. New Engl J Med 326:1456–1463 Kaban LB, Mulliken JB, Ezekowitz RA, Ebb D, Smith PS, Folkman J (1999) Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics 103:1145–1149 Folkman J (2002) Discussion: antiangiogenic therapy with interferon alpha for giant lesions of the jaws. J Oral Maxillofac Surg 60:1111–1113 Taylor S, Folkman J (1972) Protamine is an inhibitor of angiogenesis. Nature 297:307–312 Maione TE, Gray GS, Petro J, Hunt AJ, Donner AL, Bauer SI, Carson HF, Sharpe RJ (1990) Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 247:71–79 Sharpe RJ, Byers HR, Scott CF, Bauer SI, Maione TE (1990) Growth inhibition of murine melanoma and human colon carcinoma by recombinant human platelet factor 4. J Natl Cancer Inst 82:848–853 Folkman J, Langer R, Linhardt R, Haudenschild C, Taylor S (1983) Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science 221:719–725 Ingber DE, Madri JA, Folkman J (1986) A possible mechanism for inhibition of angiogenesis by angiostatic steroids: induction of capillary basement membrane dissolution. Endocrinology 119:1768–1775 Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, Folkman J (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348:355–357 Rastinejad F, Polverini PJ, Bouck NP (1989) Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell 56:345–355 O’Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastasis by a Lewis lung carcinoma. Cell 79:315–328 O’Reilly MS, Holmgren L, Chen C, Folkman J (1996) Angiostatin induces and sustain dormancy of human primary tumors in mice. Nat Med 2:689–692 O’Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277–285 D’Amato RJ, Loughnan MS, Flynn E, Folkman J (1994) Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 91:4082–4085 O’Reilly MS, Pirie-Shepherd S, Lane WS, Folkman J (1999) Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 285:1926–1928 Satchi-Fainaro R, Puder M, Davies JW, Tran HT, Sampson DA, Greene AK, Corfas G, Folkman J (2004) Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat Med 10:255–261 Satchi-Fainaro R, Mamluk R, Wang L, Short SM, Nagy JA, Feng D, Dvorak AM, Dvorak HF, Puder M, Mukhopadahyay D, Folkman J (2005) Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin. Cancer Cell 7:251–261 Browder T, Butterfield CE, Kraling BM, Shi B, Marshall B, O’Reilly MS, Folkman J (2000) Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60:1878–1886