Jeffrey A. Norton and the Multiple Endocrine Neoplasia Syndromes

Samuel A. Wells1
1Department of Surgery, Washington University School of Medicine, St. Louis, USA

Tóm tắt

Jeffrey A. Norton could have been a professional football player but instead he chose to pursue a career in medicine and in the process became an outstanding academic surgeon. This story recounts his ascent from a small town in Massachusetts to the pinnacle of academic surgery. After graduating from high school in Albany, New York, Jeff continued his education at Dartmouth University, the State University of New York Upstate Medical University at Syracuse (SUNY Upstate Medical University), and the Department of Surgery at the Duke University School of Medicine. When he completed the surgical residency, he spent 10 years at the National Cancer Institute (NCI) where he and his colleagues made significant contributions to the diagnosis and treatment of patients with endocrine tumors. After leaving the NCI, he had highly productive years as a Professor in Departments of Surgery at Washington University, the University of California at San Francisco, and Stanford University. He became a member of every major academic surgical society and won numerous awards for his accomplishments in research. His expertise in educating medical students and surgical residents is legendary. In addition to his academic accomplishments, Jeff trained legions of young surgeons who subsequently made significant contributions in surgical investigation and clinical surgery. It is most fitting that the Stanford University School of Medicine has assembled a group of Jeffrey Norton’s colleagues in academic medicine and surgery to pay tribute to his achievements as a surgical scientist.

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Tài liệu tham khảo

Wermer P. Genetic aspects of adenomatosis of endocrine glands. Am J Med. 1954;16:363–71. Chandrasekharappa SC, Guru SC, Siradanahalli C, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997;276:404–7. Zollinger RM, Ellison EH. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955;142:709–23. Norton JA, Fraker DL, Alexander HR, et al. Surgery to cure the Zollinger–Ellison syndrome. N Engl J Med. 1999;341:635–44. Sipple JH. The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med. 1961;31:163–6. Hazard JB, Hawk WA, Crile G Jr. Medullary (solid) thyroid carcinoma of the thyroid; a clinicopathology entity. J Clin Endocrinol Metabol. 1959;19:152–6. Steiner A, Goodman AA, Powers SR. Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism, and Cushing’s disease: multiple endocrine neoplasia type 2. Medicine. 1968;43:371–408. Sipple JH. Multiple endocrine type 2 syndromes. Historical perspectives. Henry Ford Hosp Med J. 1984;32:219–22. Hughes JM, Sipple JH, MacGillivray DC, et al. The sipple syndrome: from clinical description to genetic analysis in the index family. Endocrinol. 1996;6:427–30. Norton JA, Froome LC, Farrell RE, Wells SA Jr. Multiple endocrine neoplasia type IIb. The most aggressive form of medullary thyroid carcinoma. Surg Clin N Am. 1979;59:109–18. Wells SA Jr, Chi DD, Toshima K, et al. Genetic and clinical studies in the multiple endocrine neoplasia type 2 syndromes. Ann Surg. 1994;220:237–50. Norton JA. The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism. World J Surg. 1987;11:579–85. Norton JA, Cornelius MJ, Doppman JL, et al. Effect of parathyroidectomy in patients with hyperparathyroidism and Zollinger–Ellison syndrome and multiple endocrine neoplasia. Type 1: a prospective study. Surgery. 1987;102:958–66. Doherty GM, Doppman JL, Miller DL, et al. Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism. Ann Surg. 1992;215:101–6. Norton JA, Doppman JL, Collen MJ, et al. Prospective study of gastrinoma localization and resection in patients with Zollinger–Ellison Syndrome (ZES). Ann Surg. 1986;204:468–79. Perry R, Neiman L, Cutler G. Primary adrenal causes of Cushing’s syndrome: diagnosis and surgical management. Ann Surg. 1989;210:59–68. Krampitz GW, Norton JA. RET gene mutations (genotype and phenotype) of multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. Cancer. 2014;120:1920–31. Doppman JL, Miller DL, Chang R, et al. Intraarterial calcium stimulation test for detection of insulinomas. World J Surg. 1993;17:439–43.