JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models

Merkler, 2007, The burden of hyperlipidaemia and diabetes in cardiovascular diseases, Fundam Clin Pharmacol, 21, 1, 10.1111/j.1472-8206.2007.00529.x Graham, 2012, Dyslipidemias in the prevention of cardiovascular disease: risks and causality, Curr Cardiol Rep, 14, 709, 10.1007/s11886-012-0313-7 Matsumoto, 1990, Isolation and preliminary characterization of antigenic variant of echovirus type 11, J Med Virol, 31, 253, 10.1002/jmv.1890310403 Sahebkar, 2013, New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes, Clin Ther, 35, 1082, 10.1016/j.clinthera.2013.06.019 Alla, 2013, A reappraisal of the risks and benefits of treating to target with cholesterol lowering drugs, Drugs, 73, 1025, 10.1007/s40265-013-0072-9 Packard, 2004, Non-HDL cholesterol as a measure of atherosclerotic risk, J Atheroscler Thromb, 11, 6, 10.5551/jat.11.6 Miller, 2008, Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease, Am J Cardiol, 101, 1003, 10.1016/j.amjcard.2007.11.046 Sniderman, 2010, Why is non-high-density lipoprotein cholesterol a better marker of the risk of vascular disease than low-density lipoprotein cholesterol?, J Clin Lipidol, 4, 152, 10.1016/j.jacl.2010.03.005 deGoma, 2008, Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches, J Am Coll Cardiol, 51, 2199, 10.1016/j.jacc.2008.03.016 Rohatgi, 2014, HDL cholesterol efflux capacity and incident cardiovascular events, N Engl J Med, 371, 2383, 10.1056/NEJMoa1409065 Wetterau, 1997, Microsomal triglyceride transfer protein, Biochim Biophys Acta, 1345, 136, 10.1016/S0005-2760(96)00168-3 Olofsson, 1999, The assembly and secretion of apolipoprotein B-containing lipoproteins, Curr Opin Lipidol, 10, 341, 10.1097/00041433-199908000-00008 Gordon, 1995, Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles, Trends Cell Biol, 5, 317, 10.1016/S0962-8924(00)89054-6 Wierzbicki, 2009, Future challenges for microsomal transport protein inhibitors, Curr Vasc Pharmacol, 7, 277, 10.2174/157016109788340703 Mera, 2011, Pharmacological characterization of diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl) amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an intestine-specific inhibitor of microsomal triglyceride transfer protein, J Pharmacol Exp Ther, 336, 321, 10.1124/jpet.110.173807 Mera, 2014, JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, reduces food preference for fat, J Diabetes Res, 2014, 583752 Hata, 2011, JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats, Diabetes Obes Metab, 13, 446, 10.1111/j.1463-1326.2011.01368.x Hata, 2011, JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats, Diabetes Obes Metab, 13, 629, 10.1111/j.1463-1326.2011.01387.x Hildebrand, 1989, Effects of atracurium administered by continuous intravenous infusion in halothane-anesthetized horses, Am J Vet Res, 50, 2124 Okamoto, 2000, A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits, Nature, 406, 203, 10.1038/35018119 Zhao, 2014, Increased peripheral proinflammatory T helper subsets contribute to cardiovascular complications in diabetic patients, Mediat Inflamm, 2014, 596967, 10.1155/2014/596967 Chung, 2014, Effect of instant cooked giant embryonic rice on body fat weight and plasma lipid profile in high fat-fed mice, Nutrients, 6, 2266, 10.3390/nu6062266 Hussain, 2013, Regulating intestinal function to reduce atherogenic lipoproteins, Clin Lipidol, 8, 10.2217/clp.13.40 Rajagopal, 2012, High-density lipoprotein cholesterol: how High, Indian J Endocrinol Metab, 16, S236, 10.4103/2230-8210.104048 Tall, 2008, Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins, J Intern Med, 263, 256, 10.1111/j.1365-2796.2007.01898.x Khera, 2011, Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis, N Engl J Med, 364, 127, 10.1056/NEJMoa1001689 Shiomi, 2013, Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins, Atherosclerosis, 231, 39, 10.1016/j.atherosclerosis.2013.08.030 Davis, 2011, Effects of ezetimibe on atherosclerosis in preclinical models, Atherosclerosis, 215, 266, 10.1016/j.atherosclerosis.2011.02.010 Libby, 2002, Inflammation in atherosclerosis, Nature, 420, 868, 10.1038/nature01323 Koltsova, 2012, Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis, J Clin Invest, 122, 3114, 10.1172/JCI61758 Moore, 2013, Macrophages in atherosclerosis: a dynamic balance, Nat Rev Immunol, 13, 709, 10.1038/nri3520 Ye, 2011, The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice, Am J Pathol, 178, 413, 10.1016/j.ajpath.2010.11.007