JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells

Bedford, 2009, Protein arginine methylation in mammals: who, what, and why, Mol. Cell, 33, 1, 10.1016/j.molcel.2008.12.013 Beurlet, 2013, Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?, Haematologica, 98, 10, 10.3324/haematol.2012.069385 Blanc, 2017, Arginine methylation: the coming of age, Mol. Cell, 65, 8, 10.1016/j.molcel.2016.11.003 Chang, 2007, JMJD6 is a histone arginine demethylase, Science, 318, 444, 10.1126/science.1145801 Chen, 2011, Deciphering arginine methylation: Tudor tells the tale, Nat. Rev. Mol. Cell Biol., 12, 629, 10.1038/nrm3185 Chen, 2012, G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment, Genes Dev., 26, 2499, 10.1101/gad.200329.112 Chung, 2006, Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration, Blood, 108, 1208, 10.1182/blood-2006-01-010199 Cloos, 2008, Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease, Genes Dev., 22, 1115, 10.1101/gad.1652908 Cunningham, 2013, WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio, Blood, 122, 188, 10.1182/blood-2012-11-466086 Fuhrmann, 2015, Chemical biology of protein arginine modifications in epigenetic regulation, Chem. Rev., 115, 5413, 10.1021/acs.chemrev.5b00003 Girardot, 2014, PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome, Nucleic Acids Res., 42, 235, 10.1093/nar/gkt884 Greer, 2012, Histone methylation: a dynamic mark in health, disease and inheritance, Nat. Rev. Genet., 13, 343, 10.1038/nrg3173 Guo, 2010, Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding, Nat. Chem. Biol., 6, 766, 10.1038/nchembio.422 Huang, 2014, SnapShot: histone modifications, Cell, 159, 458, 10.1016/j.cell.2014.09.037 Ito, 2012, A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance, Nat. Med., 18, 1350, 10.1038/nm.2882 Jansson, 2008, Arginine methylation regulates the p53 response, Nat. Cell Biol., 10, 1431, 10.1038/ncb1802 Kim, 2012, KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia, Mol. Cell. Biol., 32, 2917, 10.1128/MCB.00133-12 Klose, 2007, Regulation of histone methylation by demethylimination and demethylation, Nat. Rev. Mol. Cell Biol., 8, 307, 10.1038/nrm2143 Klose, 2006, JmjC-domain-containing proteins and histone demethylation, Nat. Rev. Genet., 7, 715, 10.1038/nrg1945 Ku, 2012, GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry, Blood, 119, 2242, 10.1182/blood-2011-07-366070 Larsson, 2005, The role of Smad signaling in hematopoiesis, Oncogene, 24, 5676, 10.1038/sj.onc.1208920 Le Romancer, 2008, Regulation of estrogen rapid signaling through arginine methylation by PRMT1, Mol. Cell, 31, 212, 10.1016/j.molcel.2008.05.025 Lee, 2014, The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C/EBPα and C/EBPδ, Mol. Cells, 37, 734, 10.14348/molcells.2014.0180 Liebermann, 1998, AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis, Int. J. Oncol., 12, 685 Liu, 2009, p53 regulates hematopoietic stem cell quiescence, Cell Stem Cell, 4, 37, 10.1016/j.stem.2008.11.006 Liu, 2015, Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis, J. Clin. Invest., 125, 3532, 10.1172/JCI81749 Liu, 2015, The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function, Int. J. Biol. Sci., 11, 494, 10.7150/ijbs.11849 Liu, 2015, Knockout of the histone demethylase Kdm3b decreases spermatogenesis and impairs male sexual behaviors, Int. J. Biol. Sci., 11, 1447, 10.7150/ijbs.13795 Mantri, 2010, Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6, J. Mol. Biol., 401, 211, 10.1016/j.jmb.2010.05.054 Mikhaleva, 2011, JmjC-domain-containing histone demethylases of the JMJD1B type as putative precursors of endogenous DSIP, Peptides, 32, 826, 10.1016/j.peptides.2011.01.006 Ng, 2011, Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice, Blood, 118, 2454, 10.1182/blood-2011-03-344739 Qi, 2010, Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development, Nature, 466, 503, 10.1038/nature09261 Sarkar, 2013, The sox family of transcription factors: versatile regulators of stem and progenitor cell fate, Cell Stem Cell, 12, 15, 10.1016/j.stem.2012.12.007 Scheller, 2006, Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation, Nat. Immunol., 7, 1037, 10.1038/ni1387 Schones, 2014, G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors, Epigenetics Chromatin, 7, 23, 10.1186/1756-8935-7-23 Shi, 2004, Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Cell, 119, 941, 10.1016/j.cell.2004.12.012 Sims, 2011, The C-terminal domain of RNA polymerase II is modified by site-specific methylation, Science, 332, 99, 10.1126/science.1202663 Stier, 2002, Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome, Blood, 99, 2369, 10.1182/blood.V99.7.2369 Tothova, 2007, FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress, Cell, 128, 325, 10.1016/j.cell.2007.01.003 Walport, 2016, Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases, Nat. Commun., 7, 11974, 10.1038/ncomms11974 Webby, 2009, Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing, Science, 325, 90, 10.1126/science.1175865 Yang, 2013, Protein arginine methyltransferases and cancer, Nat. Rev. Cancer, 13, 37, 10.1038/nrc3409 Yu, 2009, A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation, Mol. Cell. Biol., 29, 2982, 10.1128/MCB.00042-09 Zhao, 2009, PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing, Nat. Struct. Mol. Biol., 16, 304, 10.1038/nsmb.1568