JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease
Tài liệu tham khảo
Pawankar, 2013, World Allergy Organization (WAO) white book on allergy, Update
Zuberbier, 2014, Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review, Allergy, 69, 1275, 10.1111/all.12470
Zheng, 2011, The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma, Allergy Asthma Immunol Res, 3, 67, 10.4168/aair.2011.3.2.67
Lio, 2014, Clinical management of atopic dermatitis: practical highlights and updates from the atopic dermatitis practice parameter 2012, J Allergy Clin Immunol Pract, 2, 361, 10.1016/j.jaip.2014.02.015
Muraro, 2016, Precision medicine in patients with allergic diseases: airway diseases and atopic dermatitis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology, J Allergy Clin Immunol, 137, 1347, 10.1016/j.jaci.2016.03.010
Regan, 2017, Ibrutinib, a Bruton's tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity, J Allergy Clin Immunol, 140, 875, 10.1016/j.jaci.2017.03.013
Duan, 2005, An anti–inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model, Int Immunopharmacol, 5, 495, 10.1016/j.intimp.2004.10.015
Huang, 2017, Comprehensive attenuation of IL-25-induced airway hyperresponsiveness, inflammation and remodelling by the PI3K inhibitor LY294002, Respirology, 22, 78, 10.1111/resp.12880
Cahill, 2017, KIT inhibition by imatinib in patients with severe refractory asthma, N Engl J Med, 376, 1911, 10.1056/NEJMoa1613125
Villarino, 2017, Mechanisms and consequences of Jak-STAT signaling in the immune system, Nat Immunol, 18, 374, 10.1038/ni.3691
Stark, 2018, Responses to cytokines and interferons that depend upon JAKs and STATs, Cold Spring Harb Perspect Biol, 10, 10.1101/cshperspect.a028555
Macchi, 1995, Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID), Nature, 377, 65, 10.1038/377065a0
Russell, 1995, Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development, Science, 270, 797, 10.1126/science.270.5237.797
Holland, 2007, STAT3 mutations in the Hyper-IgE syndrome, N Engl J Med, 357, 1608, 10.1056/NEJMoa073687
Hsieh, 2011, JAK-1 rs2780895 C-related genotype and allele but not JAK-1 rs10789166, rs4916008, rs2780885, rs17127114, and rs3806277 are associated with higher susceptibility to asthma, Genet Test Mol Biomarkers, 15, 841, 10.1089/gtmb.2011.0002
Jiang, 2017, Association analyses identify two susceptibility loci 5q31 and 5q22.1 for atopic dermatitis in Chinese Han population, Asian Pac J Allergy Immunol, 35, 196
Shen, 2016, Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis, Asian Pac J Allergy Immunol, 34, 124
Gandhi, 2016, Targeting key proximal drivers of type 2 inflammation in disease, Nat Rev Drug Discov, 15, 35, 10.1038/nrd4624
Rochman, 2010, Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling, Proc Natl Acad Sci USA, 107, 19455, 10.1073/pnas.1008271107
Levy, 2015, Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib citrate, J Am Acad Dermatol, 73, 395, 10.1016/j.jaad.2015.06.045
Busse, 2013, Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients, J Allergy Clin Immunol, 131, 339, 10.1016/j.jaci.2012.10.013
Barnes, 2012, A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma, Clin Exp Allergy, 42, 38, 10.1111/j.1365-2222.2011.03813.x
Singh, 2013, Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459, Eur Respir J, 41, 46, 10.1183/09031936.00092111
Horak, 2012, The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial, Allergy, 67, 1572
Miller, 2017, A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma, Allergy Asthma Proc, 38, 157, 10.2500/aap.2017.38.4034
Hall, 2015, Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment, Pulm Pharmacol Ther, 32, 37, 10.1016/j.pupt.2015.03.003
Krug, 2014, Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis, J Allergy Clin Immunol, 133, 414, 10.1016/j.jaci.2013.10.013
Erpenbeck, 2016, The oral CRTh2 antagonist QAW039 (fevipiprant): a phase II study in uncontrolled allergic asthma, Pulm Pharmacol Ther, 39, 54, 10.1016/j.pupt.2016.06.005
Gonem, 2016, Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial, Lancet Respir Med, 4, 699, 10.1016/S2213-2600(16)30179-5
Bateman, 2017, Fevipiprant, an oral prostaglandin DP2 receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids, Eur Respir J, 50, 10.1183/13993003.00670-2017
Kuna, 2016, Two phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma, Drug Des Devel Ther, 10, 2759, 10.2147/DDDT.S105142
Ratner, 2017, Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from phase 2 and phase 3 randomized, double-blind, placebo- and active-referenced studies, Allergy Asthma Clin Immunol, 13, 18, 10.1186/s13223-017-0183-z
Samrao, 2012, A pilot study of an oral phosphodiesterase inhibitor (apremilast) for atopic dermatitis in adults, Arch Dermatol, 148, 890, 10.1001/archdermatol.2012.812
Volf, 2012, A phase 2, open-label, investigator-initiated study to evaluate the safety and efficacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis, J Drugs Dermatol, 11, 341
Singh, 2010, The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma, Respir Res, 11, 26, 10.1186/1465-9921-11-26
van Schalkwyk, 2005, Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions, J Allergy Clin Immunol, 116, 292, 10.1016/j.jaci.2005.04.023
Gauvreau, 2011, Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects, Respir Res, 12, 140, 10.1186/1465-9921-12-140
Louw, 2007, Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challenge, Respiration, 74, 411, 10.1159/000095677
Bateman, 2006, Efficacy and safety of roflumilast in the treatment of asthma, Ann Allergy Asthma Immunol, 96, 679, 10.1016/S1081-1206(10)61065-4
Bousquet, 2006, Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma, Allergy, 61, 72, 10.1111/j.1398-9995.2005.00931.x
Schmidt, 2001, The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis, J Allergy Clin Immunol, 108, 530, 10.1067/mai.2001.118596
Kostenis, 2006, Emerging roles of DP and CRTH2 in allergic inflammation, Trends Mol Med, 12, 148, 10.1016/j.molmed.2006.02.005
Lipworth, 2005, Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease, Lancet, 365, 167, 10.1016/S0140-6736(05)17708-3
Jin, 2012, Phosphodiesterase 4 and its inhibitors in inflammatory diseases, Chang Gung Med J, 35, 197
Essayan, 1999, Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation, Biochem Pharmacol, 57, 965, 10.1016/S0006-2952(98)00331-1
Pieretti, 2006, Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors, Life Sci, 79, 791, 10.1016/j.lfs.2006.02.026
Hidi, 2000, Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis, Eur Respir J, 15, 342, 10.1034/j.1399-3003.2000.15b21.x
Giembycz, 1996, Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2, Br J Pharmacol, 118, 1945, 10.1111/j.1476-5381.1996.tb15629.x
Hanifin, 2007, A population-based survey of eczema prevalence in the United States, Dermatitis, 18, 82, 10.2310/6620.2007.06034
Silverberg, 2014, Associations of childhood eczema severity: a US population-based study, Dermatitis, 25, 107, 10.1097/DER.0000000000000034
Spergel, 2010, From atopic dermatitis to asthma: the atopic march, Ann Allergy Asthma Immunol, 105, 99, 10.1016/j.anai.2009.10.002
Kulig, 1999, Natural course of sensitization to food and inhalant allergens during the first 6 years of life, J Allergy Clin Immunol, 103, 1173, 10.1016/S0091-6749(99)70195-8
Gustafsson, 2000, Development of allergies and asthma in infants and young children with atopic dermatitis: a prospective follow-up to 7 years of age, Allergy, 55, 240, 10.1034/j.1398-9995.2000.00391.x
Silverberg, 2013, Adult eczema prevalence and associations with asthma and other health and demographic factors: a US population-based study, J Allergy Clin Immunol, 132, 1132, 10.1016/j.jaci.2013.08.031
Sehra, 2010, IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation, J Immunol, 184, 3186, 10.4049/jimmunol.0901860
Albanesi, 2007, IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3, J Immunol, 179, 984, 10.4049/jimmunol.179.2.984
Ong, 2002, Endogenous antimicrobial peptides and skin infections in atopic dermatitis, N Engl J Med, 347, 1151, 10.1056/NEJMoa021481
Howell, 2006, Cathelicidin deficiency predisposes to eczema herpeticum, J Allergy Clin Immunol, 117, 836, 10.1016/j.jaci.2005.12.1345
Brauweiler, 2014, Th2 cytokines increase Staphylococcus aureus alpha toxin-induced keratinocyte death through the signal transducer and activator of transcription 6 (STAT6), J Invest Dermatol, 134, 2114, 10.1038/jid.2014.43
Simon, 2004, Eosinophils and atopic dermatitis, Allergy, 59, 561, 10.1111/j.1398-9995.2004.00476.x
Molfino, 2012, Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor, Clin Exp Allergy, 42, 712, 10.1111/j.1365-2222.2011.03854.x
Dillon, 2004, Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice, Nat Immunol, 5, 752, 10.1038/ni1084
Niyonsaba, 2010, Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells, J Immunol, 184, 3526, 10.4049/jimmunol.0900712
Comeau, 2010, The influence of TSLP on the allergic response, Mucosal Immunol, 3, 138, 10.1038/mi.2009.134
Wilson, 2013, The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch, Cell, 155, 285, 10.1016/j.cell.2013.08.057
Boniface, 2005, IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes, J Immunol, 174, 3695, 10.4049/jimmunol.174.6.3695
Wolk, 2010, Biology of interleukin-22, Semin Immunopathol, 32, 17, 10.1007/s00281-009-0188-x
AbbVie, 2017
Jessup, 2008, Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response, J Immunol, 181, 4311, 10.4049/jimmunol.181.6.4311
Chevalier, 2005, Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment, J Immunol, 175, 2056, 10.4049/jimmunol.175.4.2056
Boehme, 2009, Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms, Int Immunol, 21, 1, 10.1093/intimm/dxn118
Hijnen, 2005, Differential expression of genes involved in skin homing, proliferation, and apoptosis in CD4+ T cells of patients with atopic dermatitis, J Invest Dermatol, 125, 1149, 10.1111/j.0022-202X.2005.23932.x
Iwasaki, 2002, Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis, J Invest Dermatol, 119, 609, 10.1046/j.1523-1747.2002.01862.x
Hanifin, 1995, Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis, J Invest Dermatol, 105, 84S, 10.1038/jid.1995.17
Gantner, 1997, Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study, J Allergy Clin Immunol, 100, 527, 10.1016/S0091-6749(97)70146-5
Paller, 2016, Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults, J Am Acad Dermatol, 75, 494, 10.1016/j.jaad.2016.05.046
World Health Organization, 2007
Eriksson, 2015, Aspirin-intolerant asthma in the population: prevalence and important determinants, Clin Exp Allergy, 45, 211, 10.1111/cea.12359
Gilmour, 2006, How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma, Environ Health Perspect, 114, 627, 10.1289/ehp.8380
Corren, 2013, Asthma phenotypes and endotypes: an evolving paradigm for classification, Discov Med, 15, 243
Ray, 2016, Current concepts of severe asthma, J Clin Invest, 126, 2394, 10.1172/JCI84144
Elias, 2003, New insights into the pathogenesis of asthma, J Clin Invest, 111, 291, 10.1172/JCI17748
Fahy, 2015, Type 2 inflammation in asthma: present in most, absent in many, Nat Rev Immunol, 15, 57, 10.1038/nri3786
Raundhal, 2015, High IFN-gamma and low SLPI mark severe asthma in mice and humans, J Clin Invest, 125, 3037, 10.1172/JCI80911
Vanaudenaerde, 2011, Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders, Am J Respir Crit Care Med, 183, 977, 10.1164/rccm.201007-1196PP
O'Shea, 2012, JAK and STAT signaling molecules in immunoregulation and immune-mediated disease, Immunity, 36, 542, 10.1016/j.immuni.2012.03.014
Kudlacz, 2008, The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia, Eur J Pharmacol, 582, 154, 10.1016/j.ejphar.2007.12.024
Aguilar-Pimentel, 2017, Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma, PLoS ONE, 12, 10.1371/journal.pone.0178563
Southworth, 2016, Anti-inflammatory potential of PI3Kdelta and JAK inhibitors in asthma patients, Respir Res, 17, 124, 10.1186/s12931-016-0436-2
Pettipher, 2014, Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459, Allergy, 69, 1223, 10.1111/all.12451
Diamant, 2014, Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics, Clin Exp Allergy, 44, 1044, 10.1111/cea.12357
Spina, 2003, Theophylline and PDE4 inhibitors in asthma, Curr Opin Pulm Med, 9, 57, 10.1097/00063198-200301000-00010
Boswell-Smith, 2006, Are phosphodiesterase 4 inhibitors just more theophylline?, J Allergy Clin Immunol, 117, 1237, 10.1016/j.jaci.2006.02.045
Beghe, 2013, Phosphodiesterase-4 inhibitor therapy for lung diseases, Am J Respir Crit Care Med, 188, 271, 10.1164/rccm.201301-0021PP
Adamia, 2014, PO-0990 prevalence of allergic rhinitis in children's population—Adjara region, Arch Dis Child, 99, A574
Chiang, 2012, Allergic rhinitis and non-allergic rhinitis in children in the tropics: prevalence and risk associations, Pediatr Pulmonol, 47, 1026, 10.1002/ppul.22554
Law, 2003, Direct costs of allergic rhinitis in the United States: estimates from the 1996 Medical Expenditure Panel Survey, J Allergy Clin Immunol, 111, 296, 10.1067/mai.2003.68
Sullivan, 2001, Health economics of asthma and rhinitis. II. Assessing the value of interventions, J Allergy Clin Immunol, 107, 203, 10.1067/mai.2001.112851
Holgate, 2003, New targets for allergic rhinitis—a disease of civilization, Nat Rev Drug Discov, 2, 902, 10.1038/nrd1224
Seidman, 2015, Clinical practice guideline: allergic rhinitis, Otolaryngol Head Neck Surg, 152, S1, 10.1177/0194599814561600
Durham, 2016, Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: pooled analyses, J Allergy Clin Immunol, 138, 1081, 10.1016/j.jaci.2016.04.061
Bernstein, 2016, Allergic rhinitis: mechanisms and treatment, Immunol Allergy Clin North Am, 36, 261, 10.1016/j.iac.2015.12.004
Hunter, 2009, (Oxagen) Use of CRTH2 antagonist compounds, PCT Int Appl
Willard, 2014, Characterization of QAW039 and QAV680, two novel, potent and selective CRTh2 antagonists, Eur Respir J, 44, P4072