Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Ảnh hưởng của việc nuôi cấy cách ly đến học tập xác suất và tính linh hoạt nhận thức ở chuột
Tóm tắt
Việc nuôi cấy cách ly là một phương pháp tác động đến sự phát triển thần kinh, dẫn đến những biến đổi về hóa sinh, cấu trúc và hành vi ở chuột, mà theo nhiều cách giống với triệu chứng của bệnh tâm thần phân liệt. Những triệu chứng do việc nuôi cấy cách ly gây ra phản ánh các khía cạnh lâm sàng có liên quan của bệnh tâm thần phân liệt, chẳng hạn như khiếm khuyết nhận thức, mở ra khả năng thử nghiệm các liệu pháp điều trị giả thuyết trong các động vật được nuôi cấy cách ly trước khi phát triển lâm sàng. Chúng tôi đã điều tra tác động của việc nuôi cấy cách ly đối với tính linh hoạt nhận thức, một chức năng nhận thức thường bị rối loạn trong bệnh tâm thần phân liệt. Để làm điều này, chúng tôi đã đánh giá tính linh hoạt nhận thức bằng cách sử dụng các nhiệm vụ học tập đảo ngược xác suất giữa và trong một phiên, dựa trên các bài kiểm tra lâm sàng. Các con chuột được nuôi cấy cách ly cần nhiều phiên hơn, mặc dù không cần nhiều thử nghiệm nhiệm vụ hơn, để đạt được hiệu suất tiêu chí trong giai đoạn đảo ngược của nhiệm vụ này, và chúng chậm hơn trong việc điều chỉnh chiến lược nhiệm vụ sau khi các điều kiện thưởng được thay đổi. Các con chuột được nuôi cấy cách ly cũng hoàn thành ít thử nghiệm hơn và thể hiện mức độ hoạt động tổng thể thấp hơn trong nhiệm vụ học tập đảo ngược xác suất so với các con chuột được nuôi cấy xã hội. Phát hiện này trái ngược với mức độ hoạt động điều tra không điều kiện cao hơn và mức độ habituation vận động giảm mà các con chuột nuôi cấy cách ly đã thể hiện trong bộ theo dõi mẫu hành vi. Cuối cùng, các con chuột nuôi cấy cách ly cũng thể hiện khiếm khuyết trong việc kiểm soát cảm giác-vận động, được phản ánh bởi việc giảm ức chế tiền âm thanh của phản ứng giật mình, tương thích với các nghiên cứu trước đó. Chúng tôi kết luận rằng việc nuôi cấy cách ly tạo ra một can thiệp có giá trị, không xâm lấn, để mô hình hóa các khiếm khuyết nhận thức giống như bệnh tâm thần phân liệt và đánh giá các liệu pháp điều trị giả thuyết.
Từ khóa
#nuôi cấy cách ly #bệnh tâm thần phân liệt #tính linh hoạt nhận thức #học tập xác suấtTài liệu tham khảo
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