Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability

Classen, 1989, ATP hydrolysis by ischemic mitochondria, J Cell Physiol, 141, 53, 10.1002/jcp.1041410109 Cole, 2004, Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event, Biochem J, 377, 249, 10.1042/bj20031259 Dos Santos, 2002, Mechanisms by which opening the mitochondrial ATP-sensitive K(+) channel protects the ischemic heart, Am J Physiol Heart Circ Physiol, 283, H284, 10.1152/ajpheart.00034.2002 Fang, 2010, Trends in thrombolytic use for ischemic stroke in the United States, J Hosp Med, 5, 406, 10.1002/jhm.689 Feng, 2005, Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta, Anesthesiology, 103, 987, 10.1097/00000542-200511000-00013 Hirai, 2004, PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis, Brain Res Mol Brain Res, 124, 51, 10.1016/j.molbrainres.2004.02.009 Ingall, 2004, Stroke—incidence, mortality, morbidity and risk, J Insur Med, 36, 143 Juhaszova, 2004, Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore, J Clin Invest, 113, 1535, 10.1172/JCI19906 Kim, 2009, Isoflurane induces a postconditioning effect on bovine pulmonary arterial endothelial cells exposed to oxygen-glucose deprivation, Eur J Pharmacol, 615, 144, 10.1016/j.ejphar.2009.05.007 Kroemer, 2007, Mitochondrial membrane permeabilization in cell death, Physiol Rev, 87, 99, 10.1152/physrev.00013.2006 Lee, 2008, Postconditioning with isoflurane reduced ischemia-induced brain injury in rats, Anesthesiology, 108, 1055, 10.1097/ALN.0b013e3181730257 Li, 2008, Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain, Eur J Pharmacol, 586, 106, 10.1016/j.ejphar.2008.02.073 Lin, 2011, Volatile anesthetic post-treatment induces protection via inhibition of glycogen synthase kinase 3beta in human neuron-like cells, Neuroscience, 179, 73, 10.1016/j.neuroscience.2011.01.055 Lipton, 1999, Ischemic cell death in brain neurons, Physiol Rev, 79, 1431, 10.1152/physrev.1999.79.4.1431 Martin, 1999, Births and deaths: preliminary data for 1998, Natl Vital Stat Rep, 47, 1 McMurtrey, 2010, Isoflurane preconditioning and postconditioning in rat hippocampal neurons, Brain Res, 1358, 184, 10.1016/j.brainres.2010.08.015 Memezawa, 1992, Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat, Exp Brain Res, 89, 67, 10.1007/BF00229002 Nagasawa, 1989, Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion, Stroke, 20, 1037, 10.1161/01.STR.20.8.1037 Paillard, 2009, Postconditioning inhibits mPTP opening independent of oxidative phosphorylation and membrane potential, J Mol Cell Cardiol, 46, 902, 10.1016/j.yjmcc.2009.02.017 Pebay-Peyroula, 2003, Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside, Nature, 426, 39, 10.1038/nature02056 Reeves, 2005, Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry, Stroke, 36, 1232, 10.1161/01.STR.0000165902.18021.5b Vlahos, 1994, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), J Biol Chem, 269, 5241, 10.1016/S0021-9258(17)37680-9 Wang, 1994, Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation, J Biol Chem, 269, 14566, 10.1016/S0021-9258(17)36661-9 Watanabe, 1983, Decrease in mitochondrial levels of adenine nucleotides and concomitant mitochondrial dysfunction in ischemic rat liver, J Biochem, 94, 493, 10.1093/oxfordjournals.jbchem.a134380 Zhao, 2003, Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning, Am J Physiol Heart Circ Physiol, 285, H579, 10.1152/ajpheart.01064.2002 Zheng, 2003, Isoflurane preconditioning reduces Purkinje cell death in an in vitro model of rat cerebellar ischemia, Neuroscience, 118, 99, 10.1016/S0306-4522(02)00767-4 Zhou, 2010, Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway, Stroke, 41, 1521, 10.1161/STROKEAHA.110.583757 Zorov, 2009, Regulation and pharmacology of the mitochondrial permeability transition pore, Cardiovasc Res, 83, 213, 10.1093/cvr/cvp151