Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Tổn thương thiếu máu tái tưới trong các bệnh nhân có gan nhiễm mỡ và ảnh hưởng lâm sàng của gan nhiễm mỡ đối với phẫu thuật gan
Tóm tắt
Gan nhiễm mỡ là một trong những rối loạn gan phổ biến nhất ở các nước phát triển. Đợt dịch bệnh béo phì ở các nước phát triển đã gia tăng cùng với những biến chứng đi kèm, bao gồm hội chứng chuyển hóa và bệnh gan nhiễm mỡ không do rượu. Gan nhiễm mỡ đặc biệt dễ tổn thương do thiếu máu/ tái tưới máu, dẫn đến gia tăng nguy cơ mắc bệnh tật và tử vong sau phẫu thuật gan, bao gồm cả ghép gan. Hiện nay có nhiều hiểu biết hơn về các cơ chế phân tử và tế bào cũng như các phương pháp điều trị cho tổn thương thiếu máu/tái tưới máu ở những bệnh nhân có gan nhiễm mỡ. Bài tổng quan này thảo luận về các cơ chế cơ bản giải thích sự nhạy cảm của gan nhiễm mỡ với tổn thương thiếu máu/tái tưới máu, như rối loạn chức năng ty thể và thay đổi trong dẫn truyền tín hiệu, đồng thời tóm tắt tác động lâm sàng của gan nhiễm mỡ trong bối cảnh cắt gan và ghép gan. Bài viết này cũng mô tả các phương pháp điều trị tiềm năng, như tiền điều kiện thiếu máu và điều trị bằng dược phẩm, để ngăn ngừa tổn thương thiếu máu/tái tưới máu ở những bệnh nhân có gan nhiễm mỡ. Các phương pháp khác, bao gồm tưới máu bằng máy móc, cũng đang được nghiên cứu lâm sàng; tuy nhiên, nhiều phương pháp dược lý được phát triển thông qua nghiên cứu cơ bản vẫn chưa phù hợp cho ứng dụng lâm sàng.
Từ khóa
#gan nhiễm mỡ #tổn thương thiếu máu/tái tưới máu #phẫu thuật gan #bệnh lý gan #bệnh béo phì.Tài liệu tham khảo
citation_journal_title=Hepatology; citation_title=Design and validation of a histological scoring system for nonalcoholic fatty liver disease; citation_author=DE Kleiner, EM Brunt, MV Natta, C Behling, MJ Contos, OW Cummings; citation_volume=41; citation_publication_date=2005; citation_pages=1313-1321; citation_id=CR1
citation_journal_title=Am J Physiol Endocrinol Metab; citation_title=Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population; citation_author=LS Szczepaniak, P Nurenberg, D Leonard, JD Browning, JS Reingold, S Grundy; citation_volume=288; citation_publication_date=2005; citation_pages=E462-E468; citation_id=CR2
citation_journal_title=J Gastroenterol Hepatol; citation_title=Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines; citation_author=S Chittu, GC Farrell, E Hashimoto, T Saibara, GK Lau, JD Sollano; citation_volume=22; citation_publication_date=2007; citation_pages=778-787; citation_id=CR3
citation_journal_title=J Gastroenterol Hepatol; citation_title=How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences?; citation_author=DN Amarapurkar, E Hashimoto, LA Lesmana, JD Sollano, PJ Chen, KL Goh; citation_volume=22; citation_publication_date=2007; citation_pages=788-793; citation_id=CR4
citation_journal_title=Ann Surg; citation_title=A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection; citation_author=H Petrowsky, L McCormack, M Trujillo, M Selzner, W Jochum, PA Clavian; citation_volume=244; citation_publication_date=2006; citation_pages=921-928; citation_id=CR5
citation_journal_title=Liver Transpl; citation_title=Nonalcoholic fatty liver disease and liver transplantation; citation_author=P Angulo; citation_volume=12; citation_issue=523–534; citation_publication_date=2006; citation_pages=5; citation_id=CR6
citation_journal_title=Ann Surg; citation_title=Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: a matched case–control study; citation_author=L McCormack, H Petrowsky, W Jochum, K Furrer, PA Clavien; citation_volume=245; citation_publication_date=2007; citation_pages=923-930; citation_id=CR7
citation_journal_title=Br J Surg; citation_title=Steatosis predicts postoperative morbidity following hepatic resection for colorectal metastasis; citation_author=D Gomez, HZ Malik, GK Bonney, V Wong, GJ Toogood, JP Lodge; citation_volume=94; citation_publication_date=2007; citation_pages=1395-1402; citation_id=CR8
citation_journal_title=J Hepatol; citation_title=The use of donor fatty liver for liver transplantation: a challenge or a quagmire?; citation_author=F Trevisani, A Colantoni, P Caraceni, DH Thiel; citation_volume=24; citation_publication_date=1996; citation_pages=114-121; citation_id=CR9
citation_journal_title=Hepatology; citation_title=Liver injury following normothermic ischemia in steatotic rat liver; citation_author=AM Hui, S Kawasaki, M Makuuchi, J Nakayama, T Ikegami, S Miyagawa; citation_volume=20; citation_publication_date=1994; citation_pages=1287-1293; citation_id=CR10
citation_journal_title=Acta Pathol Jpn; citation_title=Sinusoidal stenosis as the cause of portal hypertension in choline deficient diet induced fatty cirrhosis of the rat liver; citation_author=K Wada, K Fujimoto, Y Fujikawa, Y Shibayama, H Mitsui, K Nakata; citation_volume=24; citation_publication_date=1974; citation_pages=207-217; citation_id=CR11
citation_journal_title=Hepatology; citation_title=Rat hepatocytes isolated from alcohol-induced fatty liver have an increased sensitivity to anoxic injury; citation_author=P Caraceni, HS Ryu, V Subbotin, N Maria, A Colantoni, L Roberts; citation_volume=25; citation_publication_date=1997; citation_pages=943-949; citation_id=CR12
citation_journal_title=Surg Today; citation_title=Predictors of intraoperative blood loss in patients undergoing hepatectomy; citation_author=A Nanashima, T Abo, K Hamasaki, K Wakata, M Kunizaki, K Tou; citation_volume=43; citation_publication_date=2013; citation_pages=485-493; citation_id=CR13
citation_journal_title=Hepatology; citation_title=Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion; citation_author=A Lentsch, A kato, H Yoshidome, K McMasters, M Edwards; citation_volume=32; citation_publication_date=2000; citation_pages=169-173; citation_id=CR14
citation_journal_title=Hepatology; citation_title=Mechanisms of ischemic injury are different in the steatotic and normal rat liver; citation_author=M Selzner, HA Rudiger, D Sindram, J Madden, PA Clavien; citation_volume=32; citation_publication_date=2000; citation_pages=1280-1288; citation_id=CR15
citation_journal_title=Hepatology; citation_title=Apoptosis and necrosis in the liver: a tale of two deaths?; citation_author=H Malhi, G Gores, JJ Lemasters; citation_volume=43; citation_publication_date=2006; citation_pages=S31-S44; citation_id=CR16
citation_journal_title=J Hepatol; citation_title=Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis; citation_author=N Selzner, M Selzner, W Jochum, B Amann-Vesti, R Graf, PA Clavien; citation_volume=44; citation_publication_date=2006; citation_pages=694-701; citation_id=CR17
citation_journal_title=Ann Surg; citation_title=Steatosis as a risk factor in liver surgery; citation_author=R Vetelaninen, A Vliet, DJ Gouma, TM Gulik; citation_volume=245; citation_publication_date=2007; citation_pages=20-30; citation_id=CR18
citation_journal_title=J Hepatol; citation_title=Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury; citation_author=P Caraceni, C Bianchi, M Domenicali, AM Pertosa, E Maiolini, G Parenti; citation_volume=41; citation_publication_date=2004; citation_pages=82-88; citation_id=CR19
citation_journal_title=Proc Natl Acad Sci USA; citation_title=Uncoupling protein 2 and 3 are highly active H+ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone); citation_author=K Echtay, E Winkler, K Frischmuth, M Klingenberg; citation_volume=98; citation_publication_date=2001; citation_pages=1416-1421; citation_id=CR20
citation_journal_title=Nature; citation_author=K Echtay, D Roussel, J St-Pierre, MB Jekabsons, S Cadenas, JA Stuart; citation_volume=415; citation_publication_date=2002; citation_pages=96-99; citation_id=CR21
citation_journal_title=Gastroenterology; citation_title=Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes; citation_author=H Cortez-Pinto, HZ Lin, SQ Yang, SOD Costa, AM Diehl; citation_volume=116; citation_publication_date=1999; citation_pages=1184-1193; citation_id=CR22
citation_journal_title=Hepatology; citation_title=Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver; citation_author=A Rashid, TC Wu, CC Huang, CH Chen, HZ Lin, SQ Yang; citation_volume=29; citation_publication_date=1999; citation_pages=1131-1138; citation_id=CR23
citation_journal_title=J Biol Chem; citation_title=Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion; citation_author=KD Chavin, SQ Yang, HZ Lin, J Chatham, VP Chacko, JB Hoek; citation_volume=274; citation_publication_date=1999; citation_pages=5692-5700; citation_id=CR24
citation_journal_title=J Biol Chem; citation_title=Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion; citation_author=ZP Evans, JD Ellett, MG Schmit, RG Schnellmann, KD Chavin; citation_volume=283; citation_publication_date=2008; citation_pages=8573-8579; citation_id=CR25
citation_journal_title=Gut; citation_title=Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischemia–reperfusion injury; citation_author=G Serviddio, F Bellanti, R Tamborra, T Rollo, N Capitanio, AD Romano; citation_volume=57; citation_publication_date=2008; citation_pages=957-965; citation_id=CR26
citation_journal_title=Am J Transpl; citation_title=Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation; citation_author=KD Chavin, RN Fiorini, S Shafizadeh, G Cheng, C Wan, Z Evans; citation_volume=4; citation_publication_date=2004; citation_pages=1440-1447; citation_id=CR27
citation_journal_title=Liver Transpl; citation_title=Short-term administration of (−)-epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice; citation_author=RN Fiorini, JL Donovan, D Rodwell, Z Evans, G Cheng, HD May; citation_volume=11; citation_publication_date=2005; citation_pages=298-308; citation_id=CR28
citation_journal_title=Transplantation; citation_title=
l-Carnitine ameliorates abnormal vulnerability of steatotic rat livers to cold ischemic preservation; citation_author=RH Tolba, U Putz, D Decker, F Dombrowski, H Lauschke; citation_volume=76; citation_publication_date=2003; citation_pages=1681-1686; citation_id=CR29
citation_journal_title=Hepatology; citation_title=The contribution of endoplasmic reticulum stress to liver diseases; citation_author=L Dara, C Ji, N Kaplowitz; citation_volume=53; citation_publication_date=2011; citation_pages=1752-1763; citation_id=CR30
citation_journal_title=BMC Biochem; citation_title=The role of molecular chaperons in warm ischemia and reperfusion injury in the steatotic liver: a proteomic study; citation_author=V Tiriveedhi, KD Conzen, JL Lian-Conlin, G Upadhya, J Malone, RR Townsend; citation_volume=13; citation_publication_date=2012; citation_pages=17-26; citation_id=CR31
citation_journal_title=Cell Death Dis; citation_title=Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia–reperfusion; citation_author=IB Mosbah, I Alfany-Fernandez, C Martel, MA Zaouali, M Bintanel-Morcillo, A Rimola; citation_volume=1; citation_publication_date=2010; citation_pages=e52; citation_id=CR32
citation_journal_title=Liver Transpl; citation_title=Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts; citation_author=CD Anderson, G Upadhya, KD Conzen, J Jia, EM Brunt, V Tiriveedhi; citation_volume=17; citation_publication_date=2011; citation_pages=189-200; citation_id=CR33
Elias-Miro M, Jimenez-Castro MB, Mendes-Braz M, Casillas-Ramirez A, Peralta C. The current knowledge of the role of PPAR in hepatic ischemia–reperfusion injury. PPAR Res. 2012;2012:802384.
citation_journal_title=Biochim Biophys Acta; citation_title=Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion; citation_author=P Pettinelli, T Pozo, J Araya, R Rodrigo, AV Araya, G Smok; citation_volume=1792; citation_publication_date=2009; citation_pages=1080-1086; citation_id=CR35
citation_journal_title=J Clin Endocrin Metabol; citation_title=Up-regulation of PPAR-γ mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction; citation_author=O Pettineli, LA Videla; citation_volume=96; citation_publication_date=2011; citation_pages=1424-1430; citation_id=CR36
citation_journal_title=Hepatology; citation_title=Short-term therapy with peroxisome proliferation-activator receptor-α agonist wy-14,643 protects murine fatty liver agonist ischemia–reperfusion injury; citation_author=NC Teoh, J Williams, J Hartley, J Yu, RS McCuskey, GC Farrell; citation_volume=51; citation_publication_date=2010; citation_pages=996-1006; citation_id=CR37
citation_journal_title=Hepatology; citation_title=Activation of peroxisome proliferators-activated receptor-αinhibits the injurious effects of adiponectin in rat steatotic liver undergoing ischemia–reperfusion; citation_author=M Massip-Salcedo, MA Zaouali, S Padrissa-Altes, A Casillas-Ramirez, J Rodes, J Rosello-Catafau; citation_volume=47; citation_publication_date=2008; citation_pages=461-472; citation_id=CR38
citation_journal_title=Liver Transpl; citation_title=Does adiponectin benefit steatotic liver transplantation?; citation_author=M Elias-Miro, M Massip-Salcedo, M Jimenez-Castro, C Peralta; citation_volume=17; citation_publication_date=2011; citation_pages=993-1004; citation_id=CR39
citation_journal_title=Liver Transpl; citation_title=Preservation of steatotic livers in IGL-1 solution; citation_author=IB Mosbath, J Rosello-Catafau, R Franco-Gou, HB Abdennebi, D Saidane, S Ramella-Virieux; citation_volume=12; citation_publication_date=2006; citation_pages=1215-1223; citation_id=CR40
citation_journal_title=J Pineal Res; citation_title=Melatonin protects steatotic and nonsteatotic liver grafts against cold ischemia and reperfusion injury; citation_author=MA Zaouali, RJ Reiter, S Padrissa-Altes, E Boncompagni, JJ Garcia, H Ben Abnennebi; citation_volume=50; citation_publication_date=2011; citation_pages=213-221; citation_id=CR41
citation_journal_title=Am J Transpl; citation_title=Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival; citation_author=K Man, Y Zhao, A Xu, CM Lo, KSL Lam, KT Ng; citation_volume=6; citation_publication_date=2006; citation_pages=467-476; citation_id=CR42
citation_journal_title=Liver Transpl; citation_title=Does adiponectin benefit steatotic liver transplantation?; citation_author=M Elias-Miro, M Massip-Salcedo, M Jimenez-Castro, C Peralta; citation_volume=17; citation_publication_date=2011; citation_pages=993-1004; citation_id=CR43
citation_journal_title=Crit Care Med; citation_title=Inhibition of angiotensin II action protects rat steatotic livers against ischemia–reperfusion injury; citation_author=A Casillas-Ramirez, M Amine-Zaouali, M Massip-Salcedo, S Padrissa-Altes, M Bintanel-Morcillo, F Ramalho; citation_volume=36; citation_publication_date=2008; citation_pages=1256-1266; citation_id=CR44
citation_journal_title=Endocrinology; citation_title=Insulin-like growth factor and epidermal growth factor tretament: new approaches to protecting ateatotic livers against ischemia–reperfusion injury; citation_author=A Casillas-Ramirez, A Zaouali, S Padrissa-Altes, MI Ben, A Pertosa, I Alfany-Fernandez; citation_volume=150; citation_publication_date=2009; citation_pages=3153-3161; citation_id=CR45
citation_journal_title=J Parmacol Exp Ther; citation_title=Retinol-binding protein 4 and peroxisome proliferatior-activated receptor-γin steatotic liver transplantation; citation_author=A Casillas-Ramirez, I Alfany-Fernandez, M Massip-Salcedo, ME Juan, JM Planas, A Serafin; citation_volume=338; citation_publication_date=2011; citation_pages=143-153; citation_id=CR46
citation_journal_title=Am J Transpl; citation_title=Tauroursodeoxycholic acid affects PPARγ and TLR4 in steatotic liver transplantation; citation_author=MB Jimenez-Castro, M Elias-Miro, M Mendes-Braz, A Lemoine, A Rimola, J Rodes; citation_volume=12; citation_publication_date=2012; citation_pages=3257-3271; citation_id=CR47
citation_journal_title=Am J Transplt; citation_title=Therapeutic targets in liver transplantation: angiotensin II in nonsteatotic grafts and angiotensin-(1–7) in steatotic grafts; citation_author=I Alfany-Fernandez, A Casillas-Ramirez, M Bintanel-Morcillo, KB Brosnihan, CM Ferrario, A Serafin; citation_volume=9; citation_publication_date=2009; citation_pages=439-451; citation_id=CR48
citation_journal_title=Liver Transpl; citation_title=Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury; citation_author=JD Ellett, ZP Evans, C Atkinson, MG Schmidt, RG Schnellmann, KD Chavin; citation_volume=15; citation_publication_date=2009; citation_pages=1101-1109; citation_id=CR49
citation_journal_title=Am J Transpl; citation_title=Anti-endotoxin monoclonal antibodies are protective against hepatic ischemia/reperfusion injury in steatotic mice; citation_author=RN Firorini, SF Shafizadeh, C Polito, DW Rodwell, G Cheng, Z Evans; citation_volume=4; citation_publication_date=2004; citation_pages=1567-1573; citation_id=CR50
citation_journal_title=Exp Mol Path; citation_title=Proteasome inhibitors protect the steatotic and non-steatotic liver graft against cold ischemia reperfusion injury; citation_author=MA Zaouali, FB Bardag-Gorce, T Carbonell, J Oliva, E Pantazi, M Bejaoui; citation_volume=94; citation_publication_date=2013; citation_pages=352; citation_id=CR51
citation_journal_title=J Immunol; citation_title=A role for compliment in the enhanced susceptibility of steatotic livers to ischemia and reperfusion injury; citation_author=S He, C Atkinson, Z Evans, JD Ellett, M Southwood, A Elvington; citation_volume=183; citation_publication_date=2009; citation_pages=4764-4772; citation_id=CR52
citation_journal_title=J Hepatology; citation_title=Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism; citation_author=N Selzner, M Selzner, W Jochum, PA Clavian; citation_volume=39; citation_publication_date=2003; citation_pages=55-61; citation_id=CR53
citation_journal_title=Transpl Int; citation_title=Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATP synthase and mitochondrial permeability transition; citation_author=AP Rolo, JS Teodoro, C Peralta, JR Rosello-catafau, CM Palmeira; citation_volume=22; citation_publication_date=2009; citation_pages=1081-1090; citation_id=CR54
citation_journal_title=Am J Pathol; citation_title=Ischemic preconditioning increases the tolerance of fatty liver to hepatic ischemia–reperfusion injury in the rat; citation_author=A Serafin, J Rosello-Catafau, N Prats, C Xaus, E Gelpi, C Peralta; citation_volume=161; citation_publication_date=2002; citation_pages=587-601; citation_id=CR55
citation_journal_title=J Surg Res; citation_title=Heat shock preconditioning ameliorates liver injury following normothermic ischemia–reperfusion in steatotic rat livers; citation_author=K Yamagami, Y Yamamoto, M Kume, S Kimoto, H Yamamoto, N Ozaki; citation_volume=79; citation_publication_date=1998; citation_pages=47-53; citation_id=CR56
citation_journal_title=Am J Pathol; citation_title=Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia–reperfusion: some answers; citation_author=M Massip-Salcedo, A Casillas-Ramirez, R Franco-Gou, I Ben Mosban, A Serafin; citation_volume=168; citation_publication_date=2006; citation_pages=1474-1485; citation_id=CR57
citation_journal_title=Transplantation; citation_title=AMP-activated protein kinase as a target for preconditioning in transplantation medicine; citation_author=HR Bouma, ME Ketelaar, BA Yard, RJ Pleoeg, RH Henning; citation_volume=90; citation_publication_date=2010; citation_pages=353-358; citation_id=CR58
citation_journal_title=J Hepatol; citation_title=Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation; citation_author=E Carrasco-Chaumel, J Rosello-Catafau, R Bartrons, R Franco-Gou, C Xaus, A Casillas; citation_volume=43; citation_publication_date=2005; citation_pages=997-1006; citation_id=CR59
citation_journal_title=Hepatology; citation_title=Ischemic preconditioning affects interleukin release in fatty livers of rats undergoing ischemia/reperfusion; citation_author=A Serafin, J Rosello-Catafau, N Prats, E Gelpi, J Rodes, C Peralta; citation_volume=39; citation_publication_date=2004; citation_pages=688-698; citation_id=CR60
citation_journal_title=Free Radic Res; citation_title=Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: association with reduction of oxidative stress; citation_author=L Tacchini, G Cario, C Ponti, M Massip, J Rosello-Catafau, C Peralta; citation_volume=40; citation_publication_date=2006; citation_pages=1206-1217; citation_id=CR61
citation_journal_title=Gastroenterology; citation_title=In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats; citation_author=Z Sun, AS Klein, S Radaeva, F Hong, O EL-Assal, HN Pan; citation_volume=125; citation_publication_date=2003; citation_pages=202-215; citation_id=CR62
citation_journal_title=Hepatology; citation_title=Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease; citation_author=F Hong, S Radaeva, HN Pan, Z Tian, R Veech, B Gao; citation_volume=40; citation_publication_date=2004; citation_pages=933-941; citation_id=CR63
citation_journal_title=Am J Transpl; citation_title=Is ischemic preconditioning a useful strategy in steatotic liver transplantation?; citation_author=L Fernandez, E Carrasco-Chaumel, A Serafin, C Xaus, L Grande, A Rimola; citation_volume=4; citation_publication_date=2004; citation_pages=888-899; citation_id=CR64
citation_journal_title=Liver Transpl; citation_title=Preservation of steatotic livers: a comparison between cold storage and machine perfusion preservation; citation_author=M Bessems, BM Doorschodt, JLP Kolkert, RL Vetelainen, AK Vliet, H Vreeling; citation_volume=13; citation_publication_date=2007; citation_pages=497-504; citation_id=CR65
citation_journal_title=Liver Transpl; citation_title=Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase?; citation_author=M Vairetti, A Ferrigno, F Carlucci, A Tabucchi, V Rizzo, E Boncompagni; citation_volume=15; citation_publication_date=2009; citation_pages=20-29; citation_id=CR66
citation_journal_title=Transplantation; citation_title=Hepatic steatosis and normothermic perfusion-preliminary experiments in a porcine model; citation_author=RW Jamieson, M Zilvetti, D Roy, D Hughes, A Morovat, CC Coussions; citation_volume=92; citation_publication_date=2011; citation_pages=289-295; citation_id=CR67
citation_journal_title=J Hepatol; citation_title=Cold preservation of fatty liver grafts: prevent of functional and ultrastructual impairments by venous oxygen persufflation; citation_author=T Minor, S Akbar, R Tolba, F Domobrowski; citation_volume=32; citation_publication_date=2000; citation_pages=105-111; citation_id=CR68
citation_journal_title=Liver Transpl; citation_title=Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning; citation_author=T Minor, J Stegemann, A Hirner, M Koetting; citation_volume=15; citation_publication_date=2009; citation_pages=798-805; citation_id=CR69
citation_journal_title=Transplantation; citation_title=Optimal time for hypothermic reconditioning of liver grafts by venous systemic oxygen persufflation in a large animal model; citation_author=M Koetting, B Luer, P Efferz, A Paul, T Minor; citation_volume=91; citation_publication_date=2011; citation_pages=42-47; citation_id=CR70
citation_journal_title=Am J Transpl; citation_title=Hypothermic reconditioning by gaseous oxygen improves survival after liver transplantation in the pig; citation_author=T Minor, M Koetting, M Koetting, G Kaiser, P Efferz, B Luer; citation_volume=11; citation_publication_date=2011; citation_pages=2627-2634; citation_id=CR71
citation_journal_title=Liver Transpl; citation_title=Impact of venous systemic oxygen persufflation supplemented with nitric oxide gas on cold-stored, warm ischemia-damaged experimental liver grafts; citation_author=PK Srinivasan, S Yagi, B Doorschodt, K Nagai, M Afify, S Uemoto; citation_volume=18; citation_publication_date=2012; citation_pages=219-225; citation_id=CR72
citation_journal_title=Transplantation; citation_title=Impact of venous-systemic oxygen persufflation with nitric oxide gas on steatotic grafts after partial orthotopic liver transplantation in rats; citation_author=K Nagai, S Yagi, M Afify, C Bleilevens, S Uemoto, RH Tolba; citation_volume=95; citation_publication_date=2013; citation_pages=78-84; citation_id=CR73
citation_journal_title=Liver Transpl Surg; citation_title=In vivo demonstration of impaired microcirculation in steatotic human liver grafts; citation_author=AM Seifalian, V Chidambaram, K Rolles, BR Davidson; citation_volume=4; citation_publication_date=1998; citation_pages=71-77; citation_id=CR74
citation_journal_title=Microcirculation; citation_title=Impairment of hepatic microcirculation in fatty liver; citation_author=S Ijaz, W Yang, MC Winslet, AM Seifalian; citation_volume=10; citation_publication_date=2003; citation_pages=447-456; citation_id=CR75
citation_journal_title=Transpl Int; citation_title=Heat-schock preconditioning protects fatty livers in genetically obese zucker rats from microvascular perfusion failure after ischemia reperfusion; citation_author=K Yamagami, G Enders, RJ Schauer, R Leiderer, J Hutter, Y Yamamoto; citation_volume=16; citation_publication_date=2003; citation_pages=554-561; citation_id=CR76
citation_journal_title=Hepatology; citation_title=Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids; citation_author=AM El-Badry, W Moritz, C Contaldo, Y Tian, R Graf, PA Clavien; citation_volume=45; citation_publication_date=2007; citation_pages=855-863; citation_id=CR77
citation_journal_title=J Hepatol; citation_title=Chemical composition of hepatic lipids mediates reperfusion injury of the macrosteatotic mouse liver through thromboxane A2; citation_author=AM El-Badry, JH Jang, A Elsherbiny, C Contaldo, Y Tian, DA Raptis; citation_volume=55; citation_publication_date=2011; citation_pages=1291-1299; citation_id=CR78
citation_journal_title=Am J Physiol; citation_title=Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver; citation_author=JX Zhang, M Bauer, MG Clemens; citation_volume=269; citation_publication_date=1995; citation_pages=G269-G277; citation_id=CR79
citation_journal_title=Transplantation; citation_title=Prevention of ischemia–reperfusion-induced hepatic microcirculatory disruption by inhibiting stellate cell contraction using rock inhibitor; citation_author=K Mizunuma, H Ohdan, H Tashiro, Y Fudaba, H Ito, T Asahara; citation_volume=75; citation_publication_date=2003; citation_pages=579-586; citation_id=CR80
citation_journal_title=J Surg Res; citation_title=Reduction of hepatic ischemia/reperfusion-induced injury by a specific rock/rho kinase inhibitor y-27632; citation_author=F Ikeda, H Terajima, Y Shimamura, T Kondo, Y Yamaoka; citation_volume=109; citation_publication_date=2003; citation_pages=155-160; citation_id=CR81
citation_journal_title=J Hepatol; citation_title=Rho inhibitor prevents ischemia–reperfusion injury in rat steatotic liver; citation_author=S Kuroda, H Tashiro, Y Igarashi, Y Tanimoto, J Nambu, A Oshita; citation_volume=56; citation_publication_date=2012; citation_pages=146-152; citation_id=CR82
citation_journal_title=Am J Transpl; citation_title=Cytoprotective effects of acyclic RGD peptide in steatotic liver cold ischemia and reperfusion injury; citation_author=C Fondevila, XD Shen, S Duarte, RW Busuttil, AJ Coito; citation_volume=9; citation_publication_date=2009; citation_pages=2240-2250; citation_id=CR83
citation_journal_title=Am J Physiol Gastrointest Liver Physiol; citation_title=Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia–reperfusion injury in steatotic livers of ob/ob mice; citation_author=T Hasegawa, Y Ito, J Wijeweera, J Liu, E Malle, A Farhood; citation_volume=292; citation_publication_date=2007; citation_pages=G1385-G1395; citation_id=CR84
citation_journal_title=Transplantation; citation_title=Synergistic effects of brain death and liver steatosis on the hepatic microcirculation; citation_author=K Yamagami, J Hutter, Y Yamamoto, RJ Schauer, G Enders, R Leiderer; citation_volume=80; citation_publication_date=2005; citation_pages=500-505; citation_id=CR85
citation_journal_title=J Gastrointest Surg; citation_title=Surgical outcomes for hepatocellular carcinoma in nonalcoholic fatty liver disease; citation_author=T Wakai, Y Shirai, J Sakata, PV Korita, Y Ajioka, K Tatakeyama; citation_volume=15; citation_publication_date=2011; citation_pages=1450-1458; citation_id=CR86
citation_journal_title=Hepatology; citation_title=Underlying steatohepatitis, but not simple hepatic steatosis, increase morbidity after liver resection: case–control study; citation_author=SK Reddy, W Marsh, PR Varley, BK Mock, KB Chopra, DA Geller; citation_volume=56; citation_publication_date=2012; citation_pages=2221-2230; citation_id=CR87
citation_journal_title=Ann Surg; citation_title=Improvement in perioperative outcome after hepatic resection; citation_author=WR Jamagin, M Gonen, Y Fong, R DeMatteo, L Ben-Porat, S Little; citation_volume=236; citation_publication_date=2002; citation_pages=397-407; citation_id=CR88
citation_journal_title=Surgery; citation_title=Mild hepatic steatosis is not a major risk factor for hepatectomy and regenerative power is not impaired; citation_author=JY Cho, KS Suh, CH Kwon, NJ Yi, KU Lee; citation_volume=139; citation_publication_date=2006; citation_pages=508-515; citation_id=CR89
citation_journal_title=Br J Surg; citation_title=Mild hepatic marovesicular steatosis may be a risk factor for hyperbilurubinemia in living liver donors following right hepatectomy; citation_author=S Nagai, Y Fujimoto, H Kamei, T Nakamura, T Kiuchi; citation_volume=96; citation_publication_date=2009; citation_pages=437-444; citation_id=CR90
citation_journal_title=J Gastrointest Surg; citation_title=Hepatic steatosis as a potential risk for major hepatic surgery; citation_author=K Behrns, G Tsiotos, NF DeSouza, MK Krishna, F Ludwig, DM Nagorney; citation_volume=2; citation_publication_date=1998; citation_pages=292-298; citation_id=CR91
citation_journal_title=Br J Surg; citation_title=Systemic review and meta-analysis of a steatosis as a risk factor in major hepatic resection; citation_author=VE Meijer, BT Kalish, M Puder, JNM Ijzermans; citation_volume=97; citation_publication_date=2010; citation_pages=1131-1339; citation_id=CR92
citation_journal_title=J Hepatol; citation_title=Liver transplantation using fatty livers: always feasible?; citation_author=L McCormack, P Dutkowski, AM El-Badry, PA Clavien; citation_volume=54; citation_publication_date=2011; citation_pages=1055-1062; citation_id=CR93
citation_journal_title=Arch Surg; citation_title=Short-and long-term outcomes after steatotic liver transplantation; citation_author=MBM Doyle, N Vachharajani, JR Wellen, CD Anderson, JA Lowell, S Shenoy; citation_volume=145; citation_publication_date=2010; citation_pages=653-660; citation_id=CR94
citation_journal_title=Ann Surg; citation_title=Use of severely steatotic grafts in liver transplantation: a matched case-control study; citation_author=L McCormack, H Petrowsky, W Jochum, B Mullhaupt, M Weber, PA Clavien; citation_volume=246; citation_publication_date=2007; citation_pages=940-948; citation_id=CR95
citation_journal_title=Liver Transpl; citation_title=The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment; citation_author=AL Spitzer, OB Lao, AAS Dick, R Bakthavatsalam, JB Halldorson, MM Yeh; citation_volume=16; citation_publication_date=2010; citation_pages=874-884; citation_id=CR96
citation_journal_title=Transplantation; citation_title=Use of steatotic graft in living-donor liver transplantation; citation_author=Y Soejima, M Shimada, T Suehiro, K Kishikawa, T Yoshimizu, K Hashimoto; citation_volume=76; citation_publication_date=2003; citation_pages=344-348; citation_id=CR97
citation_journal_title=Transplant Proc; citation_title=Effects of fatty filtration of the graft on the outcome of living-related liver transplantation; citation_author=M Hayashi, T Fujii, T Kiuchi, K Uryuhara, M Kasahara, M Takatsuki; citation_volume=31; citation_publication_date=1999; citation_pages=403; citation_id=CR98
citation_journal_title=Transpl Proc; citation_title=Impact of donor liver microvesicular steatosis on the outcome of liver transplantation; citation_author=KF Yoong, BK Gunson, DAH Neil, DF Mirza, AD Mayer, JA Buckels; citation_volume=31; citation_publication_date=1999; citation_pages=550-551; citation_id=CR99
citation_journal_title=Transpl Int; citation_title=Hepatic steatosis is associated with intrahepatic cholestasis and transient hyperbilirubinemia during regeneration after living donor liver transplantation; citation_author=JY Cho, KS Suh, HW Lee, EH Cho, SH Yang, YB Cho; citation_volume=19; citation_publication_date=2006; citation_pages=807-813; citation_id=CR100
citation_journal_title=Transplantation; citation_title=Safety and feasibility of diet-treated donors with steatotic livers at the initial consultation for living-donor liver transplantation; citation_author=A Oshita, H Tashiro, H Amano, T Kobayashi, T Onoe, K Ide; citation_volume=93; citation_publication_date=2012; citation_pages=1024-1030; citation_id=CR101
citation_journal_title=Transplantation; citation_title=Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation; citation_author=M Nakamuta, S Morizono, Y Soejima, T Yoshizumi, S Aishima, S Takaugi; citation_volume=80; citation_publication_date=2005; citation_pages=608-612; citation_id=CR102
citation_journal_title=Ann Surg; citation_title=A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning; citation_author=PA Clavien, M Selzner, HA Rudiger, R Graf, Z Kadry, V Rousson; citation_volume=238; citation_publication_date=2003; citation_pages=843-852; citation_id=CR103
citation_journal_title=J Hepatol; citation_title=Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy; citation_author=MC Domart, DD Esposti, M Sebagh, N Olaya, F Harper, G Pierron; citation_volume=51; citation_publication_date=2009; citation_pages=881-889; citation_id=CR104
citation_journal_title=Br J Surg; citation_title=Randomized clinical trial ischaemic preconditioning in major liver resection with intermittent pringle manoeuvre; citation_author=O Scatton, Z Zalinski, D Jegou, P Compagnon, M Lesurtel, J Belghiti; citation_volume=98; citation_publication_date=2011; citation_pages=1236-1243; citation_id=CR105
citation_journal_title=Ann Surg; citation_title=A randomized controlled trial on pharmacological preconditioning in liver surgery using volatile anesthetic; citation_author=B Beck-Schimmer, S Breitenstein, S Urech, E Conno, M Wittlinger, M Puhan; citation_volume=248; citation_publication_date=2008; citation_pages=909-918; citation_id=CR106
citation_journal_title=Ann Surg; citation_title=Effects of 10 minutes of ischemic preconditioning of cadaveric liver on the grafts preservation and function: the ying and the yang; citation_author=D Azoulay, M Gaudio, P Andreani, P Ichai, M Sebag, R Adam; citation_volume=242; citation_publication_date=2005; citation_pages=133-139; citation_id=CR107
citation_journal_title=Am J Transpl; citation_title=Ischemic pre-conditioning in deceased donor liver transplantation: a prospective randomized clinical trial; citation_author=A Amador, L Grande, J Marti, R Deulofeu, R Miquel, A Sola; citation_volume=7; citation_issue=9; citation_publication_date=2007; citation_pages=2180-2189; citation_id=CR108
citation_journal_title=Liver Transpl; citation_title=Effect of ischemic preconditioning on the genomic response to reperfusion injury in deceased donor liver transplantation; citation_author=W Jassem, S Fuggle, R Thompson, M Arno, J Taylor, J Byrne; citation_volume=15; citation_publication_date=2009; citation_pages=1750-1765; citation_id=CR109
citation_journal_title=Am J Transpl; citation_title=The ischemic preconditioning paradox in deceased donor liver transplantation—evidence from a prospective randomized single blind clinical trial; citation_author=B Koneru, A Shareef, G Dikdan, K Desai, KM Klein, B Peng; citation_volume=7; citation_publication_date=2007; citation_pages=2788-2796; citation_id=CR110
citation_journal_title=Am J Transpl; citation_title=Hypothermic machine preservation in human liver transplantation; citation_author=JV Guarrera, SD Henry, B Samstein, R Odeh-Ramadan, M Kinkhabwala, MJ Goldstein; citation_volume=10; citation_publication_date=2009; citation_pages=372-381; citation_id=CR111
citation_journal_title=Am J Transpl; citation_title=Hypothermic machine preservation reduces molecular markers of ischemia/reperfusion injury in human liver transplantation; citation_author=SD Henry, E Nachber, J Tulipan, J Stone, C Bae, L Reznik; citation_volume=12; citation_publication_date=2012; citation_pages=2477-2486; citation_id=CR112
citation_journal_title=Am J Transpl; citation_title=Ex vivo normothermic machine perfusion and viability testing of discarded human donor livers; citation_author=S Op den Dries, N Karimian, ME Sutton, AC Westerkamp, MWN Nijsten, ASH Gouw; citation_volume=13; citation_publication_date=2013; citation_pages=1327-35; citation_id=CR113
citation_journal_title=Liver Transpl; citation_title=Retrograde oxygen persuflation preservation of human livers: a pilot study; citation_author=J Treckmann, T Minor, S Saad, A Ozcelik, M Malago, CE Broelsh; citation_volume=14; citation_publication_date=2008; citation_pages=358-364; citation_id=CR114
citation_journal_title=Trials; citation_title=Oxygen persufflation as adunct in liver preservation (OPAL): study protocol for a randomized controlled trial; citation_author=T Minor, C Putter, A Gallinat, C Ose, G Kaiser, A Scherag; citation_volume=12; citation_publication_date=2011; citation_pages=234; citation_id=CR115