Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Nature - Tập 515 Số 7527 - Trang 431-435 - 2014
Edward T. Chouchani1,2, Victoria R. Pell1, Edoardo Gaude3, Dunja Aksentijević4, Stephanie Y. Sundier5, Ellen L. Robb2, Angela Logan2, Sergiy M. Nadtochiy6, Emily Ord7, Anthony C. Smith2, Filmon Eyassu2, Rachel Shirley7, Chou-Hui Hu1, Anna Dare2, Andrew M. James2, Sebastian Rogatti2, Richard C. Hartley8, Simon Eaton9, Ana S.H. Costa3, Paul S. Brookes6, Sean M. Davidson10, Michael R. Duchen5, Kourosh Saeb‐Parsy11, Michael J. Shattock4, Alan J. Robinson2, Lorraine M. Work7, Christian Frezza3, Thomas Krieg1, Michael P. Murphy2
1Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK
2MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
3MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
4King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.
5Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK,
6Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
7Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK
8School of Chemistry, University of Glasgow, Glasgow, G12 8TA, UK.
9Unit of Paediatric Surgery, UCL Institute of Child Health; London WC1N 1EH UK
10Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, UK
11University Department of Surgery and Cambridge NIHR Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK

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