Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people
Tóm tắt
To explore how metabolic risk factors for cardiovascular disease (CVD) differ between shift workers and day workers in a defined population. Shift work has been associated with an increased risk of CVD. Risk factors and causal pathways for this association are only partly known.
A working population of 27 485 people from the Västerbotten intervention program (VIP) has been analysed. Cross sectional data, including blood sampling and questionnaires were collected in a health survey.
Obesity was more prevalent among shift workers in all age strata of women, but only in two out of four age groups in men. Increased triglycerides (>1.7 mmol/l) were more common among two age groups of shift working women but not among men. Low concentrations of high density lipoprotein (HDL) cholesterol (men<0.9 and women<1.0 mmol/l) were present in the youngest age group of shift workers in both men and women. Impaired glucose tolerance was more often found among 60 year old women shift workers. Obesity and high triglycerides persisted as risk factors in shift working men and women after adjusting for age and socioeconomic factors, with an OR of 1.4 for obesity and 1.1 for high triglyceride concentrations. The relative risks for women working shifts versus days with one, two, and three metabolic variables were 1.06, 1.20, and 1.71, respectively. The corresponding relative risks for men were 0.99, 1.30, and 1.63, respectively.
In this study, obesity, high triglycerides, and low concentrations of HDL cholesterol seem to cluster together more often in shift workers than in day workers, which might indicate an association between shift work and the metabolic syndrome.
Từ khóa
Tài liệu tham khảo
Bøggild, 1999, Shiftwork, risk factors and cardiovascular disease., Scand J Work Environ Health, 25, 85, 10.5271/sjweh.410
Knutsson, 2000, Shiftwork and cardiovascular disease: review of disease mechanisms., Rev Environ Health, 15, 359, 10.1515/REVEH.2000.15.4.359
Hampton, 1996, Postprandial hormone and metabolic responses in simulated shiftwork., J Endocrinol, 151, 257, 10.1677/joe.0.1510259
Theorell, 1976, Day and night work: changes in cholesterol, uric acid, glucose, and potassium in serum and in circadian patterns of urinary cathecolamine excretion., Acta Med Scand, 200, 47, 10.1111/j.0954-6820.1976.tb08194.x
Lindahl, 1993, High serum insulin, insulin resistance and their associations with cardiovascular risk factors. The northern Sweden population study., J Intern Med, 234, 263, 10.1111/j.1365-2796.1993.tb00742.x
Haffner, 1999, Epidemiology of insulin resistance and its relation to coronary artery disease., Am J Cardiol, 84, 11J, 10.1016/S0002-9149(99)00351-3
World Health Organisation (1985) Diabetes mellitus. Report of a WHO study group. (World Health Organization, Geneva) . (Technical Report Series 727.).
von Schenk, 1987, Laboratory and field evaluation of three desktop instruments for assay of cholesterol and triglyceride., Clin Chem, 33, 1230, 10.1093/clinchem/33.7.1230
Niedhammer, 1996, Prevalence of overweight and weight gain in relation to night work in nurses' cohort., Int J Obes Relat Metab Disord, 20, 625
Bøggild, 1999, Shiftwork, social class and ischaemic heart disease in middle aged and elderly men; a 22 year follow up in the Copenhagen male study., Occup Environ Med, 56, 640, 10.1136/oem.56.9.640
van Amelsvoort L (2000) Cardiovascular risk profile in shift workers [thesis]. (Wageningen University, Wageningen).
Rivera-Col, 1994, Circadian rhythmic variation in serum concentrations of clinically important lipids., Clin Chem, 40, 1549, 10.1093/clinchem/40.8.1549
Knutsson, 1988, Prevalence of risk factors for coronary artery disease among day and shift workers., Scand J Work Environ Health, 14, 317, 10.5271/sjweh.1913
Costa G Betta A Uber D (1990) Estimate of coronary risk in a group of Italian shiftworkers. in Shiftwork: health, sleep and performance. eds Costa G Cesana G Kogi K (Peter Lang, Frankfurt am Main), pp 363–369.
Mikuni, 1983, Glucose intolerance in an employed population., Tohoku J Exp Med, 141 (suppl), 251, 10.1620/tjem.141.Suppl_251
Taylor, 1972, Mortality of shift and day workers 1956–68., Br J Ind Med, 29, 201
Tenkanen, 1997, Shiftwork, occupation and coronary heart disease over 6 years follow up in the Helsinki Heart Study., Scand J Work Environ Health, 23, 257, 10.5271/sjweh.218
Groop, 2000, Genetic and metabolic heterogeneity of diabetes., International Diabetes Monitor, 12, 1