Is there an additional benefit of serial NT-proBNP measurements in patients with stable chronic heart failure receiving individually optimized therapy?

Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D’Agostino RB, Kannel WB, Murabito JM, Vasan RS, Benjamin EJ, Levy D (2002) Lifetime risk for developing congestive heart failure: the Framingham heart study. Circulation 106(24):3068–3072

Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D’Agostino RB, Levy D, Kannel WB, Vasan RS (2008) Long-term trends in the incidence of heart failure after myocardial infarction. Circulation 118(20):2057–2062. doi: 10.1161/CIRCULATIONAHA.108.784215

Cleland JG, Swedberg K, Follath F, Komajda M, Cohen-Solal A, Aguilar JC, Dietz R, Gavazzi A, Hobbs R, Korewicki J, Madeira HC, Moiseyev VS, Preda I, van Gilst WH, Widimsky J, Freemantle N, Eastaugh J, Mason J (2003) The Euroheart failure survey programme—a survey on the quality of care among patients with heart failure in Europe. Part 1: Patient characteristics and diagnosis. Eur Heart J 24(5):442–463

Levy D, Kenchaiah S, Larson MG, Benjamin EJ, Kupka MJ, Ho KK, Murabito JM, Vasan RS (2002) Long-term trends in the incidence of and survival with heart failure. N Engl J Med 347(18):1397–1402. doi: 10.1056/NEJMoa020265

Ho KK, Anderson KM, Kannel WB, Grossman W, Levy D (1993) Survival after the onset of congestive heart failure in Framingham heart study subjects. Circulation 88(1):107–115

Poses RM, Smith WR, McClish DK, Huber EC, Clemo FL, Schmitt BP, Alexander-Forti D, Racht EM, Colenda CC 3rd, Centor RM (1997) Physicians’ survival predictions for patients with acute congestive heart failure. Arch Intern Med 157(9):1001–1007

Simon T, Becker R, Voss F, Bikou O, Hauck M, Licka M, Katus HA, Bauer A (2008) Elevated b-type natriuretic peptide levels in patients with nonischemic cardiomyopathy predict occurrence of arrhythmic events. Clin Res Cardiol 97(5):306–309. doi: 10.1007/s00392-007-0629-2

Mark DB, Felker GM (2004) B-type natriuretic peptide—a biomarker for all seasons? N Engl J Med 350(7):718–720. doi: 10.1056/NEJMe038233

Koglin J, Pehlivanli S, Schwaiblmair M, Vogeser M, Cremer P, vonScheidt W (2001) Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure. J Am Coll Cardiol 38(7):1934–1941

Ndrepepa G, Braun S, Kastrati A, Schomig A (2007) Area under roc curve, sensitivity, specificity of n-terminal probrain natriuretic peptide in predicting mortality in various subsets of patients with ischemic heart disease. Clin Res Cardiol 96(10):763–765. doi: 10.1007/s00392-007-0562-4

Klingenberg R, Zugck C, Becker R, Schellberg D, Heinze G, Kell R, Remppis A, Schoels W, Katus HA, Dengler TJ (2006) Raised b-type natriuretic peptide predicts implantable cardioverter-defibrillator therapy in patients with ischaemic cardiomyopathy. Heart 92(9):1323–1324. doi: 10.1136/hrt.2005.076117

Smilde TD, Damman K, van der Harst P, Navis G, Westenbrink BD, Voors AA, Boomsma F, van Veldhuisen DJ, Hillege HL (2009) Differential associations between renal function and “modifiable” risk factors in patients with chronic heart failure. Clin Res Cardiol 98(2):121–129. doi: 10.1007/s00392-008-0732-z

Costello-Boerrigter LC, Boerrigter G, Redfield MM, Rodeheffer RJ, Urban LH, Mahoney DW, Jacobsen SJ, Heublein DM, Burnett JC Jr (2006) Amino-terminal pro-b-type natriuretic peptide and b-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction. J Am Coll Cardiol 47(2):345–353. doi: 10.1016/j.jacc.2005.09.025

Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, Wu AH, Clopton P, Steg PG, Westheim A, Knudsen CW, Perez A, Kazanegra R, Herrmann HC, McCullough PA (2002) Rapid measurement of b-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347(3):161–167. doi: 10.1056/NEJMoa020233

Troughton RW, Frampton CM, Yandle TG, Espiner EA, Nicholls MG, Richards AM (2000) Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet 355(9210):1126–1130

Bettencourt P (2004) NT-proBNP and BNP: biomarkers for heart failure management. Eur J Heart Fail 6(3):359–363. doi: 10.1016/j.ejheart.2004.01.008

Jourdain P, Jondeau G, Funck F, Gueffet P, Le Helloco A, Donal E, Aupetit JF, Aumont MC, Galinier M, Eicher JC, Cohen-Solal A, Juilliere Y (2007) Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure: the stars-BNP multicenter study. J Am Coll Cardiol 49(16):1733–1739. doi: 10.1016/j.jacc.2006.10.081

Pfisterer M, Buser P, Rickli H, Gutmann M, Erne P, Rickenbacher P, Vuillomenet A, Jeker U, Dubach P, Beer H, Yoon SI, Suter T, Osterhues HH, Schieber MM, Hilti P, Schindler R, Brunner-La Rocca HP (2009) Bnp-guided vs symptom-guided heart failure therapy: the trial of intensified vs standard medical therapy in elderly patients with congestive heart failure (TIME-CHF) randomized trial. JAMA 301(4):383–392. doi: 10.1001/jama.2009.2

Lainchbury JG, Troughton RW, Strangman KM, Frampton CM, Pilbrow A, Yandle TG, Hamid AK, Nicholls MG, Richards AM (2009) N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial. J Am Coll Cardiol 55(1):53–60. doi: 10.1016/j.jacc.2009.02.095

Jensen J, Ma LP, Fu ML, Svaninger D, Lundberg PA, Hammarsten O (2010) Inflammation increases Nt-proBNP and the NT-proBNP/BNP ratio. Clin Res Cardiol 99(7):445–452. doi: 10.1007/s00392-010-0140-z

Hwang HJ, Son JW, Nam BH, Joung B, Lee B, Kim JB, Lee MH, Jang Y, Chung N, Shim WH, Cho SY, Kim SS (2009) Incremental predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide for short-term recurrence in atrial fibrillation ablation. Clin Res Cardiol 98(4):213–218. doi: 10.1007/s00392-009-0744-3

Frankenstein L, Clark AL, Goode K, Ingle L, Remppis A, Schellberg D, Grabs F, Nelles M, Cleland JG, Katus HA, Zugck C (2009) The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age. Heart 95(10):825–829. doi: 10.1136/hrt.2008.158626

Masson S, Latini R, Anand IS, Barlera S, Angelici L, Vago T, Tognoni G, Cohn JN (2008) Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial). J Am Coll Cardiol 52(12):997–1003. doi: 10.1016/j.jacc.2008.04.069

Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW (2009) 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults a report of the American college of cardiology foundation/American heart association task force on practice guidelines developed in collaboration with the international society for heart and lung transplantation. J Am Coll Cardiol 53(15):e1–e90. doi: 10.1016/j.jacc.2008.11.013

Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A, Hoes A, Jaarsma T, Korewicki J, Levy S, Linde C, Lopez-Sendon JL, Nieminen MS, Pierard L, Remme WJ (2005) Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the task force for the diagnosis and treatment of chronic heart failure of the European society of cardiology. Eur Heart J 26(11):1115–1140. doi: 10.1093/eurheartj/ehi204

Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De Caterina R, Dean V, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European society of cardiology. Developed in collaboration with the heart failure association of the esc (HFA) and endorsed by the European society of intensive care medicine (ESICM). Eur Heart J 29(19):2388–2442. doi: 10.1093/eurheartj/ehn309

Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O’Connell J, Olsen E, Thiene G, Goodwin J, Gyarfas I, Martin I, Nordet P (1996) Report of the 1995 world health organization/international society and federation of cardiology task force on the definition and classification of cardiomyopathies. Circulation 93(5):841–842

Frankenstein L, Remppis A, Frankenstein J, Hess G, Zdunek D, Slottje K, Katus HA, Zugck C (2009) Variability of n-terminal probrain natriuretic peptide in stable chronic heart failure and its relation to changes in clinical variables. Clin Chem 55(5):923–929. doi: 10.1373/clinchem.2008.112052

Hess G, Moecks J, Zdunek D (2005) N-terminal-proBNP (NT-proBNP) as an indicator of cardiac dysfunction. A study in patients presenting with suspected cardiac disorders. Z Kardiol 94(4):247–254. doi: 10.1007/s00392-005-0205-6

Luers C, Schmidt A, Wachter R, Fritzsche F, Sutcliffe A, Kleta S, Zapf A, Hagenah G, Binder L, Maisch B, Pieske B (2010) Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure. Herz 35(7):488–495. doi: 10.1007/s00059-010-3377-4

Fonarow GC, Peacock WF, Phillips CO, Givertz MM, Lopatin M (2007) Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure. J Am Coll Cardiol 49(19):1943–1950. doi: 10.1016/j.jacc.2007.02.037

Bettencourt P, Azevedo A, Pimenta J, Frioes F, Ferreira S, Ferreira A (2004) N-terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients. Circulation 110(15):2168–2174. doi: 10.1161/01.CIR.0000144310.04433.BE

Anand IS, Fisher LD, Chiang YT, Latini R, Masson S, Maggioni AP, Glazer RD, Tognoni G, Cohn JN (2003) Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan heart failure trial (Val-heft). Circulation 107(9):1278–1283

Olsson LG, Swedberg K, Cleland JG, Spark PA, Komajda M, Metra M, Torp-Pedersen C, Remme WJ, Scherhag A, Poole-Wilson P (2007) Prognostic importance of plasma nt-pro bnp in chronic heart failure in patients treated with a beta-blocker: results from the carvedilol or metoprolol european trial (COMET) trial. Eur J Heart Fail 9(8):795–801. doi: 10.1016/j.ejheart.2007.07.010

Kubanek M, Goode KM, Lanska V, Clark AL, Cleland JG (2009) The prognostic value of repeated measurement of N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure due to left ventricular systolic dysfunction. Eur J Heart Fail 11(4):367–377. doi: 10.1093/eurjhf/hfp003

Tang WH, Girod JP, Lee MJ, Starling RC, Young JB, Van Lente F, Francis GS (2003) Plasma B-type natriuretic peptide levels in ambulatory patients with established chronic symptomatic systolic heart failure. Circulation 108(24):2964–2966. doi: 10.1161/01.CIR.0000106903.98196.B6

Hildebrandt P, Collinson PO, Doughty RN, Fuat A, Gaze DC, Gustafsson F, Januzzi J, Rosenberg J, Senior R, Richards M (2010) Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. Eur Heart J 31(15):1881–1889. doi: 10.1093/eurheartj/ehq163

Raymond I, Groenning BA, Hildebrandt PR, Nilsson JC, Baumann M, Trawinski J, Pedersen F (2003) The influence of age, sex and other variables on the plasma level of N-terminal pro brain natriuretic peptide in a large sample of the general population. Heart 89(7):745–751

deFilippi CR, Seliger SL, Maynard S, Christenson RH (2007) Impact of renal disease on natriuretic peptide testing for diagnosing decompensated heart failure and predicting mortality. Clin Chem 53(8):1511–1519. doi: 10.1373/clinchem.2006.084533

Bruins S, Fokkema MR, Romer JW, Dejongste MJ, van der Dijs FP, van den Ouweland JM, Muskiet FA (2004) High intraindividual variation of B-type natriuretic peptide (BNP) and amino-terminal proBNP in patients with stable chronic heart failure. Clin Chem 50(11):2052–2058. doi: 10.1373/clinchem.2004.038752

Wu AH, Smith A, Wieczorek S, Mather JF, Duncan B, White CM, McGill C, Katten D, Heller G (2003) Biological variation for N-terminal pro- and B-type natriuretic peptides and implications for therapeutic monitoring of patients with congestive heart failure. Am J Cardiol 92(5):628–631

Murdoch DR, McDonagh TA, Byrne J, Blue L, Farmer R, Morton JJ, Dargie HJ (1999) Titration of vasodilator therapy in chronic heart failure according to plasma brain natriuretic peptide concentration: randomized comparison of the hemodynamic and neuroendocrine effects of tailored versus empirical therapy. Am Heart J 138(6 Pt 1):1126–1132

Rothenburger M, Wichter T, Schmid C, Stypmann J, Tjan TD, Berendes E, Etz C, Pioux A, Loher A, Wenzelburger F, Drees G, Hoffmeier A, Breithardt G, Scheld HH (2004) Aminoterminal pro type B natriuretic peptide as a predictive and prognostic marker in patients with chronic heart failure. J Heart Lung Transplant 23(10):1189–1197. doi: 10.1016/j.healun.2004.07.006

Logeart D, Thabut G, Jourdain P, Chavelas C, Beyne P, Beauvais F, Bouvier E, Solal AC (2004) Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure. J Am Coll Cardiol 43(4):635–641. doi: 10.1016/j.jacc.2003.09.044

Bettencourt P, Azevedo A, Fonseca L, Araujo JP, Ferreira S, Almeida R, Rocha-Goncalves F, Ferreira A (2007) Prognosis of decompensated heart failure patients with preserved systolic function is predicted by NT-proBNP variations during hospitalization. Int J Cardiol 117(1):75–79. doi: 10.1016/j.ijcard.2006.06.004

Miller WL, Hartman KA, Burritt MF, Borgeson DD, Burnett JC Jr, Jaffe AS (2005) Biomarker responses during and after treatment with nesiritide infusion in patients with decompensated chronic heart failure. Clin Chem 51(3):569–577. doi: 10.1373/clinchem.2004.041582

Schou M, Gustafsson F, Kjaer A, Hildebrandt PR (2007) Long-term clinical variation of NT-proBNP in stable chronic heart failure patients. Eur Heart J 28(2):177–182. doi: 10.1093/eurheartj/ehl449

Maeda K, Tsutamoto T, Wada A, Mabuchi N, Hayashi M, Tsutsui T, Ohnishi M, Sawaki M, Fujii M, Matsumoto T, Kinoshita M (2000) High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure. J Am Coll Cardiol 36(5):1587–1593