Is the robotic approach the future of distal pancreatectomy with splenectomy? A propensity score matched analysis

Sharona B. Ross1, Iswanto Sucandy1, Prakash Vasanthakumar1,2, Maria Christodoulou1, Tara M. Pattilachan1, Cameron Syblis2,1, Alexander Rosemurgy1
1Digestive Health Institute, AdventHealth Tampa, Tampa, USA
2University of South Florida Morsani College of Medicine Tampa, Tampa, USA

Tóm tắt

Our study provides a comparative analysis of the Laparo-Endoscopic Single Site (LESS) and robotic surgical approaches for distal pancreatectomy and splenectomy, examining their cosmetic advantages, patient outcomes, and operative efficiencies through propensity score matching (PSM). We prospectively followed 174 patients undergoing either the LESS or robotic procedure, matched by cell type, tumor size, age, sex, and BMI from 2012 to 2023. Propensity score matching (PSM) was utilized for data adjustment, with results presented as median (mean ± SD). Post-PSM analysis showed no significant differences in age or BMI between the two groups. LESS approach exhibited a shorter operative duration (180(180 ± 52.0) vs. 248(262 ± 78.5) minutes, p = 0.0002), but increased estimated blood loss (200(317 ± 394.4) vs. 100 (128 ± 107.2) mL, p = 0.04). Rates of intraoperative and postoperative complications, length of hospital stay, readmissions within 30 days, in-hospital mortalities, and costs were comparably similar between the two procedures. While the robotic approach led to lower blood loss, LESS was more time-efficient. Patient outcomes were similar in both methods, suggesting that the choice between these surgical techniques should balance cosmetic appeal with technical considerations.

Từ khóa


Tài liệu tham khảo

Pfister M, Probst P, Müller PC, Antony P, Klotz R, Kalkum E, Merz D, Renzulli P, Hauswirth F, Muller MK (2023) Minimally invasive versus open pancreatic surgery: meta-analysis of randomized clinical trials. BJS Open. 7(2):zrad007. https://doi.org/10.1093/bjsopen/zrad007

Bramhe S, Pathak SS (2022) Robotic surgery: a narrative review. Cureus. https://doi.org/10.7759/cureus.29179

Rosemurgy AS, Luberice K, Krill E, Castro M, Espineira GR, Sucandy I, Ross SB (2020) 100 Robotic distal pancreatectomies: the future at hand. Am Surg 86:958–964

Ross SB, Choung E, Teta AF, Colibao L, Luberice K, Paul H, Rosemurgy AS (2013) The learning curve of laparoendoscopic single-Site (LESS) fundoplication: definable, short, and safe. JSLS 17:376–384

Inoue S, Ikeda K, Kobayashi K, Kajiwara M, Teishima J, Matsubara A (2014) Patientreported satisfaction and cosmesis outcomes following laparoscopic adrenalectomy: Laparoendoscopic single-site adrenalectomy vs. conventional laparoscopic adrenalectomy. Can Urol Assoc J 8:E20–E25

Hernandez J, Ross SB, Morton C, McFarlin K, Dahal S, Golkar F, Albrink M, Rosemurgy AS (2010) The learning curve of laparoendoscopic single-site (LESS) cholecystectomy: definable, short, and safe. J Am Coll Surg 211:652–657

Ross SB, Roddenbery A, Luberice K, Paul H, Farrior T, Vice M, Patel K, Rosemurgy AS (2013) Laparoendoscopic single site (LESS) vs. conventional laparoscopic fundoplication for GERD: is there a difference? Surg Endosc 27:538–547

Ross SB, Hernandez JM, Sperry S, Morton CA, Vice M, Luberice K, Rosemurgy AS (2012) Public perception of LESS surgery and NOTES. J Gastrointest Surg 16:344–355

Sandberg EM, la Chapelle CF, van den Tweel MM, Schoones JW, Jansen FW (2017) Laparoendoscopic single-site surgery versus conventional laparoscopy for hysterectomy: a systematic review and meta-analysis. Arch Gynecol Obstet. https://doi.org/10.1007/s00404-017-4323-y

Toomey P, Hernandez J, Golkar F, Ross SB, Luberice K, Rosemurgy AS (2012) Pancreatic adenocarcinoma: complete tumor extirpation improves survival benefit despite larger tumors for patients who undergo distal pancreatectomy and splenectomy. J Gastrointest Surg 16:376–381

Ryan CE, Ross SB, Sukharamwala PB, Sadowitz BD, Wood TW, Rosemurgy AS (2015) Distal pancreatectomy, and splenectomy: a robotic or LESS approach. JSLS. https://doi.org/10.4293/JSLS.2014.00246

Liao CH, Yeh CN, Yang SJ, Wang SY, Ouyang CH, Tsai CY, Liu KH, Liu YY, Kuo IM, Fu CY, Yeh TS (2014) Effectiveness and feasibility of laparoscopic distal pancreatectomy on patients at high anesthetic risk. J Laparoendosc Adv Surg Tech A. https://doi.org/10.1089/lap.2014.0255

Wang K, Fan Y (2016) Minimally invasive distal pancreatectomy: review of the english literature. J Laparoendosc Adv Surg Tech A. https://doi.org/10.1089/lap.2016.0132

Takagi K, Umeda Y, Yoshida R, Fuji T, Yasui K, Kimura J, Hata N, Yagi T, Fujiwara T (2023) Role of the pfannenstiel incision in robotic hepato-pancreato-biliary surgery. J Clin Med 12(5):1971. https://doi.org/10.3390/jcm12051971

Chen JW, van Ramshorst TME, Lof S, Al-Sarireh B, Bjornsson B, Boggi U, Burdio F, Butturini G, Casadei R, Coratti A, D’Hondt M, Dokmak S, Edwin B, Esposito A, Fabre JM, Ferrari G, Ftériche FS, Fusai GK, Groot Koerkamp B, Hackert T, Jah A, Jang JY, Kauffmann EF, Keck T, Manzoni A, Marino MV, Molenaar Q, Pando E, Pessaux P, Pietrabissa A, Soonawalla Z, Sutcliffe RP, Timmermann L, White S, Yip VS, Zerbi A, Abu Hilal M, Besselink MG (2023) Robot-assisted versus laparoscopic distal pancreatectomy in patients with resectable pancreatic cancer: an international. Ann Surg Oncol Retrospective, Cohort Study. https://doi.org/10.1245/s10434-022-13054-2

Gavriilidis P, Lim C, Menahem B, Lahat E, Salloum C, Azoulay D (2016) Robotic versus laparoscopic distal pancreatectomy—The first meta-analysis. HPB (Oxford). https://doi.org/10.1016/j.hpb.2016.04.008

Lee SY, Allen PJ, Sadot E, D’Angelica MI, DeMatteo RP, Fong Y, Jarnagin WR, Kingham TP (2014) Distal pancreatectomy: a single institution’s experience in open, laparoscopic, and robotic approaches. J Am Coll Surg. https://doi.org/10.1016/j.jamcollsurg.2014.10.004

Han HJ, Kang CM (2018) Reduced port minimally invasive distal pancreatectomy: single-port laparoscopic versus robotic single-site plus one-port distal pancreatectomy. Surg Endosc. https://doi.org/10.1007/s00464-018-6361-3

Kim SH, Kang CM, Lee WJ (2017) Robotic single-site plus ONE port distal pancreatectomy. Surg Endosc. https://doi.org/10.1007/s00464-017-5476-2

Zhou JY, Xin C, Mou YP, Xu XW, Zhang MZ, Zhou YC, Lu C, Chen RG (2016) Robotic versus laparoscopic distal pancreatectomy: a meta-analysis of short-term outcomes. PLoS ONE. https://doi.org/10.1371/journal.pone.0151189

Liu R, Liu Q, Zhao ZM, Tan XL, Gao YX, Zhao GD (2017) Robotic versus laparoscopic distal pancreatectomy: a propensity score-matched study. J Surg Oncol. https://doi.org/10.1002/jso.24676

Souche R, Fuks D, Perinel J, Herrero A, Guillon F, Pirlet I, Perniceni T, Borie F, Cunha AS, Gayet B, Fabre JM (2018) Impact of laparoscopy in patients aged over 70 years requiring distal pancreatectomy: a French multicentric comparative study. Surg Endosc. https://doi.org/10.1007/s00464-018-6033-3

Sharpe SM, Talamonti MS, Wang E, Bentrem DJ, Roggin KK, Prinz RA, Marsh RD, Stocker SJ, Winchester DJ, Baker MS (2014) The laparoscopic approach to distal pancreatectomy for ductal adenocarcinoma results in shorter lengths of stay without compromising oncologic outcomes. Am J Surg. https://doi.org/10.1016/j.amjsurg.2014.11.001

Fung G, Sha M, Kunduzi B et al (2022) Learning curves in minimally invasive pancreatic surgery: a systematic review. Langenbecks Arch Surg 407:2217–2232. https://doi.org/10.1007/s00423-022-02470-3

Xu Q, Liu T, Zou X et al (2022) The learning curve for robot-assisted distal pancreatectomy: a single-center experience of 301 cases. J Pancreatol 5(3):118–124. https://doi.org/10.1097/JP9.0000000000000096