Is it possible docking and scoring new ligands with few experimental data? Preliminary results on estrogen receptor as a case study

Tora, 1989, Cell, 59, 477, 10.1016/0092-8674(89)90031-7 Cenni, 1999, Trends Endocrinol. Metab., 10, 41, 10.1016/S1043-2760(98)00121-0 Moras, 1998, Curr. Opin. Cell. Biol., 10, 384, 10.1016/S0955-0674(98)80015-X Sato, 1999, J. Med. Chem, 42, 1, 10.1021/jm980344o Kanis, 1996, Bone, 19, 185S, 10.1016/S8756-3282(96)90163-5 Torgerson, 2000, Exp. Opin. Pharmacother., 1, 1163, 10.1517/14656566.1.6.1163 Palacios, 1994, Int. J. Fertil. Menopausal Stud, 39, 93 Dutertre, 2000, J. Pharmacol. Exp. Ther, 295, 431 McDonnell, 1999, Trends Endocrinol. Metab, 10, 301, 10.1016/S1043-2760(99)00177-0 Maricic, 2002, Expert Opin. Pharmacother, 3, 767, 10.1517/14656566.3.6.767 White, 1999, Carcinogenesis, 20, 1153, 10.1093/carcin/20.7.1153 Jordan, 2003, J. Med. Chem, 46, 1081, 10.1021/jm020450x Shiau, 1998, Cell, 95, 927, 10.1016/S0092-8674(00)81717-1 Kellogg, 1992, Med. Chem. Res, 1, 444 Abraham, 1987, J. Protein-Struct. Funct. Genet., 2, 130, 10.1002/prot.340020207 Goodsell, 1996, J. Mol. Recognit, 9, 1, 10.1002/(SICI)1099-1352(199601)9:1<1::AID-JMR241>3.0.CO;2-6 Morris, 1996, J. Comput. Chem., 10, 293 Cozzini, 2002, J. Med. Chem, 45, 2469, 10.1021/jm0200299 Fornabaio, 2003, J Med Chem, 46, 4487, 10.1021/jm0302593 Marabotti, 2000, Bioorg. Med Chem Lett, 10, 2129, 10.1016/S0960-894X(00)00414-5 Aliau, 2002, Biochemistry, 41, 7979, 10.1021/bi0121914 Brzozowski, 1997, Nature, 389, 753, 10.1038/39645 Judson, 1997, Genetic algorithms and their use in chemistry, 10, 1 Chiche, 1990, Proc. Natl. Acad. Sci. USA, 87, 3240, 10.1073/pnas.87.8.3240 Mehler, 1991, Protein Eng, 4, 903, 10.1093/protein/4.8.903 Abraham, 1997, J. Mol. Biol, 272, 613, 10.1006/jmbi.1997.1249 Hansch, 1979