Is adiposopathy (sick fat) an endocrine disease?

International Journal of Clinical Practice - Tập 62 Số 10 - Trang 1474-1483
Harold Bays1, J. Michael González-Campoy2, Robert C. Welsh3,4, Donald A. Bergman5, Abbas E. Kitabchi6, Alan B. Schorr7, Helena W. Rodbard8
1L-MARC Research Center, Louisville, KY, USA
2Minnesota Center for Obesity, Metabolism and Endocrinology (MNCOME), Eagan, MN, USA
3San Diego VA Healthcare System, San Diego, CA, USA
4University of California, San Diego, CA, USA
5Department of Medicine, Division of Endocrinology, Metabolism, and Metabolic Bone Diseases, Mount Sinai School of Medicine, New York, NY, USA
6The University of Tennessee Health Science Center, Memphis, TN, USA
7Subsection Head-Endocrinology, Saint Mary Medical Center, Langhorne, PA, USA
8Endocrine and Metabolic Consultants, Rockville, MD, USA

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World Health Organization Global Strategy on Diet, Physical Activity and Health http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/ 2008

Bays, 2007, The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys, Int J Clin Pract, 61, 737, 10.1111/j.1742-1241.2007.01336.x

Bays, 2008, Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity, Expert Rev Cardiovasc Ther, 3, 343, 10.1586/14779072.6.3.343

Karelis, 2004, Metabolic and body composition factors in subgroups of obesity: what do we know?, J Clin Endocrinol Metab, 89, 2569, 10.1210/jc.2004-0165

Bays, 2006, Adiposopathy is a more rational treatment target for metabolic disease than obesity alone, Curr Atheroscler Rep, 8, 144, 10.1007/s11883-006-0052-6

Bays, 2006, Adiposopathy: why do adiposity and obesity cause metabolic disease?, Future Lipidol, 1, 389, 10.2217/17460875.1.4.389

Bays, 2007, Adiposopathy: treating pathogenic adipose tissue to reduce cardiovascular disease risk, Curr Treat Options Cardiovasc Med, 9, 259, 10.1007/s11936-007-0021-6

Bays, 2006, Adiposopathy: how do diet, exercise, weight loss and drug therapies improve metabolic disease?, Expert Rev Cardiovasc Ther, 4, 871, 10.1586/14779072.4.6.871

Bays, 2005, Adiposopathy: sick fat causes high blood sugar, high blood pressure, and dyslipidemia, Future Cardiol, 1, 39, 10.1517/14796678.1.1.39

Bray, 1977, Spontaneous and experimental human obesity: effects of diet and adipose cell size on lipolysis and lipogenesis, Metabolism, 26, 739, 10.1016/0026-0495(77)90061-0

Weyer, 2000, Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance, Diabetologia, 43, 1498, 10.1007/s001250051560

Kelley, 2000, Fuel selection in human skeletal muscle in insulin resistance: a re-examination, Diabetes, 49, 677, 10.2337/diabetes.49.5.677

Bays, 2004, Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach, J Clin Endocrinol Metab, 89, 463, 10.1210/jc.2003-030723

Nadler, 2000, The expression of adipogenic genes is decreased in obesity and diabetes mellitus, Proc Natl Acad Sci USA, 97, 11371, 10.1073/pnas.97.21.11371

Heilbronn, 2004, Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus, Int J Obes Relat Metab Disor, 28, S12, 10.1038/sj.ijo.0802853

Ravussin, 2002, Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus, Ann NY Acad Sci, 967, 363, 10.1111/j.1749-6632.2002.tb04292.x

Karlsson, 1998, Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II, J Clin Endocrinol Metab, 83, 3925

Hegele, 2004, Unbuckling lipodystrophy from insulin resistance and hypertension, J Clin Invest, 114, 163, 10.1172/JCI200422382

Lee, 2003, Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1), J Clin Invest, 111, 453, 10.1172/JCI15924

Salans, 1974, Glucose metabolism and the response to insulin by human adipose tissue in spontaneous and experimental obesity. Effects of dietary composition and adipose cell size, J Clin Invest, 53, 848, 10.1172/JCI107625

Haller, 1979, Relationship between adipocyte hypertrophy and metabolic disturbances, Endokrinologie, 74, 63

Pausova, 2006, From big fat cells to high blood pressure: a pathway to obesity-associated hypertension, Curr Opin Nephrol Hypertens, 15, 173, 10.1097/01.mnh.0000214775.42103.a5

Ehrhart-Bornstein, 2003, Human adipocytes secrete mineralocorticoid-releasing factors, Proc Natl Acad Sci USA, 100, 14211, 10.1073/pnas.2336140100

Blouin, 2005, Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women, Am J Physiol Endocrinol Metab, 288, E398, 10.1152/ajpendo.00312.2004

Arsenault, 2007, Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome, Arch Intern Med, 167, 1518, 10.1001/archinte.167.14.1518

Rader, 2007, Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus, Am J Med, 120, S12, 10.1016/j.amjmed.2007.01.003

Hayashi, 2004, Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans, Ann Intern Med, 140, 992, 10.7326/0003-4819-140-12-200406150-00008

Hall, 2003, Obesity-associated hypertension and kidney disease, Curr Opin Nephrol Hypertens, 12, 195, 10.1097/00041552-200303000-00011

Wilding, 2007, The importance of free fatty acids in the development of type 2 diabetes, Diabet Med, 24, 934, 10.1111/j.1464-5491.2007.02186.x

Sarafidis, 2007, Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance?, J Hum Hypertens, 21, 12, 10.1038/sj.jhh.1002103

Fagot-Campagna, 1998, High free fatty acid concentration: an independent risk factor for hypertension in the Paris Prospective Study, Int J Epidemiol, 27, 808, 10.1093/ije/27.5.808

Koutsari, 2006, Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity, J Lipid Res, 47, 1643, 10.1194/jlr.R600011-JLR200

Kershaw, 2004, Adipose tissue as an endocrine organ, J Clin Endocrinol Metab, 89, 2548, 10.1210/jc.2004-0395

Lenz, 2008, Obesity: the hormonal milieu, Curr opin Endocrinol Diabetes Obes, 15, 9, 10.1097/MED.0b013e3282f43a5b

Mukherjee, 2005, Leptin as a common link to obesity and hypertension, Drugs Today (Barc), 41, 687, 10.1358/dot.2005.41.10.899612

Antuna-Puente, 2008, Adipokines: the missing link between insulin resistance and obesity, Diabetes Metab, 1, 2, 10.1016/j.diabet.2007.09.004

Calabro, 2007, Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ, Subcell Biochem, 42, 63, 10.1007/1-4020-5688-5_3

Trayhurn, 2005, Signalling role of adipose tissue: adipokines and inflammation in obesity, Biochem Coc Trans, 33, 1078, 10.1042/BST0331078

Pauletto, 2006, Inflammation and hypertension: the search for a link, Nephrol Dial Transplant, 21, 850, 10.1093/ndt/gfl019

Chudek, 2006, Adipose tissue, inflammation and endothelial dysfunction, Pharmacol Rep, 58, 81

Yu, 2005, Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue, Circ Res, 96, 1042, 10.1161/01.RES.0000165803.47776.38

Tomas, 2004, Metabolic and hormonal interactions between muscle and adipose tissue, Proc Nutr Soc, 63, 381, 10.1079/PNS2004356

Bays, 2007, Adiposopathy: the endocannabinoid system as a therapeutic treatment target for dysfunctional ‘sick’ fat, Californian J Health Promot, 19, 32

Rumantir, 1999, Neural mechanisms in human obesity-related hypertension, J Hypertens, 17, 1125, 10.1097/00004872-199917080-00012

Altman, 2002, Weight in the balance, Neuroendocrinology, 76, 131, 10.1159/000064528

Schling, 2002, Cross talk between adipose tissue cells: impact on pathophysiology, News Physiol Sci, 17, 99

Storlien, 2004, Metabolic flexibility, Proc Nutr Soc, 63, 363, 10.1079/PNS2004349

Schaffler, 2006, Role of adipose tissue as an inflammatory organ in human diseases, Endocr Rev, 27, 449, 10.1210/er.2005-0022

Flegal, 2007, Cause-specific excess deaths associated with underweight, overweight, and obesity, JAMA, 298, 2028, 10.1001/jama.298.17.2028

Uretsky, 2007, Obesity paradox in patients with hypertension and coronary artery disease, Am J Med, 120, 863, 10.1016/j.amjmed.2007.05.011

Tchoukalova, 2008, Subcutaneous adipocyte size and body fat distribution, Am J Clin Nutr, 87, 56, 10.1093/ajcn/87.1.56

Vague, 1947, La differenciation sexuelle, facteur determinant des formes de l’obesite, Presse Med, 30, 339

Tchkonia, 2007, Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns, Am J Physiol Endocrinol Metab, 292, E298, 10.1152/ajpendo.00202.2006

Wajchenberg, 2000, Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome, Endocr Rev, 21, 697, 10.1210/edrv.21.6.0415

Baker, 2006, Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease, Cardiovasc Diabetol, 5, 1, 10.1186/1475-2840-5-1

Higuchi, 2002, Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries, Arq Bras Cardiol, 79, 20, 10.1590/S0066-782X2002001000003

Mazurek, 2003, Human epicardial adipose tissue is a source of inflammatory mediators, Circulation, 108, 2460, 10.1161/01.CIR.0000099542.57313.C5

Engeli, 2005, Is there a pathophysiological role for perivascular adipocytes?, Am J Physiol Heart Circ Physiol, 289, H1794, 10.1152/ajpheart.00762.2005

Imbeault, 1999, Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: is there a contribution of subcutaneous fat cell hypertrophy?, Metabolism, 48, 355, 10.1016/S0026-0495(99)90085-9

Van Harmelen, 1998, Leptin secretion from subcutaneous and visceral adipose tissue in women, Diabetes, 47, 913, 10.2337/diabetes.47.6.913

Couillard, 2000, Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia, Int J Obes Relat Metab Disord, 24, 782, 10.1038/sj.ijo.0801227

Franks, 2005, Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity, Obes Res, 13, 1476, 10.1038/oby.2005.178

Bravo, 2006, Leptin and hypertension in obesity, Vasc Health Risk Manag, 2, 163, 10.2147/vhrm.2006.2.2.163

Acree, 2007, The influence of obesity on arterial compliance in adult men and women, Vasc Med, 12, 183, 10.1177/1358863X07079323

Johnson, 2001, Impaired insulin action in subcutaneous adipocytes from women with visceral obesity, Am J Physiol Endocrinol Metab, 280, E40, 10.1152/ajpendo.2001.280.1.E40

Jensen, 2006, Is visceral fat involved in the pathogenesis of the metabolic syndrome?, Human model Obes (Silver Spring), 14, 20S, 10.1038/oby.2006.278

Petersen, 2003, Mitochondrial dysfunction in the elderly: possible role in insulin resistance, Science, 300, 1140, 10.1126/science.1082889

Adams, 2004, Ceramide content is increased in skeletal muscle from obese insulin-resistant humans, Diabetes, 53, 25, 10.2337/diabetes.53.1.25

Chavez, 2005, Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling, J Biol Chem, 280, 20148, 10.1074/jbc.M412769200

Kelley, 2001, Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance, Diabetes Care, 24, 933, 10.2337/diacare.24.5.933

Nadler, 2001, Please pass the chips: genomic insights into obesity and diabetes, J Nutr, 131, 2078, 10.1093/jn/131.8.2078

Grill, 1999, Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects, Diabetologia, 42, 15, 10.1007/s001250051106

Williams, 2001, Study of distribution and factors affecting syphilis epidemic among inner-city minorities of Baltimore, Public Health, 115, 387, 10.1016/S0033-3506(01)00484-X

Krause, 1991, Syphilis during 1900-1910: similarities to present-day AIDS, Allergy Proc, 12, 127, 10.2500/108854191779011756

Bays, 2002, Anti-obesity drug development, Expert Opin Investig Drugs, 11, 1189, 10.1517/13543784.11.9.1189

Bray, 2004, Medical consequences of obesity, J Clin Endocrinol Metab, 89, 2583, 10.1210/jc.2004-0535

Kushner, 2003, Assessment of the obese patient, Endocrinol Metab Clin North Am, 32, 915, 10.1016/S0889-8529(03)00068-9

Munoz, 2007, Why patients seek bariatric surgery: a qualitative and quantitative analysis of patient motivation, Obes Surg, 17, 1487, 10.1007/s11695-008-9427-9

Cawley, 2007, Predicting complications after bariatric surgery using obesity-related co-morbidities, Obes Surg, 17, 1451, 10.1007/s11695-008-9422-1

WHO Expert Consultation, 2004, Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies, Lancet, 363, 157, 10.1016/S0140-6736(03)15268-3

Bays, 2005, Adiposopathy, metabolic syndrome, quantum physics, general relativity, chaos and the Theory of Everything, Expert Rev Cardiovasc Ther, 3, 393, 10.1586/14779072.3.3.393

Bays, 2006, High Prevalence of Misdiagnosis of the Metabolic Syndrome in a Self-Reported Survey: Possible Confusion with having ‘a Metabolism Problem’