Is Vitamin D Supplementation Useful for Weight Loss Programs? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Medicina (Lithuania) - Tập 55 Số 7 - Trang 368
Simone Perna1
1Department of Biology, College of Science, University of Bahrain, Sakhir Campus, P. O. Box 32038, Bahrain

Tóm tắt

Background and Objectives: The controversy about the impact of vitamin D supplementation on weight loss treatment was observed in several randomized controlled trials (RCTs). This meta-analysis investigates the effects of vitamin D supplementation (cholecalciferol or ergocalciferol) on weight loss through holistic measurements of Body Mass Index (BMI), weight and waist circumference. Materials and Methods: Google Scholar, WOS, PubMed and Scopus were explored to collect relevant studies. The selected articles focused on vitamin D supplementation in overweight and obese individuals with different conditions. Eleven RCTs were included into this meta-analysis with a total of 947 subjects, with a mean of the follow-up from 1 to 12 months and different vitamin D interventions (from 25,000 to 600,000 IU/monthly of cholecalciferol). Results: The meta-analyzed mean differences for random effects showed that cholecalciferol supplementation deceases the BMI by −0.32 kg/m2 (CI95% −0.52, −0.12 kg/m2, p = 0.002) and the waist circumference by −1.42 cm (CI95% −2.41, −0.42 cm, p = 0.005), but does not statistically affect weight loss −0.43 kg (CI95% −1.05, +0.19 kg, p = 0.17). Conclusions: This meta-analysis lays the foundation for defining the potential clinical efficacy of vitamin D supplementation as a potential therapeutic option for weight loss programs, but further studies are needed to confirm the validity of these findings and delineate potential underlying mechanisms.

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Tài liệu tham khảo

Cefalo, 2018, Effect of Vitamin D Supplementation on Obesity-Induced Insulin Resistance: A Double-Blind, Randomized, Placebo-Controlled Trial, Obesity, 26, 651, 10.1002/oby.22132

Haidar, 2011, Obesity epidemiology, Clin. Colon. Rectal. Surg., 24, 205, 10.1055/s-0031-1295684

Duggan, 2015, Effect of vitamin D3 supplementation in combination with weight loss on inflammatory biomarkers in postmenopausal women: A randomized controlled trial, Cancer Prev. Res., 8, 628, 10.1158/1940-6207.CAPR-14-0449

Esmaeli, 2018, Vitamin D supplementation decreased body weight and body mass index of Iranian type-2 diabetic patients: A randomised clinical trial study, Malays. J. Nutr., 24, 1

Shapses, 2013, Vitamin D supplementation and calcium absorption during caloric restriction: A randomized double-blind trial, Am. J. Clin. Nutr., 97, 637, 10.3945/ajcn.112.044909

Sneve, 2008, Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects, Eur. J. Endocrinol., 159, 675, 10.1530/EJE-08-0339

Salehpour, 2012, A 12-week double-blind randomized clinical trial of vitamin D 3 supplementation on body fat mass in healthy overweight and obese women, Nutr. J., 11, 78, 10.1186/1475-2891-11-78

Costa, 2015, Obesity and vitamin D deficiency: A systematic review and meta-analysis, Obes. Rev., 16, 341, 10.1111/obr.12239

Parikh, 2004, The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults, J. Clin. Endocrinol. Metab., 89, 1196, 10.1210/jc.2003-031398

Khosravi, 2018, Effect of Vitamin D supplementation on weight loss, glycemic indices, and lipid profile in obese and overweight women: A clinical trial study, Int. J. Prev. Med., 9, 63, 10.4103/ijpvm.IJPVM_329_15

Zhu, 2013, Calcium plus vitamin D 3 supplementation facilitated Fat loss in overweight and obese college students with very-low calcium consumption: A randomized controlled trial, Nutr. J., 12, 8, 10.1186/1475-2891-12-8

Higgins, 2011, The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials, BMJ, 343, 5928, 10.1136/bmj.d5928

Mason, 2014, Vitamin D3 supplementation during weight loss: A double-blind randomized controlled trial, Am. J. Clin. Nutr., 99, 1015, 10.3945/ajcn.113.073734

Mai, S., Walker, G., Vietti, R., Cattaldo, S., Mele, C., Priano, L., and Marzullo, P. (2017). Acute vitamin D3 supplementation in severe obesity: Evaluation of multimeric adiponectin. Nutrients, 9.

Zittermann, 2018, Effects of vitamin D supplementation on renin and aldosterone concentrations in patients with advanced heart failure: The EVITA trial, Intern. J. Endocrinol., 2018, 5015417, 10.1155/2018/5015417

Major, 2008, Calcium plus vitamin D supplementation and fat mass loss in female very low-calcium consumers: Potential link with a calcium-specific appetite control, Br. J. Nutr., 101, 659, 10.1017/S0007114508030808

Vanlint, 2013, Vitamin D and obesity, Nutrients, 5, 949, 10.3390/nu5030949

Dalfardi, 2013, The Correlation of Serum Calcium Level and Obesity; Is There Any Explanation?, Galen. Med. J., 2, 26, 10.31661/gmj.v2i1.28

Soares, 2012, Mechanistic roles for calcium and vitamin D in the regulation of body weight, Obes. Rev., 13, 592, 10.1111/j.1467-789X.2012.00986.x

Caan, 2007, Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain, Arch. Intern. Med., 167, 893, 10.1001/archinte.167.9.893

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Medicina (Lithuania)

Tập 55 Số 7

368

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