Is Combihaler usable for aerosol delivery in single limb non-invasive mechanical ventilation?

Michotte, 2014, In vitro comparison of five nebulizers during noninvasive ventilation: analysis of inhaled and lost doses, J. Aerosol Med. Pulm. Drug Deliv., 27, 430, 10.1089/jamp.2013.1070 Duarte, 2004, Inhaled bronchodilator administration during mechanical ventilation, Respir. Care, 49, 623 Berlinski, 2013, Albuterol delivery by 4 different nebulizers placed in 4 different positions in a pediatric ventilator in vitro model, Respir. Care, 58, 1124, 10.4187/respcare.02074 Sidler-Moix, 2015, Physicochemical aspects and efficiency of albuterol nebulization: comparison of three aerosol types in an in vitro pediatric model, Respir. Care, 60, 38, 10.4187/respcare.02490 Ghazanfari, 2007, The influence of fluid physicochemical properties on vibrating-mesh nebulization, Int. J. Pharm., 339, 103, 10.1016/j.ijpharm.2007.02.035 Hassan, 2016, In-vitro characterization of the aerosolized dose during non-invasive automatic continuous positive airway pressure ventilation, Pulm. Ther., 2, 115, 10.1007/s41030-015-0010-y ElHansy, 2016, In vitro aerodynamic characteristics of aerosol delivered from different inhalation methods in mechanical ventilation, Pharm. Dev. Technol., 1 Dhand, 1997, Inhaled bronchodilator therapy in mechanically ventilated patients, Am. J. Respir. Crit. Care Med., 156, 3, 10.1164/ajrccm.156.1.9610025 Dhand, 2004, New frontiers in aerosol delivery during mechanical ventilation, Respir. Care, 49, 667 Ari, 2010, Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation, Respir. Care, 55, 845 Waldrep, 2008, Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation, Curr. Drug Deliv., 5, 114, 10.2174/156720108783954815 Dhand, 2002, Nebulizers that use a vibrating mesh or plate with multiple apertures to generate aerosol, Respir. Care, 47, 1406 Dhand, 2003, New nebuliser technology-aerosol generation by using a vibrating mesh or plate with multiple apertures, Bus. Brief. long-therm health care Strateg., 1 Watts, 2008, Current therapies and technological advances in aqueous aerosol drug delivery, Drug Dev. Ind. Pharm., 34, 913, 10.1080/03639040802144211 Abdelrahim, 2010, In-vitro characterisation of the nebulised dose during non-invasive ventilation, J. Pharm. Pharmacol., 62, 966, 10.1111/j.2042-7158.2010.01134.x Fink, 2001, Aerosol delivery during mechanical ventilation with high frequency oscillation: an in-vitro evaluation, Chest, 120, 277S Fink, 2003, In vitro comparison of a novel nebulizer with ultrasonic and pneumatic nebulizers, J. Allergy Clin. Immunol. Pract., 111, S143, 10.1016/S0091-6749(03)80454-2 Chrystyn, 2004, Relative bioavailability of salbutamol to the lungs following inhalation by three nebulised methods, Abstr. Am. Thorac. Soc. Meet. Boukhettala, 2015, In vitro performance of spacers for aerosol delivery during adult mechanical ventilation, J. Aerosol Med. Pulm. Drug Deliv., 28, 130, 10.1089/jamp.2013.1091 Ari, 2015, Performance comparisons of jet and mesh nebulizers using different interfaces in simulated spontaneously breathing adults and children, J. Aerosol Med. Pulm. Drug Deliv., 28, 281, 10.1089/jamp.2014.1149 Harvey, 1995, Effect of a spacer on pulmonary aerosol deposition from a jet nebuliser during mechanical ventilation, Thorax, 50, 50, 10.1136/thx.50.1.50 Labiris, 2003, Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications, Br. J. Clin. Pharmacol., 56, 588, 10.1046/j.1365-2125.2003.01892.x Lourenço, 1972, Patterns of distribution and clearance of aerosols in patients with bronchiectasis 1, 2, Am. Rev. Respir. Dis., 106, 857, 10.1164/arrd.1972.106.6.857 Laube, 1986, The effect of bronchial obstruction on central airway deposition of a saline aerosol in patients with asthma, Am. Rev. Respir. Dis., 133, 740 Pavia, 1977, Effect of lung function and mode of inhalation on penetration of aerosol into the human lung, Thorax, 32, 194, 10.1136/thx.32.2.194 Ilowite, 1987, Quantitative deposition of aerosolized gentamicin in cystic Fibrosis1-3, Am. Rev. Respir. Dis., 136, 1445, 10.1164/ajrccm/136.6.1445 Boukhettala, 2012, In vitro evaluation of a new spacer for pMDI and nebulizers in mechanical ventilation, Eur. Respir. J., 40, P2012 Boukhettala, 2013, Study of the performances of a new spacer in adult mechanical ventilation, Eur. Respir. J., 42, P3861 Abdelrahim, 2011, The relative lung and systemic bioavailability of terbutaline following nebulisation in non-invasively ventilated patients, Int. J. Pharm., 420, 313, 10.1016/j.ijpharm.2011.09.005 Hassan, 2017, In-vitro/in-vivo comparison of inhaled salbutamol dose delivered by jet nebulizer, vibrating mesh nebulizer and metered dose inhaler with spacer during non-invasive ventilation, Exp. Lung Res., 43, 19, 10.1080/01902148.2017.1282993 Hussein, 2017, In vitro/in vivo correlation and modeling of emitted dose and lung deposition of inhaled salbutamol from metered dose inhalers with different types of spacers in noninvasively ventilated patients, Pharm. Dev. Technol., 1 Rabea, 2017, Modelling of in-vitro and in-vivo performance of aerosol emitted from different vibrating mesh nebulisers in non-invasive ventilation circuit, Eur. J. Pharm. Sci., 97, 182, 10.1016/j.ejps.2016.11.018 Madney, 2017, Nebulizers and spacers for aerosol delivery through adult nasal cannula at low oxygen flow rate: an in-vitro study, J. Drug Deliv. Sci. Technol., 39, 260, 10.1016/j.jddst.2017.04.014 Ari, 2015, Pressurized metered-dose inhalers versus nebulizers in the treatment of mechanically ventilated subjects with artificial airways: an in vitro study, Respir. Care, 60, 1570, 10.4187/respcare.04125 Berlinski, 2013, Albuterol delivery via metered dose inhaler in a spontaneously breathing pediatric tracheostomy model, Pediatr. Pulmonol., 48, 1026, 10.1002/ppul.22715 Berg, 2007, Determination of nebulizer droplet size distribution: a method based on impactor refrigeration, J. Aerosol Med., 20, 97, 10.1089/jam.2007.0556 Abdelrahim, 2009, Aerodynamic characteristics of nebulized terbutaline sulphate using the next generation impactor (NGI) and CEN method, J. Aerosol Med. Pulm. Drug Deliv., 22, 19, 10.1089/jamp.2008.0650 2011, Aerodynamic characteristics of nebulized terbutaline sulphate using the Andersen Cascade Impactor compared to the next generation impactor, Pharm. Dev. Technol., 16, 137, 10.3109/10837450903511194 Dai, 2014, Influence of exhalation valve and nebulizer position on albuterol delivery during noninvasive positive pressure ventilation, J. Aerosol Med. Pulm. Drug Deliv., 27, 125, 10.1089/jamp.2012.1024 Calvert, 2006, Enhanced delivery of nebulised salbutamol during non-invasive ventilation, J. Pharm. Pharmacol., 58, 1553, 10.1211/jpp.58.11.0017 Morén, 1978, Drug deposition of pressurized inhalation aerosols I. Influence of actuator tube design, Int. J. Pharm., 1, 205, 10.1016/0378-5173(78)90009-1 Williams, 1998, Influence of propellant composition on drug delivery from a pressurized metered-dose inhaler, Drug Dev. Ind. Pharm., 24, 763, 10.3109/03639049809082724 Dhand, 2004, Basic techniques for aerosol delivery during mechanical ventilation, Respir. Care, 49, 611 Barry, 1995, The optimum size and shape of spacer devices for inhalational therapy, J. Aerosol Med., 8, 303, 10.1089/jam.1995.8.303 Nikander, 2014, The evolution of spacers and valved holding chambers, J. Aerosol Med. Pulm. Drug Deliv., 27, S-4, 10.1089/jamp.2013.1076 Doyle, 2009 Boukhettala, 2015, In vitro evaluation of a spacer in a pediatric model of mechanical ventilation, Eur. Respir. J., 46, PA1868 Zanen, 1996, Optimal particle size for beta 2 agonist and anticholinergic aerosols in patients with severe airflow obstruction, Thorax, 51, 977, 10.1136/thx.51.10.977 Usmani, 2005, Regional lung deposition and bronchodilator response as a function of β2-agonist particle size, Am. J. Respir. Crit. care Med., 172, 1497, 10.1164/rccm.200410-1414OC Newman, 2005, Principles of metered-dose inhaler design, Respir. Care, 50, 1177 Wildhaber, 2000, Reducing electrostatic charge on spacer devices and bronchodilator response, Br. J. Clin. Pharmacol., 50, 277, 10.1046/j.1365-2125.2000.00251.x Kenyon, 1998, The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients, Eur. Respir. J., 11, 606, 10.1183/09031936.98.11030606 Barry, 1995, The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler, Br. J. Clin. Pharmacol., 40, 76, 10.1111/j.1365-2125.1995.tb04538.x Li, 1992, Dispersion and deposition of spherical particles from point sources in a turbulent channel flow, Aerosol Sci. Technol., 16, 209, 10.1080/02786829208959550