Iron metabolism in the eye: A review

Experimental Eye Research - Tập 88 Số 2 - Trang 204-215 - 2009
Małgorzata Goralska1, J. Ferrell, Jill Harned, Marilyn M. Lall, Steven Nagar, Lloyd N. Fleisher, M. Christine McGahan
1Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27606, USA

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Abraham, 2008, Pharmacological and clinical aspects of heme oxygenase, Pharmacol. Rev., 60, 79, 10.1124/pr.107.07104

Acland, 2001, Gene therapy restores vision in a canine model of childhood blindness, Nat. Genet., 28, 92, 10.1038/ng0501-92

Agarwal, 1976, Distribution of calcium, magnesium, iron, copper, zinc and manganese in common mammalian eye lenses, Ind. J. Exp. Biol., 14, 217

Alberghini, 2005, Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells, J. Biol. Chem., 280, 3120, 10.1074/jbc.M500971200

Alldredge, 2003, Pathophysiology of the optic neuropathy associated with Friedreich ataxia, Arch. Ophthalmol., 121, 1582, 10.1001/archopht.121.11.1582

Arjamaa, 2006, Oxygen-dependent disease in the retina: role of hypoxia-inducible factors, Exp. Eye Res., 83, 473, 10.1016/j.exer.2006.01.016

Aslan, 2008, Oxidative and nitrative stress markers in glaucoma, Free Radic. Biol. Med., 45, 367, 10.1016/j.freeradbiomed.2008.04.026

Bainbridge, 2008, Effect of gene therapy on visual function in Leber's congenital amaurosis, N. Engl. J. Med., 358, 2231, 10.1056/NEJMoa0802268

Baranano, 2002, Biliverdin reductase: a major physiologic cytoprotectant, Proc. Natl. Acad. Sci. U.S.A., 99, 16093, 10.1073/pnas.252626999

Bavic, 1992, Characterization of a plasma retinol-binding protein membrane receptor expressed in the retinal pigment epithelium, J. Biol. Chem., 267, 23035, 10.1016/S0021-9258(18)50052-1

Beatty, 2000, The role of oxidative stress in the pathogenesis of age-related macular degeneration, Surv. Ophthalmol., 45, 115, 10.1016/S0039-6257(00)00140-5

Beazley, 2008, Corneal epithelial nuclear ferritin: developmental regulation of ferritin and its nuclear transporter ferritoid, Dev. Dyn., 237, 2529, 10.1002/dvdy.21691

Bridle, 2003, Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis, Lancet, 361, 669, 10.1016/S0140-6736(03)12602-5

Brooks, 2002, Ferritin crystal cataracts in hereditary hyperferritinemia cataract syndrome, Investig. Ophthalmol. Vis. Sci., 43, 1121

Bruinink, 1996, Neurotrophic effects of transferrin on embryonic chick brain and neural retinal cell cultures, Int. J. Dev. Neurosci., 14, 785, 10.1016/S0736-5748(96)00035-4

Cai, 1997, Ferritin is a developmentally regulated nuclear protein of avian corneal epithelial cells, J. Biol. Chem., 272, 12831, 10.1074/jbc.272.19.12831

Cai, 2008, Nuclear ferritin-mediated protection of corneal epithelial cells from oxidative damage to DNA, Dev. Dyn, 237, 2676, 10.1002/dvdy.21494

Cai, 1998, Nuclear ferritin protects DNA from UV damage in corneal epithelial cells, Mol. Biol. Cell, 9, 1037, 10.1091/mbc.9.5.1037

Cai, 2001, Nuclear translocation of ferritin in corneal epithelial cells, J. Cell Sci., 114, 2327, 10.1242/jcs.114.12.2327

Cellier, 1995, Nramp defines a family of membrane proteins, Proc. Natl. Acad. Sci. U.S.A., 92, 10.1073/pnas.92.22.10089

Chen, H., Liu, B., Lukas, T.J., Suyeoka, G., Wu, G., Neufeld, A.H. Changes in iron-regulatory proteins in the aged rodent neural retina. Neurobiol. Aging, in press., doi:10.1016/j.neurobiolaging.2008.01.002

Chen, 2003, Increased expression of ceruloplasmin in the retina following photic injury, Mol. Vis., 9, 151

Cheng, 2000, High level of ferritin light chain mRNA in lens, Biochem. Biophys. Res. Commun., 270, 349, 10.1006/bbrc.2000.2425

Cho, 1991, The ontogeny of transferrin receptors in the embryonic chick retina: an immunohistochemical study, Brain Res., 549, 327, 10.1016/0006-8993(91)90476-C

Chong, 2002, A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3 and vascular endothelial growth factor in cancer cell lines, Cancer Res., 62, 6924

Chowers, 2006, The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration, Investig. Ophthalmol. Vis. Sci., 47, 2135, 10.1167/iovs.05-1135

Cideciyan, 2008, Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics, Proc. Natl. Acad. Sci. U.S.A., 10.1073/pnas.0807027105

Corsi, 2002, Human mitochondrial ferritin expressed in HeLa cells incorporatese iron and affects cellular iron metabolism, J. Biol. Chem., 277, 22430, 10.1074/jbc.M105372200

Cozzi, 2000, Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity, J. Biol. Chem., 275, 25122, 10.1074/jbc.M003797200

Cozzi, 2003, Role of iron and ferritin in TNFalpha-induced apoptosis in HeLa cells, FEBS Lett., 537, 187, 10.1016/S0014-5793(03)00114-5

Dawczynski, 2002, Increased content of zinc and iron in human cataractous lenses, Biol. Trace Elem. Res., 90, 15, 10.1385/BTER:90:1-3:15

De Domenico, 2006, Ferroportin-medicated mobilization of ferritin iron precedes ferritin degradation by the proteasome, EMBO J., 25, 5396, 10.1038/sj.emboj.7601409

De Domenico, 2007, Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin, EMBO J., 26, 2823, 10.1038/sj.emboj.7601735

De Domenico, 2005, The molecular basis of ferroportin-linked hemochromatosis, Proc. Natl. Acad. Sci. U.S.A., 102, 8955, 10.1073/pnas.0503804102

Dentchev, 2005, Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration, Arch. Ophthalmol., 123, 1745, 10.1001/archopht.123.12.1745

Dernouchamps, 1975, La transferrine des liquides endoculaires chez le lapin, Ophthalmologica (Basel), 170, 72, 10.1159/000307163

Dunaief, 2006, Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture, Investig. Ophthalmol. Vis. Sci., 47, 4660, 10.1167/iovs.06-0568

Dunaief, 2005, Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload, Ophthalmology, 112, 1062, 10.1016/j.ophtha.2004.12.029

Eisenstein, 1991, Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron, Proc. Natl. Acad. Sci. U.S.A., 88, 688, 10.1073/pnas.88.3.688

Elkins, 2003, Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α, J. Biol. Chem., 278, 1802, 10.1074/jbc.C200644200

Farkas, 2004, Increased expression of iron regulating genes in monkey and human glaucoma, Investig. Ophthalmol. Vis. Sci., 45, 1410, 10.1167/iovs.03-0872

Feng, 2007, Incipient diabetic retinopathy – insights from an experimental model, Ophthalmologica, 221, 269, 10.1159/000101930

Forooghian, 2007, Hypoxia-inducible factor expression in human RPE cells, Br. J. Ophthalmol., 91, 1406, 10.1136/bjo.2007.123125

Garland, 1990, Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis, Exp. Eye Res., 50, 677, 10.1016/0014-4835(90)90113-9

Garner, 2000, Formation of hydroxyl radicals in the human lens is related to the severity of nuclear cataract, Exp. Eye Res., 70, 81, 10.1006/exer.1999.0754

Garner, 1999, Redox availability of lens iron and copper: implications for HO generation in cataract, Redox Rep., 4, 313, 10.1179/135100099101535007

Garner, 2000, Distribution of ferritin and redox-active transition metals in normal and cataractous human lenses, Exp. Eye Res., 71, 599, 10.1006/exer.2000.0912

Ghosh, 2008, Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IFP2 knockout mice, Proc. Natl. Acad. Sci. U.S.A., 105, 12028, 10.1073/pnas.0805361105

Giblin, 2000, Glutathione: a vital lens antioxidant, J. Ocul. Pharmacol. Ther., 16, 121, 10.1089/jop.2000.16.121

Gnana-Prakasam, 2008, Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe, Biochem. J., 411, 79, 10.1042/BJ20071377

Goldenberg-Cohen, 2008, Molecular and histological changes following central retinal artery occlusion in a mouse model, Exp. Eye Res., 10.1016/j.exer.2008.06.014

Goralska, 2003, Alpha lipoic acid changes Fe uptake and storage in lens epithelial cells, Exp. Eye Res., 76, 241, 10.1016/S0014-4835(02)00307-X

Goralska, M., Fleisher, L.N., McGahan, M.C. Ferritin H- and L-chains in fiber cells from canine and human lenses of different ages. Investig. Ophthalmol. Vis. Sci., in press, doi:10.1167/iovs.08.2230

Goralska, 2000, The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells, Biochim. Biophys. Acta, 1497, 51, 10.1016/S0167-4889(00)00038-0

Goralska, 2001, Overexpression of H and L ferritin subunits in lens epithelial cells alters Fe metabolism and cellular response to UVB irradiation, Investig. Ophthalmol. Vis. Sci., 42, 1721

Goralska, 2003, Identification of a mechanism by which lens epithelial cells limit accumulation of overexpressed H-chain ferritin, J. Biol. Chem., 278, 42920, 10.1074/jbc.M305827200

Goralska, M., Nagar, S., Colitz, C., Fleisher, L.N., McGahan, M.C. Changes in ferritin H- and L-chains in canine lenses with age-related nuclear cataract. Investig. Ophthalmol. Vis. Sci., in press.

Goralska, 2005, Differential degradation of ferritin H- and L-chains: accumulation of L-chain-rich ferritin in lens epithelial cells, Investig. Ophthalmol. Vis. Sci., 46, 3521, 10.1167/iovs.05-0358

Gruenheid, 1999, The iron transport protein NRAMP2 is an integrin membrane glycoprotein that colocalizes with transferrin in the recycling endosomes, J. Exp. Med., 189, 831, 10.1084/jem.189.5.831

Gunshin, 1997, Cloning and characterization of a proton-coupled mammalian metal-ion transporter, Nature, 388, 482, 10.1038/41343

Guo, 1998, Suppression of cell growth by heavy chain ferritin, Biochem. Biophys. Res. Commun., 242, 39, 10.1006/bbrc.1997.7910

Gutteridge, 1981, Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts, Biochem. J., 199, 263, 10.1042/bj1990263

Hadziahmetovic, 2008, Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD, Investig. Ophthalmol. Vis. Sci., 10.1167/iovs.07-1472

Hahn, 2004, Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina, Mol. Vis., 10, 598

Hahn, 2004, Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration, Proc. Natl. Acad. Sci. U.S.A., 101, 13850, 10.1073/pnas.0405146101

Hahn, 2006, Iron levels in human retina: sex difference and increase with age, Neuroreport, 17, 1803, 10.1097/WNR.0b013e3280107776

Hamel, 1993, Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro, J. Biol. Chem., 268, 15751, 10.1016/S0021-9258(18)82319-5

Harned, 2006, Lens epithelial cells synthesize and secrete ceruloplasmin: effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics, Exp. Eye Res., 83, 721, 10.1016/j.exer.2006.01.018

Harned, 2003, The effect of UVB irradiation on ferritin subunit synthesis, ferritin assembly and Fe metabolism in cultured canine lens epithelial cells, Photochem. Photobiol., 77, 440

Harris, 2003, Aceruloplasminemia, J. Neurol. Sci., 207, 108, 10.1016/S0022-510X(02)00434-3

Harris, 1998, Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis, Am. J. Clin. Nutr., 67, 972S, 10.1093/ajcn/67.5.972S

He, 2007, Iron homeostasis and toxicity in retinal degeneration, Prog. Retin. Eye Res., 26, 649, 10.1016/j.preteyeres.2007.07.004

Hewitson, 2003, The role of iron and 2-oxoglutarate oxygenases in signalling, Biochem. Soc. Trans., 31, 510, 10.1042/bst0310510

Hunt, 1992, Release of iron by human retinal pigment epithelial cells, J. Cell Physiol., 152, 102, 10.1002/jcp.1041520114

Hyndman, 1991, Transferrin can alter physiological properties of retinal neurons, Brain Res., 561, 318, 10.1016/0006-8993(91)91610-D

Iancu, 1985, Iron overload in the liver in the baboon. An ultrastructural study, J. Hepatol., 1, 261, 10.1016/S0168-8278(85)80054-4

Jaakkola, 2001, Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation, Science, 292, 468, 10.1126/science.1059796

Johnson, 2004, Diferric transferrin regulates transferrin receptor 2 protein stability, Blood, 104, 4287, 10.1182/blood-2004-06-2477

Kappas, 2004, A method for interdicting the development of severe jaundice in newborns by inhibiting the production of bilirubin, Pediatrics, 113, 119, 10.1542/peds.113.1.119

Kim, 2007, Regulation of immune cells by eicosanoid receptors, Scientific World J., 1307, 10.1100/tsw.2007.181

Kleiman, 1990, Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells, Mutat. Res., 240, 35, 10.1016/0165-1218(90)90006-N

Kohgo, 1980, Differential turnover of rat liver isoferritins, J. Biol. Chem., 255, 5195, 10.1016/S0021-9258(19)70770-4

Krishna, 1996, Do nitroxide antioxidants act as scavengers of superoxide or as SOD mimics, J. Biol. Chem., 271, 26026, 10.1074/jbc.271.42.26026

Krishna, 1994, Nitroxides as antioxidants, Methods Enzymol., 234, 580, 10.1016/0076-6879(94)34130-3

Kuesap, 2008, Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells, Biochem. Biophys. Res. Commun., 367, 413, 10.1016/j.bbrc.2007.12.148

Lakomaa, 1978, Trace element analysis of human cataractous lenses by neutron activation analysis and atomic absorption spectrometry with special reference to pseudo-exfoliation of the lens capsule, Ophthamol. Res., 10, 302, 10.1159/000264972

Lall, 2008, Iron regulates l-glutamate secretion, Xc− activity and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase, Investig. Ophthalmol. Vis. Sci., 49, 310, 10.1167/iovs.07-1041

Lee, 1997, Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia, J. Biol. Chem., 272, 5375, 10.1074/jbc.272.9.5375

Levi, 2001, A human mitochondrial ferritin encoded by an intronless gene, J. Biol. Chem., 276, 24437, 10.1074/jbc.C100141200

Levi, 1998, Analysis of ferritins in lymphoblastoid cell lines and in the lens of subjects with hereditary hyperferritinemia-cataract syndrome, Blood, 91, 4180, 10.1182/blood.V91.11.4180

Linsenmayer, 2005, Nuclear ferritin in corneal epithelial cells: tissue-specific nuclear transport and protection from UV-damage, Prog. Retin. Eye Res., 2005, 139, 10.1016/j.preteyeres.2004.08.004

Lok, 1999, Identification of a hypoxia response element in the transferrin receptor gene, J. Biol. Chem., 274, 24147, 10.1074/jbc.274.34.24147

Lou, 2003, Redox regulation in the lens, Prog. Retin. Eye Res., 22, 657, 10.1016/S1350-9462(03)00050-8

Ma, 2004, Cellular and subcellular localization of heme oxygenase-2 in monkey retina, J. Neurocytol., 33, 407, 10.1023/B:NEUR.0000046571.90786.6e

Mackenzie, 2004, SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1, Pflugers Arch. Eur. J. Physiol., 447, 571, 10.1007/s00424-003-1141-9

MacKenzie, 2008, Intracellular iron transport and storage: from molecular mechanisms to health implications, Antioxid. Redox Signalling, 10, 997, 10.1089/ars.2007.1893

Maguire, 2008, Safety and efficacy of gene transfer for Leber's congenital amaurosis, N. Engl. J. Med., 358, 2240, 10.1056/NEJMoa0802315

Marlhens, 1997, Mutations in RPE65 cause Leber's congenital amaurosis, Nat. Genet., 17, 139, 10.1038/ng1097-139

Martin, 2006, Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium, Investig. Ophthalmol. Vis. Sci., 47, 4238, 10.1167/iovs.06-0026

McDermott, 1988, Fe2+ oxidation of a-crystallin produces a 43,000Da aggregate composed of A and B chains cross-linked by non-reducible covalent bonds, Biochem. Biophys. Res. Commun., 157, 626, 10.1016/S0006-291X(88)80296-1

McGahan, 1992, Does the lens serve as a ‘sink’ for iron during ocular inflammation?, Exp. Eye Res., 54, 525, 10.1016/0014-4835(92)90131-B

McGahan, 2008, Proteins integral to iron metabolism are regulated by hypoxia-inducible factor-1 in retinal pigmented epithelial cells, Investig. Ophthalmol. Vis. Sci.

McGahan, 1986, Antioxidant activity of aqueous and vitreous humor from the inflamed rabbit eye, Curr. Eye Res., 5, 641, 10.3109/02713688609015131

McGahan, 1986, A micromethod for the determination of iron and total iron-binding capacity in intraocular fluids and plasma using electrothermal atomic absorption spectroscopy, Anal. Biochem., 156, 397, 10.1016/0003-2697(86)90271-X

McGahan, 1988, Inflammation-induced changes in the iron concentration and total iron-binding capacity of the intraocular fluids of rabbits, Graefe's Arch. Clin. Exp. Ophthalmol., 226, 27, 10.1007/BF02172712

McGahan, 1992, Cellular response to intravitreal injection of endotoxin and xanthine oxidase in rabbits, Graefe's Arch. Clin. Exp. Ophthalmol., 230, 463, 10.1007/BF00175935

McGahan, 1994, Transferrin inhibits the ocular inflammatory response, Exp. Eye Res., 58, 509, 10.1006/exer.1994.1044

McGahan, 1995, Transferrin secretion by lens epithelial cells in culture, Exp. Eye Res., 60, 667, 10.1016/S0014-4835(05)80008-9

McGahan, 1994, Regulation of ferritin levels in cultured lens epithelial cells, Exp. Eye Res., 59, 551, 10.1006/exer.1994.1140

McGahan, 2005, Iron alters glutamate secretion by regulating cytosolic aconitase activity, Am. J. Physiol. Cell Physiol., 288, C1117, 10.1152/ajpcell.00444.2004

Merle, 2007, Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes, Histochem. Cell Biol., 127, 221, 10.1007/s00418-006-0229-7

Millholland, 2003, Ferritoid, a tissue-specific nuclear transport protein for ferritin in corneal epithelial cells, J. Biol. Chem., 278, 23963, 10.1074/jbc.M210050200

Mitchell, 1990, Biologically active metal-independent superoxide dismutase mimics, Biochemistry, 29, 2802, 10.1021/bi00463a024

Mittag, 1985, Ocular responses to superoxide generated by intraocular injection of xanthine oxidase, Exp. Eye Res., 40, 411, 10.1016/0014-4835(85)90153-8

Moiseyev, 2006, RPE65 is an iron (II) dependent isomerohydrolase in the retinoid visual cycle, J. Biol. Chem., 281, 2835, 10.1074/jbc.M508903200

Morimura, 1998, Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or Leber congenital amaurosis, Proc. Natl. Acad. Sci. U.S.A., 95, 3088, 10.1073/pnas.95.6.3088

Muckenthaler, 2003, Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis, Nat. Genet., 34, 102, 10.1038/ng1152

Muckenthaler, 2008, Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network, Annu. Rev. Nutr., 28, 197, 10.1146/annurev.nutr.28.061807.155521

Mukhopadhyay, 2000, Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency, J. Biol. Chem., 275, 21048, 10.1074/jbc.M000636200

Nakano, 2000, Ischemic preconditioning: from basic mechanisms to clinical applications, Pharmacol. Ther., 86, 263, 10.1016/S0163-7258(00)00058-9

Narahari, 2000, The aconitase function of iron regulatory protein 1: genetic studies in yeast implicate its role in iron-mediated redox regulation, J. Biol. Chem., 275, 16227, 10.1074/jbc.M910450199

Nemeth, 2006, Regulation of iron metabolism by hepcidin, Annu. Rev. Nutr., 26, 323, 10.1146/annurev.nutr.26.061505.111303

Nemeth, 2004, Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization, Science, 306, 2090, 10.1126/science.1104742

Nicolas, 2003, Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis, Nat. Genet., 34, 97, 10.1038/ng1150

Novotny, 2008, Alpha-lipoic acid: the potential for use in cancer therapy, Neoplasma, 55, 81

Obolensky, 2008, Ischemic preconditioning of the rat retina: protective role of ferritin, Free Radic. Biol. Med., 44, 1286, 10.1016/j.freeradbiomed.2007.10.060

Ohta, 2003, Protective role of heme oxygenase-1 against endotoxin-induced uveitis in rats, Exp. Eye Res., 77, 665, 10.1016/j.exer.2003.08.014

Oksala, 1954, On the occurrence of some trace metals in the eye, Acta Ophthalmol., 32, 235, 10.1111/j.1755-3768.1954.tb05046.x

Osaki, 1971, Mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase I, J. Biol. Chem., 246, 3018, 10.1016/S0021-9258(18)62284-7

Packer, 1995, Alpha-lipoic acid as a biological antioxidant, Free Radic. Biol. Med., 19, 227, 10.1016/0891-5849(95)00017-R

Pannen, 1998, Differential regulation of hepatic arterial and portal venous vascular resistance by nitric oxide and carbon monoxide in rats, Life Sci., 62, 2025, 10.1016/S0024-3205(98)00174-X

Patel, 1997, A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes, J. Biol. Chem., 272, 20185, 10.1074/jbc.272.32.20185

Patel, 2000, Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain, J. Biol. Chem., 275, 4305, 10.1074/jbc.275.6.4305

Patil, 2008, Heme oxygenase-1 induction attenuates corneal inflammation and accelerates wound healing after epithelial injury, Investig. Ophthalmol. Vis. Sci., 49, 3379, 10.1167/iovs.07-1515

Petersen Shay, 2008, Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity, IUBMB Life, 60, 362, 10.1002/iub.40

Picard, 1996, Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution, Blood, 87, 2057, 10.1182/blood.V87.5.2057.2057

Privitera, 2007, Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits, J. Ocul. Pharmacol. Ther., 23, 232, 10.1089/jop.2006.101

Rachmilewitz, 1994, A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats, Gut, 35, 1181, 10.1136/gut.35.9.1181

Redmond, 1998, Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle, Nat. Genet., 20, 344, 10.1038/3813

Robb, 2004, Regulation of transferrin receptor 2 protein levels by transferrin, Blood, 104, 4294, 10.1182/blood-2004-06-2481

Rolfs, 1997, Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1, J. Biol. Chem., 272, 20055, 10.1074/jbc.272.32.20055

Rouault, 2006, The role of iron regulatory proteins in mammalian iron homeostasis and disease, Nat. Chem. Biol., 2, 406, 10.1038/nchembio807

Rzymkiewicz, 2000, Induction of heme oxygenase-1 modulates cis-aconitase activity in lens epithelial cells, Biochem. Biophys. Res. Commun., 270, 324, 10.1006/bbrc.2000.2408

Salceda, 1997, Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquiting-proteasome system under normoxic conditions: its stabilization by hypoxia depends upon redox-induced changes, J. Biol. Chem., 272, 22642, 10.1074/jbc.272.36.22642

Salinthone, 2008, Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS, Endocr. Metab. Immune Disord. Drug Targets, 8, 132, 10.2174/187153008784534303

Saraswathy, 2008, Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis, Ophthamol. Res., 40, 160, 10.1159/000119869

Schaller, 2002, Cerebral ischemic preconditioning: an experimental phenomenon or a clinical important entity of stroke prevention?, J. Neurol., 249, 1503, 10.1007/s00415-002-0933-8

Schmidt, 2008, The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression, Cell Metab., 7, 205, 10.1016/j.cmet.2007.11.016

Scott, 1994, Lipoic acid and dihydrolipoic acid as antioxidants. A critical evaluation, Free Radic. Res., 20, 119, 10.3109/10715769409147509

Sedlak, 2004, Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle, Pediatrics, 113, 1776, 10.1542/peds.113.6.1776

Semenza, 2003, Targeting HIF-1 for cancer therapy, Nature Rev. Cancer, 3, 721, 10.1038/nrc1187

Sery, 1984, Superoxide anion radical as an indirect mediator in ocular inflammatory disease, Curr. Eye Res., 3, 243, 10.3109/02713688408997206

Shi, 2008, A cytosolic iron chaperone that delivers iron to ferritin, Science, 320, 1207, 10.1126/science.1157643

Shoham, 2008, Oxidative stress in diseases of the human cornea, Free Radic. Biol. Med., 45, 1047, 10.1016/j.freeradbiomed.2008.07.021

Shui, 2008, HIF-1: an age-dependent regulator of lens cell proliferation, Investig. Ophthalmol. Vis. Sci., 49, 4961, 10.1167/iovs.08-2118

Siu, 2008, Toxicology of the retina: advances in understanding the defence mechanisms and pathogenesis of drug- and light-induced retinopathy, Clin. Exp. Ophthalmol., 36, 176, 10.1111/j.1442-9071.2008.01699.x

Smith, 1990, Characterization and accumulation of ferritin in hepatocyte nuclei of mice with iron overload, Hepatology, 12, 1399, 10.1002/hep.1840120622

Sommerschild, 2002, Preconditioning-endogenous defence mechanisms of the heart, Acta Anaesthesiol. Scand., 46, 123, 10.1034/j.1399-6576.2002.460202.x

Spector, 1995, Oxidative stress-induced cataract: mechanism of action, FASEB J., 9, 1173, 10.1096/fasebj.9.12.7672510

Spector, 2000, Review: oxidative stress and disease, J. Ocul. Pharmacol. Ther., 16, 193, 10.1089/jop.2000.16.193

Stocker, 1987, Bilirubin is an antioxidant of possible physiological importance, Science, 235, 1043, 10.1126/science.3029864

Sun, 2007, Photoreceptor protection against light damage by AAV-mediated overexpression of heme oxygenase-1, Investig. Ophthalmol. Vis. Sci., 49, 5699, 10.1167/iovs.07-0340

Tacchini, 1999, Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation, J. Biol. Chem., 274, 24142, 10.1074/jbc.274.34.24142

Tauber, 1943, The role of iron, copper, zinc and manganese in the metabolism of the ocular tissues, with special reference to the lens, Am. J. Ophthalmol., 26, 260, 10.1016/S0002-9394(43)92830-2

Taylor, 1989, The biological effects of UV-B on the eye, Photochem. Photobiol., 50, 489, 10.1111/j.1751-1097.1989.tb05553.x

Thompson, 2000, Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration, Investig. Ophthalmol. Vis. Sci., 41, 4293

Truscott, 2005, Age-related nuclear cataract-oxidation is the key, Exp. Eye Res., 80, 709, 10.1016/j.exer.2004.12.007

Wang, 2006, Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump, Hypertension, 48, 685, 10.1161/01.HYP.0000239673.80332.2f

West, 1998, Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project, JAMA, 280, 714, 10.1001/jama.280.8.714

Whitnall, 2008, The MCK mouse heart model of Friedreich's ataxia: alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation, Proc. Natl. Acad. Sci. U.S.A., 105, 9757, 10.1073/pnas.0804261105

Wu, 2005, Carbon monoxide: endogenous production, physiological functions and pharmacological applications, Pharmacol. Rev., 57, 585, 10.1124/pr.57.4.3

Yamaguchi, 1980, An application of neutron activation analysis to biological materials. IV. Approach to simultaneous determination of trace elements in human eye tissues with non-destructive neutron activation analysis, J. Radioanal. Chem., 57, 169, 10.1007/BF02519876

Yanjun, 2007, Study of hypoxia-induced expression of IF-1alpha in retinal pigment epithelium, Bull. Exp. Biol. Med., 143, 323, 10.1007/s10517-007-0101-3

Yefimova, 2000, Iron, ferritin, transferrin and transferrin receptor in the adult rat retina, Investig. Ophthalmol. Vis. Sci., 41

Yefimova, 2002, Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats, Investig. Ophthalmol. Vis. Sci., 43, 537

Zhu, 2007, Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1 alpha and heme oxygenase-1, Investig. Ophthalmol. Vis. Sci., 48, 1735, 10.1167/iovs.06-1037