Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress

Ganz T (2009) Iron in innate immunity: starve the invaders. Curr Opin Immunol 21(1):63–67. doi: 10.1016/j.coi.2009.01.011

MacKenzie EL, Iwasaki K, Tsuji Y (2008) Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal 10(6):997–1030. doi: 10.1089/ars.2007.1893

Li GF, Pan YZ, Sirois P, Li K, Xu YJ (2012) Iron homeostasis in osteoporosis and its clinical implications. Osteoporos Int J Established Result Coop Eur Found Osteoporos Natl Osteoporos Found USA. doi: 10.1007/s00198-012-1982-1

Weinberg ED (2006) Iron loading: a risk factor for osteoporosis. Biometals Int J Role Met Ions Biol Biochem Med 19(6):633–635. doi: 10.1007/s10534-006-9000-8

Guggenbuhl P, Fergelot P, Doyard M, Libouban H, Roth MP, Gallois Y, Chales G, Loreal O, Chappard D (2011) Bone status in a mouse model of genetic hemochromatosis. Osteoporos Int J Established Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 22(8):2313–2319. doi: 10.1007/s00198-010-1456-2

Guggenbuhl P, Brissot P, Loreal O (2011) Haemochromatosis: the bone and the joint. Best Pract Res Clin Rheumatol 25(5):649–664. doi: 10.1016/j.berh.2011.10.014

Sarrai M, Duroseau H, D'Augustine J, Moktan S, Bellevue R (2007) Bone mass density in adults with sickle cell disease. Br J Haematol 136(4):666–672. doi: 10.1111/j.1365-2141.2006.06487.x

Sadat-Ali M, Sultan O, Al-Turki H, AlElq A (2011) Does high serum iron level induce low bone mass in sickle cell anemia ? Biometals Int J Role Met Ions Biol Biochem Med 24(1):19–22. doi: 10.1007/s10534-010-9391-4

Wibaux C, Legroux-Gerot I, Dharancy S, Boleslawski E, Declerck N, Canva V, Mathurin P, Pruvot FR, Cortet B (2011) Assessing bone status in patients awaiting liver transplantation. Joint Bone Spine 78(4):387–391. doi: 10.1016/j.jbspin.2011.03.001

Loria I, Albanese C, Giusto M, Galtieri PA, Giannelli V, Lucidi C, Di Menna S, Pirazzi C, Corradini SG, Mennini G, Rossi M, Berloco P, Merli M (2010) Bone disorders in patients with chronic liver disease awaiting liver transplantation. Transplant Proc 42(4):1191–1193. doi: 10.1016/j.transproceed.2010.03.096

Matsushima S, Hoshimoto M, Torii M, Ozaki K, Narama I (2001) Iron lactate-induced osteopenia in male Sprague–Dawley rats. Toxicol Pathol 29(6):623–629

Guggenbuhl P, Deugnier Y, Boisdet JF, Rolland Y, Perdriger A, Pawlotsky Y, Chales G (2005) Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. Osteoporos Int J Established Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 16(12):1809–1814. doi: 10.1007/s00198-005-1934-0

Mahachoklertwattana P, Sirikulchayanonta V, Chuansumrit A, Karnsombat P, Choubtum L, Sriphrapradang A, Domrongkitchaiporn S, Sirisriro R, Rajatanavin R (2003) Bone histomorphometry in children and adolescents with beta-thalassemia disease: iron-associated focal osteomalacia. J Clin Endocrinol Metab 88(8):3966–3972

Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, Takebe G, Takahashi K, Nishihira J, Izumi H, Sakamoto W (2004) Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 197(2):93–100. doi: 10.1016/j.tox.2003.12.006

Jian J, Pelle E, Huang X (2009) Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid Redox Signal 11(12):2939–2943. doi: 10.1089/ARS.2009.2576

Jia P, Xu YJ, Zhang ZL, Li K, Li B, Zhang W, Yang H (2012) Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species. J Orthop Res 30(11):1843–1852. doi: 10.1002/jor.22133

Christenson RH (1997) Biochemical markers of bone metabolism: an overview. Clin Biochem 30(8):573–593

Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408(6809):239–247. doi: 10.1038/35041687

Zarjou A, Jeney V, Arosio P, Poli M, Zavaczki E, Balla G, Balla J (2010) Ferritin ferroxidase activity: a potent inhibitor of osteogenesis. J Bone Miner Res Off J Am Soc Bone Miner Res 25(1):164–172. doi: 10.1359/jbmr.091002

Halliwell B, Gutteridge JM (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1–85

Fridovich I (1978) The biology of oxygen radicals. Science 201(4359):875–880

Hinoi E, Fujimori S, Wang L, Hojo H, Uno K, Yoneda Y (2006) Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation. J Biol Chem 281(26):18015–18024. doi: 10.1074/jbc.M600603200

Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ (2004) Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 314(1):197–207

Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC (2007) Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem 282(37):27298–27305. doi: 10.1074/jbc.M702811200

Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG (2010) Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 116(14):2582–2589. doi: 10.1182/blood-2009-12-260083

Guggenbuhl P, Filmon R, Mabilleau G, Basle MF, Chappard D (2008) Iron inhibits hydroxyapatite crystal growth in vitro. Metab Clin Exp 57(7):903–910. doi: 10.1016/j.metabol.2008.02.004

Yamasaki K, Hagiwara H (2009) Excess iron inhibits osteoblast metabolism. Toxicol Lett 191(2–3):211–215. doi: 10.1016/j.toxlet.2009.08.023

Qu Z-H, Zhang X-L, Tang T-T, Dai K-R (2008) Promotion of osteogenesis through beta-catenin signaling by desferrioxamine. Biochem Bioph Res Co 370(2):332–337. doi: 10.1016/j.bbrc.2008.03.092

Messer JG, Kilbarger AK, Erikson KM, Kipp DE (2009) Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone 45(5):972–979. doi: 10.1016/j.bone.2009.07.073