Iron‐Catalyzed C(sp2)H and C(sp3)H Arylation by Triazole Assistance
Tóm tắt
Modular 1,2,3‐triazoles enabled iron‐catalyzed CH arylations with broad scope. The novel triazole‐based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user‐friendly iron‐catalyzed C(sp2)H functionalizations of arenes and alkenes with excellent chemo‐ and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)H functionalizations, and proceeds by an organometallic mode of action. The triazole‐assisted CH activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries.
Từ khóa
Tài liệu tham khảo
Selected recent reviews on CH activation:
Recent reviews on the use of inexpensive first‐row transition‐metal catalysts for CH functionalization:
Kulkarni A. A., 2009, Synthesis, 4087
Representative examples of iron‐catalyzed CH activation:
Selected reviews:
Recent reviews on CH activation with bidentate directing groups:
The power of bidentate directing groups is illustrated by the following recent examples:
Illustrative reviews:
Ruthenium(II)‐catalyzed direct arylations of monodentateN‐aryl‐1 2 3‐triazoles:
The di‐ortho‐arylated products2′ could also be isolated as follows:2 n′: 10 % 2 q′: 16 %;2 r′: 5 %;2 s′: 5 %.
Reviews on C(sp3)H bond transformations: