Iron‐Catalyzed C(sp2)H and C(sp3)H Arylation by Triazole Assistance

Angewandte Chemie - International Edition - Tập 53 Số 15 - Trang 3868-3871 - 2014
Qing Gu1, Hamad H. Al Mamari1, Karolina Graczyk1, Emelyne Diers1, Lutz Ackermann1
1Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni‐goettingen.de/ackermann

Tóm tắt

AbstractModular 1,2,3‐triazoles enabled iron‐catalyzed CH arylations with broad scope. The novel triazole‐based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user‐friendly iron‐catalyzed C(sp2)H functionalizations of arenes and alkenes with excellent chemo‐ and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)H functionalizations, and proceeds by an organometallic mode of action. The triazole‐assisted CH activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries.

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Tài liệu tham khảo

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Angewandte Chemie - International Edition

Tập 53 Số 15

3868-3871

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