Iron Biology in Immune Function, Muscle Metabolism and Neuronal Functioning

The Journal of Nutrition - Tập 131 Số 2 - Trang 568S-580S - 2001
John L. Beard1
1Nutrition Department, College of Human Development, The Pennsylvania State State University, University Park, PA 16802

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Aoki, 1989, Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T, Radiology, 172, 381, 10.1148/radiology.172.2.2748819

Ashkenazi, 1982, Nutritional iron deficiency and dopamine binding sites in the rat brain, Pharmacol. Biochem. Behav, 17, 43, 10.1016/0091-3057(82)90509-3

Baynes, 1990, Iron deficiency, Annu. Rev. Nutr, 10, 133, 10.1146/annurev.nu.10.070190.001025

Beard, 1993, Iron on the brain, Nutr. Rev, 51, 157, 10.1111/j.1753-4887.1993.tb03096.x

Beard, J. & Dawson, H. (1996) Iron. In: Handbook on Nutritionally Essential Elements (Sunde, R. & O’Dell, B., eds.), pp. 275–334. Marcel Dekker, New York, NY.

Beard, 1988, Iron deficiency anemia and steady-state work performance at high altitude, J. Appl. Physiol, 64, 1878, 10.1152/jappl.1988.64.5.1878

Beard, 1988, Norepinephrine turnover in iron deficiency at three environmental temperatures, Am. J. Physiol, 255, R90

Beaton, 1989, Conceptual and methodological issues regarding the epidemiology of iron deficiency and the implications for studies of the functional consequences of iron deficiency, Am. J. Clin. Nutr, 50, 575, 10.1093/ajcn/50.3.575

Benkovic, 1993, Ferritin, transferrin and iron in normal and aged rat brains, J. Comp. Neurol, 337, 97, 10.1002/cne.903380108

Borel, 1993, Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats, Am. J. Physiol, 264, E662

Bothwell, T. H., Charlton, R. W., Cook, J. D. & Finch, C. A. (1979) Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats. Iron Metabolism in ManBlackwell Scientific PublicationsOxford, UK.

Bradbury, 1997, Transport of iron in the blood-brain-cerebrospinal fluid system, J. Neurochem, 69, 443, 10.1046/j.1471-4159.1997.69020443.x

Byrd, 1989, Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron, J. Clin. Investig, 83, 1457, 10.1172/JCI114038

Canonne-Hergaux, 1999, The NRAMP 1 protein and its role in resistance to infection and macrophage function, Proc. Assoc. Am. Physicians, 111, 283, 10.1046/j.1525-1381.1999.99236.x

Casey, 1998, Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation, Science (Washington, DC), 240, 924, 10.1126/science.2452485

Celsing, 1986, Effects of iron deficiency on endurance and muscle activity in man, Med. Sci. Sports Exerc, 18, 156, 10.1249/00005768-198604000-00002

Chen, 1995, Abnormal rat brain metabolism in iron deficiency anemia, J. Nutr. Biochem, 6, 486, 10.1016/0955-2863(95)00074-A

Chen, 1995, Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats, J. Nutr, 125, 1529

Cole, 1971, Sources of variation in menstrual blood loss, J. Obstet. Gynaecol. Br. Commun, 78, 933, 10.1111/j.1471-0528.1971.tb00208.x

Connor, 1992, Iron regulation in the brain: histochemical, biochemical, and molecular considerations, Ann. Neurol, 32, S51, 10.1002/ana.410320710

Connor, 1990, Altered cellular distribution of iron in the CNS of myelin deficient rats, Neuroscience, 34, 265, 10.1016/0306-4522(90)90320-4

Crichton, 1992, Iron metabolism—new perspectives in view, Biochemistry, 31, 11255, 10.1021/bi00161a001

Crowe, 1992, Iron and transferrin uptake by brain and cerebrospinal fluid in the rat, Brain Res, 592, 8, 10.1016/0006-8993(92)91652-U

Dallman, 1982, Manifestations of iron deficiency, Semin. Hematol, 19, 19

Dallman, 1986, Biochemical basis for the manifestations of iron deficiency, Anun. Rev. Nutr, 6, 13, 10.1146/annurev.nu.06.070186.000305

Dallman, 1975, Brain iron, persistent deficiency following short term iron deprivation in the young rat, Br. J. Haematol, 31, 209, 10.1111/j.1365-2141.1975.tb00851.x

Dallman, 1977, Brain iron in the rat: extremely slow turnover in normal rat may explain the long-lasting effects of early iron-deficiency, J. Nutr, 107, 1075, 10.1093/jn/107.6.1075

Damsdaran, 1979, Anemia and morbidity in rural preschool children, Indian J. Med. Res, 69, 448

Davies, 1984, Distinguishing effects of anemia and muscle iron deficiency on exercise bioenergetics in the rats, Am. J. Physiol, 246, E535

Davies, 1982, Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion, Am. J. Physiol, 242, E418

Dillman, 1980, Hypothermia in iron deficiency due to altered triiodothyronine metabolism, Am. J. Physiol, 239, R377

Dwork, A. J. (1995) Effects of diet and development upon the uptake and distribution of cerebral iron. J. Neurol. Sci. 134(suppl.):45–51.

Dwork, 1988, Non-identical distribution of transferrin and ferric iron in human brain, Neuroscience, 27, 333, 10.1016/0306-4522(88)90242-4

Earley, C. J., Allen, R. P, Beard, J. L. & Connor, J. R (2000a) Insight into the pathophysiology of restless legs syndrome. J. Neurosci. Res. (in press).

Earley, 2000, Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome, Neurology, 54, 1698, 10.1212/WNL.54.8.1698

Edgerton, 1979, Iron-deficiency anemia and its effect on worker productivity and activity patterns, Br. Med. J, 2, 1546, 10.1136/bmj.2.6204.1546

Edgerton, 1981, Elevation of hemoglobin and work tolerance in iron-deficient subjects, J. Nutr. Sci. Vitaminol. (Tokyo), 27, 77, 10.3177/jnsv.27.77

Ekblom, 1997, Micronutrients: effects of variation in [Hb] and iron deficiency on physical performance, World Rev. Nutr. Diet, 82, 122

Epstein, D. K. & Connor, J. R. (1999) The role of iron in neurodegenerative disease. In: Chemicals & Neurodegenerative Disease (S. C. Bondyed). Frontiers in Bioscience, pp. 28–50, Prominent Press, Scottsdale, AZ.

Erikson, 1998, Distribution of brain iron, ferritin and transferrin in the 28-day old piglet, J. Nutr. Biochem, 9, 276, 10.1016/S0955-2863(98)00021-7

Erikson, 2000, Iron deficiency alters dopamine transporter functioning in rat striatum, J. Nutr, 130, 2831, 10.1093/jn/130.11.2831

Erikson, 1997, Iron status and distribution of iron in the brain of developing rats, J. Nutr, 127, 2030, 10.1093/jn/127.10.2030

Fahmay, 1993, Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: changes in transferrin uptake, iron handling and ferritin mRNA, Biochem. J, 296, 175, 10.1042/bj2960175

Farrell, 1988, Increased insulin sensitivity in iron-deficient rats, J. Nutr, 118, 1104, 10.1093/jn/118.9.1104

Felt, 1996, Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development, J. Nutr, 126, 693, 10.1093/jn/126.3.693

Finch, 1970, Ferrokinetics in man, Medicine, 49, 17, 10.1097/00005792-197001000-00002

Finch, 1979, Lactic acidosis as a result of iron deficiency, J. Clin. Investig, 64, 129, 10.1172/JCI109431

Finch, 1982, Perspectives in iron metabolism, N. Engl. J. Med, 306, 1520, 10.1056/NEJM198206243062504

Fishbach, 1965, An X-ray scattering study of ferritin and apoferritin, J. Mol. Biol, 14, 458, 10.1016/S0022-2836(65)80196-6

Fishbane, 1999, Review of issues relating to iron and infection, Am. J. Kidney Dis, 34, S47, 10.1053/ajkd.1999.v34.aajkd0344b0047

Fishman, 1987, Receptor mediated uptake of transferrin across the blood brain barrier, J. Neurosci. Res, 18, 299, 10.1002/jnr.490180206

Frassinelli-Gunderson, 1985, Iron stores in users of oral contraceptive agents, Am. J. Clin. Nutr, 41, 703, 10.1093/ajcn/41.4.703

Galan, 1992, Interleukin 2 production in iron-deficient children, Biol. Trace Elem. Res, 32, 421, 10.1007/BF02784628

Gardner, 1977, Physical work capacity and metabolic stress in subjects with iron deficiency anemia, Am J. Clin. Nutr, 30, 910, 10.1093/ajcn/30.6.910

Green, 1968, Body iron excretion in man. A collaborative study, Am. J. Med, 45, 336, 10.1016/0002-9343(68)90069-7

Guillebaud, 1979, Plasma ferritin levels as an index of iron deficiency in women using intrauterine devices, Br. J. Obset. Gynaecol, 86, 51, 10.1111/j.1471-0528.1979.tb10684.x

Hallberg, 2000, Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron, Am. J. Clin. Nutr, 71, 1147, 10.1093/ajcn/71.5.1147

Hallquist, 1992, Maternal-iron-deficiency effects on peritoneal macrophage and peritoneal natural-killer-cell cytotoxicity in rat pups, Am. J. Clin. Nutr, 55, 741, 10.1093/ajcn/55.3.741

Han, 2000, Iron deficiency alters H and L ferritin in rat brain, Cell. Mol. Biol, 46, 517

Henderson, 1986, Glucose turnover and oxidation are increased in the iron-deficient anemic rat, Am. J. Physiol, 250, E414

Hershko, 1996, Iron and infection, Iron Nutr. Health Dis, 22, 231

Hill, J. M. (1988) The distribution of iron in the brain. In: Brain Iron: Neurochemistry and Behavioural Aspects (Youdim, M.B.H., ed.), pp. 1–24. Taylor and Francis, London, UK.

Hill, 1985, TfR in rat brain: neuropeptide-like pattern and relationship to iron distribution, Proc. Natl. Acad. Sci. U.S.A, 82, 4553, 10.1073/pnas.82.13.4553

Hulet, 1999, Characterization and distribution of ferritin binding sites in the adult mouse brain, J. Neurochem, 72, 868, 10.1046/j.1471-4159.1999.720868.x

Ike, 1992, Serum resistance and aerobactin iron uptake in avian Escherichia coli mediated by conjugative 100-megadalton plasmid, J. Vet. Med. Sci, 54, 1091, 10.1292/jvms.54.1091

Kivijarvi, 1986, Iron deficiency in women using modern copper intrauterine devices, Obstet. Gynecol, 67, 95

Klempa, 1989, Iron deficiency decreases gluconeogenesis in isolated rat hepatocytes, J. Appl. Physiol, 67, 1868, 10.1152/jappl.1989.67.5.1868

Kochanowski, 1985, Cellular growth in iron-deficient rats: effect of pre- and post-weanling iron repletion, J. Nutr, 115, 279, 10.1093/jn/115.2.279

Konijn, 1977, Ferritin synthesis in inflammation: I. Pathogenesis of impaired iron release, Br. J. Haematol, 37, 7, 10.1111/j.1365-2141.1977.tb08806.x

Kuvibidila, 1999, In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells, J. Cell. Biochem, 74, 468, 10.1002/(SICI)1097-4644(19990901)74:3<468::AID-JCB14>3.0.CO;2-G

Lane, 1991, Iron limitation and the gamma interferon-mediated anthihistoplasma state of murine macrophages, Infect. Immun, 59, 2274, 10.1128/iai.59.7.2274-2278.1991

Larkin, E. C. & Rao, G. A. (1990) Importance of fetal and neonatal iron: adequacy for normal development of central nervous system. In: Brain, Behavior and Iron in the Infant Diet (Dobbing, J., ed.), pp. 43–63. SpringerVerlag, London, UK.

Levi, 1988, Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site, J. Biol. Chem, 263, 18086, 10.1016/S0021-9258(19)81326-1

Levis, 1989, Expression and structure and functional properties of human ferritin L-chain from Escherichia coli, Biochemistry, 28, 5179, 10.1021/bi00438a040

Li, 1998, Effects of iron deficiency on iron distribution and gamma-aminobutyric acid metabolism in young rat brain tissue, Hakkaido Igaku Zasshi, 73, 215

Lozoff, 1988, Behavioral alterations in iron deficiency, Adv. Pediatr, 35, 331, 10.1016/S0065-3101(24)00181-6

Mackler, 1979, Iron deficiency in the rat: effects on phenylalanine metabolism, Pediatr. Res, 13, 1010, 10.1203/00006450-197909000-00012

Maguire, 1982, Effects of dietary deficiency on iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria, Biochim. Biophys. Acta, 679, 210, 10.1016/0005-2728(82)90292-4

Malecki, 1998, Transferrin response and Mn uptake in normal and iron-deficient mice heterozygotic for hypotransferrinemia, Biometals, 11, 265, 10.1023/A:1009280922387

Martinez-Torres, 1984, Effect of exposure to low temperature on normal and iron-deficient subjects, Am. J. Physiol, 246, R380

Mash, 1990, Characterization and distribution of transferrin receptors in the rat brain, J. Neurochem, 55, 1972, 10.1111/j.1471-4159.1990.tb05784.x

McKay, 1983, Tissue effects of iron deficiency in the rat, Biochim. Biophys. Acta, 757, 352, 10.1016/0304-4165(83)90061-2

McLane, 1981, Physiological and biochemical effects of iron deficiency on rat skeletal muscle function, Am. J. Physiol, 241, C47, 10.1152/ajpcell.1981.241.1.C47

Mederios, 1998, Dietary iron-deficiency results in cardiac eccentric hypertrophy in rats, Proc. Soc. Exp. Biol. Med, 218, 370, 10.3181/00379727-218-44306

Miller, 1996, Iron regulation in the developing rat brain: effect of in utero ethanol exposure, J. Neurochem, 65, 371

Morris, 1992, Uptake and distribution of iron and transferrin in the adult rat brain, J. Neurochem, 59, 300, 10.1111/j.1471-4159.1992.tb08904.x

Morse, 1999, Behavioral and neurochemical alterations in iron deficient mice, Proc. Soc. Exp. Biol. Med, 220, 147, 10.3181/00379727-220-44357

Morse, 1999, Sex and genetics are important cofactors in assessing the impact of iron deficiency on the developing mouse brain, Nutr. Neurosci, 2, 323, 10.1080/1028415X.1999.11747287

Murray, 1978, The adverse effect of iron repletion on the course of certain infections, Br. Med. J, 2, 1113, 10.1136/bmj.2.6145.1113

Nelson, 1997, In vivo dopamine metabolism is altered in iron-deficient rats, J. Nutr, 127, 2282, 10.1093/jn/127.12.2282

Ohira, 1986, Adaptations of lactate metabolism in iron-deficient rats, Proc. Soc. Exp. Biol. Med, 173, 213, 10.3181/00379727-173-41633

Perkkio, 1985, Work performance in iron deficiency of increasing severity, J. Appl. Physiol, 58, 1477, 10.1152/jappl.1985.58.5.1477

Pinero, 2000, Alterations in brain iron metabolism in response to dietary iron changes, J. Nutr, 130, 254, 10.1093/jn/130.2.254

Pollitt, 1997, Iron deficiency and educational deficiency, Nutr. Rev, 55, 133, 10.1111/j.1753-4887.1997.tb06464.x

Ponka, 1998, Function and regulation of transferrin and ferritin, Semin. Hematol, 35, 35

Princiotto, 1976, Functional heterogeneity and pH dependent dissociation properties of human transferrin, Biochim. Biophys. Acta, 428, 766, 10.1016/0304-4165(76)90207-5

Rao, 1986, Transcriptional regulation by iron of the gene for transferrin receptor, Mol. Cell. Biol, 6, 236

Rocangliolo, 1996, Delayed maturation of auditory brainstem responses in iron-deficient anemic infants, Pediatr. Res, 39, 20A, 10.1203/00006450-199604001-00123

Sourkes, 1973, Influence of specific nutrients on catecholamine synthesis and metabolism, Pharmacol. Rev, 24, 359

Spear, 1992, Iron deficiency alters DMBA-induced tumor burden and natural killer cell cytotoxicity rats, J. Nutr, 122, 46, 10.1093/jn/122.1.46

Sussman, M. (1974) Iron and infection. In: Iron in Biochemistry and Medicine (Jacobs, A. & Worwood, A. M., eds.), pp. 649–679. Academic Press, New York, NY.

Taneja, 1986, Effect of early iron deficiency in the rat on gamma aminobutyric acid shunt in brain, J. Neurochem, 46, 1670, 10.1111/j.1471-4159.1986.tb08483.x

Taylor, 1991, Transferrin and iron uptake by the brain: effects of altered iron status, J. Neurochem, 57, 1584, 10.1111/j.1471-4159.1991.tb06355.x

Thompson, 1993, The effect of iron deficiency on skeletal muscle metabolism of the rat, Acta Physiol. Scand, 147, 85, 10.1111/j.1748-1716.1993.tb09475.x

Viteri, F. E. & Torun, B. (1974) Anemia and physical work capacity. Garby, L. eds. Clinics in Haematology 3:609–626 W. B. Saunders London, UK.

Webb, E. C. (1992) Anemia and physical work capacity. Enzyme NomenclatureAcademic PressSan Diego, CA.

Wiesinger, 2000, Iron deficiency decreases 2,3-cyclic nucleotide 3′ phosphorylase activity in developing rats, FASEB J, 14, A752

Willis, 1987, Effects of iron deficiency and training on mitochondrial enzymes in skeletal muscle, J. Appl. Physiol, 62, 2442, 10.1152/jappl.1987.62.6.2442

Willis, 1990, Iron deficiency improved exercise performance within 15 hours of iron treatment in rats, J. Nutr, 120, 909, 10.1093/jn/120.8.909

Yehuda, S. (1990) Neurochemical basis of behavioral effects of brain iron deficiency in animals. In: Brain, Behavior and Iron in the Infant Diet (Dobbing, J., ed.), pp. 63–82. Springer-Verlag, London, UK.

Youdim, M.B.H. (1990) Neuropharmacological and neurobiochemical aspects of iron deficiency. In: Brain, Behavior and Iron in the Infant Diet (Dobbing, J., ed.), pp. 83–106. Springer-Verlag, London, UK.

Youdim, 1989, Putative biological mechanisms on the effects of iron deficiency on brain biochemistry, Am. J. Clin. Nutr, 50, 607S, 10.1093/ajcn/50.3.607

Youdim, 1975, Some properties of human platelet monamine oxidase in iron-deficiency anemia, Clin. Sci. Mol. Med, 50, 479

Youdim, M.B.H. & Green A. R. (1977) Biogenic monoamine metabolism and functional activity in iron-deficient rats: behavioral correlates. In: Iron Metabolism (Porter, R. R. & Knight, J., eds.), pp. 201–227. Ciba Foundation Symposium 51 (New Series). Elseveir, Amsterdam, TheNetherlands.

Youdim, 1978, Iron deficiency and neurotransmitter synthesis and function, Proc. Nutr. Soc, 37, 173, 10.1079/PNS19780022

Youdim, 1980, The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats, Neuropharmacology, 19, 259, 10.1016/0028-3908(80)90148-3