Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems
Tóm tắt
There are now well-established examples of carriers and pores which facilitate the transfer of ions across thin lipid membranes. In the absence of such agents, lipid bilayer membranes are extremely impermeable to the common inorganic ions. Thus, the conductance of a pure lecithin + decane or glyceryl mono-oleate + decane membrane in M/10 NaCl is less than10−9Ω−1cm−2. However, on the addition of small lipid-soluble molecules such as valinomycin, or surface-active polypeptides such as gramicidin A, the conductance may become so high (> 10−1ω−lcm−2) that the resistance of the membrane merges into that of the aqueous phase. This review is concerned with the extent to which we now understand how these added substances transfer ions across lipid membranes. Attention has been concentrated on the simpler systems, i.e. the lipid-soluble ions, the 1–1 carriets, a simple pore and, with some loss of simplicity, a substance which prodeces interacting pores. Only molecules of known primary structure are discussed.
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Tài liệu tham khảo
Urry, 1971, Biomolecular conformation and biological activity, Adv. them. Phys., 21, 581
Tosteson, 1968, The effects of macrocyclic compounds on cation transport in sheep red cells and thin and thick lipid membranes, J. gen. Physiol., 51, 373, 10.1085/jgp.51.5.373
Smythe, 1939, Static and Dynamic Electricity
Panofesky, 1962, Classical Electricity and Magnetism
Vetter, 1967, Electrochemical Kinetics
Pressman, 1968, lonophorous antibiotics as models for biological transport, Fedn Proc. Fedn Am. Socs exp. Biol., 27, 1283
Markin, 1969, Membrane potential and short circuit current in artificial phospholipid membranes in the presence of agents uncoupling oxidative phosphorylation, Biophysics, 14, 487
Myers V. B. & Haydon D. A. (1972). Ion transfer across lipid membranes in the presence of gramicidin A. II. The ion selectivity. (To be published.)
Liberman, 1969, Permeability of bimolecular phospholipid membranes for fat soluble ions, Biophysics, 14, 477
Liberman, 1970, Mechanism of permeability of phospholipid membranes for cations in the presence of antibiotics, Biophysics, 15, 639
Liberman, 1968, Effect of uncoupling agents of oxidative phosphorylation on bimolecular phospholipid membranes, Biophysics, 13, 226
LeBlanc O. H. Jr (1970). Single ion conductances in lipid bilayers. TPMA3. Abstracts of Biophysical Society 14th Annual Meeting. Baltimore, Maryland.
Ivanov, 1971, Conformational states of valinomycin and its complexes with the cations of alkalimetals in solutions, Khim. Prir. Soedin, 3, 221
Hodgman, 1961, Handbook of Chemistry and Physics, 211
Hladky S. B. & Haydon D. A. (1972). Ion transfer across lipid membranes in the presence of gramicidin A. I. Studies of the unit conductance channel. (Submitted for publication.)
Hladky, 1971, Symposium on Molecular Mechanisms of Antibiotic Action on Protein Biosynthesis and Membranes
Hladky S. B. (1971). On the mechanism of ion transport across thin lipid membranes. Fellowship dissertation, Churchill College, Cambridge.
Haydon, 1970, In Membranes and Ion Transport, 1, 64
Haydon, 1970, In Permeability and Function of Biological Membranes, 185
Grell, 1971, In Symposium on Molecular Mechanisms of Antibiotic Action on Protein Biosynthesis and Membranes
Jackson, 1962, Classical Electrodynamics
Tostenson, 1968, Effect of macrocyclic compounds on the ionic permeability of artificial and natural membranes, Fedn Proc. Fedn Am. Socs exp. Biol., 27, 1269
Babakov, 1968, Effect of metal ions on the conductivity and current—voltage characteristics of bimolecular membranes with tetrachlorotrifluoromethylbenzimidazole, Biophysics, 13, 1302
Liberman, 1968, Transfer of ions across bimolecular membranes and classification of uncouplers of oxidative phosphorylation, Biophysics, 13, 1195
Hladky S. B. (1972 b). The steady-state kinetics of the nonactin induced conductance of a thin lipid membrane. (In preparation.)
Liberman, 1971, Membranes (ionic permeability, excitability, control)., Neurosci. Transl., 15, 69
Markin, 1969, Mechanism of conductivity of artificial phospholipid membranes in presence of ion carriers, Biophysics, 14, 272
Liberman, 1970, Comparison of the properties of the bimolecular phospholipid membranes from the brain, mitochondria and bacteria, Biophysics, 15, 67
Gurney, 1953, Ionic Processes in Solution
Carslaw, 1969, Conduction of Heat in Solids
Szabo, 1970, In Physical Principles of Biological Membranes, 79
Haydon, 1969, In The Molecular Basis of Membrane Function, 111
Eisenamn, 1971, In Symposium on Molecular Mechanisms of Antibiotic Action on Protein Biosynthesis and Membranes
Haydon, 1962, Surface potentials and molecular structure at hydrocarbon/water interfaces, Kolloidzeitschrift, 185, 148
Bran, 1969, Discrete conductance fluctuations in lipid bilayer protein membranes, J. gen. Physiol., 53, 741, 10.1085/jgp.53.6.741
Cook, 1968, The molecular composition of black hydrocarbon films in aqueous solutions, Kolloidzeitschrift, 227, 28
Donnan, 1911, Theorie derMembrangleichgewichte und Membranepotentiale bei Vorhandensein von nicht dialysierenden Electrolyten. Ein Beitrag zur physikalisch-chemischen Physiologie, Z. Elektrochem., 17, 572
Eisenman, 1968, Some theoretically expected and experimentally observed properties of lipid bilayer membranes containing neutral molecular carriers of ions, Fedn Proc. Fedn Am. Socs exp. Biol., 27, 1289