Ion‐selective membranes with low plasticizer content: Electroanalytical characterization and biocompatibility studies

Wiley - Tập 28 Số 5 - Trang 591-601 - 1994
Ernö Lindner1, Vasile V. Coșofreţ2, S. Ufer2, Richard P. Buck2, Weiyuan John Kao3, Michael R. Neuman3, James M. Anderson3
1Department of Chemistry, University of North Carolina at Chapel Hill 27599-3290.
2Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599–3290
3Institute of Pathology, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106‐4907

Tóm tắt

AbstractHigh molecular weight poly(vinyl chloride) and aliphatic polyurethane (Tecoflex)‐based ion selective membranes, with normal and reduced amounts of plasticizer, as well as without plasticizer, were tested with respect to their analytical properties, their biocompatibility, and cellular responses. The analytical properties of the membranes did not change significantly within a wide range of polymer to plasticizer rations. However, the membranes with reduced plasticizer content had better adhesive properties, less anion interference, extended life time, and better biocompatibility. Using the cage implant system, the results showed that an increase of plasticizer weight percent in Tecoflex membranes correlated positively with the increase in host inflammatory response up to 14 days of implantation. The results also demonstrated that both PVC and Tecoflex‐based ion‐selective membranes with the most common membrane composition (1:2 polymer to plasticizer ratio) exhibited a similar acute inflammatory response, but the PVC‐based membrane elicited a reduced chronic inflammatory response when compared with the Tecoflex‐based membrane. © 1994 John Wiley & Sons, Inc.

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Wiley

Tập 28 Số 5

591-601

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