Ion mobility spectrometry of solid surfaces for pharmaceutical residues using electrospray laser desorption and ionization
Tóm tắt
Pharmaceutical residues on solid surfaces were determined in air at ambient pressure using ion mobility spectrometry (IMS) with electrospray ionization laser desorption (ELDI) methods. Substances were desorbed from surfaces with a pulsed Nd-YAG laser at 266 nm and ionized in an electrospray ion source. Ions derived from substances by ELDI were measured using ion mobility spectrometry. Substances with strong proton affinities produced ions which were mass-identified as MH+ and produced mobility spectra with a single, intense, product ion peak. Ablation rates were determined as 0.038 pg/s and sampling at a fixed location led to decreases in product ion intensity with complete removal of residue on the surface. A dependence of intensity on the substrate for five pharmaceuticals was observed and could be associated with substrate porosity. The area of sampling was 12 mm2 and linear resolution of a line of pharmaceuticals over 20 mm length demonstrated a capability to image residue by ELDI IMS.
Tài liệu tham khảo
Berkel GJV, Pasilis SP, Ovchinnikova OJ (2008) Mass Spectrom 43:1161
Harris GA, Galhena AA, Fernandez FM (2011) Anal Chem 83:4508
Shiea J, Huang MZ, Hsu HJ, Lee CY, Yuan CH, Beech I, Sunner J (2005) Rapid Commun Mass Spectrom 19:3701
Huang MZ, Hsu HJ, Lee JY, Jeng JJ, Shiea J, Proteome J (2006) Research 5:1107
Lin SY, Huang MZ, Chang HC, Shiea J (2007) Anal Chem 79:8789
Borsdorf H, Mayer T, Zarejousheghani M, Eiceman GA (2011) Appl Spectrosc Rev 46:472
Eiceman GA, Karpas Z, Hill HH (2013) Ion Mobility Spectrometry, 3rd edn. Taylor and Frances, Boca Raton, pp 269–298
Kirk AT, Allers M, Cochems P, Langejuergen J, Zimmermann S (2013) Analyst 138:5200
Young D, Douglas KM, Eiceman GA, Lake DA, Johnston MV (2002) Anal Chim ACTA 453:231
Beitz T, Laudien R, Lohmannsroben HG, Kallies BJ (2006) Phys Chem A 110:3514
Eiceman GA, Young D, Smith G (2005) Microchim Acta 81:108
Harris GA, Kwasnik M, Fernandez FM (2011) Anal Chem 83:1908
Weston DJ, Bateman R, Wilson ID, Wood TR, Creaser CS (2005) Anal Chem 77:7572
Wittmer D, Chen YH, Luckenbill BK, Hill HH (1994) Anal Chem 66:2348
Hilton CK, Krueger CA, Midey AJ, Osgood M, Wu J, Wu C (2010) Int J Mass Spectrom 298:64
Commercial Brochure (2013) GA2100 Electrospray Ionization High Performance Ion Mobility Spectrometer. Excellims Corporation, available at http://www.excellims.com/public/downloads/GA2100-Product-Information.pdf
Tam M, Hill HH (2004) Anal Chem 76:2741
Dillon LA, Stone VN, Groasdell LA, Fielden PR, Goddard N, Thomas PCL (2010) Analyst 135:306
Lee CY, Shiea J (1998) Anal Chem 70:2757
Chan ECY, New LS, Yap CW, Goh LT (2009) Rapid Commun Mass Spectrom 23:384
Harry EL, Reynolds JC, Bristow AWT, Wilson ID, Creaser CS (2009) Rapid Commun Mass Spectrom 23:2597
Femandez-Maestre R, Hill HH (2009) Int J Ion Mobility Spectrom 12:91
Harris GA, Graf S, Knochenmuss R, Fernandez FM (2012) Analyst 137:3039
Eiceman GA, Nazarov JE, Stone JA (2001) Rev Sci Instrum 72:3610
McCarley TD, Brodbelt J (1993) Anal Chem 65:2380