Involvement of actin cytoskeletal modifications in the inhibition of triple-negative breast cancer growth and metastasis by nimbolide

Molecular Therapy - Oncolytics - Tập 20 - Trang 596-606 - 2021
Arunkumar Arumugam1, Ramadevi Subramani1,2, Rajkumar Lakshmanaswamy1,2
1Center of Emphasis in Cancer Research, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
2Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA

Tài liệu tham khảo

Ovcaricek, 2011, Triple negative breast cancer - prognostic factors and survival, Radiol. Oncol., 45, 46, 10.2478/v10019-010-0054-4 Neophytou, 2018, Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis, Front. Oncol., 8, 31, 10.3389/fonc.2018.00031 2005, Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials, Lancet, 365, 1687, 10.1016/S0140-6736(05)66544-0 Chiang, 2008, Molecular basis of metastasis, N. Engl. J. Med., 359, 2814, 10.1056/NEJMra0805239 Fife, 2014, Movers and shakers: cell cytoskeleton in cancer metastasis, Br. J. Pharmacol., 171, 5507, 10.1111/bph.12704 Langley, 2011, The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs, Int. J. Cancer, 128, 2527, 10.1002/ijc.26031 Gkretsi, 2018, Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis, Front. Oncol., 8, 145, 10.3389/fonc.2018.00145 Zhang, 2006, Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration, J. Biol. Chem., 281, 12397, 10.1074/jbc.M512107200 Böttcher, 2009, How ILK and kindlins cooperate to orchestrate integrin signaling, Curr. Opin. Cell Biol., 21, 670, 10.1016/j.ceb.2009.05.008 Horton, 2016, Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome, Exp. Cell Res., 343, 7, 10.1016/j.yexcr.2015.10.025 Horton, 2015, Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly, Nat. Cell Biol., 17, 1577, 10.1038/ncb3257 Legate, 2009, Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails, J. Cell Sci., 122, 187, 10.1242/jcs.041624 Gupta, 2010, Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents, J. Biol. Chem., 285, 35406, 10.1074/jbc.M110.161984 Kavitha, 2012, Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells, Eur. J. Pharmacol., 681, 6, 10.1016/j.ejphar.2012.01.024 Roy, 2007, Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica), Phytother. Res., 21, 245, 10.1002/ptr.2058 Bodduluru, 2014, Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms, Toxicol. In Vitro, 28, 1026, 10.1016/j.tiv.2014.04.011 Lin, 2017, Nimbolide suppresses non-small cell lung cancer cell invasion and migration via manipulation of DUSP4 expression and ERK1/2 signaling, Biomed. Pharmacother., 92, 340, 10.1016/j.biopha.2017.05.072 Kowshik, 2017, Nimbolide upregulates RECK by targeting miR-21 and HIF-1alpha in cell lines and in a hamster oral carcinogenesis model, Sci. Rep, 7, 2045, 10.1038/s41598-017-01960-5 Subramani, 2016, Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition, Sci. Rep., 6, 19819, 10.1038/srep19819 Wang, 2016, Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development, Oncotarget, 7, 44790, 10.18632/oncotarget.8316 Laronga, 2000, Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression, J. Biol. Chem., 275, 23106, 10.1074/jbc.M905616199 Burridge, 2017, Focal adhesions: a personal perspective on a half century of progress, FEBS J., 284, 3355, 10.1111/febs.14195 Horton, 2016, The integrin adhesome network at a glance, J. Cell Sci., 129, 4159 Giancotti, 1999, Integrin signaling, Science, 285, 1028, 10.1126/science.285.5430.1028 Follo, 2015, PLC and PI3K/Akt/mTOR signalling in disease and cancer, Adv. Biol. Regul., 57, 10, 10.1016/j.jbior.2014.10.004 Burris, 2013, Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway, Cancer Chemother. Pharmacol., 71, 829, 10.1007/s00280-012-2043-3 Obenauf, 2015, Surviving at a Distance: Organ-Specific Metastasis, Trends Cancer, 1, 76, 10.1016/j.trecan.2015.07.009 Nguyen, 2009, Metastasis: from dissemination to organ-specific colonization, Nat. Rev. Cancer, 9, 274, 10.1038/nrc2622 Ross, 2013, Integrins in mechanotransduction, Curr. Opin. Cell Biol., 25, 613, 10.1016/j.ceb.2013.05.006 Humphrey, 2014, Mechanotransduction and extracellular matrix homeostasis, Nat. Rev. Mol. Cell Biol., 15, 802, 10.1038/nrm3896 Bokoch, 2003, Biology of the p21-activated kinases, Annu. Rev. Biochem., 72, 743, 10.1146/annurev.biochem.72.121801.161742 Szczepanowska, 2009, Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements, Acta Biochim. Pol., 56, 225, 10.18388/abp.2009_2453 Krause, 2014, Steering cell migration: lamellipodium dynamics and the regulation of directional persistence, Nat. Rev. Mol. Cell Biol., 15, 577, 10.1038/nrm3861 Chesarone, 2009, Actin nucleation and elongation factors: mechanisms and interplay, Curr. Opin. Cell Biol., 21, 28, 10.1016/j.ceb.2008.12.001 Loureiro, 2002, Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration, Mol. Biol. Cell, 13, 2533, 10.1091/mbc.e01-10-0102 Zhang, 2016, Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model, Antioxid. Redox Signal., 24, 575, 10.1089/ars.2015.6418 Liu, 2015, Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma, Int. J. Mol. Sci., 16, 23405, 10.3390/ijms161023405 Babykutty, 2012, Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells, Mol. Carcinog., 51, 475, 10.1002/mc.20812 Rich, 2002, Kinetic analysis of estrogen receptor/ligand interactions, Proc. Natl. Acad. Sci. USA, 99, 8562, 10.1073/pnas.142288199