Involvement of Kir4.1 in pain insensitivity of the BTBR mouse model of autism spectrum disorder

Fifth, 2013, Diagnostic and statistical manual of mental disorders, Am Psychiatric Assoc., 21, 591 Baio, 2018, Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2014, MMWR. Surveill. Summ. (Washington, D.C. : 2002), 67, 1, 10.15585/mmwr.ss6706a1 Shaw, 2021, Early identification of autism spectrum disorder among children aged 4 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2018, MMWR. Surveill. Summ. (Washington, D.C. : 2002), 70, 1, 10.15585/mmwr.ss7010a1 Thye, 2018, The impact of atypical sensory processing on social impairments in autism spectrum disorder, Dev. Cogn. Neuros-neth., 29, 151, 10.1016/j.dcn.2017.04.010 Almai, 2019, 93 Yin, 2020, dmPFC-vlPAG projection neurons contribute to pain maintenance thresholds and anxiolytic behaviors, J. Clin. Invest., 130, 6555, 10.1172/JCI127607 Wang, 2023, Incidental physical pain reduces brain activities associated with affective social feedback and increases aggression, Soc. Cogn. Affect. Neur., 18, 10.1093/scan/nsac048 Wang, 2019, Increased expression of Kv10. 2 in the hippocampus attenuates valproic acid-induced autism-like behaviors in rats, Neurochem. Res., 44, 2796, 10.1007/s11064-019-02903-4 Lee, 2014, Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation, Hum. Mol. Genet., 23, 3481, 10.1093/hmg/ddu056 Garg, 2013, Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of rett syndrome, J. Neurosci., 33, 13612, 10.1523/JNEUROSCI.1854-13.2013 Chien, 2017, Attenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder, Sci. Rep-uk., 7, 1 Orefice, 2016, Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs, Cell, 166, 299, 10.1016/j.cell.2016.05.033 Basbaum, 2009, Cellular and molecular mechanisms of pain, Cell, 139, 267, 10.1016/j.cell.2009.09.028 Pannese, 2010, The structure of the perineuronal sheath of satellite glial cells (SGCs) in sensory ganglia, Neuron Glia Biol., 6, 3, 10.1017/S1740925X10000037 Hanani, 2012, Intercellular communication in sensory ganglia by purinergic receptors and gap junctions: implications for chronic pain, Brain Res., 1487, 183, 10.1016/j.brainres.2012.03.070 Tang, 2010, Inwardly rectifying potassium channel Kir4. 1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia, Neuroscience, 166, 397, 10.1016/j.neuroscience.2010.01.005 Huang, 2021, Phenotypical peculiarities and species-specific differences of canine and murine satellite glial cells of spinal ganglia, J. Cell. Mol. Med., 25, 6909, 10.1111/jcmm.16701 Blum, 2017, Long term effects of lipopolysaccharide on satellite glial cells in mouse dorsal root ganglia, Exp. Cell Res., 350, 236, 10.1016/j.yexcr.2016.11.026 Avraham, 2020, Satellite glial cells promote regenerative growth in sensory neurons, Nat. Commun., 11, 1, 10.1038/s41467-020-18642-y Sun, 2018, Association study between inwardly rectifying potassium channels 2.1 and 4.1 and autism spectrum disorders, Life Sci., 213, 183, 10.1016/j.lfs.2018.10.012 Binda, 2018, A novel KCNJ2 mutation identified in an autistic proband affects the single channel properties of Kir2. 1, Front. Cell. Neurosci., 12, 76, 10.3389/fncel.2018.00076 Xu, 2014, Complete Freund’s adjuvant–induced acute inflammatory pain could be attenuated by triptolide via inhibiting spinal glia activation in rats, J. Surg. Res., 188, 174, 10.1016/j.jss.2013.11.1087 Leslie, 2011, Neonatal inflammatory pain increases hippocampal neurogenesis in rat pups, Neurosci. Lett., 501, 78, 10.1016/j.neulet.2011.06.047 Lima, 2014, Sex-related long-term behavioral and hippocampal cellular alterations after nociceptive stimulation throughout postnatal development in rats, Neuropharmacology, 77, 268, 10.1016/j.neuropharm.2013.10.007 Malheiros, 2014, Repetitive noxious neonatal stimuli increases dentate gyrus cell proliferation and hippocampal brain-derived neurotrophic factor levels, Hippocampus, 24, 415, 10.1002/hipo.22235 Bravo-Hernández, 2016, The α5 subunit-containing GABAA receptors contribute to chronic pain, Pain, 157, 613, 10.1097/j.pain.0000000000000410 Chen, 2015, Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion, J. Clin. Investig., 125, 3226, 10.1172/JCI80883 Han, 2016, SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons, Neuron, 92, 1279, 10.1016/j.neuron.2016.11.007 Barry, 2020, Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors, Nat. Commun., 11, 1, 10.1038/s41467-020-15230-y Tegeder, 2004, Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I, Proc. Natl. Acad. Sci., 101, 3253, 10.1073/pnas.0304076101 Tang, 2009, Heterogeneity of Kir4. 1 channel expression in glia revealed by mouse transgenesis, Glia, 57, 1706, 10.1002/glia.20882 Kharade, 2018, Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4. 1 potassium channel pore blocker, VU0134992, Mol. Pharmacol., 94, 926, 10.1124/mol.118.112359 Nimitvilai-Roberts, 2021, Ethanol inhibition of lateral orbitofrontal cortex neuron excitability is mediated via dopamine D1/D5 receptor-induced release of astrocytic glycine, Neuropharmacology, 192, 10.1016/j.neuropharm.2021.108600 Hagenacker, 2005, Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats, Brain Res., 1062, 74, 10.1016/j.brainres.2005.09.033 Cao, 2018, Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage, Brain Res. Bull., 143, 83, 10.1016/j.brainresbull.2018.10.007 Liu, 2010, Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose, Neuroscience, 169, 596, 10.1016/j.neuroscience.2010.05.028 Pfaffl, 2001, A new mathematical model for relative quantification in real-time RT–PCR, Nucleic Acids Res., 29, e45, 10.1093/nar/29.9.e45 Jett, 1997, The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization, Pain, 69, 161, 10.1016/S0304-3959(96)03231-9 Cope, 2022, Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction, Mol. Psychiatry, 27, 3520, 10.1038/s41380-021-01174-2 Pajarillo, 2019, The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics, Neuropharmacology, 161, 10.1016/j.neuropharm.2019.03.002 Elwin, 2012, Autobiographical accounts of sensing in asperger syndrome and high-functioning autism, Arch. Psychiat. Nurs., 26, 420, 10.1016/j.apnu.2011.10.003 Puts, 2014, Impaired tactile processing in children with autism spectrum disorder, J. Neurophysiol., 111, 1803, 10.1152/jn.00890.2013 Wang, 2020, Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization, Brain Res. Bull., 156, 58, 10.1016/j.brainresbull.2020.01.004 Martin, 2022, Altered nociceptive behavior and emotional contagion of pain in mouse models of autism, Genes Brain Behav., 21, 10.1111/gbb.12778 Takeda, 2011, Peripheral inflammation suppresses inward rectifying potassium currents of satellite glial cells in the trigeminal ganglia, Pain, 152, 2147, 10.1016/j.pain.2011.05.023 Vit, 2008, Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury, J. Neurosci., 28, 4161, 10.1523/JNEUROSCI.5053-07.2008 Leo, 2021, Cisplatin-induced activation and functional modulation of satellite glial cells lead to cytokine-mediated modulation of sensory neuron excitability, Exp. Neurol., 341, 10.1016/j.expneurol.2021.113695 Schmitt, 2020, Activation and functional modulation of satellite glial cells by oxaliplatin lead to hyperexcitability of sensory neurons in vitro, Mol. Cell. Neurosci., 105, 10.1016/j.mcn.2020.103499 Amodeo, 2019, Differences in the expression of restricted repetitive behaviors in female and male BTBR T+ tf/J mice, Behav. Brain Res., 372, 10.1016/j.bbr.2019.112028 Mahmoud, 2019, Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release, Cells-basel, 8, 184, 10.3390/cells8020184 Maragakis, 2004, Glutamate transporters: animal models to neurologic disease, Neurobiol. Dis., 15, 461, 10.1016/j.nbd.2003.12.007 Kim, 2003, Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes, J. Neurochem., 87, 1485, 10.1046/j.1471-4159.2003.02128.x Kim, 2012, Electroacupuncture confers antinociceptive effects via inhibition of glutamate transporter downregulation in complete Freund's adjuvant-injected rats, Evid-based. Compl. Alt, 10.1155/2012/643973 Zhang, 2021, MiRNA-107 contributes to inflammatory pain by down-regulating GLT-1 expression in rat spinal dorsal horn, Eur. J. Pain, 25, 1254, 10.1002/ejp.1745 Pottabathini, 2016, Ameliorative potential of pioglitazone and ceftriaxone alone and in combination in rat model of neuropathic pain: targeting PPARγ and GLT-1 pathways, Pharmacol. Rep., 68, 85, 10.1016/j.pharep.2015.06.010 Kanai, 2003, The glutamate and neutral amino acid transporter family: physiological and pharmacological implications, Eur. J. Pharmacol., 479, 237, 10.1016/j.ejphar.2003.08.073 Mennerick, 1999, Substrate turnover by transporters curtails synaptic glutamate transients, J. Neurosci., 19, 9242, 10.1523/JNEUROSCI.19-21-09242.1999 Otis, 2000, Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2, J. Neurosci., 20, 2749, 10.1523/JNEUROSCI.20-08-02749.2000 D'Ambrosio, 2004, The role of glial membrane ion channels in seizures and epileptogenesis, Pharmacol. Therapeut., 103, 95, 10.1016/j.pharmthera.2004.05.004 Neusch, 2006, Lack of the Kir4. 1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation, J. Neurophysiol., 95, 1843, 10.1152/jn.00996.2005 Olsen, 2006, Functional expression of Kir4. 1 channels in spinal cord astrocytes, Glia, 53, 516, 10.1002/glia.20312 Olsen, 2008, Functional implications for Kir4. 1 channels in glial biology: from K+ buffering to cell differentiation, J. Neurochem., 107, 589, 10.1111/j.1471-4159.2008.05615.x