Investigation of the role of the autophagic protein LC3B in the regulation of human airway epithelium cell differentiation in COPD using a biomimetic model

Materials Today Bio - Tập 13 - Trang 100182 - 2022
Shiue-Luen Chen1,2, Hsiao-Chun Chou2, Kuan-Chen Lin2,3, Jia-Wei Yang1,2, Ren-Hao Xie1,2, Chong-You Chen1,2, Xin-Yi Liu2, Johnson H.Y. Chung4, Guan-Yu Chen1,2,5
1Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
2Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
3Division of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital (Linkou), Taoyuan, Taiwan
4ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, University of Wollongong, Wollongong, NSW, Australia
5Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

Tài liệu tham khảo

Agustí, 2019, Update on the pathogenesis of chronic obstructive pulmonary disease, N. Engl. J. Med., 381, 1248, 10.1056/NEJMra1900475 Celli, 2019, Update on clinical aspects of chronic obstructive pulmonary disease, N. Engl. J. Med., 381, 1257, 10.1056/NEJMra1900500 Roth, 2018, Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet, 392, 1736, 10.1016/S0140-6736(18)32203-7 Aguiar, 2019, The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cells, Sci. Rep., 9, 1, 10.1038/s41598-018-36248-9 Veerati, 2020, Airway epithelial cell immunity is delayed during rhinovirus infection in asthma and COPD, Front. Immunol., 11, 974, 10.3389/fimmu.2020.00974 Nachmias, 2019, NLRP3 inflammasome activity is upregulated in an in-vitro model of COPD exacerbation, PLoS One, 14, 10.1371/journal.pone.0214622 Bodas, 2019, Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis, Free Radic. Biol. Med., 131, 81, 10.1016/j.freeradbiomed.2018.11.023 Wu, 2020, Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation, Autophagy, 16, 435, 10.1080/15548627.2019.1628536 Lv, 2020, 559 McAlinden, 2019, Autophagy activation in asthma airways remodeling, Am. J. Respir. Cell Mol. Biol., 60, 541, 10.1165/rcmb.2018-0169OC Arora, 2020, AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals, J. Biol. Chem., 295, 14250, 10.1074/jbc.RA120.013703 Lystad, 2019, Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes, Nat. Cell Biol., 21, 372, 10.1038/s41556-019-0274-9 Baeken, 2020, Novel insights into the cellular localization and regulation of the autophagosomal proteins LC3A, LC3B and LC3C, Cells, 9, 2315, 10.3390/cells9102315 Pampliega, 2013, Functional interaction between autophagy and ciliogenesis, Nature, 502, 194, 10.1038/nature12639 Gies, 2020, Beyond anti-viral effects of chloroquine/hydroxychloroquine, Front. Immunol., 11, 1409, 10.3389/fimmu.2020.01409 Mauthe, 2018, Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion, Autophagy, 14, 1435, 10.1080/15548627.2018.1474314 Koukourakis, 2015, Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines, PLoS One, 10, 10.1371/journal.pone.0137675 Caly, 2020, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antivir. Res., 178, 104787, 10.1016/j.antiviral.2020.104787 Chen, 2012, A graphene-based platform for induced pluripotent stem cells culture and differentiation, Biomaterials, 33, 418, 10.1016/j.biomaterials.2011.09.071 Tan, 2019, Dysregulated autophagy in COPD: a pathogenic process to be deciphered, Pharmacol. Res., 144, 1, 10.1016/j.phrs.2019.04.005 Ryter, 2015, Autophagy in lung disease pathogenesis and therapeutics, Redox. Biol., 4, 215, 10.1016/j.redox.2014.12.010 Chen, 2008, Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease, PLoS One, 3, 10.1371/journal.pone.0003316 Matter, 2005, Mammalian tight junctions in the regulation of epithelial differentiation and proliferation, Curr. Opin. Cell Biol., 17, 453, 10.1016/j.ceb.2005.08.003 Kyung, 2004, Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium, Pathology, 164 Shaykhiev, 2014, Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells, Ann. Am. Thorac. Soc., 11, S252, 10.1513/AnnalsATS.201402-049AW Staudt, 2014, Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 190, 955, 10.1164/rccm.201406-1167LE Rokicki, 2016, The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases, Kardiochir Torakochirurgia Pol, 13, 26 Shen, 2018, Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition), Int. J. Chronic Obstr. Pulm. Dis., 13, 399, 10.2147/COPD.S144312 Nanjundappa, 2019, Regulation of cilia abundance in multiciliated cells, Elife, 8, 10.7554/eLife.44039 Mercey, 2019, Massive centriole production can occur in the absence of deuterosomes in multiciliated cells, Nat. Cell Biol., 21, 1544, 10.1038/s41556-019-0427-x Mizumura, 2018, Autophagy, selective autophagy, and necroptosis in COPD, Int. J. Chronic Obstr. Pulm. Dis., 13, 3165, 10.2147/COPD.S175830 Mizumura, 2016, Autophagy: friend or foe in lung disease?, Ann. Am. Thorac. Soc., 13, S40, 10.1513/AnnalsATS.201507-450MG Vij, 2018, Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis, Am. J. Physiol. Cell Physiol., 314, C73, 10.1152/ajpcell.00110.2016 Racanelli, 2018, Autophagy and inflammation in chronic respiratory disease, Autophagy, 14, 221, 10.1080/15548627.2017.1389823 Johansen, 2020, Selective autophagy: ATG8 family proteins, LIR Motifs and cargo receptors, J. Mol. Biol., 432, 80, 10.1016/j.jmb.2019.07.016 Yoshida, 2019, Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis, Nat. Commun., 10, 3145, 10.1038/s41467-019-10991-7 Allegretti, 2020, In-cell architecture of the nuclear pore and snapshots of its turnover, Nature, 586, 796, 10.1038/s41586-020-2670-5 Serramito-Gómez, 2020, Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain, Nat. Commun., 11, 5919, 10.1038/s41467-020-19670-4 Huang, 2015, Deacetylation of nuclear LC3 drives autophagy initiation under starvation, Mol. Cell, 57, 456, 10.1016/j.molcel.2014.12.013 Huang, 2015, Identifying an essential role of nuclear LC3 for autophagy, Autophagy, 11, 852, 10.1080/15548627.2015.1038016 Papandreou, 2019, Nucleophagy: from homeostasis to disease, Cell Death Differ., 26, 630, 10.1038/s41418-018-0266-5 Shim, 2020, The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress, Autophagy, 16, 1248, 10.1080/15548627.2019.1662584 Pham, 2017, Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma, Clin. Exp. Allergy, 47, 57, 10.1111/cea.12859 Jiang, 2017, TLR2 regulates allergic airway inflammation and autophagy through PI3K/Akt signaling pathway, Inflammation, 40, 1382, 10.1007/s10753-017-0581-x Artzy-Schnirman, 2021, Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics, Adv. Drug Deliv. Rev., 113901, 10.1016/j.addr.2021.113901 Artzy-Schnirman, 2020, Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips, Expet Opin. Drug Deliv., 17, 621, 10.1080/17425247.2020.1738380 Sakagami, 2020, In vitro, ex vivo and in vivo methods of lung absorption for inhaled drugs, Adv. Drug Deliv. Rev., 161-162, 63, 10.1016/j.addr.2020.07.025 Zamprogno, 2021, Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane, Communication. Biol., 4, 168, 10.1038/s42003-021-01695-0 Doryab, 2021, A bioinspired in vitro lung model to study particokinetics of nano-/microparticles under cyclic stretch and air-liquid interface conditions, Front. Bioeng. Biotechnol., 9, 616830, 10.3389/fbioe.2021.616830 Felder, 2019, Impaired wound healing of alveolar lung epithelial cells in a breathing lung-on-A-chip, Front. Bioeng. Biotechnol., 7, 3, 10.3389/fbioe.2019.00003 Li, 2020, Recent advances in the development of novel drug candidates for regulating the secretion of pulmonary mucus, Biomolecules therapeutics, 28, 293, 10.4062/biomolther.2020.002 Dinu, 2020, Policy, toxicology and physicochemical considerations on the inhalation of high concentrations of food flavour, NPJ Sci. Food, 4, 1, 10.1038/s41538-020-00075-y Benam, 2017, Human lung small airway-on-a-chip protocol, Methods Mol. Biol., 1612, 345, 10.1007/978-1-4939-7021-6_25 Benam, 2016, Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro, Nat. Methods, 13, 151, 10.1038/nmeth.3697 Benam, 2017, 345 Humayun, 2018, Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions, Lab Chip, 18, 1298, 10.1039/C7LC01357D Hassell, 2017, Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro, Cell Rep., 21, 508, 10.1016/j.celrep.2017.09.043 Shrestha, 2020, Lung-on-a-chip: the future of respiratory disease models and pharmacological studies, Crit. Rev. Biotechnol., 40, 213, 10.1080/07388551.2019.1710458 Dominelli, 2018, Sex differences in large conducting airway anatomy, J. Appl. Physiol., 125, 960, 10.1152/japplphysiol.00440.2018 Raghavan, 2016, Increasing awareness of sex differences in airway diseases, Respirology, 21, 449, 10.1111/resp.12702 Ambhore, 2021, Sex-steroid signaling in lung diseases and inflammation, Adv. Exp. Med. Biol., 1303, 243, 10.1007/978-3-030-63046-1_14 Vega-Naredo, 2009, Sexual dimorphism of autophagy in Syrian hamster Harderian gland culminates in a holocrine secretion in female glands, Autophagy, 5, 1004, 10.4161/auto.5.7.9610 Campesi, 2013, Protein oxidation seems to be linked to constitutive autophagy: a sex study, Life Sci., 93, 145, 10.1016/j.lfs.2013.06.001 Alderden, 2020, Risk factors for hospital-acquired pressure injury in surgical critical care patients, Am. J. Crit. Care : Off. Pub. Am. Assoc. Critical Care Nurses, 29, e128, 10.4037/ajcc2020810 Lee, 2020, ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs, Nat. Commun., 11, 5453, 10.1038/s41467-020-19145-6 Qi, 2017, Effect of Xiaoqinglong decoction on mucus hypersecretion in the airways and cilia function in a murine model of asthma, J. Traditional Chinese Sci., 4, 290 Bae, 2019, Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model, Cell Death Dis., 10, 1, 10.1038/s41419-019-2184-y