Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake

Caroline R. Espada1, Rubens M. Magalhães2, Mario C. Cruz3, Paulo R. Machado4, Albert Schriefer5, Edgar M. Carvalho4,6, Valentín Hornillos7, João M. Alves1, Angela K. Cruz2, Adriano C. Coelho1, Silvia R.B. Uliana1
1Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
2Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil
3Centro de Facilidades para Apoio a Pesquisa, CEFAP-USP, Universidade de São Paulo, São Paulo, Brazil
4Serviço de Imunologia, HUPES, Universidade Federal da Bahia, Salvador, Brazil
5Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
6Centro de Pesquisas Gonçalo Moniz, Fiocruz-Bahia, Salvador, Brazil
7Departamento de Química Orgánica, Universidad de Sevilla and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Sevilla, Spain

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