Investigation of the neurotrophic effect of dairy phospholipids on cortical neuron outgrowth and stimulation

AOAC (1896). Lactose in milk. Polarimetric method, method no. 896.01. In Latimer (Ed) Official methods of analysis of AOAC International (19th ed). Gaithersburg, MD, USA: AOAC International, 2012. Astaire, 2003, Concentration of polar MFGM lipids from buttermilk by microfiltration and supercritical fluid extraction, Journal of Dairy Science, 86, 2297, 10.3168/jds.S0022-0302(03)73822-3 Avalli, 2005, Determination of phospholipids in dairy products by SPE/HPLC/ELSD, Journal of Chromatography A, 1071, 185, 10.1016/j.chroma.2005.01.072 Barry, 2017, Selective enrichment of dairy phospholipids in a buttermilk substrate through investigation of enzymatic hydrolysis of milk proteins in conjunction with ultrafiltration, International Dairy Journal, 68, 80, 10.1016/j.idairyj.2016.12.016 Barry, 2017, Pilot scale production of a phospholipid- enriched dairy ingredient by means of an optimised integrated process employing enzymatic hydrolysis, ultrafiltration and super-critical fluid extraction, Innovative Food Science and Emerging Technologies, 41, 301, 10.1016/j.ifset.2017.04.004 Barry, 2016, Comparison of dairy phospholipid preparative extraction protocols in combination with analysis by high performance liquid chromatography coupled to a charged aerosol detector, International Dairy Journal, 56, 179, 10.1016/j.idairyj.2016.01.022 Berra, 2002, Dietary sphingolipids in colorectal cancer prevention, European Journal of Cancer Prevention, 1 Bitman, 1984, Comparison of the phospholipid composition of breast milk from mothers of term and pre-term infants during lactation, The American Journal of Clinical Nutrition, 40, 1103, 10.1093/ajcn/40.5.1103 Buccoliero, 2003, The roles of ceramide and complex sphingolipids in neuronal cell function, Pharmacological Research, 47, 409, 10.1016/S1043-6618(03)00049-5 Burling, 2008, Milk – a new source for bioactive phospholipids for use in food formulations, Lipid Technology, 20, 229, 10.1002/lite.200800058 Cao, 2005, Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures, Journal of Nutritional Biochemistry, 16, 538, 10.1016/j.jnutbio.2005.02.002 Christie, 1987, Phospholipids in milk and dairy products, Journal of the Society of Dairy Technology, 40, 10, 10.1111/j.1471-0307.1987.tb02385.x Cinque, 2003, Sphingolipids and the immune response, Pharmacological Research, 47, 421, 10.1016/S1043-6618(03)00051-3 Cohn, 2010, Dietary phospholipids and intestinal cholesterol absorption, Nutrients, 2, 116, 10.3390/nu2020116 Contarini, 2013, Phospholipids in milk fat: Composition, biological and technological significance, and analytical strategies, International Journal of Molecular Science, 14, 2808, 10.3390/ijms14022808 Corredig, 1997, Isolates from industrial buttermilk: Emulsifying properties of materials derived from the milk fat globule membrane, Journal of Agricultural and Food Chemistry, 45, 4595, 10.1021/jf970531f Corredig, 1998, Buttermilk properties in emulsions with soybean oil as affected by fat globule membrane derived proteins, Journal of Food Science, 63, 466, 10.1111/j.1365-2621.1998.tb15767.x Corredig, 2003, Production of a novel ingredient from buttermilk, Journal of Dairy Science, 86, 2744, 10.3168/jds.S0022-0302(03)73870-3 Costa, 2010, Use of ultrafiltration and supercritical fluid extraction to obtain a whey buttermilk powder enriched in milk fat globule membrane phospholipids, International Dairy Journal, 20, 598, 10.1016/j.idairyj.2010.03.006 Delton-Vandenbroucke, 2001, Dual regulation of glutathione peroxidase by docosahexaenoic acid in endothelial cells depending on concentration and vascular bed origin, Free Radical Biology & Medicine, 30, 895, 10.1016/S0891-5849(01)00482-8 Dewettinck, 2008, Nutrtional and technological aspects of milk fat globule membrane material, International Dairy Journal, 18, 436, 10.1016/j.idairyj.2007.10.014 Donato, 2011, Determination of phospholipids in milk samples by means of hydrophilic interaction liquid chromatography coupled to evaporative light scattering ad mass spectrometry detection, Journal of Chromatography A, 1218, 6476, 10.1016/j.chroma.2011.07.036 Eckhart, 2002, Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers, Gasteroenterology, 122, 244 Ferreiro, 2016, Evolution of phospholipid contents during the production of quark cheese from buttermilk, Journal of Dairy Science, 99, 4194, 10.3168/jds.2016-10861 Folch, 1957, A simple method for the isolation and purification of total lipids from animal tissue, Journal of Biological Chemistry, 226, 497, 10.1016/S0021-9258(18)64849-5 Gassi, 2016, Preparation and characterisation of a milk polar lipids enriched ingredient from fresh industrial liquid butter serum: Combination of physico- chemical modifications and technological treatments, International Dairy Journal, 52, 26, 10.1016/j.idairyj.2015.08.012 Grundy, 1987, Dietary lecithin: Metabolism, fate, and effects on metabolism of lipids and lipoproteins, 415 Harel, 1993, Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons, Journal of Biological Chemistry, 268, 14476, 10.1016/S0021-9258(19)85263-8 Hertervig, 2003, Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells, Journal of Cancer Research and Clinical Oncology, 129, 577, 10.1007/s00432-003-0466-2 Holzmüller, 2016, Technical difficulties and future challenges in isolating membrane material from milk fat globules in industrial settings – a critical review, International Dairy Journal, 61, 51, 10.1016/j.idairyj.2016.03.013 ISO (2010). Milk, cream and evaporated milk - determination of total solids content. ISO 6731. Geneva, Switzerland: International Organisation for Standardization. ISO (2014). Milk and milk products - determination of nitrogen content. Part 1: Kjeldahl principle & crude protein. ISO 8968-1. Geneva, Switzerland: International Organisation for Standardization. Kanno, 1991, Physiochemical properties of milk fat emulsions stabilised with bovine milk fat globule membrane, Journal of Food Science, 56, 1219, 10.1111/j.1365-2621.1991.tb04738.x Khodosevich, 2011, Signaling in migrating neurons: From molecules to networks, Frontiers in Neuroscience, 5, 1, 10.3389/fnins.2011.00028 Kidd, 2000, Dietary phospolipids as anti-aging nutraceutical, Vol. IV, 282 Konrad, 2013, Ultrafiltration of whey buttermilk to obtain a phospholipid concentrate, International Dairy Journal, 30, 39, 10.1016/j.idairyj.2012.11.007 Kuchta-Noctor, 2016, Anticancer activity of buttermilk against SW480 colon cancer cells is associated with caspase-independent cell death and attenuation of Wnt, Akt, and ERK signaling, Nutrition and Cancer, 68, 1234, 10.1080/01635581.2016.1206580 Latifi, 2016, Natural lecithin promotes neural network complexity and activity, Scientific Reports, 10.1038/srep25777 Lopez, 2011, Milk fat globules enveloped by their biological membrane: Unique colloidal assemblies with a specific composition and structure, Current Opinions in Colloid and Interface Science, 16, 391, 10.1016/j.cocis.2011.05.007 Mather, 1998, Origin and secretion of milk lipids, Journal of Mammary Gland Biology and Neoplasma, 3, 259, 10.1023/A:1018711410270 Matsuo, 2016, Possible application of apoliprotein E-containing lipoproteins and polyunsaturated fatty acids in neural regeneration, Neural Regeneration Research, 11, 715, 10.4103/1673-5374.182686 Mills, 2011, Milk intelligence: Mining milk for bioactive substances associated with human health, International Dairy Journal, 21, 377, 10.1016/j.idairyj.2010.12.011 Morin, 2007, Microfiltration of buttermilk and washed cream buttermilk for concentration of milk fat globule membrane components, Journal of Dairy Science, 90, 2132, 10.3168/jds.2006-832 Morin, 2004, Effect of temperature and pore size on the fractionation of fresh and reconstituted buttermilk by microfiltration, Journal of Dairy Science, 87, 267, 10.3168/jds.S0022-0302(04)73165-3 Morin, 2006, A comparative study of the fractionation of regular buttermilk and whey buttermilk by microfiltration, Journal of Food Engineering, 77, 521, 10.1016/j.jfoodeng.2005.06.065 Nakato, 2015, Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells, Journal of Lipid Research, 56, 1880, 10.1194/jlr.M058164 Nilsson, 1968, Metabolism of sphingomyelin in the intestinal tract of the rat, Biochimica et Biophysica Acta, 164, 575, 10.1016/0005-2760(68)90187-2 Oshida, 2003, Effects of dietary sphingomyelin on central nervous system myelination in developing rats, Paediatric Research, 53, 589, 10.1203/01.PDR.0000054654.73826.AC Parodi, 2003, Anti-cancer agents in milk fat, The Australian Journal of Dairy Technology, 58, 114 Roesch, 2004, Emulsifying properties of fractions prepared from commercial buttermilk by microfiltration, Journal of Dairy Science, 87, 4080, 10.3168/jds.S0022-0302(04)73550-X Rombaut, 2007, Filtration of milk fat globule membrane fragments from acid buttermilk cheese whey, Journal of Dairy Science, 89, 1915, 10.3168/jds.S0022-0302(06)72259-7 Rombaut, 2007, Phospho- and sphingolipid content of selected dairy products as determined by HPLC coupled to an evaporative light scattering detector (HPLC–ELSD), Journal of Food Composition and Analysis, 20, 308, 10.1016/j.jfca.2006.01.010 Rombaut, 2005, Analysis of phospho- and sphingolipids in dairy products by a new HPLC method, Journal of Dairy Science, 88, 482, 10.3168/jds.S0022-0302(05)72710-7 Rombaut, 2006, Phospho- and sphingolipid distribution during processing of milk, butter and whey, International Journal of Food Science and Technology, 41, 435, 10.1111/j.1365-2621.2005.01091.x Sachdeva, 1997, Recovery of phospholipids from buttermilk using membrane processing, Kieler Milchwirtschaftliche Forschungsberichte, 49, 47 Sánchez-Juanes, 2009, Distribution and fatty acid content of phospholipids from bovine milk and bovine milk fat globule membranes, International Dairy Journal, 19, 273, 10.1016/j.idairyj.2008.11.006 Schwarz, 1998, Inhibition of sphingolipid synthesis, but not degradation, alters the rate of dendrite growth in cultured hippocampal neurons, Developmental Brain Research, 108, 125, 10.1016/S0165-3806(98)00041-8 Singh, 2006, The milk fat globule membrane – A biophysical system for food applications, Current Opinions in Colloids and Interface Science, 11, 154, 10.1016/j.cocis.2005.11.002 Singh, 1990, Effects of preheat treatments and buttermilk addition on the seasonal variations in the heat stability of recombined evaporated milk and reconstituted concentrated milk, Australian Journal of Dairy Technology, 45, 10 Sodini, 2006, Compositional and functional properties of buttermilk: A comparison between sweet, sour, and whey buttermilk, Journal of Dairy Science, 89, 525, 10.3168/jds.S0022-0302(06)72115-4 Spence, 2009, Phospholipid enrichment in sweet and whey cream buttermilk powders using supercritical fluid extraction, Journal of Dairy Science, 92, 2373, 10.3168/jds.2008-1534 Spitsberg, 2005, Invited review: Bovine milk fat globule membrane as a potential nutraceutical, Journal of Dairy Science, 88, 2289, 10.3168/jds.S0022-0302(05)72906-4 Surel, 1995, Ability of ceramic membranes to reject lipids of dairy products, Australian Journal of Dairy Technology, 50, 36 Timby, 2014, Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: A randomized controlled trial, American Journal of Clinical Nutrition, 99, 860, 10.3945/ajcn.113.064295 Timby, 2017, Oral microbiota in infants fed a formula supplemented with bovine milk fat globule membranes – A randomized controlled trial, PLoS ONE, 10.1371/journal.pone.0169831 Vanderghem, 2011, Study of the susceptibility of the bovine milk fat globule membrane proteins to enzymatic hydrolysis and organization of some of the proteins, International Dairy Journal, 21, 312, 10.1016/j.idairyj.2010.12.006