Nghiên cứu bằng quang phổ ESR về các phân tử 1,10-phenanthrocyanines hoạt tính sinh học chứa điện tử d (Kính keo mềm)

Applied Magnetic Resonance - Tập 54 - Trang 1015-1051 - 2023
Viktor N. Demidov1, Stanislav M. Sukharzhevsky2, Tatiana B. Pakhomova3, Alexandra G. Ivanova1, Sofia V. Paston4, Evgenia V. Bogomolova5
1Laboratory of Inorganic Synthesis, I.V. Grebenshchikov Institute of Silicate Chemistry of the Russian Academy of Sciences, Saint Petersburg, Russia
2Resource Center “magnetic resonance methods of investigation”, St. Petersburg State University, Peterhof, Russia
3Department of Inorganic Chemistry, St. Petersburg State Technological Institute (Technical University), Saint Petersburg, Russia
4Department of Molecular Biophysics and Polymer Physics, St. Petersburg State University, Peterhof, Russia
5Laboratory of Systematics and Geography of Fungi, V.L. Komarov Botanical Institute of the Russian Academy of Sciences, Saint Petersburg, Russia

Tóm tắt

Các phân tử 1,10-phenanthrocyanines của các yếu tố d đã được nghiên cứu bằng quang phổ ESR, cả trong trạng thái rắn (thủy tinh) và trong dung dịch. Đây là các hợp chất phối hợp thuộc một lớp cấu trúc mới của apocyanines: các phức cation nhị phân chromophore [M2+Ln(µ-PC)]2Xm (M2+ = Zn2+, Cd2+, Co2+, Pd2+ và Pt2+; L = 1,10-phenanthroline, 2,9-Me2-1,10-phenanthroline, pyridine; X = AcO−, Cl−) với các ligand 1,10-phenanthrocyanine cầu nối giàu electron µ-PC. Chúng được trình bày như là các kính keo mềm có khả năng hoạt động như các tác nhân ức chế sự phát triển của tế bào tumor, thuốc diệt nấm và các hợp chất phức DNA. Nghiên cứu chúng bằng quang phổ ESR cho thấy rằng một trong những cơ chế có thể cho sự hình thành trung tâm spin là các quá trình chuyển tiếp S0 → Tlow, được chỉ hướng nhiệt.

Từ khóa

#quang phổ ESR #1 #10-phenanthrocyanines #hợp chất phối hợp #cation nhị phân #kính keo mềm #hoạt tính sinh học #ức chế sự phát triển tế bào #thuốc diệt nấm #phức DNA

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