Investigation and validation of intersite fMRI studies using the same imaging hardware

Journal of Magnetic Resonance Imaging - Tập 28 Số 1 - Trang 21-28 - 2008
Bradley P. Sutton1,2, Joshua Oon Soo Goh1,3,4, Andrew Hebrank1,5, Robert C. Welsh6, Michael J. Thorpy3, Denise C. Park1,5,4
1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois
2Bioengineering Department, University of Illinois at Urbana-Champaign, Urbana, Illinois
3Cognitive Neuroscience Laboratory, Duke-NUS Graduate Medical School, Singapore
4Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, Illinois
5Center for Brain Health, University of Texas at Dallas, Dallas, Texas
6Radiology, University of Michigan, Ann Arbor, Michigan

Tóm tắt

AbstractPurposeTo provide a between‐site comparison of functional MRI (fMRI) signal reproducibility in two laboratories equipped with identical imaging hardware and software. Many studies have looked at within‐subject reliability and more recent efforts have begun to calibrate responses across sites, magnetic field strengths, and software. By comparing identical imaging hardware and software, we provide a benchmark for future multisite comparisons.Materials and MethodsWe evaluated system compatibility based on noise and stability properties of phantom scans and contrast estimates from repeated runs of a blocked motor and visual task on the same four subjects at both sites.ResultsAnalysis of variance (ANOVA) and region of interest (ROI) analysis confirmed that site did not play a significant role in explaining variance in our large fMRI dataset. Effect size analysis shows that between‐subject differences account for nearly 10 times more variance than site effects.ConclusionWe show that quantitative comparisons of contrast estimates derived from cognitive experiments can reliably be compared across two sites. This allows us to establish an effective platform for comparing group differences between two sites using fMRI when group effects are potentially confounded with site, as in the study of neurocultural differences between countries or multicenter clinical trials. J. Magn. Reson. Imaging 2008;28:21–28. © 2008 Wiley‐Liss, Inc.

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Journal of Magnetic Resonance Imaging

Tập 28 Số 1

21-28

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