Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma

International Journal of Urology - Tập 11 Số 11 - Trang 948-953 - 2004
Tetsuya Imao1, Masayuki Egawa1, Hiroshi Takashima1, Kiyoshi Koshida1, Mikio Namiki1
1Department of Urology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan

Tóm tắt

AbstractBackground: Although a correlation between microvessel density (MVD) and tumor aggressiveness has been established for several malignancies, the data for renal cell carcinoma (RCC) is conflicting. In order to clarify the significance of MVD, we investigated the relationships between MVD and tumor stage, grade, size, occurrence of metastasis and patient survival.Methods: Tumor specimens from 70 patients with primary renal cell carcinoma were examined by immunohistochemical staining for CD34.Results: There was a tendency for MVD to decrease from G1 to G3 tumors or from stage T1 to T3 tumors, although this was not statistically significant. However, the MVD for 56 non‐metastatic and 14 metastatic tumors were significantly different (P = 0.005) at 109 ± 67 and 58 ± 35 per ×400 field (mean ± SD), respectively. Microvessel density for 36 large and 34 small tumors was also significantly different (P < 0.0001) at 48 ± 22 and 142 ± 54 per ×400 field, respectively. The survival rate of patients with small, low grade and hypervascular tumors was significantly higher than that of patients with large (P = 0.0015), high grade (P = 0.05) or low MVD (P = 0.039) tumors. Cox proportional hazards regression analysis showed that tumor grade and size emerged as independent prognostic factors.Conclusion: High MVD in RCC was inversely associated with tumor aggressiveness, but MVD was not the independent prognostic factor.

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Tài liệu tham khảo

10.1016/0046-8177(92)90344-3

Graham CH, 1994, Extent of vascularization as a prognostic indicator in thin (<0.76 mm) malignant melanomas, Am. J. Pathol., 145, 510

Weidner N, 1993, Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma, Am. J. Pathol., 143, 401

10.1093/jnci/87.21.1603

Tanigawa N, 1997, Tumor angiogenesis and mode of metastasis in patients with colorectal cancer, Cancer Res., 57, 1043

Tanigawa N, 1996, Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinomas, Cancer Res, 56, 2671

10.1002/(SICI)1097-0142(19971215)80:12<2257::AID-CNCR6>3.0.CO;2-R

10.1016/S0022-5347(01)65028-6

Takahashi A, 1994, Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis, Cancer Res., 54, 4233

10.1111/j.1442-2042.1995.tb00445.x

10.1007/s004280050458

10.1016/S0090-4295(99)80153-8

10.1007/s002400000154

10.1016/S0002-9440(10)64016-3

10.1046/j.1464-410X.1997.00374.x

10.1053/hupa.2001.28957

Sabo E, 2001, Microscopic analysis and significance of vascular architectural complexity in renal cell carcinoma, Clin. Cancer Res., 7, 533

10.1046/j.1464-410X.1996.08544.x

10.1007/s004280100464

10.1177/39.6.1709656

10.1002/cncr.21979

CoxDR OakesD.Analysis of survival data.Chapman and Hall New York 1990.

10.1097/00000658-197203000-00014

10.1016/0090-4295(86)90412-7

10.1002/(SICI)1096-9896(199802)184:2<119::AID-PATH17>3.0.CO;2-D

Tanigawa N, 1996, Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinoma, Cancer Res., 56, 2671

10.1182/blood.V75.12.2417.2417

Schlingemann RO, 1990, Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma, Lab. Invest., 62, 690

10.1038/bjc.1997.506

Tnigawa N, 1997, Quantitation of sinusoid‐like vessels in hepatocellular carcinoma: Its clinical and prognostic significance, Hepatology, 26, 1216

10.1007/s004320050147

10.1016/0304-419X(89)90004-8

10.1083/jcb.95.3.974

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International Journal of Urology

Tập 11 Số 11

948-953

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