Inverse agonist activity of agouti and agouti-related protein

Peptides - Tập 24 - Trang 603-609 - 2003
Biao-Xin Chai1, Richard R. Neubig2, Glenn L. Millhauser3, Darren A. Thompson3, Pilgrim J. Jackson3, Gregory S. Barsh4, Chris J. Dickinson5, Ji-Yao Li1, Yu-Mei Lai1, Ira Gantz1
1Department of Surgery, University of Michigan Medical Center, 6504 MSRB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0682, USA
2Department of Pharmacology and Internal Medicine, University of Michigan Medical Center, 6504 MSRB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA
3Departments of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
4Departments of Pediatrics and Genetics and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
5Department of Pediatrics, University of Michigan Medical Center, 6504 MSRB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA

Tài liệu tham khảo

Argiolas, 2000, ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors, Brain Res. Bull., 51, 425, 10.1016/S0361-9230(99)00270-1 Barovsky, 1985, Forskolin potentiation of cholera toxin-stimulated cyclic AMP accumulation in intact C6-2B cells. Evidence for enhanced Gs-C coupling, Mol. Pharmacol., 28, 502 Blanchard, 1995, Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line, Biochemistry, 35, 10406, 10.1021/bi00033a012 Bourne HR, Roberts JM. Drug receptors and pharmacodynamics. In: Katzung BG, editor. Basic and clinical pharmacology. Connecticut: Appleton and Lange; 1992. p. 10–34. Daeffler, 1999, Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors, Br. J. Pharmacol., 126, 1246, 10.1038/sj.bjp.0702407 DeBlasi, 1998, Calculating receptor number from binding experiments using same compound as radioligand and competitor, Trends Pharmacol. Sci., 10, 227, 10.1016/0165-6147(89)90266-6 Dinulescu, 2000, Agouti and agouti-related protein: analogies and contrasts, J. Biol. Chem., 275, 6695, 10.1074/jbc.275.10.6695 Fong, 1997, ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors, Biochem. Biophys. Res. Commun., 237, 629, 10.1006/bbrc.1997.7200 Gunn, 1999, The mouse mahogany locus encodes a transmembrane form of human attractin, Nature, 398, 152, 10.1038/18217 Haskell-Luevano, 2001, Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor, Regul. Pept., 99, 1, 10.1016/S0167-0115(01)00234-8 He, 2001, A biochemical function for attractin in agouti-induced pigmentation and obesity, Nat. Genet., 27, 40, 10.1038/83741 Jackson, 2002, Design, pharmacology and NMR structure of a minimized cystine knot with agouti-related protein activity, Biochemistry, 41, 7565, 10.1021/bi012000x Kask, 1999, Long-term administration of MC4 receptor antagonist HS014 causes hyperphagia and obesity in rats, Neuroreport, 10, 707, 10.1097/00001756-199903170-00009 Kenakin, 2001, Inverse, protean, and ligand-selective agonism: matters of receptor conformation, FASEB J., 15, 598, 10.1096/fj.00-0438rev Kiefer, 1998, Melanocortin receptor binding determinants in the agouti protein, Biochemistry, 37, 991, 10.1021/bi971913h Leff, 1995, The two-state model of receptor activation, Trends Pharmacol. Sci., 16, 89, 10.1016/S0165-6147(00)88989-0 Lu, 1994, Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor, Nature, 371, 799, 10.1038/371799a0 McNulty, 2001, High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87–132) of the agouti-related protein, Biochemistry, 40, 15520, 10.1021/bi0117192 Norton, 1998, The cystine knot structure of ion channel toxins and related polypeptides, Toxicon, 36, 1573, 10.1016/S0041-0101(98)00149-4 Ollmann, 1997, Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein, Science, 278, 135, 10.1126/science.278.5335.135 Reizes, 2001, Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3, Cell, 106, 105, 10.1016/S0092-8674(01)00415-9 Schioth, 1999, Further pharmacological characterization of the selective melanocortin 4 receptor antagonist HS014: comparison with SHU9119, Neuropeptides, 33, 191, 10.1054/npep.1999.0760 Shutter, 1997, Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated on obese and diabetic mutant mice, Genes Dev., 11, 593, 10.1101/gad.11.5.593 Siegrist, 1997, Interactions of α-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti, J. Recept. Signal Transduct. Res., 17, 75, 10.3109/10799899709036595 Tota, 1999, Molecular interaction of agouti protein and agouti-related protein with human melanocortin receptors, Biochemistry, 38, 897, 10.1021/bi9815602 Wouter, 2001, AgRP (83–132) acts as an inverse agonist on the human melanocortin-4 receptor, Mol. Endocrinol., 15, 164, 10.1210/me.15.1.164 Yang, 2001, Functional properties of a chemically synthesized agouti signaling protein variant and binding characteristics of its cognate radioligand, Am. J. Physiol., 281, R1877 Yang, 1997, Effects of recombinant agouti-signaling protein on melanocortin action, Mol. Endocrinol., 11, 274, 10.1210/me.11.3.274 Yang, 1999, Characterization of agouti-related protein binding to melanocortin receptors, Mol. Endocrinol., 13, 148, 10.1210/me.13.1.148