Invadopodia: At the cutting edge of tumour invasion

Kleihues, 1993, The new WHO classification of brain tumours, Brain Pathol, 3, 255, 10.1111/j.1750-3639.1993.tb00752.x

Stupp, 2005, Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma, N Engl J Med, 352, 987, 10.1056/NEJMoa043330

Stylli, 2004, Photodynamic therapy of brain tumours: evaluation of porphyrin uptake versus clinical outcome, J Clin Neurosci, 11, 584, 10.1016/j.jocn.2004.02.001

Stylli, 2005, Photodynamic therapy of high grade glioma-long term survival, J Clin Neurosci, 12, 389, 10.1016/j.jocn.2005.01.006

Stylli, 2006, Photodynamic therapy of cerebral glioma - a review. Part II - clinical studies, J Clin Neurosci, 13, 709, 10.1016/j.jocn.2005.11.012

Giese, 1996, Glioma invasion in the central nervous system, Neurosurgery, 39, 235, 10.1097/00006123-199608000-00001

Giese, 2003, Cost of migration: invasion of malignant gliomas and implications for treatment, J Clin Oncol, 21, 1624, 10.1200/JCO.2003.05.063

Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, 444, 756, 10.1038/nature05236

Rao, 2003, Molecular mechanisms of glioma invasiveness: the role of proteases, Nat Rev Cancer, 3, 489, 10.1038/nrc1121

Nakada, 2007, Molecular targets of glioma invasion, Cell Mol Life Sci, 64, 458, 10.1007/s00018-007-6342-5

Demuth, 2004, Molecular mechanisms of glioma cell migration and invasion, J Neurooncol, 70, 217, 10.1007/s11060-004-2751-6

Bello, 2004, Angiogenesis and invasion in gliomas, Cancer Treat Res, 117, 263, 10.1007/978-1-4419-8871-3_16

Bellail, 2004, Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion, Int J Biochem Cell Biol, 36, 1046, 10.1016/j.biocel.2004.01.013

D’Abaco, 2007, Integrins: molecular determinants of glioma invasion, J Clin Neurosci, 14, 1041, 10.1016/j.jocn.2007.06.019

Morokoff, 2004, Targeted therapy for malignant gliomas, J Clin Neurosci, 11, 807, 10.1016/j.jocn.2004.03.004

D’Abaco GM, Kaye AH. Integrin-linked kinase: A potential therapeutic target for the treatmnet of Glioma. J Clin Neurosci (in Press). 2008.

Buccione, 2004, Foot and mouth: podosomes, invadopodia and circular dorsal ruffles, Nat Rev Mol Cell Biol, 5, 647, 10.1038/nrm1436

Linder, 2007, The matrix corroded: podosomes and invadopodia in extracellular matrix degradation, Trends Cell Biol, 17, 107, 10.1016/j.tcb.2007.01.002

Coopman, 1998, Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity, Clin Cancer Res, 4, 507

Bowden, 1999, An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation, Oncogene, 18, 4440, 10.1038/sj.onc.1202827

Yamaguchi, 2005, Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin, J Cell Biol, 168, 441, 10.1083/jcb.200407076

Tague, 2004, ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway, Proc Natl Acad Sci USA, 101, 9671, 10.1073/pnas.0403531101

Hashimoto, 2004, Requirement for Arf6 in breast cancer invasive activities, Proc Natl Acad Sci USA, 101, 6647, 10.1073/pnas.0401753101

Seals, 2005, The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells, Cancer Cell, 7, 155, 10.1016/j.ccr.2005.01.006

Artym, 2006, Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function, Cancer Res, 66, 3034, 10.1158/0008-5472.CAN-05-2177

Onodera, 2005, Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities, EMBO J, 24, 963, 10.1038/sj.emboj.7600588

Chen, 1989, Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells, J Exp Zool, 251, 167, 10.1002/jez.1402510206

Kelly, 1998, Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases, Clin Exp Metastasis, 16, 501, 10.1023/A:1006538200886

Chen, 1984, Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites, J Cell Biol, 98, 1546, 10.1083/jcb.98.4.1546

Yamaguchi, 2006, Invadopodia and podosomes in tumor invasion, Eur J Cell Biol, 85, 213, 10.1016/j.ejcb.2005.10.004

Bowden, 2006, Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells, Exp Cell Res, 10.1016/j.yexcr.2005.12.012

Tarone, 1985, Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes, Exp Cell Res, 159, 141, 10.1016/S0014-4827(85)80044-6

Chen, 1985, Local degradation of fibronectin at sites of expression of the transforming gene product pp60src, Nature, 316, 156, 10.1038/316156a0

Mueller, 1991, Cellular invasion into matrix beads: localization of beta 1 integrins and fibronectin to the invadopodia, J Cell Sci, 99, 213, 10.1242/jcs.99.2.213

Baldassarre, 2003, Dynamin participates in focal extracellular matrix degradation by invasive cells, Mol Biol Cell, 14, 1074, 10.1091/mbc.E02-05-0308

Lorenz, 2004, Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells, Curr Biol, 14, 697, 10.1016/j.cub.2004.04.008

Clark, 2007, Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia, Cancer Res, 67, 4227, 10.1158/0008-5472.CAN-06-3928

Mizutani, 2002, Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts, Cancer Res, 62, 669

Mueller, 1992, Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells, J Cell Biol, 119, 1309, 10.1083/jcb.119.5.1309

Mueller, 1999, A novel protease-docking function of integrin at invadopodia, J Biol Chem, 274, 24947, 10.1074/jbc.274.35.24947

Chuang, 2004, Role of synaptojanin 2 in glioma cell migration and invasion, Cancer Res, 64, 8271, 10.1158/0008-5472.CAN-04-2097

Angers-Loustau, 2004, SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions, Mol Cancer Res, 2, 595, 10.1158/1541-7786.595.2.11

Gimona, 2008, Assembly and biological role of podosomes and invadopodia, Curr Opin Cell Biol, 10.1016/j.ceb.2008.01.005

Co, 2007, Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains, Cell, 128, 901, 10.1016/j.cell.2006.12.049

Wyckoff, 2004, A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors, Cancer Res, 64, 7022, 10.1158/0008-5472.CAN-04-1449

Condeelis, 2006, Macrophages: obligate partners for tumor cell migration, invasion, and metastasis, Cell, 124, 263, 10.1016/j.cell.2006.01.007

Linder, 2003, Podosomes: adhesion hot-spots of invasive cells, Trends Cell Biol, 13, 376, 10.1016/S0962-8924(03)00128-4

Hynes, 2002, Integrins: Bidirectional, allosteric signaling machines, Cell, 110, 673, 10.1016/S0092-8674(02)00971-6

Parsons, 2000, Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement, Oncogene, 19, 5606, 10.1038/sj.onc.1203877

Nakahara, 1996, A mechanism for regulation of melanoma invasion. Ligation of alpha6beta1 integrin by laminin G peptides, J Biol Chem, 271, 27221, 10.1074/jbc.271.44.27221

Nakahara, 1998, Activation of beta 1 integrin signaling stimulates tyrosine phosphorylation of p190(RhoGAP) and membrane-protrusive activities at invadopodia, J Biol Chem, 273, 9, 10.1074/jbc.273.1.9

Gingras, 1995, Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue, J Neuroimmunol, 57, 143, 10.1016/0165-5728(94)00178-Q

Mahesparan, 2003, Expression of extracellular matrix components in a highly infiltrative in vivo glioma model, Acta Neuropathol, 105, 49, 10.1007/s00401-002-0610-0

Rooprai, 1999, The role of integrin receptors in aspects of glioma invasion in vitro, Int J Dev Neurosci, 17, 613, 10.1016/S0736-5748(99)00051-9

Paulus, 1996, Diffuse brain invasion of glioma cells requires beta 1 integrins, Lab Invest, 75, 819

Gladson, 1995, Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors, J Cell Sci, 108, 947, 10.1242/jcs.108.3.947

Pfaff, 2001, Podosomes in osteoclast-like cells: structural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk2) and integrin alphaVbeta3, J Cell Sci, 114, 2775, 10.1242/jcs.114.15.2775

Deryugina, 2001, MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells, Exp Cell Res, 263, 209, 10.1006/excr.2000.5118

Deryugina, 2002, Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase, J Biol Chem, 277, 9749, 10.1074/jbc.M110269200

Nabors, 2007, Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma, J Clin Oncol, 25, 1651, 10.1200/JCO.2006.06.6514

Poincloux, 2007, Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells, J Cell Physiol, 213, 212, 10.1002/jcp.21112

Webb, 2006, Cortactin regulates podosome formation: roles of the protein interaction domains, Exp Cell Res, 312, 760, 10.1016/j.yexcr.2005.11.032

Park, 2005, Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation, EMBO J, 24, 1557, 10.1038/sj.emboj.7600586

Bharti, 2007, Src-dependent phosphorylation of ASAP1 regulates podosomes, Mol Cell Biol, 27, 8271, 10.1128/MCB.01781-06

Badowski, 2007, Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization, Mol Biol Cell, 10.1091/mbc.E06-01-0088

Abram, 2003, The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells, J Biol Chem, 278, 16844, 10.1074/jbc.M300267200

Friedl, 2003, Tumour-cell invasion and migration: diversity and escape mechanisms, Nat Rev Cancer, 3, 362, 10.1038/nrc1075

Ayala, 2008, Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation, J Cell Sci, 121, 369, 10.1242/jcs.008037

Daly, 2004, Cortactin signalling and dynamic actin networks, Biochem J, 382, 13, 10.1042/BJ20040737

Rothschild, 2006, Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification, Cancer Res, 66, 8017, 10.1158/0008-5472.CAN-05-4490

Bryce, 2005, Cortactin promotes cell motility by enhancing lamellipodial persistence, Curr Biol, 15, 1276, 10.1016/j.cub.2005.06.043

Patel, 1998, Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro, Oncogene, 16, 3227, 10.1038/sj.onc.1201850

Weaver, 2001, Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation, Curr Biol, 11, 370, 10.1016/S0960-9822(01)00098-7

Clark ES, Weaver AM. A new role for cortactin in invadopodia: Regulation of protease secretion. Eur J Cell Biol 2008; (in press).

Nam, 2007, CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery, EMBO J, 26, 647, 10.1038/sj.emboj.7601534

Soubeyran, 2002, Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors, Nature, 416, 183, 10.1038/416183a

Petrelli, 2002, The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met, Nature, 416, 187, 10.1038/416187a

Lock, 1998, A new method for isolating tyrosine kinase substrates used to identify Fish, an SH3 and PX domain-containing protein, and Src substrate, EMBO J, 17, 4346, 10.1093/emboj/17.15.4346

Zhou, 2006, Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells, Am J Physiol Cell Physiol, 290, C463, 10.1152/ajpcell.00350.2005

Brabek, 2004, CAS promotes invasiveness of Src-transformed cells, Oncogene, 23, 7406, 10.1038/sj.onc.1207965

Tehrani, 2007, Src phosphorylation of cortactin enhances actin assembly, Proc Natl Acad Sci USA, 104, 11933, 10.1073/pnas.0701077104

Ivankovic-Dikic, 2000, Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins, Nat Cell Biol, 2, 574, 10.1038/35023515

Maher, 2001, Malignant glioma: genetics and biology of a grave matter, Genes Dev, 15, 1311, 10.1101/gad.891601

Etienne-Manneville, 2002, Rho GTPases in cell biology, Nature, 420, 629, 10.1038/nature01148

Nobes, 1999, Rho GTPases control polarity, protrusion, and adhesion during cell movement, J Cell Biol, 144, 1235, 10.1083/jcb.144.6.1235

Berdeaux, 2004, Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function, J Cell Biol, 166, 317, 10.1083/jcb.200312168

Linder, 1999, Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages, Proc Natl Acad Sci USA, 96, 9648, 10.1073/pnas.96.17.9648

Nakahara, 2003, Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells, Genes Cells, 8, 1019, 10.1111/j.1365-2443.2003.00695.x

Rohatgi, 2001, Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway, J Biol Chem, 276, 26448, 10.1074/jbc.M103856200

Wildenberg, 2006, p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho, Cell, 127, 1027, 10.1016/j.cell.2006.09.046

Donaldson, 2003, Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane, J BiolChem, 278, 41573

Palacios, 2001, An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration, EMBO J, 20, 4973, 10.1093/emboj/20.17.4973

Santy, 2001, Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D, J Cell Biol, 154, 599, 10.1083/jcb.200104019

Tushir, 2007, ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development, EMBO J, 26, 1806, 10.1038/sj.emboj.7601644

Ochoa, 2000, A functional link between dynamin and the actin cytoskeleton at podosomes, J Cell Biol, 150, 377, 10.1083/jcb.150.2.377

Schafer, 2002, Dynamin2 and cortactin regulate actin assembly and filament organization, Curr Biol, 12, 1852, 10.1016/S0960-9822(02)01228-9

Zhu, 2007, Receptor-mediated endocytosis involves tyrosine phosphorylation of cortactin, J Biol Chem, 282, 16086, 10.1074/jbc.M701997200

Cao, 2005, Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport, Nat Cell Biol, 7, 483, 10.1038/ncb1246

Wu, 2005, FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation, Dev Cell, 9, 185, 10.1016/j.devcel.2005.06.006

Nagase, 1999, Matrix metalloproteinases, J Biol Chem, 274, 21491, 10.1074/jbc.274.31.21491

Chen, 1999, Specialized surface protrusions of invasive cells, invadopodia and lamellipodia, have differential MT1-MMP, MMP-2, and TIMP-2 localization, Ann NY Acad Sci, 878, 361, 10.1111/j.1749-6632.1999.tb07695.x

Nakahara, 1997, Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion, Proc Natl Acad Sci USA, 94, 7959, 10.1073/pnas.94.15.7959

Monsky, 1994, A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells, Cancer Res, 54, 5702

Monsky, 1993, Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia, Cancer Res, 53, 3159

VanMeter, 2001, The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis, J Neurooncol, 53, 213, 10.1023/A:1012280925031

Yamamoto, 1996, Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro, Cancer Res, 56, 384

Rao, 1996, Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas, Clin Exp Metastasis, 14, 12, 10.1007/BF00157681

Forsyth, 1999, Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas, Br J Cancer, 79, 1828, 10.1038/sj.bjc.6690291

Nakada, 2001, Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma, J Neurosurg, 94, 464, 10.3171/jns.2001.94.3.0464

Uhm, 1996, Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C, Clin ExpMetastasis, 14, 421, 10.1007/BF00128958

Lampert, 1998, Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors, Am J Pathol, 153, 429, 10.1016/S0002-9440(10)65586-1

Nakada, 1999, Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors, Am J Pathol, 154, 417, 10.1016/S0002-9440(10)65288-1

Kondraganti, 2000, Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion, Cancer Res, 60, 6851

Mori, 2002, CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain, EMBO J, 21, 3949, 10.1093/emboj/cdf411

Itoh, 2004, MT1-MMP: an enzyme with multidimensional regulation, Trends Biochem Sci, 29, 285, 10.1016/j.tibs.2004.04.001

Chabadel, 2007, CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts, Mol Biol Cell, 18, 4899, 10.1091/mbc.E07-04-0378

Seals, 2003, The ADAMs family of metalloproteases: multidomain proteins with multiple functions, Genes Dev, 17, 7, 10.1101/gad.1039703

Novak, 2004, ADAM proteins in the brain, J Clin Neurosci, 11, 227, 10.1016/j.jocn.2003.10.006

Chen, 2003, Seprase complexes in cellular invasiveness, Cancer Metastasis Rev, 22, 259, 10.1023/A:1023055600919

Ghersi, 2006, The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices, Cancer Res, 66, 4652, 10.1158/0008-5472.CAN-05-1245

Liotta, 1980, Metastatic potential correlates with enzymatic degradation of basement membrane collagen, Nature, 284, 67, 10.1038/284067a0

Overall, 2006, Tumour microenvironment-opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy, Nat Rev Cancer, 6, 227, 10.1038/nrc1821

Overall, 2006, Towards third generation matrix metalloproteinase inhibitors for cancer therapy, Br J Cancer, 94, 941, 10.1038/sj.bjc.6603043

Summy, 2003, Src family kinases in tumor progression and metastasis, Cancer Metastasis Rev, 22, 337, 10.1023/A:1023772912750

Trevino, 2006, SRC inhibitors as potential therapeutic agents for human cancers, Mini Rev Med Chem, 6, 681, 10.2174/138955706777435724

Chen, 2006, Src tyrosine kinase as a chemotherapeutic target: is there a clinical case?, Anticancer Drugs, 17, 123, 10.1097/00001813-200602000-00002

Lee, 2006, Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines, Cancer Cell, 9, 391, 10.1016/j.ccr.2006.03.030