Introduction

Folkman J: Tumor angiogenesis: therapeutic implications. New England Journal of Medicine 285: 1182–1186, 1971 Folkman J: Anti-angiogenesis: new concept for therapy of solid tumors. Annals of Surgery 175: 409–416, 1972. Noden DM: Embryonic origins and assembly of blood vessels. Am Rev Respir Dis 140: 1097–1103, 1989 Rastinejad F, Polverini PJ, Bouck NP: Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell 56: 345–355, 1989 Grant DS, Tashiro K-I, Sequi-Real B, Yamada Y, Martin GB, Kleinman HK: Two differential laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro. Cell 58: 933–943, 1989. Thomas KA, DiSalvo J, Ortega S, Conn G, Schaeffer MT, Gimenez-Gallego G, Soderman D, Melin T, Busch B, Capparella J, Menke J, Kelly L, Linemeyer D. In:Growth, Factors and Their Receptors: Genetic Control and Rational Application. Alan R. Liss, Inc. 1989, pp 253–258 Folkman J: The angiogenic activity of FGF and its possible clinical applications. In: Vicki R, Sara, Kerstin Hall, Hans Low (ed)Growth Factors, From Genes to Clinical Application. Karolinska Institute, Nobel Conference Series. Raven Press, New York, 1990 Casscells W, Spier E, Sasse J, Klagsbrun M, Allen P, Lee M, Calvo B, Chibi M, Haggroth L, Folkman J, Epstein SE: Jour Clincal Investigation. 85: 433–441, 1990 Folkman J: How is blood vessel growth regulated in normal and neoplastic tissue? Cancer Research 46: 467–473, 1986 D'Amore P: Modes of FGF release in vivo and in vitro. This issue Denekamp J: Vascular attack as a therapeutic strategy for cancer. This issue Gullino PM, Ziche M, Allesandri G: Gangliosides, copper ions and angiogenic activity of adult tissues. This issue Jain RK: Vascular and interstitial barriers to delivery of therapeutic agents in tumors. This issue Pauli BU, Augustin-Voss HG, El-Sabban ME, Johnson RC, Hammer DA: Organ-preference of metastasis: The role of endothelial cell adhesion molecules. This issue Vlodavsky I, Korner G, Ishai-Michaeli R, Bashkin P, Bar-Shavit R, Fuks Z: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. This issue Yayon A, Klagsbrun M: Autocrine regulation of cell growth and transformation by basic fibroblast growth factor. This issue Folkman J: What is the evidence that tumors are angiogenesis-dependent? Jour Natl Cancer Inst 82 (1): 4–6, 1990 Folkman J: Angiogenesis. 24: 583–596. In: Verstraete M, Vermylen J, Lijnan R, Arnout J (ed):Thrombosis and Haemostasis. Leuven University Press, Leuven, 1987 Srivastava A, Laidler P, Davies R, Horgan K: The prognostic significance of tumor vascularity in intermediate thickness (0.76–4.0 mm thick) skin melanoma. Amer Jour Pathol 133: 419–423, 1988 Folkman J, Watson K, Ingber D, Hanhan D: Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339: 58–61, 1989 Ziche M, Gullino P: Angiogenesis and neoplastic progression in vitro. Jour Natl Cancer Inst 69: 483–487, 1982 Zajchowski DA, Band V, Trask DK, Kling D, Connolly, Sager R: Suppression of tumor-forming ability and related traits in MCF-7 human breast cancer cells by fusion with immortal mammary epithelial cells. Proc Natl Acad Sci 87: 2314–2318, 1990 Folkman J, Klagsbrun M: Angiogenic factors. Science 235: 442–447, 1987 Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for endothelial cells. Biochem Biophys Res Commun 161: 851–855, 1989 Gospodarowicz D, Abraham JA, Schilling J: Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86: 7311–7315, 1989 Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly D: Vascular permeability factor, an endothelial mitogen related to PDGF. Science 246: 1309–1313, 1989 Kull FCJr, Brent DA, Parikh I, Cuatrecasas P: Chemical identification of a tumor-derived angiogenic factor. Science 236: 843–845, 1987 Dobson DE, Kambe A, Block E, Dion T, Lu H, Castellott JJJr, Spiegelman BM: 1 butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell 61: 223–230, 1990 Herlyn M, Clark WH, Rodeck U, Mancianti ML, Jambrosic J, Koprowski H: Biology of tumor progression in human melanoma. Laboratory Investigation 56 (5): 461–474, 1987 Liebovich SJ, Polverini PJ, Shephard HM, Wiseman DM, Shively N, Nuseir N: Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature 329: 630–632, 1987 Folkman J, Klagsbrun M, Sasse J, Wadzinski M, Ingber D, Vlodavsky I: A heparin-binding angiogenic protein-basic fibroblast growth factor-is stored within basement membrane. American Journal of Pathology 130 (2): 393–400, 1988 Liotta L, Kleinerman J, Saidel G: Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation. Cancer Research 34: 997–1004, 1974 Zetter BR: The cellular basis of site-specific tumor metastasis. England Journal of Medicine 322: 605–612, 1990 Weidner N, Semple J, Folkman J: Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. Submitted for publication 1990 Folkman J: Anti-angiogenesis. In: Hellman S (ed), DeVita VT, Rosenberg SA:Biologic Therapy of Cancer: Principles and Practice. In press 1990