Introduction of a 6-cyano group in 14-oxygenated N-methylmorphinans influences in vitro and in vivo pharmacological activities

BMC Pharmacology - Tập 11 - Trang 1-2 - 2011
Valeria Follia1, Mario D Aceto2, Louis S Harris2, Andrew Coop3, Helmut Schmidhammer1, Mariana Spetea1
1Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
2Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
3Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, USA

Tài liệu tham khảo

Schmidhammer H, Spetea M: Synthesis of 14-alkoxymorphinan derivatives and their pharmacological actions. Top Curr Chem. 2011, 299: 63-91.